专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US6069143A Fibrinogen receptor antagonists 失效
标题翻译：纤维蛋白原受体拮抗剂
公开(公告)号：US6069143A
公开(公告)日：2000-05-30
申请号：US584030
申请日：1996-01-11
申请人： Fadia El-Fehail Ali , William Edward Bondinell , Raul Rolando Calvo , Thomas Wen-Fu Ku , William Henry Miller , James Samanen , Joseph Walter Venslavsky , Tobias Oregon Yellin
发明人： Fadia El-Fehail Ali , William Edward Bondinell , Raul Rolando Calvo , Thomas Wen-Fu Ku , William Henry Miller , James Samanen , Joseph Walter Venslavsky , Tobias Oregon Yellin
IPC分类号： C07D295/12 , A61K31/454 , A61K31/495 , A61P7/02 , A61P9/00 , A61P43/00 , C07D211/58 , C07D211/62 , C07D295/135 , C07D295/20 , C07D295/215 , C07D401/12 , A61K31/445 , C07D401/14
CPC分类号： C07D295/215 , C07D211/58 , C07D211/62 , C07D295/135
摘要： This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
摘要翻译：本发明涉及下列化合物：其有效抑制血小板聚集，用于实现这种活性的药物组合物和抑制血小板聚集的方法。

2. 发明授权

US5900422A Fibrinogen receptor antagonists 失效
标题翻译：纤维蛋白原受体拮抗剂
公开(公告)号：US5900422A
公开(公告)日：1999-05-04
申请号：US875358
申请日：1997-06-20
申请人： Fadia El-Fehail Ali
发明人： Fadia El-Fehail Ali
IPC分类号： C07D211/26 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/74 , A61K31/445 , A61K31/495 , C07D401/10 , C07D401/14
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
摘要翻译： PCT No.PCT / US95 / 16960 Sec。 371日期：1997年6月20日 102（e）日期1997年6月20日PCT 1995年12月22日PCT PCT。公开号WO96 / 19221 日期1996年6月27日本发明涉及对抑制血小板聚集有效的下式化合物，用于实现这种活性的药物组合物和抑制血小板聚集的方法。

3. 发明授权

US5977101A Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity 失效
标题翻译：与具有Vitronectin受体拮抗剂活性的纤维蛋白原受体拮抗剂模板相关的苯并咪唑/咪唑
公开(公告)号：US5977101A
公开(公告)日：1999-11-02
申请号：US505171
申请日：1996-12-20
申请人： Fadia El-Fehail Ali , William Bondinell , William Francis Huffman , M. Amparo Lago , Richard McCulloch Keenan , Chet Kwon , William Henry Miller , Thomas Nguyen , Dennis T. Takata
发明人： Fadia El-Fehail Ali , William Bondinell , William Francis Huffman , M. Amparo Lago , Richard McCulloch Keenan , Chet Kwon , William Henry Miller , Thomas Nguyen , Dennis T. Takata
IPC分类号： C07D235/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/55 , C07D403/06
CPC分类号： C07D403/12 , C07D235/14 , C07D403/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporsis.
摘要翻译： PCT No.PCT / US95 / 08306 Sec。 371日期1996年12月20日第 102（e）日期1996年12月20日PCT提交1995年6月29日PCT公布。公开号WO96 / 00730 日期1996年1月11日具有下列通式的维甲酸受体拮抗剂：其可用于治疗炎症，癌症和心血管疾病，例如动脉粥样硬化和再狭窄，以及骨吸收是骨质疏松症的疾病。

4. 发明授权

US5643872A Cyclic anti-aggregatory peptides 失效
公开(公告)号：US5643872A
公开(公告)日：1997-07-01
申请号：US296621
申请日：1994-08-26
申请人： Fadia El-Fehail Ali , James Martin Samanen
发明人： Fadia El-Fehail Ali , James Martin Samanen
IPC分类号： A61K38/00 , C07K5/09 , C07K5/10 , C07K5/103 , C07K5/11 , C07K5/12 , C07K7/06 , C07K7/64 , C07K14/75
CPC分类号： C07K7/06 , C07K14/75 , C07K5/0817 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K5/123 , C07K7/64 , A61K38/00
摘要： This invention relates to compounds of the formula: ##STR1## wherein: A' is absent, Asn, Gln, Ala or Abu;A is absent or a D- or L-amino acid chosen from Arg, HArg, (Me.sub.2)Arg, (Et.sub.2)Arg, Abu, Ala, Gly, His, Lys, or an .alpha.-R' substituted derivative thereof, Dtc, Tpr and Pro;B is a D- or L-amino acid chosen from Arg, HArg, NArg, (Me.sub.2)Arg, (Et.sub.2)Arg and Lys or an .alpha.-R' substituted derivative thereof;Q is absent or a D or L amino acid chosen from Tyr, (Alk)Tyr, Phe, (4'W)Phe, HPhe, Phg, Pro, Trp, His, Ser, (Alk)Ser, Thr, (Alk)Thr, (Alk)Cys, (Alk)Pen, Ala, Val, Nva, Met, Leu, Ile, Nle and Nal, or an .alpha.-R' substituted derivative thereof;M is absent or Gly or a D- or L-amino acid chosen from Glu, Phe, Pro, Lys and Ser or, provided n is 1, B-Gly-Glu-Q;W is halogen or Alk;R' is Alk or PhCH.sub.2 ; ##STR2## wherein Z.sub.1 and Z.sub.2 are linked via a covalent bond between L.sup.1 and L.sup.2 ; or Z.sub.1 and Z.sub.2 are, taken together, a covalent bond between the amino terminal residue and the carboxy terminal residue;L.sup.1 and L.sup.2 are --S-- or --(CH.sub.2).sub.p --;X is R.sub.4 R.sub.5 N or H;Y is H, CONR.sub.1 R.sub.2 or CO.sub.2 R.sub.2 ;R.sub.1 and R.sub.2 are H, Alk or (CH.sub.2).sub.p Ar;R.sub.3 and R.sub.3' are H, Alk, (CH.sub.2).sub.p Ar or taken together are --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --;R.sub.4 is H or Alk;R.sub.5 is R.sub.11, R.sub.11 CO, R.sub.11 OCO, R.sub.11 OCH(R.sub.11')CO, R.sub.11 NHCH(R.sub.11')CO, R.sub.11 SCH(R.sub.11')CO, R.sub.11 SO.sub.2 or R.sub.11 SO;R.sub.6 is Alk, OAlk, halogen or X;R.sub.7 is H, Alk, OAlk, halogen or Y;R.sub.8 and R.sub.8' are H, Alk, (CH.sub.2).sub.p Ph, (CH.sub.2).sub.p Nph or taken together are --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --;R.sub.9 is H, Alk or Y;R.sub.10 is H or Alk;R.sub.11 and R.sub.11' are H, C.sub.1-5 alkyl, C.sub.3-7 cycloalkyl, Ar, Ar--C.sub.1-5 alkyl, Ar--C.sub.3-7 cycloalkyl;Ar is phenyl or phenyl substituted by one or two C.sub.1-5 alkyl, trifluoromethyl, hydroxy, C.sub.1-5 alkoxy or halogen groups;n is 1 or 2;q is 0 or 1; andp is 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof;which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, a method for inhibiting platelet aggregation and clot formation in a mammal, and a method for inhibiting reocclusion of a blood vessel following fibrinolytic therapy.

5. 发明授权

US6037343A Fibrinogen receptor antagonists 失效
标题翻译：纤维蛋白原受体拮抗剂
公开(公告)号：US6037343A
公开(公告)日：2000-03-14
申请号：US875356
申请日：1995-12-22
申请人： Fadia El-Fehail Ali
发明人： Fadia El-Fehail Ali
IPC分类号： A61K31/445 , A61K31/4465 , A61P7/02 , C07D211/26 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/74 , A61K31/495 , C07D211/08 , C07D211/30 , C07D213/02 , C07D401/02 , C07D413/02
CPC分类号： C07D213/40 , C07D211/26 , C07D213/38
摘要： This invention relates to compound of formula (I) which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation. ##STR1##
摘要翻译： PCT No.PCT / US95 / 16963 Sec。 371 1995年12月22日第 102（e）日期1995年12月22日PCT 1995年12月22日PCT PCT。 WO96 / 19223 PCT出版物日期1996年6月27日本发明涉及抑制血小板聚集有效的式（I）化合物，用于实现这种活性的药物组合物和抑制血小板聚集的方法。

6. 发明授权

US5849690A Anti-aggregatory peptides 失效
标题翻译：抗聚集肽
公开(公告)号：US5849690A
公开(公告)日：1998-12-15
申请号：US918487
申请日：1992-07-22
申请人： Fadia El-Fehail Ali , James Samanen
发明人： Fadia El-Fehail Ali , James Samanen
IPC分类号： A61K38/00 , A61P7/02 , C07K1/04 , C07K1/06 , C07K1/113 , C07K5/08 , C07K5/10 , C07K7/06 , C07K14/745 , C07K14/75 , C07K14/78 , C07K17/08 , C07K4/00
CPC分类号： C07K14/75 , C07K14/78 , A61K38/00
摘要： This invention relates to compounds which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, a method for inhibiting platelet aggregation and clot formation in a mammal, and a method for inhibiting reocclusion of a blood vessel following fibrinolytic therapy.
摘要翻译：本发明涉及有效抑制血小板聚集的化合物，用于实现这种活性的药物组合物，抑制哺乳动物血小板凝集和凝块形成的方法，以及纤维蛋白溶解治疗后血管再闭塞的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式