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1. 发明授权

US06011861A Cytological system illumination integrity checking apparatus and method 失效
标题翻译：细胞学照明完整性检查装置及方法
公开(公告)号：US06011861A
公开(公告)日：2000-01-04
申请号：US911612
申请日：1997-08-15
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/60
CPC分类号： G06K9/00127
摘要： A method for checking cytological system illumination including the steps of checking global illumination variation, static field uniformity, dynamic field uniformity, specimen thickness variation, strobe repeatability, calibration plate cleanliness, and strobe dropout. A calibration plate and test target is employed for various illumination checks.
摘要翻译：一种检查细胞学系统照明的方法，包括检查全局照明变化，静态场均匀性，动态场均匀性，样本厚度变化，选通重复性，校准板清洁度和选通脉冲脱落的步骤。校准板和测试目标被用于各种照明检查。

2. 发明授权

US5557097A Cytological system autofocus integrity checking apparatus 失效
公开(公告)号：US5557097A
公开(公告)日：1996-09-17
申请号：US309130
申请日：1994-09-20
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.

3. 发明授权

US5991462A Cytological system illumination integrity checking method 失效
标题翻译：细胞学照明完整性检查方法
公开(公告)号：US5991462A
公开(公告)日：1999-11-23
申请号：US911807
申请日：1997-08-15
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/36
CPC分类号： G06K9/00127
摘要： A method for checking cytological system illumination including the steps of checking global illumination variation, static field uniformity, dynamic field uniformity, specimen thickness variation, strobe repeatability, calibration plate cleanliness, and strobe dropout. A calibration plate and test target is employed for various illumination checks.
摘要翻译：一种检查细胞学系统照明的方法，包括检查全局照明变化，静态场均匀性，动态场均匀性，样本厚度变化，选通重复性，校准板清洁度和选通脉冲脱落的步骤。校准板和测试目标被用于各种照明检查。

4. 发明授权

US5892218A Cytological system autofocus integrity checking apparatus 失效
标题翻译：细胞学系统自动对焦完整性检查装置
公开(公告)号：US5892218A
公开(公告)日：1999-04-06
申请号：US821699
申请日：1997-03-20
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.
摘要翻译：一种用于检查细胞学系统自动对焦完整性的自动化方法。自动化方法包括检查对焦照明完整性，检查对焦相机调制传递功能，检查对焦相机位置完整性以及检查闭环精度的步骤。检查聚焦照明完整性包括检查聚焦照明系统的完整性，并检查聚焦噪声底层。检查对焦摄像机位置完整性包括检查对焦摄像机纵向分离，以及检查对焦摄像机横向分离。检查对焦相机位置完整性包括检查对焦滤镜频率响应。

5. 发明授权

US5677762A Apparatus for illumination stabilization and homogenization 失效
标题翻译：照明稳定和匀化装置
公开(公告)号：US5677762A
公开(公告)日：1997-10-14
申请号：US650048
申请日：1996-05-16
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G01N21/01 , G01N21/27 , G02B21/06 , G02B21/08 , G01N21/84
CPC分类号： G02B21/082
摘要： An illumination device provides temporally, spatially and angularly stable illumination for microscopic evaluations. An arc lamp serves as the light source. An input optical train gathers and focuses the light through an aperture stop to place an image of the arc incident on an input aperture of a light pipe. The magnification of the arc lamp is chosen to reduce the variation due to occlusion. The light pipe spatially homogenizes the light while preserving the angular integrity. An exit window may be placed over the exit aperture of the light pipe to keep dust and debris out of focus. Another optical train receives the spatially homogenized, angularly preserved light and may focus a many arclet images to fill the pupil of a condenser lens. The condenser lens also may focus the exit aperture of the light pipe onto or near the specimen on a microscope slide. A feedback system samples the light and corrects for residual temporal variations by electronically modifying the image as it leaves a CCD. A neutral density filter controls the overall energy passed through the system.
摘要翻译：照明装置为时间，空间和角度稳定的照明提供微观评估。弧光灯用作光源。输入光学系统通过孔径光阑聚集和聚焦光，以将入射在光管的输入孔上的电弧的图像放置。选择弧光灯的放大倍率来减少由于遮挡引起的变化。光管在空间上均匀化光，同时保持角度完整性。出口窗口可以放置在光管的出口孔上方，以防止灰尘和碎屑离开聚焦。另一个光学列车接收空间均匀的角保护光，并且可以聚焦许多弧形图像以填充聚光透镜的光瞳。聚光透镜还可以将光管的出射孔聚焦在显微镜载片上或附近的样品上。反馈系统通过在离开CCD时电子修改图像来对光进行采样并校正残留时间变化。中性密度滤波器控制通过系统的总能量。

6. 发明授权

US5654535A Cytological system autofocus integrity checking apparatus 失效
标题翻译：细胞学系统自动对焦完整性检查装置
公开(公告)号：US5654535A
公开(公告)日：1997-08-05
申请号：US666748
申请日：1996-06-19
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.
摘要翻译：一种用于检查细胞学系统自动对焦完整性的自动化方法。自动化方法包括检查对焦照明完整性，检查对焦相机调制传递功能，检查对焦相机位置完整性以及检查闭环精度的步骤。检查聚焦照明完整性包括检查聚焦照明系统的完整性，并检查聚焦噪声底层。检查对焦摄像机位置完整性包括检查对焦摄像机纵向分离，以及检查对焦摄像机横向分离。检查对焦相机位置完整性包括检查对焦滤镜频率响应。

7. 发明授权

US5991432A Cytological system illumination integrity checking apparatus and method 失效
公开(公告)号：US5991432A
公开(公告)日：1999-11-23
申请号：US911644
申请日：1997-08-15
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G06K9/00 , G01J1/32 , G06K9/38
CPC分类号： G06K9/00127
摘要： A method for checking cytological system illumination including the steps of checking global illumination variation, static field uniformity, dynamic field uniformity, specimen thickness variation, strobe repeatability, calibration plate cleanliness, and strobe dropout. A calibration plate and test target is employed for various illumination checks.

8. 发明授权

US5912699A Method and apparatus for rapid capture of focused microscopic images 失效
标题翻译：用于快速捕获聚焦显微镜图像的方法和装置
公开(公告)号：US5912699A
公开(公告)日：1999-06-15
申请号：US302355
申请日：1994-09-07
申请人： Jon W. Hayenga , Louis R. Piloco
发明人： Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B21/26 , G02B21/36 , G06T1/60 , H04N5/232 , H04N5/235 , H04N7/18
CPC分类号： G06T1/60 , G02B21/26 , G02B21/367 , H04N5/23212 , H04N5/2354
摘要： A high speed image capture apparatus includes a camera with an integration period between consecutive flashes of an illuminating light pulse, where the camera has an image read out period and an image output. A timer for provides a strobe output representative of the start of a flash. An image capture apparatus captures a first image during the integration period and a second image within a predetermined time after capturing the first image but before the image read out period has elapsed so as to substantially increase a rate of producing usable image outputs. The image capture apparatus is coupled to the strobe output and the image output.
摘要翻译：高速图像拍摄装置包括具有相机具有图像读出期间和图像输出的照明光脉冲的连续闪光之间的积分周期的照相机。用于提供表示闪光灯开始的频闪输出的定时器。图像捕获装置在积分期间捕获第一图像，并且在拍摄第一图像之后但在图像读出期间经过之前的预定时间内捕获第二图像，从而显着提高产生可用图像输出的速率。图像捕获装置耦合到选通输出和图像输出。

9. 发明授权

US5875258A Biological specimen analysis system processing integrity checking apparatus 失效
标题翻译：生物样本分析系统处理完整性检查装置
公开(公告)号：US5875258A
公开(公告)日：1999-02-23
申请号：US697480
申请日：1996-08-26
申请人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
发明人： William E. Ortyn , Louis R. Piloco , Jon W. Hayenga
IPC分类号： G01N1/28 , G01N35/00 , G02B21/00 , G06K9/00
CPC分类号： G02B21/0004 , G01N35/00594 , G01N2001/2893 , G01N35/00693 , Y10S128/922
摘要： A suite of tests and parameter monitoring methods for at least five major subsystems that are found in most automated image processing systems, as well as calibration routines for three major system functions. The five areas of subsystem verification include processing quality, illumination quality, image collection quality, autofocus quality, and position quality. An automated biological specimen analysis system uses self measures of system parameters to provide a system status. The system status is reported to the user.
摘要翻译：用于至少五个主要子系统的测试和参数监测方法，可在大多数自动化图像处理系统中找到，以及用于三个主要系统功能的校准程序。子系统验证的五个方面包括加工质量，照明质量，图像采集质量，自动对焦质量和位置质量。自动化生物样本分析系统采用系统参数的自我测量来提供系统状态。向用户报告系统状态。

10. 发明授权

US5763871A Cytological system autofocus integrity checking apparatus 失效
公开(公告)号：US5763871A
公开(公告)日：1998-06-09
申请号：US821695
申请日：1997-03-20
申请人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
发明人： William E. Ortyn , Jon W. Hayenga , Louis R. Piloco
IPC分类号： G02B7/28 , G02B7/36 , G02B21/00 , G02B21/24 , H04N5/232 , H04N7/18 , G01M11/02
CPC分类号： H04N7/183 , G02B21/241 , G02B21/244 , G02B7/36 , H04N7/18 , H04N7/181 , H04N7/188
摘要： An automated method for checking cytological system autofocus integrity. The automated method includes the steps of checking focus illumination integrity, checking focus camera Modulation Transfer Function, checking focus camera position integrity, and checking closed loop accuracy. Checking focus illumination integrity includes checking focus illumination system integrity, and checking a focus noise floor level. Checking focus camera position integrity includes checking focus camera longitudinal separation, and checking focus camera lateral separation. Checking focus camera position integrity includes checking focus filter frequency response.

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