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1. 发明授权

US5338512A Method for oxygenation of a patient's blood 失效
标题翻译：患者血液氧合的方法
公开(公告)号：US5338512A
公开(公告)日：1994-08-16
申请号：US024998
申请日：1993-03-02
申请人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
发明人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M1/36 , B01D63/02
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , B01D2313/105 , B01D2313/125 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
摘要翻译：一种包括整体形成的膜氧合器和定位在单个壳体中的热交换装置的装置。该装置包括在其表面上形成有多个血液通道的导热体，以及透气膜，或位于外壳中的膜，与热交换体基本接触以覆盖或位于每个通路的一部分内。膜定义了与通过气体引导的血液通路分离的气体通路。血液通过个体血液通路。该装置还包括用于将血液输送到各个通道的各种端口和通道，以及用于从装置收集和移除血液。

2. 发明授权

US5290236A Low priming volume centrifugal blood pump 失效
标题翻译：低起动体积离心血泵
公开(公告)号：US5290236A
公开(公告)日：1994-03-01
申请号：US918721
申请日：1992-07-21
申请人： Wilfred F. Mathewson
发明人： Wilfred F. Mathewson
IPC分类号： A61M1/10 , A61M1/16 , A61M1/26 , B01D63/02 , B01D65/08 , F04D29/22 , F04D29/24 , A61M5/142
CPC分类号： A61M1/101 , A61M1/1006 , A61M1/1625 , A61M1/1698 , A61M1/262 , A61M1/267 , B01D63/02 , B01D63/021 , B01D65/08 , F04D29/2255 , F04D29/242 , B01D2321/20
摘要： A low priming volume centrifugal pump comprising a disc shaped impeller having opposite faces and an inlet hole centrally disposed therein. The impeller has flow channels disposed on at least one of the faces of the impeller which radiate outward from said inlet hole. The volume of the flow channels is small relative to the total impeller envelope volume providing for efficient momentum transfer with a minimum of turbulence and backflow Thus, priming volume is reduced and flow within the pump is more efficient. The pump can be used as stand alone device, or it can be integrated with a blood oxygenator into a common housing.
摘要翻译：一种低起动体积离心泵，其包括具有相对面的盘形叶轮和中心地设置在其中的入口孔。叶轮具有设置在从所述入口孔向外辐射的叶轮的至少一个面上的流动通道。流动通道的体积相对于总叶轮包络体积较小，提供了具有最小湍流和回流的有效动量传递。因此，引燃体积减小并且泵内的流动更有效。该泵可用作独立装置，也可将其与血液充氧器整合到共同的外壳中。

3. 发明授权

US5071609A Process of manufacturing porous multi-expanded fluoropolymers 失效
标题翻译：制造多孔多层氟聚合物的方法
公开(公告)号：US5071609A
公开(公告)日：1991-12-10
申请号：US266745
申请日：1988-11-03
申请人： Roger H. Tu , Wilfred F. Mathewson , Mark A. Roberts
发明人： Roger H. Tu , Wilfred F. Mathewson , Mark A. Roberts
IPC分类号： B29C55/00 , C08J9/00 , C08L21/00 , C08L27/18
CPC分类号： C08J9/00 , B29C55/005 , C08L27/18 , B29K2027/18 , B29K2105/0088 , B29K2105/04 , C08J2327/18 , C08L21/00 , Y10T428/31544
摘要： Interpenetrated matrix of polytetrafluoroethylene and elastomer is disclosed. The matrix is formed into a composite material which is flexible, durable, highly porous with a tight microporous structure and improved retractability. The composite material is subjected to a multi-expansion process to produce shaped articles such as films, tubes, rods and filaments with excellent flexibility and elasticity. More particularly, the composite material can be utilized to produce vascular grafts with excellent biological compatibility.
摘要翻译：公开了聚四氟乙烯和弹性体的互穿基体。该基质形成复合材料，其具有柔性，耐用，高度多孔性，具有紧密的微孔结构和改进的收缩性。将复合材料进行多次膨胀处理以产生具有优异的柔性和弹性的成形制品，例如薄膜，管，棒和长丝。更具体地，复合材料可用于生产具有优异生物相容性的血管移植物。

4. 发明授权

US5225161A Integrated membrane blood oxygenator/heat exchanger 失效
标题翻译：集成膜血液充氧器/换热器
公开(公告)号：US5225161A
公开(公告)日：1993-07-06
申请号：US848897
申请日：1992-03-10
申请人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
发明人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
IPC分类号： A61M1/16 , B01D63/02
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
摘要翻译：一种包括整体形成的膜氧合器和定位在单个壳体中的热交换装置的装置。该装置包括在其表面上形成有多个血液通道的导热体，以及透气膜，或位于外壳中的膜，与热交换体基本接触以覆盖或位于每个通路的一部分内。膜定义了与通过气体引导的血液通路分离的气体通路。血液通过个体血液通路。该装置还包括用于将血液输送到各个通道的各种端口和通道，以及用于从装置收集和移除血液。

5. 发明授权

US4882113A Heterogeneous elastomeric compositions containing a fluoroelastomer and PTFE and methods for manufacturing said compositions 失效
标题翻译：含有氟弹性体和PTFE的非均相弹性体组合物及其制造方法
公开(公告)号：US4882113A
公开(公告)日：1989-11-21
申请号：US303520
申请日：1989-01-26
申请人： Roger Tu , Wilfred F. Mathewson
发明人： Roger Tu , Wilfred F. Mathewson
IPC分类号： C08L27/12 , C08L27/18
CPC分类号： C08L27/12 , C08L27/18 , Y10S521/919
摘要： A composition comprising a homogenous mixture of unsintered porous fluoropolymer particles and fluoroelastomers, processes for manufacturing the composition, and devices made from the composition.
摘要翻译：包含未烧结的多孔含氟聚合物颗粒和含氟弹性体的均匀混合物的组合物，用于制备组合物的方法，以及由该组合物制成的装置。

6. 发明授权

US5316724A Multiple blood path membrane oxygenator 失效
标题翻译：多路血管膜充氧器
公开(公告)号：US5316724A
公开(公告)日：1994-05-31
申请号：US945998
申请日：1992-09-15
申请人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David Karshmer
发明人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David Karshmer
IPC分类号： A61M1/16 , B01D63/04 , A61M1/14
CPC分类号： A61M1/1698 , A61M1/1625 , B01D63/024 , B01D63/04 , B01D2313/105 , B01D2313/20 , Y10S128/03
摘要： A membrane oxygenator designed to provide blood flow evenly across a gas permeable membrane in a direction substantially perpendicular to the longitudinal direction of the gas permeable membrane. In particular, the present invention is directed to a membrane oxygenator wherein the blood is distributed substantially evenly and at a substantially constant velocity, in a cross-wise direction across the gas permeable membrane. In accordance with a preferred embodiment, the membrane is a bundle of gas permeable hollow fibers with the blood being distributed in a direction substantially perpendicular to the longitudinal direction of the individual hollow fiber membranes.
摘要翻译：一种膜氧合器，设计用于在基本上垂直于气体可渗透膜的纵向方向的方向上使气流均匀地跨越透气膜。特别地，本发明涉及一种膜氧合器，其中血液基本上均匀地并且以基本上恒定的速度跨越气体可渗透膜的横向方向分布。根据优选实施方案，膜是一束透气中空纤维，其中血液沿基本上垂直于各个中空纤维膜的纵向的方向分布。

7. 发明授权

US5263924A Integrated low priming volume centrifugal pump and membrane oxygenator 失效
标题翻译：集成低启动体积离心泵和膜式氧合器
公开(公告)号：US5263924A
公开(公告)日：1993-11-23
申请号：US765307
申请日：1991-09-25
申请人： Wilfred F. Mathewson
发明人： Wilfred F. Mathewson
IPC分类号： A61M1/10 , A61M1/16 , A61M1/26 , B01D63/02 , B01D65/08 , A61M1/03
CPC分类号： B01D63/021 , A61M1/1006 , A61M1/101 , A61M1/1625 , A61M1/1698 , A61M1/262 , A61M1/267 , B01D63/02 , B01D63/025 , B01D65/08 , B01D2313/02 , B01D2321/2066 , Y10S128/03 , Y10S261/28
摘要： A low priming volume integrated centrifugal pump and membrane oxygenator comprising a housing containing a mass transfer bed comprising gas permeable hollow membrane fibers placed circumferentially in a ring around an impeller. The mass transfer bed is formed by a multiple wrap of a fiber ribbon comprising at least two layers of fibers bonded in precise orientation with fibers in alternate layers are positioned in line with the opening between fibers in the layers above and below. Adhesion means ensure precise orientation of the fibers. Priming volume is further reduced by a small impeller flow channel volume.
摘要翻译：一种低起动体积的离心泵和膜式氧合器，其包括含有传质床的壳体，该传质床包括围绕叶轮环绕在圆周上的透气中空膜纤维。传质床由纤维带的多重包裹形成，该纤维带包括至少两层纤维，其以精确取向与交替层中的纤维接合，定位成与上述和下面的层中的纤维之间的开口一致。粘合意味着确保纤维的精确取向。通过小的叶轮流动通道体积进一步降低启动体积。

8. 发明授权

US5236665A Hollow fiber treatment apparatus and membrane oxygenator 失效
标题翻译：中空纤维治疗仪和膜式氧合器
公开(公告)号：US5236665A
公开(公告)日：1993-08-17
申请号：US971717
申请日：1992-11-04
申请人： Wilfred F. Mathewson , Philip L. Ritger
发明人： Wilfred F. Mathewson , Philip L. Ritger
IPC分类号： A61M1/16 , B01D63/02 , B01D63/04
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , B01D63/026 , B01D63/04 , B01D69/084 , B01D2313/14 , Y10S128/03 , Y10S261/28
摘要： A hollow fiber membrane fluid treatment apparatus for the transfer of mass or energy through the membrane is disclosed. It is designed particularly, but not only, for use in membrane oxygenators. Hollow fiber membranes extend substantially longitudinally, first inert fibers are spaced between them and also extend substantially longitudinally. Second inert fibers extend generally transverse to the hollow fibers and generally contiguous therewith, so that a first fluid (preferably an oxygen-containing gas) can pass through the hollow fibers and a second fluid (preferably blood) can be passed over their exterior for mass or energy transfer through the membrane. Usually the second inert fibers form a weft and the first inert fibers are spaced one between each two hollow fibers so that the warp consists of alternating strands of hollow fiber and first inert fiber passing over the weft in an oscillating fashion to define at least in part the size of the fluid film to be passed over the hollow fiber membrane for mass or energy transfer through the membrane. The inert fibers are usually biocompatible monofilament polymers which provide precise spacing of the hollow fibers to produce even blood films. Usually, the apparatus is disposed in a blood passageway of a membrane oxygenator, and layered in ribbons sized to fit the blood channel with the first inert fibers spacing the hollow fibers so that the hollow fibers are offset with respect to each other from layer to layer.
摘要翻译：公开了一种通过膜转移质量或能量的中空纤维膜流体处理装置。它特别设计，但不仅用于膜式氧合器。中空纤维膜基本纵向地延伸，第一惰性纤维在它们之间间隔开并且基本纵向地延伸。第二惰性纤维通常横贯中空纤维延伸并且通常与其邻接，使得第一流体（优选含氧气体）可以通过中空纤维，并且第二流体（优选血液）可以在其外部通过以进行质量或通过膜的能量转移。通常，第二惰性纤维形成纬纱，并且第一惰性纤维在每两个中空纤维之间间隔开，使得经纱由交替的中空纤维股和第一惰性纤维组成，其以振荡方式通过纬纱，以至少部分地限定要通过中空纤维膜的流体膜的尺寸，以通过膜进行质量或能量传递。惰性纤维通常是生物相容的单丝聚合物，其提供中空纤维的精确间隔以产生均匀的血液膜。通常，将该装置设置在膜式氧合器的血液通道中，并分层成尺寸以使血液通道与第一惰性纤维隔开的间隔中空纤维，使得中空纤维相对于彼此偏移一层。

9. 发明授权

US5024671A Microporous vascular graft 失效
标题翻译：微孔血管移植
公开(公告)号：US5024671A
公开(公告)日：1991-06-18
申请号：US246578
申请日：1988-09-19
申请人： Roger Tu , David Chen , Wilfred F. Mathewson
发明人： Roger Tu , David Chen , Wilfred F. Mathewson
IPC分类号： A61F2/00 , A61F2/06 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L27/56 , A61F2/06 , A61L27/54 , A61L27/58 , A61F2250/0067 , A61L2300/606
摘要： A vascular graft at least partially formed from porous hollow fibers, with at least some of the porous hollow fibers being located adjacent an inner surface of the vascular graft. The vascular grafts of the invention have a relatively small pore size for promoting tissue growth while inhibiting bleeding during the healing process. The porous hollow fibers used to form the vascular grafts of the invention further provide a storage situs for temporarily holding a drug or other material for delivery into the blood stream during the healing process. This storage capability may also be used for holding an inert gas while providing the graft with greater resilency and cushioning characteristics than achievable with presently available vascular grafts.
摘要翻译：至少部分地由多孔中空纤维形成的血管移植物，其中至少一些多孔中空纤维位于血管移植物的内表面附近。本发明的血管移植物具有相对较小的孔径以促进组织生长，同时抑制愈合过程中的出血。用于形成本发明的血管移植物的多孔中空纤维还提供用于在愈合过程期间暂时保持药物或其它材料以输送到血流中的储存部位。这种储存能力也可用于保持惰性气体，同时为移植物提供比目前可用的血管移植物可实现的更大的弹性和缓冲特性。

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