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1. 发明授权

US5114674A Added array of molecular chains for interfering with electrical fields 失效
标题翻译：添加分子链的阵列，用于干扰电场
公开(公告)号：US5114674A
公开(公告)日：1992-05-19
申请号：US44767
申请日：1987-05-01
申请人： William D. Stanbro , Kenneth W. Hunter, Jr. , Arnold L. Newman
发明人： William D. Stanbro , Kenneth W. Hunter, Jr. , Arnold L. Newman
IPC分类号： G01N27/02 , G01N27/22 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3276
摘要： An array of molecular chains is added to a dielectric material between two electrodes of a capacitive affinity sensor. Such an array of molecular chains greatly changes dielectric properties between the two electrodes to greatly enhance sensitivity of the sensor. In a sensor using direct binding, a viral fragment is bound to the sensor's surface. A molecular chain, comprising an anti-viral antibody, an anti-human antibody, and a protein molecule, binds to the viral fragment. In a sensor using competitive binding a hapten is bound to the sensor's surface. A molecular chain, comprising an antibody with attached aliphatic hydrocarbons, binds to the hapten. A free analyte competes with the hapten to bind with the antibody.
摘要翻译：分子链阵列被添加到电容式亲和度传感器的两个电极之间的电介质材料。这种分子链阵列极大地改变了两个电极之间的介电特性，从而大大提高了传感器的灵敏度。在使用直接结合的传感器中，病毒片段与传感器的表面结合。包含抗病毒抗体，抗人抗体和蛋白质分子的分子链与病毒片段结合。在使用竞争性绑定的传感器中，半抗原与传感器的表面结合。包含具有连接的脂族烃的抗体的分子链与半抗原结合。游离的分析物与半抗原竞争结合抗体。

2. 发明授权

US4935207A Capacitive chemical sensor using an ion exchange surface 失效
标题翻译：电容化学传感器使用离子交换面
公开(公告)号：US4935207A
公开(公告)日：1990-06-19
申请号：US368926
申请日：1989-06-19
申请人： William D. Stanbro , Arnold L. Newman
发明人： William D. Stanbro , Arnold L. Newman
IPC分类号： G01N27/22
CPC分类号： G01N27/227 , G01N27/3276 , Y10S435/817 , Y10S436/806
摘要： A capacitive chemical sensor is disclosed that uses an ion exchange layer to detect analyte ions in a liquid medium. An exchange mechanism occurs on the surface of the ion exchange layer, wherein a portion of the counter-ions are removed from the surface in favor of analyte ions. The resulting movement of counter-ions from the surface of the ion exchange layer alters the dielectric constant of the liquid medium along the surface of the ion exchange layer. This change in dielectric constant produces a change in capacitance of the capacitive chemical sensor.
摘要翻译：公开了一种电容化学传感器，其使用离子交换层来检测液体介质中的分析物离子。在离子交换层的表面上发生交换机制，其中一部分抗衡离子从表面去除，有助于分析物离子。从离子交换层的表面产生的抗衡离子的运动改变沿着离子交换层表面的液体介质的介电常数。这种介电常数的变化产生电容化学传感器的电容变化。

3. 发明授权

US4912059A Phase sensitive differential polarimetry technique and apparatus 失效
标题翻译：相敏微分极化法技术和装置
公开(公告)号：US4912059A
公开(公告)日：1990-03-27
申请号：US260962
申请日：1988-10-21
申请人： Arnold L. Newman , William D. Stanbro
发明人： Arnold L. Newman , William D. Stanbro
IPC分类号： C12M1/34 , C12M1/00 , G01J4/04 , G01N21/21 , G01N21/75
CPC分类号： G01J4/04 , G01N21/21 , G01N2021/1751 , G01N2021/755
摘要： A differential polarimeter is disclosed for detecting changes in optical rotation between a test cell and reference cell. The test cell contains a fluid sample exposed to an analyte specific enzyme; the reference cell contains a fluid sample not exposed to the enzyme. To enhance the sensitivity of the system a phase sensitive differential polarimetric technique is taught. In this technique, the phase difference between two resulting sinewave voltages is a measure of analyte concentration.
摘要翻译：公开了用于检测测试单元和参考单元之间的旋转旋转的差分偏振计。测试池含有暴露于分析物特异性酶的流体样品; 参考细胞含有不暴露于酶的流体样品。为了提高系统的灵敏度，教授了相敏微分偏振技术。在这种技术中，两个产生的正弦波电压之间的相位差是分析物浓度的量度。

4. 发明授权

US4708765A Regulation of the exposure of active surfaces 失效
标题翻译：调节活性表面的暴露
公开(公告)号：US4708765A
公开(公告)日：1987-11-24
申请号：US915602
申请日：1986-10-06
申请人： Arnold L. Newman , William D. Stanbro
发明人： Arnold L. Newman , William D. Stanbro
IPC分类号： G01N33/543 , B44C1/22 , C03C15/00 , C03C25/06
CPC分类号： G01N33/54393 , Y10S436/81
摘要： This invention relates to an apparatus and method for regulating the exposure of active surfaces by covering the surface with an erodible protection coating. The rate of erosion is controlled by chemical and/or physical means so that the surface is progressively and gradually exposed.
摘要翻译：本发明涉及通过用可侵蚀保护涂层覆盖表面来调节活性表面的曝光的装置和方法。侵蚀速率由化学和/或物理手段控制，使得表面逐渐暴露。

5. 发明授权

US4728882A Capacitive chemical sensor for detecting certain analytes, including hydrocarbons in a liquid medium 失效
标题翻译：用于检测某些分析物的电容化学传感器，包括液体介质中的碳氢化合物
公开(公告)号：US4728882A
公开(公告)日：1988-03-01
申请号：US846778
申请日：1986-04-01
申请人： William D. Stanbro , Arnold L. Newman
发明人： William D. Stanbro , Arnold L. Newman
IPC分类号： G01N27/06 , G01N27/22 , G01N33/18 , G01R27/26
CPC分类号： G01N33/1833 , G01N27/227
摘要： An apparatus for detecting the concentration of certain analytes, including hydrocarbons, in a liquid medium, is disclosed. The apparatus uses a planar or "open" capacitor containing an active layer. In response to selected analyte in the liquid medium, the active layer causes capacitance to decrease with increasing analyte concentration. The capacitance decreases because higher dielectric water molecules are displaced from a region of the capacitor's electric field. For certain hydrocarbon analytes having high Henry's Law constants, the active layer causes bubbles to nucleate in the liquid medium on the surface of the active layer. Bubble formation displaces water molecules and decreases capacitance.
摘要翻译：公开了一种在液体介质中检测某些分析物（包括烃）的浓度的装置。该装置使用包含活性层的平面或“开放”电容器。响应于液体介质中选定的分析物，活性层导致电容随着分析物浓度的增加而降低。电容降低，因为较高的介电水分子从电容器的电场的位置偏移。对于具有较高亨利定律常数的某些烃分析物，活性层会在有源层表面的液体介质中使气泡成核。气泡形成排除水分子并降低电容。

6. 发明授权

US5045479A Continuous flow competitive assay with reference system 失效
标题翻译：连续流动竞争性测定与参考系统
公开(公告)号：US5045479A
公开(公告)日：1991-09-03
申请号：US215106
申请日：1988-07-05
申请人： Arnold L. Newman , William D. Stanbro
发明人： Arnold L. Newman , William D. Stanbro
IPC分类号： G01N33/543 , G01N35/08
CPC分类号： G01N35/08 , G01N33/54366 , G01N2021/6439 , Y10S435/808 , Y10T436/117497 , Y10T436/13
摘要： The invention relates to a continuous flow competitive assay system for the detection and measurement of chemical and biochemical analytes. It is a time-based, continuous on-line measurement of analyte concentrations comprising three functional assemblies connected in series: a sampler, a reactor and a detector. Tagged immunochemical discharged from the reactor is detected in the detector which contains a model of system response with the tagged immunochemical and keeps track of the amount of tagged immunochemical lost during the course of the operation of the reactor.
摘要翻译：本发明涉及用于检测和测量化学和生化分析物的连续流动竞争性测定系统。它是一种基于时间的连续在线测量分析物浓度，包括串联连接的三个功能组件：采样器，反应器和检测器。在检测器中检测到从反应器排出的标记的免疫化学物质，其含有带有标记免疫化学物质的系统应答模型，并跟踪在反应器操作过程中损失的标记的免疫化学物质的量。

7. 发明授权

US07607631B2 Frame leveler 失效
标题翻译：矫正机
公开(公告)号：US07607631B2
公开(公告)日：2009-10-27
申请号：US11139123
申请日：2005-05-28
申请人： Arnold L. Newman
发明人： Arnold L. Newman
IPC分类号： A47G1/16
CPC分类号： A47G1/18
摘要： A frame leveler is disclosed that automatically levels picture frames, and mirror frames. A pivotable, weighted bob is used as a gravity reference to control a lock that unlocks the extension of a cable on the side of a frame that is tilted up with respect to the other side, when the frame is not level. The extensible cable is let out until the frame is once again level, at which point the extensible cable is locked and prevented from extending further. When the frame side is tilted down with respect to the other side, or the frame is level, the extensible cable is locked and prevented from extending on that side.
摘要翻译：公开了一种自动调整图像帧和镜像帧的平衡器。使用可枢转的加重锤作为重力参考，以控制当框架不平坦时，可以解锁在相对于另一侧向上倾斜的框架侧上的电缆的延伸的锁。可伸展电缆放出直到框架再一次水平，此时可伸缩电缆被锁定并防止其延伸。当框架侧相对于另一侧倾斜下降或框架水平时，可伸缩电缆被锁定并防止在该侧延伸。

8. 发明授权

US10258959B2 Methods of producing heterodiamond and apparatus therefor 有权
公开(公告)号：US10258959B2
公开(公告)日：2019-04-16
申请号：US14934679
申请日：2015-11-06
申请人： Arnold L. Newman , Daniel Hodes
发明人： Arnold L. Newman , Daniel Hodes
IPC分类号： B01J19/12 , C01B21/06 , C30B29/04 , C01B32/25 , C01B32/28 , C01B32/956
摘要： A combinatorial synthesis of a heterodiamond unit cell, which entails a step of reacting a tetrahedranoidal molecule with a heteroatom to form heterodiamond unit cell and then heterodiamond mass.

9. 发明授权

US5106751A Apparatus for supporting a biochemical sensor responsive to bubbles 失效
标题翻译：用于支持响应于气泡的生化传感器的装置
公开(公告)号：US5106751A
公开(公告)日：1992-04-21
申请号：US350222
申请日：1989-05-11
申请人： Arnold L. Newman
发明人： Arnold L. Newman
IPC分类号： C12M1/34 , C12Q1/00 , G01N33/543
CPC分类号： C12M41/34 , C12Q1/001 , G01N33/5438 , Y10S435/807 , Y10S435/808 , Y10S435/817
摘要： A biochemical sensor includes a material that nucleates as bubbles on the surface of an electrical conductor, optical fiber, or acoustic medium. The nucleating bubbles respectively change the conductivity, refraction, or propagation of such surfaces according to the concentration of the analyte in a solution over the sensor.
摘要翻译：生物化学传感器包括在电导体，光纤或声学介质的表面上成核的材料。成核气泡根据溶液中分析物在传感器上的浓度分别改变这些表面的电导率，折射或传播。

10. 发明授权

US4881939A Implantable helical cuff 失效
标题翻译：植入式螺旋箍
公开(公告)号：US4881939A
公开(公告)日：1989-11-21
申请号：US702570
申请日：1985-02-19
申请人： Arnold L. Newman
发明人： Arnold L. Newman
IPC分类号： A61B5/022 , A61B17/00 , A61B17/12 , A61B19/00
CPC分类号： A61B5/6876 , A61B17/12009 , A61B5/02233 , A61B5/42 , A61B5/6884 , A61B2017/00557 , A61B90/06 , Y10S128/25
摘要： The invention concerns an implantable, inflatable helical cuff which is wrapped about a tubular body member such as a nerve cord, esophagus, colon, intestine, or blood vessel in a pressure transferring relationship. The cuff may be completely inflated to function as an occluder, or partially inflated to function as a pressure sensor or transducer in an appropriate system.
摘要翻译：本发明涉及一种可植入的可膨胀的螺旋形袖带，其在压力转移关系下缠绕在诸如神经绳，食道，结肠，肠或血管的管状本体构件周围。袖带可以完全充气以用作闭塞器，或部分膨胀以用作适当系统中的压力传感器或换能器。

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