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1. 发明授权

US09248240B2 Formulation delivery device 有权
标题翻译：配方输送装置
公开(公告)号：US09248240B2
公开(公告)日：2016-02-02
申请号：US12579028
申请日：2009-10-14
申请人： William J. Casey , Tyler J. Holschlag
发明人： William J. Casey , Tyler J. Holschlag
IPC分类号： A61M5/32 , A61M5/145 , A61M5/50 , A61M5/20 , A61M5/158
CPC分类号： A61M5/32 , A61M5/1452 , A61M5/3232 , A61M5/3287 , A61M5/5013 , A61M5/504 , A61M2005/1585 , A61M2005/2073 , A61M2205/8281
摘要： The present invention provides a device for injection of formulations into a patient. In one embodiment the injection is sub-cutaneous. The device is convenient for injecting viscous formulations that would otherwise clog conventional injection devices, for example formulations containing microspheres, suspensions, and other viscous substances. Generally, the device features a needle for piercing the skin, an internal chamber for holding and transmitting fluid, a plunger for applying pressure to the internal chamber, a switch for triggering withdrawal of the needle, a sheath at least partially encompassing the needle and having a flow path within the sheath, and a spring that expands when the switch is triggered, and which thereby at least partially withdraws the needle from the sheath.
摘要翻译：本发明提供了用于将制剂注射到患者体内的装置。在一个实施方案中，注射是皮下的。该装置便于注入粘性制剂，否则会阻塞常规注射装置，例如含有微球，悬浮液和其它粘性物质的制剂。通常，该装置具有用于刺穿皮肤的针头，用于保持和传送流体的内部腔室，用于向内部腔室施加压力的柱塞，用于触发抽出针头的开关，至少部分地包围针头并具有护套内的流路，以及当开关被触发时膨胀的弹簧，并且由此至少部分地将针从护套中取出。

2. 发明申请

US20100094254A1 Formulation Delivery Device 有权
标题翻译：配方输送装置
公开(公告)号：US20100094254A1
公开(公告)日：2010-04-15
申请号：US12579028
申请日：2009-10-14
申请人： William J. Casey , Tyler J. Holschlag
发明人： William J. Casey , Tyler J. Holschlag
IPC分类号： A61M5/32 , A61M5/20
CPC分类号： A61M5/32 , A61M5/1452 , A61M5/3232 , A61M5/3287 , A61M5/5013 , A61M5/504 , A61M2005/1585 , A61M2005/2073 , A61M2205/8281
摘要： The present invention provides a device for injection of formulations into a patient. In one embodiment the injection is sub-cutaneous. The device is convenient for injecting viscous formulations that would otherwise clog conventional injection devices, for example formulations containing microspheres, suspensions, and other viscous substances. Generally, the device features a needle for piercing the skin, an internal chamber for holding and transmitting fluid, a plunger for applying pressure to the internal chamber, a switch for triggering withdrawal of the needle, a sheath at least partially encompassing the needle and having a flow path within the sheath, and a spring that expands when the switch is triggered, and which thereby at least partially withdraws the needle from the sheath.
摘要翻译：本发明提供了用于将制剂注射到患者体内的装置。在一个实施方案中，注射是皮下的。该装置便于注入粘性制剂，否则会阻塞常规注射装置，例如含有微球，悬浮液和其它粘性物质的制剂。通常，该装置具有用于刺穿皮肤的针头，用于保持和传送流体的内部腔室，用于向内部腔室施加压力的柱塞，用于触发抽出针头的开关，至少部分地包围针头并具有护套内的流路，以及当开关被触发时膨胀的弹簧，并且由此至少部分地将针从护套中取出。

3. 发明申请

US20100298768A1 Pen Injection Device and Method of Using Same 失效
标题翻译：笔式注射装置及其使用方法
公开(公告)号：US20100298768A1
公开(公告)日：2010-11-25
申请号：US12669255
申请日：2008-07-16
申请人： Reynaldo B. Halili, JR. , Victor Wei-Chung Chang , Phillip A. Estepa , Tyler J. Holschlag , Philip J. Simpson , David G. Matsuura
发明人： Reynaldo B. Halili, JR. , Victor Wei-Chung Chang , Phillip A. Estepa , Tyler J. Holschlag , Philip J. Simpson , David G. Matsuura
IPC分类号： A61M5/31
CPC分类号： A61M5/24 , A61J1/201 , A61J1/2013 , A61J1/2075 , A61J1/2096 , A61M5/2448 , A61M2206/16
摘要： Pen injection devices (10) and methods of using a pen injection device are disclosed. Pen injection devices include a sterile dual transfer spike assembly (150) including a dual transfer spike defining a fluidic pathway; a first cartridge assembly (12) including a first cartridge (20) containing a first substance; a second cartridge assembly (14) including a second cartridge (30) containing a second substance; a plunger rod (50) translatable in a first direction; and a biasing mechanism (60) configured to bias the plunger rod in a second direction opposite the first direction. Methods of using a pen injection device having a first container, a second container, a plunger rod, and a biasing mechanism include activating the pen injection device, thereby creating a fluidic pathway between the first container and the second container; and translating the plunger rod at least once, thereby transferring a first substance from one container to the other container to mix with a second substance.
摘要翻译：公开了笔注射装置（10）和使用笔式注射装置的方法。笔注射装置包括无菌双转移钉组件（150），其包括限定流体通路的双转移尖峰; 第一盒组件（12），包括容纳第一物质的第一盒（20）; 第二盒组件（14），包括容纳第二物质的第二盒（30）; 可在第一方向上平移的柱塞杆（50）以及偏置机构（60），其构造成沿与第一方向相反的第二方向偏压柱塞杆。使用具有第一容器，第二容器，柱塞杆和偏置机构的笔式注射装置的方法包括启动笔式注射装置，从而在第一容器和第二容器之间形成流体通路; 并且将所述柱塞杆翻转至少一次，从而将第一物质从一个容器转移到另一容器以与第二物质混合。

4. 发明授权

US08636689B2 Pen injection device and method of using same 失效
标题翻译：笔式注射装置及其使用方法
公开(公告)号：US08636689B2
公开(公告)日：2014-01-28
申请号：US12669255
申请日：2008-07-16
申请人： Reynaldo B. Halili, Jr. , Victor Wei-Chung Chang , Phillip A. Estepa , Tyler J. Holschlag , Philip J. Simpson , David G. Matsuura
发明人： Reynaldo B. Halili, Jr. , Victor Wei-Chung Chang , Phillip A. Estepa , Tyler J. Holschlag , Philip J. Simpson , David G. Matsuura
IPC分类号： A61M37/00
CPC分类号： A61M5/24 , A61J1/201 , A61J1/2013 , A61J1/2075 , A61J1/2096 , A61M5/2448 , A61M2206/16
摘要： Pen injection devices (10) and methods of using a pen injection device are disclosed. Pen injection devices include a sterile dual transfer spike assembly (150) including a dual transfer spike defining a fluidic pathway; a first cartridge assembly (12) including a first cartridge (20) containing a first substance; a second cartridge assembly (14) including a second cartridge (30) containing a second substance; a plunger rod (50) translatable in a first direction; and a biasing mechanism (60) configured to bias the plunger rod in a second direction opposite the first direction. Methods of using a pen injection device having a first container, a second container, a plunger rod, and a biasing mechanism include activating the pen injection device, thereby creating a fluidic pathway between the first container and the second container; and translating the plunger rod at least once, thereby transferring a first substance from one container to the other container to mix with a second substance.
摘要翻译：公开了笔注射装置（10）和使用笔式注射装置的方法。笔注射装置包括无菌双转移钉组件（150），其包括限定流体通路的双转移尖峰; 第一盒组件（12），包括容纳第一物质的第一盒（20）; 第二盒组件（14），包括容纳第二物质的第二盒（30）; 可在第一方向上平移的柱塞杆（50）以及偏置机构（60），其构造成沿与第一方向相反的第二方向偏压柱塞杆。使用具有第一容器，第二容器，柱塞杆和偏置机构的笔式注射装置的方法包括启动笔式注射装置，从而在第一容器和第二容器之间形成流体通路; 并且将所述柱塞杆翻转至少一次，从而将第一物质从一个容器转移到另一容器以与第二物质混合。

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