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1. 发明授权

US5726192A Platelet aggregation inhibiting compounds 失效
标题翻译：血小板聚集抑制化合物
公开(公告)号：US5726192A
公开(公告)日：1998-03-10
申请号：US464728
申请日：1995-08-08
申请人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Brian Walter Metcalf , James Samanen , Tobias Oregon Yellin
发明人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Brian Walter Metcalf , James Samanen , Tobias Oregon Yellin
IPC分类号： A61K31/195 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K38/00 , A61P7/02 , A61P9/00 , C07D213/56 , C07D213/73 , C07D213/75 , C07D235/30 , C07D277/64 , C07D417/12 , C07K5/02 , C07K5/087 , C07K5/09 , C07K5/11 , C07D213/02
CPC分类号： C07D213/73 , C07D213/56 , C07D235/30 , C07D277/64 , C07D417/12 , C07K5/0202 , C07K5/0205 , C07K5/0812 , C07K5/0815 , C07K5/0817 , A61K38/00
摘要： This invention relates to compounds of the formula: W--Z--(CR'R.sup.10).sub.r --U--(CR'.sub.2).sub.s --V--A wherein: ##STR1## A is W is R'R"N--; Z is Het; U and V independently are absent or present as CO, CR'.sub.2, C(.dbd.CR'.sub.2), S(O).sub.r, O, NR', CR'OR', CR'(OR")CR'.sub.2, CR'.sub.2 CR'(OR"), C(O)CR'.sub.2, CR'.sub.2 C(O), CONR', NR'CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR', NR'C(S), S(O).sub.r NR', NR'S(O).sub.r, N.dbd.N, NR'NR', NR'CR'.sub.2, NR'CR'.sub.2, CR'.sub.2 O, OCR'.sub.2, .sup.c.tbd.c, CR'.dbd.CR', or CR'(NR'R")C(O); each r independently is 0 to 3; s is 0 to 2; each R' independently is H, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl, or Ar--C.sub.0-4 alkyl; each R" independently is R', --C(O)R', or --C(O)OR.sup.15 ; R.sup.10 is as H, C.sub.1-4 alkyl, or --NR'R'; each R.sup.15 independently is C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl, or AR--C.sub.0-4 alkyl; R.sup.2 is present once or twice as C.sub.1-4 alkyl, J--CO.sub.2 R', CONR', SR', NR'R", C.sub.1-4 alkoxy, hydroxy, CN, CF.sub.3, halo, or ##STR2## with the proviso that at least one R.sup.2 is J--CO.sub.2 R; J is a single bond, --OCR'.sub.2 --, --NR'CR'.sub.2 --, CR'.sub.2 --CR'.sub.2 --, --CR'.sub.2 --, --CR'.dbd.CR', or --C(O)NR'CR'.sub.2 --; and each R.sup.14 independently is C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl, Ar--C.sub.0-4 alkyl, C(O)R', CN, NO.sub.2, SO.sub.2 R', or C(O)OR.sup.15 ; or a pharmaceutically acceptable salt thereof.
摘要翻译： PCT No.PCT / US93 / 12530 Sec。 371日期：1995年8月8日 102（e）日期1995年8月8日PCT提交1993年12月22日PCT公布。第WO94 / 14775号公报日期：1994年7月7日本发明涉及下式的化合物：WZ-（CR'R10）rU-（CR'2）sV-A其中：不存在或作为CO，CR'2，C（= CR'2），S（O）r，O，NR'，CR'OR'，CR'（OR“）CR'2，CR'2CR'（OR”），C（O）CR'2， CR（O），CONR'，NR'CO，OC（O），C（O）O，C（S）O，OC（S），C（S）NR'，NR'C（S） S（O）rNR'，NR'（O）r，N = N，NR'NR'，NR'CR'2，NR'CR'2，CR'2O，OCR'2，c 3BOND c，CR'= CR '或CR'（NR'R“）C（O）; 每个r独立为0至3; s为0〜2; 每个R'独立地为H，C 1-4烷基，C 3-7环烷基-C 0-4烷基或Ar-C 0-4烷基; 每个R“独立地是R'，-C（O）R'或-C（O）OR 15; R 10为H，C 1-4烷基或-NR'R'; 每个R 15独立地为C 1-4烷基，C 3-7环烷基-C 0-4烷基或AR-C 0-4烷基; R2存在一次或两次作为C 1-4烷基，J-CO 2 R'，CONR'，SR'，NR'R“，C 1-4烷氧基，羟基，CN，CF 3，卤素或”IMAGE“，条件是至少一个R2是J-CO2R; J是单键，-OCR'2-，-NR'CR'2-，CR'2-CR'2-，-CR'2-，-CR'= CR'或-C（O）NR' CR'2-; 并且每个R 14独立地为C 1-4烷基，C 3-7环烷基-C 0-4烷基，Ar-C 0-4烷基，C（O）R'，CN，NO 2，SO 2 R'或C（O）OR 15; 或其药学上可接受的盐。

2. 发明授权

US6028087A Platelet aggregation inhibiting compounds 失效
标题翻译：血小板聚集抑制化合物
公开(公告)号：US6028087A
公开(公告)日：2000-02-22
申请号：US10238
申请日：1998-01-21
申请人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Brian Walter Metcalf , James Samanen , Tobias Oregon Yellin
发明人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Brian Walter Metcalf , James Samanen , Tobias Oregon Yellin
IPC分类号： A61K38/00 , C07D213/56 , C07D213/73 , C07D417/12 , C07K5/083 , C07K5/09 , A61K31/44
CPC分类号： C07D213/73 , C07D213/56 , C07D417/12 , C07K5/0806 , C07K5/0815 , C07K5/0817 , A61K38/00
摘要： Compounds of the formula (I):W--Z--(CR'R.sup.10).sub.r --U--(CR'.sub.2).sub.s --V--A (I)wherein:A is ##STR1## W is .sup.N ; Z is (CH.sub.2).sub.1-2 ;U and V independently are present as CO, CR'.sub.2, C(.dbd.CR'.sub.2), S(O).sub.r, O, NR', CR'OR', CR'(OR")CR'.sub.2, CR'.sub.2 CR'(OR"), C(O)CR'.sub.2, CR'.sub.2 C(O), CONR', NR'CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR', NR'C(S), S(O).sub.r NR', NR'S(O).sub.r, N.dbd.N, NR'NR', NR'CR'.sub.2, NR'CR'.sub.2, CR'.sub.2 O, OCR'.sub.2, C.tbd.C, CR'.dbd.CR', or CR'(NR'R")C(O);each r independently is 0 to 3;s is 0 to 2;each R' independently is H, C.sub.1-4 alkyl, C.sub.3-7 cycloalky-C.sub.0-4 alkyl, or Ar-C.sub.0-4 alkyl;each R" independently is R', --C(O)R', or --C(O)OR.sup.15 ;R.sup.10 is H, C.sub.1-4 alkyl, or --NR'R';each R.sup.15 independently is C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl, or Ar-C.sub.0-4 alkyl;R.sup.2 is present once or twice as C.sub.1-4 alkyl, J--CO.sub.2 R', CONR', SR', NR'R", C .sub.1-4 alkoxy, hydroxy, CN, CF.sub.3, halo, or ##STR2## with the proviso that at least one R.sup.2 is J--CO.sub.2 R; and J is a single bond, --OCR'.sub.2 --, --NR'CR'.sub.2 --, CR'.sub.2 --CR'.sub.2 --, --CR'.sub.2 --, --CR'.dbd.CR', or --C(O)NR'CR'.sub.2 --;each R.sup.14 independently is C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl, Ar-C.sub.0-4 alkyl, C(O)R', CN, NO.sub.2, SO.sub.2 R', or C(O)OR.sup.15 ;or a pharmaceutically acceptable salt thereof, are effective for inhibiting platelet aggregation.
摘要翻译：式（I）的化合物：W-Z-（CR'R10）r-U-（CR'2）s-V-A（I）其中：A是W是+ E，crc N + EE; Z是（CH 2）1-2; U和V独立地作为CO，CR'2，C（= CR'2），S（O）r，O，NR'，CR'OR'，CR'（OR“）CR'2，CR' （OR），C（O）CR'2，CR'2C（O），CONR'，NR'CO，OC（O），C（O）O，C（O）），C（S）NR'，NR'C（S），S（O）rNR'，NR'S（O）r，N = N，NR'NR'，NR'CR'2，NR'CR'2， CR'2O，OCR'2，C 3BOND C，CR'= CR'或CR'（NR'R“）C（O）; 每个r独立为0至3; s为0〜2; 每个R'独立地为H，C 1-4烷基，C 3-7环烷基-C 0-4烷基或Ar-C 0-4烷基; 每个R“独立地是R'，-C（O）R'或-C（O）OR 15; R 10是H，C 1-4烷基或-NR'R'; 每个R 15独立地为C 1-4烷基，C 3-7环烷基-C 0-4烷基或Ar-C 0-4烷基; R 2存在一次或两次作为C 1-4烷基，J-CO 2 R'，CONR'，SR'，NR'R“，C 1-4烷氧基，羟基，CN，CF 3，卤素，或条件是至少一个R 2 是J-CO2R; 并且J是单键，-OCR'2 - ，-NR'CR'2 - ，CR'2-CR'2，-CR'2-，-CR'= CR'或-C（O）NR 'CR'2-; 每个R 14独立地是C 1-4烷基，C 3-7环烷基-C 0-4烷基，Ar-C 0-4烷基，C（O）R'，CN，NO 2，SO 2 R'或C（O）OR 15; 或其药学上可接受的盐对抑制血小板聚集是有效的。

3. 发明授权

US6127359A Bicyclic fibrinogen antagonists 失效
标题翻译：双相纤维蛋白原拮抗剂
公开(公告)号：US6127359A
公开(公告)日：2000-10-03
申请号：US312006
申请日：1999-05-14
申请人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
发明人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
IPC分类号： C07D223/16 , C07D243/14 , C07D267/14 , C07D281/10 , A61K31/55 , C07D227/08 , A61K37/48
CPC分类号： C07D223/16 , C07D243/14 , C07D267/14 , C07D281/10
摘要： Compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form a seven-membered ring containing one optionally substituted nitrogen atom and one heteroatom selected from oxygen and nitrogen;D.sup.1 to D.sup.4 form a substituted six membered ring, optionally containing up to two nitrogen atoms;R is preferably at least one acid containing substituent;R* is is one or more groups chosen from H, Q-C.sub.1-6 alkyl, Q-C.sub.1-6 oxoalkyl, Q-C.sub.2-6 alkenyl, Q-C.sub.3-4 oxoalkenyl, Q-C.sub.3-4 oxoalkynyl, Q-C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, Ar or Het;Q is H, C.sub.3-6 cycloalkyl, Het or Ar;R.sup.6 is preferably a basic nitrogen containing substituent;are inhibitors of platelet aggregation.
摘要翻译：下式的化合物：其中A1至A5形成含有一个任选取代的氮原子和一个选自氧和氮的杂原子的七元环; D1至D4形成任选含有至多两个氮原子的取代六元环; R优选为至少一种含酸取代基; R *是一个或多个选自H，Q-C 1-6烷基，Q-C 1-6氧基烷基，Q-C 2-6烯基，Q-C 3-4烯基，Q-C 3-4氧代炔基，Q-C 2-4亚炔基， 6环烷基，Ar或Het; Q是H，C 3-6环烷基，Het或Ar; R6优选为碱性含氮取代基; 是血小板聚集的抑制剂。

4. 发明授权

US5693636A Bicyclic fibrinogen antagonists 失效
标题翻译：双相纤维蛋白原拮抗剂
公开(公告)号：US5693636A
公开(公告)日：1997-12-02
申请号：US923794
申请日：1992-06-26
申请人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
发明人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/675 , A61K31/69 , A61P7/02 , A61P9/08 , A61P9/10 , C07D223/16 , C07D243/12 , C07D243/14 , C07D267/14 , C07D281/10 , C07D471/04 , C07D491/048 , C07F9/40 , C07D403/00
CPC分类号： C07D223/16 , C07D243/14 , C07D267/14 , C07D281/10
摘要： This invention relates to compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and N wherein S and N may be optionally oxidized; D.sup.1 to D.sup.4 form an accessible substituted six membered ring, optionally containing up to two nitrogen atoms; R is at least one substituent chosen from the group of R.sup.7, or Q--C.sub.1-4 alkyl, Q--C.sub.2-4 alkenyl, Q--C.sub.2-4 alkynyl, preferably substituted by an acidic function; R* is H, Q--C.sub.1-6 alkyl, Q--C.sub.1-6 oxoalkyl, Q--C.sub.2-6 alkenyl or Q--C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, Ar or Het, optionally substituted by one or more substitutents; and R.sup.6 is preferably a substituent containing a basic nitrogen moiety; or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
摘要翻译： PCT No.PCT / US92 / 05463 Sec。 371日期：1992年6月26日 102（e）日期1992年6月26日PCT提交1992年6月26日PCT公布。第WO93 / 00095号公报日本1993年1月7日本发明涉及下式的化合物：其中A1至A5形成可取代的七元环，其可以是饱和或不饱和的，任选地含有至多两个选自O， S和N，其中S和N可以任选被氧化; D1至D4形成可取代的六元环，任选地含有至多两个氮原子; R是选自R7或Q-C1-4烷基，Q-C2-4链烯基，Q-C2-4炔基，优选被酸性官能团取代的至少一个取代基; R *是任选被一个或多个取代基取代的H，Q-C 1-6烷基，Q-C 1-6氧代烷基，Q-C 2-6烯基或Q-C 2-4亚炔基，C 3-6环烷基，Ar或Het。并且R 6优选为含有碱性氮部分的取代基; 或其药学上可接受的盐，其有效抑制血小板聚集，用于实现这种活性的药物组合物和抑制血小板聚集的方法。

5. 发明授权

US06403578B1 Bicyclic fibrinogen antagonists 失效
标题翻译：双相纤维蛋白原拮抗剂
公开(公告)号：US06403578B1
公开(公告)日：2002-06-11
申请号：US08464779
申请日：1995-08-04
申请人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander , James Martin Samanen , Irene Nijole Uzinskas
发明人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander , James Martin Samanen , Irene Nijole Uzinskas
IPC分类号： A61K3155
CPC分类号： C07D223/16 , A61K31/55 , A61K31/551 , A61K31/5513 , C07D243/14 , C07D401/12
摘要： This invention relates to compounds of the formulae: wherein A1 is O, S, N—R1 or CHR1; A4 is N—R4 or CHR4; R2 is a sidechain containing an acid or ester group; R1, R4 and R5 are substituents such as H, alkyl and aryl alkyl, and R6 is a sidechain containing a nitrogen group; and pharmaceutically acceptable salts thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
摘要翻译：本发明涉及下式的化合物：其中A 1是O，S，N-R 1或CHR 1; A 4是N-R 4或CHR 4; R 2是含有酸或酯基的侧链; R 1，R 4和R 5是取代基，例如H ，烷基和芳基烷基，R 6是含有氮基的侧链; 其抑制血小板聚集有效的药学上可接受的盐，以及用于抑制血小板聚集的方法。

6. 发明授权

US5939412A Bicyclic fibrinogen antagonists 失效
标题翻译：双相纤维蛋白原拮抗剂
公开(公告)号：US5939412A
公开(公告)日：1999-08-17
申请号：US953039
申请日：1997-10-17
申请人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
发明人： William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
IPC分类号： C07D223/16 , C07D243/14 , C07D267/14 , C07D281/10 , A61K31/55
CPC分类号： C07D223/16 , C07D243/14 , C07D267/14 , C07D281/10
摘要： Compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form a seven-membered ring containing one optionally substituted nitrogen atom;D.sup.1 to D.sup.4 form a substituted six membered ring, optionally containing up to two nitrogen atoms;R is preferably at least one acid containing substituent;R* is is one or more groups chosen from H, Q-C.sub.1-6 alkyl, Q-C.sub.1-6 oxoalkyl, Q-C.sub.2-6 alkenyl, Q-C.sub.3-4 oxoalkenyl, Q-C.sub.3-4 oxoalkynyl, Q-C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, Ar or Het;Q is H, C.sub.3-6 cycloalkyl, Het or Ar;R.sup.6 is preferably a basic nitrogen containing substituent; are inhibitors of platelet aggregation.
摘要翻译：下式的化合物：其中A1至A5形成含有一个任选取代的氮原子的七元环; D1至D4形成任选含有至多两个氮原子的取代六元环; R优选为至少一种含酸取代基; R *是一个或多个选自H，Q-C 1-6烷基，Q-C 1-6氧基烷基，Q-C 2-6烯基，Q-C 3-4烯基，Q-C 3-4氧代炔基，Q-C 2-4亚炔基， 6环烷基，Ar或Het; Q是H，C 3-6环烷基，Het或Ar; R6优选为碱性含氮取代基; 是血小板聚集的抑制剂。

7. 发明授权

US5977101A Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity 失效
标题翻译：与具有Vitronectin受体拮抗剂活性的纤维蛋白原受体拮抗剂模板相关的苯并咪唑/咪唑
公开(公告)号：US5977101A
公开(公告)日：1999-11-02
申请号：US505171
申请日：1996-12-20
申请人： Fadia El-Fehail Ali , William Bondinell , William Francis Huffman , M. Amparo Lago , Richard McCulloch Keenan , Chet Kwon , William Henry Miller , Thomas Nguyen , Dennis T. Takata
发明人： Fadia El-Fehail Ali , William Bondinell , William Francis Huffman , M. Amparo Lago , Richard McCulloch Keenan , Chet Kwon , William Henry Miller , Thomas Nguyen , Dennis T. Takata
IPC分类号： C07D235/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/55 , C07D403/06
CPC分类号： C07D403/12 , C07D235/14 , C07D403/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporsis.
摘要翻译： PCT No.PCT / US95 / 08306 Sec。 371日期1996年12月20日第 102（e）日期1996年12月20日PCT提交1995年6月29日PCT公布。公开号WO96 / 00730 日期1996年1月11日具有下列通式的维甲酸受体拮抗剂：其可用于治疗炎症，癌症和心血管疾病，例如动脉粥样硬化和再狭窄，以及骨吸收是骨质疏松症的疾病。

8. 发明授权

US4122086A Isopenicillins 失效
标题翻译：异青霉素
公开(公告)号：US4122086A
公开(公告)日：1978-10-24
申请号：US819197
申请日：1977-07-26
申请人： Ralph Floyd Hall , William Francis Huffman
发明人： Ralph Floyd Hall , William Francis Huffman
IPC分类号： A61K31/425 , A61P31/04 , C07D205/085 , C07D499/00 , C07D513/04
CPC分类号： C07D513/04 , C07D205/085 , C07D499/00
摘要： A new bicyclic .beta.-lactam containing the novel 7-oxo-1-aza-3-thiabicyclo[3.2.0]heptane nucleus (isopenicillin) is disclosed. The compounds have antibacterial activity against gram positive and gram negative organisms. Intermediates useful for the preparation of these active products are also disclosed.
摘要翻译： {PG，1 A公开了包含新型7-氧代-1-氮杂-3-硫杂双环{8 3.2.0 {9庚烷核（异青霉素）的新双环{62-内酰胺）。该化合物对革兰氏阳性和革兰氏阴性菌具有抗菌活性。还公开了可用于制备这些活性产物的中间体。

9. 发明授权

US5776900A Hemoregulatory peptides 失效
标题翻译：血液调节肽
公开(公告)号：US5776900A
公开(公告)日：1998-07-07
申请号：US453123
申请日：1995-05-30
申请人： Pradip Kumar Bhatnagar , William Francis Huffman , James Edward Talmadge
发明人： Pradip Kumar Bhatnagar , William Francis Huffman , James Edward Talmadge
IPC分类号： A61K38/00 , C07K7/02 , C07K7/06 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/067 , C07K7/02 , A61K38/00
摘要： The invention provides compounds of the general formula: ##STR1## The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
摘要翻译：本发明提供了以下通式的化合物：化合物具有调节活性，可用于刺激造血和用于治疗病毒，真菌和细菌感染性疾病。

10. 发明授权

US06194544B1 Cyclic semi-random peptide libraries 失效
标题翻译：循环半随机肽库
公开(公告)号：US06194544B1
公开(公告)日：2001-02-27
申请号：US08571869
申请日：1996-01-05
申请人： William Francis Huffman , Michael Lee Moore
发明人： William Francis Huffman , Michael Lee Moore
IPC分类号： C07K764
CPC分类号： C07K1/047 , A61K38/00 , C07K7/64
摘要： Cyclic penta- and hexa-peptide libraries containing one or more known amino acids, one or more randomized amino acids and a conformationally constraining element are disclosed. These peptide libraries may be used for screening for new bioactive peptides and for elucidating structural information pertinent to drug design.
摘要翻译：公开了含有一种或多种已知氨基酸，一种或多种随机氨基酸和构象约束元件的环状五肽和六肽文库。这些肽文库可用于筛选新的生物活性肽和用于阐明与药物设计有关的结构信息。

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