专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06794542B2 Method for the preparation of enantiomerically enriched compounds 失效
标题翻译：制备对映体富集化合物的方法
公开(公告)号：US06794542B2
公开(公告)日：2004-09-21
申请号：US10148853
申请日：2002-10-09
申请人： Wilhelmus Hubertus Joseph Boesten , Harold Monro Moody , Bernardus Kaptein , Johannes Paulus Gerardus Seerden , Marcelles Van Der Sluis , Ben Lange De , Quirinus Bernardus Broxterman
发明人： Wilhelmus Hubertus Joseph Boesten , Harold Monro Moody , Bernardus Kaptein , Johannes Paulus Gerardus Seerden , Marcelles Van Der Sluis , Ben Lange De , Quirinus Bernardus Broxterman
IPC分类号： C07C23305
CPC分类号： C07C253/00 , C07B2200/07 , C07C209/62 , C07C227/32 , C07C231/06 , C07C231/18 , C07C253/08 , C07C253/30 , C07C229/08 , C07C233/06 , C07C237/20 , C07C255/25 , C07C255/43
摘要： Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2—C(O)—R3, and the Schiff base obtained is subsequently converted into the diastereomerically enriched phenyglycine amide derivative with the aid of a cyanide source, a reducing agent or an allyl organometallic compound. The phenylglycine amide derivatives obtained are interesting starting materials for the preparation of for example enantiomerically enriched &agr;- and or &bgr;-amino acids and derivatives thereof, such as amides and esters, and amines.
摘要翻译：制备非对映体富集的苯基甘氨酸酰胺衍生物的方法，其中通过化合物R2-C（O）-R3将对映异构体富集的苯基甘氨酸酰胺转化成相应的希夫碱，随后将获得的席夫碱转化为非对映异构体在氰化物源，还原剂或烯丙基有机金属化合物的帮助下，富集的苯基甘氨酸酰胺衍生物。获得的苯基甘氨酸酰胺衍生物是用于制备例如对映体富集的α-和/或β-氨基酸及其衍生物如酰胺和酯以及胺的令人感兴趣的起始原料。

2. 发明申请

US20080255349A1 METHOD FOR THE PREPARATION OF AN ENANTIOMERICALLY PURE BENZAZEPINE 失效
标题翻译：制备纯化苯并噻吩的方法
公开(公告)号：US20080255349A1
公开(公告)日：2008-10-16
申请号：US12098677
申请日：2008-04-07
申请人： Gerardus Johannes Kemperman , Johannes Paulus Gerardus Seerden
发明人： Gerardus Johannes Kemperman , Johannes Paulus Gerardus Seerden
IPC分类号： C07D487/06
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention relates to a method for the preparation of a cyclic compound according to formula III comprising reacting a compound according to Formula I and a compound according to formula II, wherein in Formula I, R1, R2, R3 and R4 may be hydrogen or substituent groups comprising one or more carbon atoms and/or hetero-atoms, wherein R1, R2, R3 and R4 can be combined in aromatic or aliphatic ring structures, —Y is a ring element comprising 1-3 substituted or unsubstituted carbon atoms and/or heteroatoms in the ring and —R5 is hydrogen or a hydrocarbon substituent group comprising one or more carbon atoms and optionally one or more hetero atoms, and wherein in Formula II, Z1 and Z2 are, leaving groups, X is a reactive functional hydrocarbon group for subsequent ring closure, comprising one or more carbon atoms and a reactive functional group and having a chain of between 1 to 6 atoms between the carbon atom attached to the central carbon atom of formula II and the reactive functional group and R8 is hydrogen or a hydrocarbon substituent different from X making the central carbon atom of formula II a chiral centre in Formula III and wherein reactive functional group X can be or can be extended to be compound of formula IV which can be ring closed to produce the polycyclic component of formula V. More in particular, the invention relates to the preparation of mirtazapine precursors and mirtazapine preferably having a substantial enantiomeric excess.
摘要翻译：本发明涉及一种制备根据式III的环状化合物的方法，包括使根据式I的化合物与式II化合物反应，其中在式I中R 1，R 2， R 3，R 3和R 4可以是氢或包含一个或多个碳原子和/或杂原子的取代基，其中R

3. 发明授权

US07994314B2 Method for the preparation of an enantiomerically pure benzazepine 失效
标题翻译：制备对映体纯的苯并氮平的方法
公开(公告)号：US07994314B2
公开(公告)日：2011-08-09
申请号：US12098677
申请日：2008-04-07
申请人： Gerardus Johannes Kemperman , Johannes Paulus Gerardus Seerden
发明人： Gerardus Johannes Kemperman , Johannes Paulus Gerardus Seerden
IPC分类号： C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention relates to the preparation of mirtazapine precursors and mirtazapine preferably having a substantial enantiomeric excess.
摘要翻译：本发明涉及米氮平前体和米氮平的制备，其优选具有显着的对映体过量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式