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1. 发明授权

US5933519A Cytological slide scoring apparatus 失效
标题翻译：细胞学评分仪
公开(公告)号：US5933519A
公开(公告)日：1999-08-03
申请号：US867017
申请日：1997-06-03
申请人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
发明人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/62 , G06K9/68 , G06K9/70
CPC分类号： G06K9/00127 , G06K9/6253 , G06K9/685
摘要： The invention detects areas of interest at low magnification, locating possible abnormal cells or other cells of interest using image processing and statistical pattern recognition techniques. Next, at high magnification, the areas identified at low magnification are re-examined. The information from the low magnification and high magnification scans is collated and a determination is made about the slide--whether it is normal, abnormal, contains endocervical component, and so forth. The invention also provides a method and apparatus to train object feature and slide feature classifiers. The invention provides an automated cytology system that can process training slides for use in a feed back classifier development environment. The invention also can classify endocervical groups of cells.
摘要翻译：本发明使用图像处理和统计模式识别技术来检测低放大倍数的感兴趣区域，定位可能的异常细胞或感兴趣的其它细胞。接下来，在高放大倍数下，重新检查在低倍率下识别的区域。对来自低放大倍数和高倍率扫描的信息进行整理，并确定载玻片是否正常，异常，包含宫颈内部成分等。本发明还提供了一种训练对象特征和幻灯片特征分类器的方法和装置。本发明提供了一种自动细胞学系统，其可以处理用于反馈分类器开发环境中的训练幻灯片。本发明还可以分类宫颈癌细胞群。

2. 发明授权

US5581631A Cytological system image collection integrity checking apparatus 失效
标题翻译：细胞系统图像采集完整性检查装置
公开(公告)号：US5581631A
公开(公告)日：1996-12-03
申请号：US309078
申请日：1994-09-20
申请人： William E. Ortyn , Keith L. Frost , Jon W. Hayenga
发明人： William E. Ortyn , Keith L. Frost , Jon W. Hayenga
IPC分类号： G01N33/483 , G01N21/27 , G06K9/00 , G06T1/00
CPC分类号： G06K9/00127
摘要： An automated apparatus for checking cytological system image collection integrity in an automated cytological system including an imaging apparatus controlled by a digital processor. The automated apparatus includes linearity checking apparatus, coupled to the imaging apparatus and the digital processor. System frequency response is checked using a modulation transfer function, where the sampling frequency may be determined by pixel size so as to allow the MTF to be determined beyond the sampling frequency of a system detector. A system signal to noise ratio is also checked for specific regions of the frequency spectrum.
摘要翻译：一种用于在自动细胞学系统中检查细胞学系统图像收集完整性的自动化装置，包括由数字处理器控制的成像装置。该自动化装置包括耦合到成像装置和数字处理器的线性检查装置。使用调制传递函数检查系统频率响应，其中采样频率可以由像素尺寸确定，以便允许MTF被确定超过系统检测器的采样频率。还对频谱的特定区域检查系统信噪比。

3. 发明授权

US5991462A Cytological system illumination integrity checking method 失效
标题翻译：细胞学照明完整性检查方法
公开(公告)号：US5991462A
公开(公告)日：1999-11-23
申请号：US911807
申请日：1997-08-15
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/36
CPC分类号： G06K9/00127
摘要： A method for checking cytological system illumination including the steps of checking global illumination variation, static field uniformity, dynamic field uniformity, specimen thickness variation, strobe repeatability, calibration plate cleanliness, and strobe dropout. A calibration plate and test target is employed for various illumination checks.
摘要翻译：一种检查细胞学系统照明的方法，包括检查全局照明变化，静态场均匀性，动态场均匀性，样本厚度变化，选通重复性，校准板清洁度和选通脉冲脱落的步骤。校准板和测试目标被用于各种照明检查。

4. 发明授权

US5892218A Cytological system autofocus integrity checking apparatus 失效
标题翻译：细胞学系统自动对焦完整性检查装置
公开(公告)号：US5892218A
公开(公告)日：1999-04-06
申请号：US821699
申请日：1997-03-20
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.
摘要翻译：一种用于检查细胞学系统自动对焦完整性的自动化方法。自动化方法包括检查对焦照明完整性，检查对焦相机调制传递功能，检查对焦相机位置完整性以及检查闭环精度的步骤。检查聚焦照明完整性包括检查聚焦照明系统的完整性，并检查聚焦噪声底层。检查对焦摄像机位置完整性包括检查对焦摄像机纵向分离，以及检查对焦摄像机横向分离。检查对焦相机位置完整性包括检查对焦滤镜频率响应。

5. 发明授权

US5677762A Apparatus for illumination stabilization and homogenization 失效
标题翻译：照明稳定和匀化装置
公开(公告)号：US5677762A
公开(公告)日：1997-10-14
申请号：US650048
申请日：1996-05-16
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G01N21/01 , G01N21/27 , G02B21/06 , G02B21/08 , G01N21/84
CPC分类号： G02B21/082
摘要： An illumination device provides temporally, spatially and angularly stable illumination for microscopic evaluations. An arc lamp serves as the light source. An input optical train gathers and focuses the light through an aperture stop to place an image of the arc incident on an input aperture of a light pipe. The magnification of the arc lamp is chosen to reduce the variation due to occlusion. The light pipe spatially homogenizes the light while preserving the angular integrity. An exit window may be placed over the exit aperture of the light pipe to keep dust and debris out of focus. Another optical train receives the spatially homogenized, angularly preserved light and may focus a many arclet images to fill the pupil of a condenser lens. The condenser lens also may focus the exit aperture of the light pipe onto or near the specimen on a microscope slide. A feedback system samples the light and corrects for residual temporal variations by electronically modifying the image as it leaves a CCD. A neutral density filter controls the overall energy passed through the system.
摘要翻译：照明装置为时间，空间和角度稳定的照明提供微观评估。弧光灯用作光源。输入光学系统通过孔径光阑聚集和聚焦光，以将入射在光管的输入孔上的电弧的图像放置。选择弧光灯的放大倍率来减少由于遮挡引起的变化。光管在空间上均匀化光，同时保持角度完整性。出口窗口可以放置在光管的出口孔上方，以防止灰尘和碎屑离开聚焦。另一个光学列车接收空间均匀的角保护光，并且可以聚焦许多弧形图像以填充聚光透镜的光瞳。聚光透镜还可以将光管的出射孔聚焦在显微镜载片上或附近的样品上。反馈系统通过在离开CCD时电子修改图像来对光进行采样并校正残留时间变化。中性密度滤波器控制通过系统的总能量。

6. 发明授权

US5654535A Cytological system autofocus integrity checking apparatus 失效
标题翻译：细胞学系统自动对焦完整性检查装置
公开(公告)号：US5654535A
公开(公告)日：1997-08-05
申请号：US666748
申请日：1996-06-19
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.
摘要翻译：一种用于检查细胞学系统自动对焦完整性的自动化方法。自动化方法包括检查对焦照明完整性，检查对焦相机调制传递功能，检查对焦相机位置完整性以及检查闭环精度的步骤。检查聚焦照明完整性包括检查聚焦照明系统的完整性，并检查聚焦噪声底层。检查对焦摄像机位置完整性包括检查对焦摄像机纵向分离，以及检查对焦摄像机横向分离。检查对焦相机位置完整性包括检查对焦滤镜频率响应。

7. 发明授权

US5991432A Cytological system illumination integrity checking apparatus and method 失效
公开(公告)号：US5991432A
公开(公告)日：1999-11-23
申请号：US911644
申请日：1997-08-15
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G06K9/00 , G01J1/32 , G06K9/38
CPC分类号： G06K9/00127
摘要： A method for checking cytological system illumination including the steps of checking global illumination variation, static field uniformity, dynamic field uniformity, specimen thickness variation, strobe repeatability, calibration plate cleanliness, and strobe dropout. A calibration plate and test target is employed for various illumination checks.

8. 发明授权

US5875258A Biological specimen analysis system processing integrity checking apparatus 失效
标题翻译：生物样本分析系统处理完整性检查装置
公开(公告)号：US5875258A
公开(公告)日：1999-02-23
申请号：US697480
申请日：1996-08-26
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G01N1/28 , G01N35/00 , G02B21/00 , G06K9/00
CPC分类号： G02B21/0004 , G01N35/00594 , G01N2001/2893 , G01N35/00693 , Y10S128/922
摘要： A suite of tests and parameter monitoring methods for at least five major subsystems that are found in most automated image processing systems, as well as calibration routines for three major system functions. The five areas of subsystem verification include processing quality, illumination quality, image collection quality, autofocus quality, and position quality. An automated biological specimen analysis system uses self measures of system parameters to provide a system status. The system status is reported to the user.
摘要翻译：用于至少五个主要子系统的测试和参数监测方法，可在大多数自动化图像处理系统中找到，以及用于三个主要系统功能的校准程序。子系统验证的五个方面包括加工质量，照明质量，图像采集质量，自动对焦质量和位置质量。自动化生物样本分析系统采用系统参数的自我测量来提供系统状态。向用户报告系统状态。

9. 发明授权

US5763871A Cytological system autofocus integrity checking apparatus 失效
公开(公告)号：US5763871A
公开(公告)日：1998-06-09
申请号：US821695
申请日：1997-03-20
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.

10. 发明授权

US5760387A Cytological system autofocus integrity checking apparatus 失效
公开(公告)号：US5760387A
公开(公告)日：1998-06-02
申请号：US821693
申请日：1997-03-20
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.

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