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1. 发明申请

US20050131034A1 Compounds capable of activating cholinergic receptors 审中-公开
标题翻译：能够激活胆碱能受体的化合物
公开(公告)号：US20050131034A1
公开(公告)日：2005-06-16
申请号：US11048212
申请日：2005-02-01
申请人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks
发明人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks
IPC分类号： A61K31/44 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D239/26 , A61K31/70 , C07D213/24
CPC分类号： A61K31/44 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D239/24 , C07D239/26
摘要： Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.
摘要翻译：提供了包含芳基取代的烯属胺的化合物。代表性的化合物是（4E）-N-甲基-5-（3-吡啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（5-嘧啶基）-4-戊烯-2-胺，（ 4E）-N-甲基-5-（5-甲氧基-3-吡啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（6-氨基-5-甲基-3-吡啶基）（2R） - （4E）-N-甲基-5-（3-吡啶基）-4-戊烯-2-胺，（2R） - （4E）-N-甲基-5 - （5-异丙氧基-3-吡啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（5-溴-3-吡啶基）-4-戊烯-2-胺，（4E） -N-甲基-5-（5-乙氧基-3-吡啶基）-4-戊烯-2-胺，（2S） - （4E）-N-甲基-5-（3-吡啶基）-4-戊烯-2 （4E）-N-甲基-5-（5-异丙氧基-3-吡啶基）-4-戊烯-2-胺和（2S） - （4E）-N-甲基-5-（5-异丙氧基 - -3-吡啶基）-4-戊烯-2-胺。

2. 发明申请

US20060293289A1 Compounds Capable of Activating Cholinergic Receptors 审中-公开
标题翻译：能激活胆碱能受体的化合物
公开(公告)号：US20060293289A1
公开(公告)日：2006-12-28
申请号：US11277664
申请日：2006-03-28
申请人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks , Patrick Lippiello , Merouane Bencherif
发明人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks , Patrick Lippiello , Merouane Bencherif
IPC分类号： A61K31/513 , A61K31/506 , A61K31/655 , C07D239/42 , C07D403/02
CPC分类号： C07D239/26 , A61K31/44 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D403/06
摘要： The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.
摘要翻译：本发明一般涉及以芳基取代的烯属化合物形式的烟碱化合物，以及前药，N-氧化物，代谢产物和药学上可接受的盐形式。还公开了通过施用化合物，前药，N-氧化物和/或药学上可接受的盐调节神经递质释放的方法。

3. 发明申请

US20060264445A1 Compounds Capable of Activating Cholinergic Receptors 失效
标题翻译：能激活胆碱能受体的化合物
公开(公告)号：US20060264445A1
公开(公告)日：2006-11-23
申请号：US11379443
申请日：2006-04-20
申请人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks
发明人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks
IPC分类号： C07D239/02
CPC分类号： A61K31/44 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D239/24 , C07D239/26
摘要： Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.
摘要翻译：提供了包含芳基取代的烯属胺的化合物。代表性的化合物是（4E）-N-甲基-5-（3-吡啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（5-嘧啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（5-甲氧基-3-吡啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（6-氨基-5-甲基-3- 吡啶基）-4-戊烯-2-胺，（2R） - （4E）-N-甲基-5-（3-吡啶基）-4-戊烯-2-胺，（2R） - （4E）-N-甲基 -5-（5-异丙氧基-3-吡啶基）-4-戊烯-2-胺，（4E）-N-甲基-5-（5-溴-3-吡啶基）-4-戊烯-2-胺，（ 4E）-N-甲基-5-（5-乙氧基-3-吡啶基）-4-戊烯-2-胺，（2S） - （4E）-N-甲基-5-（3-吡啶基）-4-戊烯（4E）-N-甲基-5-（5-异丙氧基-3-吡啶基）-4-戊烯-2-胺和（2S） - （4E）-N-甲基-5-（5- 异丙氧基-3-吡啶基）-4-戊烯-2-胺。

4. 发明申请

US20050148611A1 Compounds capable of activating cholinergic receptors 失效
公开(公告)号：US20050148611A1
公开(公告)日：2005-07-07
申请号：US10971543
申请日：2004-10-22
申请人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks , Patrick Lippiello , Merouane Bencherif
发明人： William Caldwell , Gary Dull , Balwinder Bhatti , Srishailkumar Hadimani , Haeil Park , Jared Wagner , Peter Crooks , Patrick Lippiello , Merouane Bencherif
IPC分类号： A61K31/44 , A61K31/505 , A61P25/28 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D239/26 , A61K31/513 , A61K31/137 , A61K31/47
CPC分类号： C07D239/26 , A61K31/44 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/73 , C07D403/06
摘要： The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

5. 发明申请

US20050081581A1 Locking system for a door 失效
标题翻译：门锁系统
公开(公告)号：US20050081581A1
公开(公告)日：2005-04-21
申请号：US10687527
申请日：2003-10-16
申请人： William Caldwell , William Caldwell
发明人： William Caldwell , William Caldwell
IPC分类号： E05B15/12 , E05B47/06 , E05B65/16 , E05B67/38 , E05C9/04 , E05B13/00
CPC分类号： E05B17/2023 , E05B47/0696 , E05B67/383 , E05B77/44 , E05B83/12 , E05C9/048 , Y10S292/32 , Y10T70/498 , Y10T70/5199 , Y10T70/5319 , Y10T70/5739 , Y10T70/577 , Y10T70/5779 , Y10T292/1025 , Y10T292/1028
摘要： A security locking system for trailers that features an interior locking bar that is controlled from the outside. The locking bar is traversed in a linear motion parallel to the door by means of a toggle mechanism. The bar is guided into the locking mechanism by two guides mounted to the inside of the trailer door. The toggle mechanism is turned using a common trailer latch that also locks by use of a key. Alternatively the latch could be modified to lock or unlock by means of a remote. Once the latch is turned all the way (90 degrees), it will raise the locking bar into the upper secure bracket. The lower part of the locking bar will be lowered into the lock housing which is hidden just under the trailer floor; it will then be in position in the locking mechanism for the key pin to be inserted and then locked. The locking mechanism can also be modified to be controlled by means of a remote.
摘要翻译：一种用于拖车的安全锁定系统，具有从外部控制的内部锁定杆。锁定杆通过肘节机构以平行于门的直线运动方式移动。通过安装在拖车门内部的两个导轨将该杆引导到锁定机构中。肘节机构使用也通过使用钥匙锁定的公共拖车闩锁来转动。或者，可以通过遥控器修改闩锁来锁定或解锁。一旦闩锁完全转动（90度），就会将锁定杆抬起到上部固定支架上。锁定杆的下部将被下降到隐藏在拖车底部下方的锁壳中; 然后它将在锁定机构中的位置中，以便将钥匙销插入并锁定。锁定机构也可以通过遥控器进行修改。

6. 发明授权

US6128433A Controlling frequency drift of a digital video tape drive 失效
标题翻译：控制数字录像带的频率漂移
公开(公告)号：US6128433A
公开(公告)日：2000-10-03
申请号：US1743
申请日：1997-12-31
申请人： Melvin Gable , William Caldwell
发明人： Melvin Gable , William Caldwell
IPC分类号： G11B15/467 , G11B15/473 , H04N9/804 , H04N5/76
CPC分类号： H04N9/8042 , G11B15/4671 , G11B15/4731
摘要： A digital video tape drive and a method of controlling frequency drift in the tape drive. The tape drive includes a helical scan recorder in which the recording drum motor and the capstan motor arc synchronized to the frequency of a long-term reference clock derived from a reference signal (e.g. an MPEG program clock reference (PCR) signal or system clock reference (SCR) signal) embedded in digital video data to be recorded by the tape drive. The drum motor is also phase locked to the long-term reference clock signal. In addition, the drum motor is synchronized to a reference clock derived from the reference signal during playback of the digital video data.
摘要翻译：一种数字录像带驱动器和一种控制磁带驱动器中的频率漂移的方法。磁带驱动器包括螺旋扫描记录器，其中记录鼓电动机和主导轴电动机与从参考信号（例如MPEG程序时钟参考（PCR）信号或系统时钟参考）导出的长期参考时钟的频率同步（SCR）信号）嵌入数字视频数据中以由磁带驱动器记录。鼓电机也被锁定到长期参考时钟信号。此外，在数字视频数据的回放期间，鼓马达与参考信号同步。

7. 发明申请

US20050091908A1 Trotline leader system 失效
标题翻译： Trotline领导系统
公开(公告)号：US20050091908A1
公开(公告)日：2005-05-05
申请号：US10979615
申请日：2004-11-02
申请人： William Caldwell
发明人： William Caldwell
IPC分类号： A01K91/18
CPC分类号： A01K91/18 , Y10S24/908
摘要： A trotline leader system for fishing including a trotline, with a plurality of clips, hangers, drop lines, and fishing hooks, each clip including a head portion, a neck and a base and each hanger includes a head, a shank and an eyelet. The head portion is connected to the neck which extends from the base which is adapted to receive the hanger head. The hanger head is connected to the shank which connects and seperates the eyelet from the head. The head portion includes a tab, a channel, a slot and an apeture, the tab extending from the head and forming the channel with the base, the channel leading to the slot which guides the trotline into the apeture. Each drop line is connected to and extends from the hanger eyelet to each fishing hook. In addition, the trotline may optionally include plastic beads or spherical weights to separate and secure each clip to the trotline.
摘要翻译：一种用于钓鱼的小腿领导系统，包括多条裤子，多个夹子，衣架，落线和钓鱼钩，每个夹子包括头部，颈部和底部，每个衣架包括头部，柄部和孔眼。头部连接到从基座延伸的颈部，颈部适于接纳衣架头部。吊架头连接到与头部连接和分离孔眼的柄部。头部包括突片，通道，狭槽和爪，所述突出部从头部延伸并与基部形成通道，通道通向引导小腿线进入开口的狭槽。每个下落线连接到衣架孔眼并延伸到每个钓鱼钩。此外，小跑可以可选地包括塑料珠或球形重物以将每个夹子分离并固定到小跑线上。

8. 发明授权

US08328141B2 Apparatus and method for stowing suspension lines 失效
标题翻译：装载悬挂线的装置和方法
公开(公告)号：US08328141B2
公开(公告)日：2012-12-11
申请号：US12500339
申请日：2009-07-09
申请人： William Caldwell
发明人： William Caldwell
IPC分类号： B64D17/40 , B64D17/22
CPC分类号： B64D17/40
摘要： An apparatus for packing a parachute is presented, the apparatus including an expander member extending along a longitudinal axis and having at least a ramp portion that extends in the direction from a first end of the expander member to a second end of the expander member. The ramp portion has an outer surface expanding in perimeter shape from the first end to the second end of the expander member. A channel defined from inner surfaces of the ramp portion extends along the longitudinal axis from an opening at the second end of the expander member towards the first end. The first end of the expander member is configured to engage a substantially unexpanded loop of a stowage device and to expand the perimeter shape of the loop as the loop is moved along the longitudinal axis from the first end to the second end.
摘要翻译：提供了一种用于包装降落伞的装置，该装置包括沿着纵向轴线延伸的膨胀器构件，并且至少具有沿从膨胀器构件的第一端向扩展器构件的第二端延伸的斜面部分。斜坡部分具有从膨胀器构件的第一端到第二端的周边形状的外表面。从斜坡部分的内表面限定的通道沿着纵向轴线从膨胀器构件的第二端处的开口向第一端延伸。膨胀器构件的第一端构造成接合装载装置的基本上未膨胀的环并且当环沿着纵向轴线从第一端移动到第二端时扩展环的周边形状。

9. 发明授权

US6151443A Digital video and data recorder 失效
标题翻译：数字视频和数据记录仪
公开(公告)号：US6151443A
公开(公告)日：2000-11-21
申请号：US858084
申请日：1997-05-16
申请人： Melvin Gable , Roy Lewis , William Caldwell
发明人： Melvin Gable , Roy Lewis , William Caldwell
IPC分类号： H04N5/7826 , G11B20/10 , G11B20/12 , G11B27/032 , G11B27/034 , G11B27/30 , H04N1/00 , H04N5/782 , H04N5/91 , H04N5/92 , H04N7/32 , H04N9/79 , H04N9/804 , H04N9/82 , H04N9/888 , H04N21/4147 , H04N21/43 , H04N21/432 , H04N21/433 , H04N21/44 , H04N21/845 , H04N5/917 , H04N5/928
CPC分类号： G11B27/032 , G11B27/034 , G11B27/3027 , H04N21/4147 , H04N21/4305 , H04N21/4325 , H04N21/4334 , H04N21/44016 , H04N21/8455 , H04N9/8042 , H04N9/8205 , G11B2220/20 , G11B2220/2512 , G11B2220/90 , G11B2220/913 , G11B27/3063 , H04N5/782 , H04N9/7925 , H04N9/888
摘要： A "pause and resume" function and a "channel change" function for recording and playing interframe compressed audiovideo data, particularly MPEG data. The invention includes a digital track format and a method for recording one or more sessions from one or more streams of interframe compressed audiovideo data which has been synchronized to a reference clock. The invention adds special "splice point" indicators to recorded video material. The splice point indicators are added either periodically (e.g., by recording a special reference clock) or when a discontinuity occurs in recording audiovideo data streams. Splice point indicators are used to determine the existence of a point of discontinuity in the recorded audiovideo data. The system and method enable pausing and later resuming recording of an audiovideo data stream such that the audiovideo data can be played back with proper resynchronization at each point of discontinuity (the "pause and resume" function). The format and method also allow for recording an abrupt change from one audiovideo data stream to a different audiovideo data stream having a different clock reference, such that the two recorded sequences are spliced together as one continuous recorded sequence that can be played back with resynchronization of the program audiovideo data at each splice point (the "channel change" function). As a consequence of using an added special reference clock as a splice point indicator, the invention also provides random access playback. In addition, the invention permits recording of conventional data in standard storage formats.
摘要翻译： “暂停和恢复”功能和用于记录和播放帧间压缩音频视频数据，特别是MPEG数据的“频道改变”功能。本发明包括数字轨道格式和用于从已经被同步到参考时钟的帧间压缩音频视频数据的一个或多个流记录一个或多个会话的方法。本发明为记录的视频材料添加了特殊的“拼接点”指示器。拼接点指示符周期性地添加（例如，通过记录特殊参考时钟）或者当记录音频视频数据流时发生不连续性。拼接点指示符用于确定记录的音视频数据中是否存在不连续点。系统和方法使得能够暂停并且稍后恢复音频视频数据流的记录，使得音频视频数据可以在每个不连续点（“暂停和恢复”功能）下以适当的重新同步进行播放。格式和方法还允许记录从一个音频视频数据流到具有不同时钟参考的不同音频视频数据流的突然改变，使得两个记录的序列被拼接在一起作为一个连续的记录序列，可以通过重新同步每个拼接点的节目音视频数据（“频道切换”功能）。作为使用附加的特殊参考时钟作为拼接点指示符的结果，本发明还提供了随机访问重放。此外，本发明允许以标准存储格式记录常规数据。

10. 发明申请

US20110006161A1 Apparatus and Method for Stowing Suspension Lines 失效
标题翻译：装载悬挂系统的装置和方法
公开(公告)号：US20110006161A1
公开(公告)日：2011-01-13
申请号：US12500339
申请日：2009-07-09
申请人： William Caldwell
发明人： William Caldwell
IPC分类号： B64D17/40
CPC分类号： B64D17/40
摘要： An apparatus for packing a parachute is presented, the apparatus including an expander member extending along a longitudinal axis and having at least a ramp portion that extends in the direction from a first end of the expander member to a second end of the expander member. The ramp portion has an outer surface expanding in perimeter shape from the first end to the second end of the expander member. A channel defined from inner surfaces of the ramp portion extends along the longitudinal axis from an opening at the second end of the expander member towards the first end. The first end of the expander member is configured to engage a substantially unexpanded loop of a stowage device and to expand the perimeter shape of the loop as the loop is moved along the longitudinal axis from the first end to the second end.
摘要翻译：提供了一种用于包装降落伞的装置，该装置包括沿着纵向轴线延伸的膨胀器构件，并且至少具有沿从膨胀器构件的第一端向扩展器构件的第二端延伸的斜面部分。斜坡部分具有从膨胀器构件的第一端到第二端的周边形状的外表面。从斜面部分的内表面限定的通道沿着纵向轴线从膨胀器构件的第二端处的开口向第一端延伸。膨胀器构件的第一端构造成接合装载装置的基本上未膨胀的环并且当环沿着纵向轴线从第一端移动到第二端时扩展环的周边形状。

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