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1. 发明授权

US5137897A 2-substituted 4-(3-alkyl-5-tert.-butyl-4-hydroxyphenyl) thiazoles, processes for their preparation, pharmaceuticals containing them and their use 失效
标题翻译： 2-取代的4-（3-烷基-5-叔丁基-4-羟基苯基）噻唑，其制备方法，包含它们的药物及其用途
公开(公告)号：US5137897A
公开(公告)日：1992-08-11
申请号：US626784
申请日：1990-12-13
申请人： Werner Thorwart , Rudolf Schleyerbach , Robert Bartlett , Klaus U. Weithmann
发明人： Werner Thorwart , Rudolf Schleyerbach , Robert Bartlett , Klaus U. Weithmann
IPC分类号： A61K31/425 , A61K31/426 , A61P29/00 , A61P37/00 , C07D277/24 , C07D277/26 , C07D277/28 , C07D277/30 , C07D417/06 , C07D417/12
CPC分类号： C07D417/06 , C07D277/24 , C07D277/26 , C07D277/28 , C07D277/30
摘要： Novel substituted thiazoles of the formula I ##STR1## in which R.sup.1 is a saturated or unsaturated, straight-chain or branched C.sub.1 -C.sub.5 -alkyl group,R.sup.2 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms,A is an intermediate chain of the formula--(CH.sub.2).sub.n --Y--CR.sup.3 R.sup.4 --; --CH.dbd.CR.sup.3 --(CH.sub.2).sub.m -- or --CH.dbd.N--O--(CH.sub.2).sub.n -- whereY is a single bond, an oxygen or sulfur atom or a carbonyl group,R.sup.3 and R.sup.4 are identical or different and are a hydrogen atom or an alkyl radical having up to two carbon atoms, m is a number from 0 to 3 and n is a number from 1 to 4, andZ is a tetrazole or CN group, or a radical of the formula ##STR2## X is a hydroxyl group or a radical of the formula R.sup.5 O-- or R.sup.6 R.sup.7 N--, where R.sup.5 is a straight-chain or branched C.sub.1 -C.sub.4 -alkyl radical which is optionally substituted by hydroxyl, C.sub.1 -C.sub.3 -alkoxy or C.sub.1 -C.sub.3 -alkylamino,R.sup.6 and R.sup.7 are identical or different and are a hydrogen atom, a straight-chain or branched C.sub.1 -C.sub.6 -alkyl radicall or, for the case in which R.sup.6 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl radical,R.sup.7 is a hydroxyl, a C.sub.1 -C.sub.3 -alkoxy or a tetrazol-5-yl group or X, together with the structural element --A--(C.dbd.O)--, is a radical of the formula II ##STR3## where R.sup.8 is a hydrogen atom, a C.sub.1 -C.sub.3 -alkyl radical or a C.sub.1 -C.sub.3 -alkoxy radical, and physiologically tolerable salts of such compounds of the formula I in which X is a hydroxyl or hydroxyamino group,are prepared by various processes.They are preferably suitable for the treatment and prophylaxis of inflammatory diseases - in particular inflammatory rheumatic diseases.
摘要翻译： R1是饱和或不饱和的直链或支链C1-C5-烷基，R2是氢原子或具有1至3个碳原子的烷基的式I（I）的新型取代的噻唑， A是式 - （CH 2）n Y-CR 3 R 4 - 的中间链; -CH = CR 3 - （CH 2）m - 或-CH = NO-（CH 2）n - ，其中Y为单键，氧或硫原子或羰基，R 3和R 4相同或不同，为氢原子或具有至多两个碳原子的烷基，m为0至3的数，n为1至4的数，Z为四唑或CN基团，或式X的基团为羟基或式R5O-或R6R7N-的基团，其中R5是任选被羟基，C 1 -C 3 - 烷氧基或C 1 -C 3 - 烷基氨基取代的直链或支链C 1 -C 4烷基，R 6和 R7相同或不同，为氢原子，直链或支链C1-C6烷基，或对于R6为氢原子或C1-C4烷基的情况，R7为羟基， C 1 -C 3 - 烷氧基或四唑-5-基或X与结构元件-A-（C = O） - 一起是式II（II）的基团，其中R 8是氢原子，C 1 -C 3 - 烷基或C 1 -C 3 - 烷氧基，以及生理上的耐受性这些其中X是羟基或羟基氨基的式I化合物的盐通过各种方法制备。它们优选适用于治疗和预防炎症性疾病，特别是炎性风湿性疾病。

2. 发明申请

US20160022523A1 INTERLOCK VESSEL FOR HYPERBARIC TRANSFER SYSTEM 审中-公开
标题翻译：用于高速传输系统的互锁船
公开(公告)号：US20160022523A1
公开(公告)日：2016-01-28
申请号：US14728202
申请日：2015-06-02
申请人： Robert Bartlett
发明人： Robert Bartlett
IPC分类号： A61G10/02 , A62B9/02
CPC分类号： A61G10/026 , A62B9/02 , B63C11/32 , Y10T137/86308
摘要： An interlock vessel having an air-tight body with opposing ends. A portion of the body is designed to fit into a decompression (hyperbaric) chamber, wherein a diver or a patient undergoing a decompression treatment is positioned. The opposing ends are closed by pivotally moveable doors and locking assemblies that retain the doors in a closed position until the pressure inside the decompression chamber and the exterior of the chamber can be equalized. The outer door has two locking systems: (a) an interlock system and (b) a safety/delay locking system. Both locking assemblies are manually operated.
摘要翻译：一种具有相对端的气密体的互锁容器。身体的一部分被设计成适合于减压（高压）室，其中定位潜水员或进行减压治疗的患者。相对的端部被可枢转地移动的门和锁定组件封闭，所述门和锁定组件将门保持在关闭位置，直到减压室内部的压力和室的外部能够相等。外门具有两个锁定系统：（a）联锁系统和（b）安全/延迟锁定系统。两个锁定组件都是手动操作的。

3. 发明申请

US20050080118A1 Pharmaceuticals for the treatment of rejection reactions in organ transplantations 失效
标题翻译：用于治疗器官移植排斥反应的药物
公开(公告)号：US20050080118A1
公开(公告)日：2005-04-14
申请号：US10626600
申请日：2003-07-25
申请人： Robert Bartlett
发明人： Robert Bartlett
IPC分类号： A61K31/165 , A61K31/275 , A61K31/277 , A61K31/42 , A61P37/06 , A61P41/00 , C07C255/24 , C07D261/18
CPC分类号： A61K31/42 , A61K31/275 , A61K31/277 , Y10S514/885
摘要： The use of compound 1 and/or 2 of the formulae and of physiologically tolerable salts of compound 2 for the treatment of rejection reactions of the organ recipient to the transplanted organ is described.
摘要翻译：描述了化合物1和/或2的化合物和化合物2的生理可耐受盐用于治疗器官受体对移植器官的排斥反应的用途。

4. 发明申请

US20080302990A1 Air Lock for Pressure Vessels for Human Occupancy 审中-公开
标题翻译：用于人员压力容器的气锁
公开(公告)号：US20080302990A1
公开(公告)日：2008-12-11
申请号：US11626648
申请日：2007-01-24
申请人： Robert Bartlett
发明人： Robert Bartlett
IPC分类号： F16K31/44
CPC分类号： E05C7/002 , B63C11/325 , E05B51/023
摘要： What is provided is an interlocking vent valve which when mounted on the body of the air lock is connected to a moving interlock pin with a linkage. When the interlock valve is closed the connected interlock pin extends through a hole in the body ring. The interlock pin blocks the path which the door ring lug must follow in order to open. In order to open the exterior door of the air lock, the operators must retract the interlock pin. The action which retracts the interlock pin also opens the interlock/vent valve which allows the pressure in the interlock to rapidly vent.
摘要翻译：提供了一种互锁排气阀，当安装在气锁的主体上时，连接到具有连杆的移动联锁销。当联动阀关闭时，连接的互锁销延伸穿过主体环中的孔。互锁销阻塞门环凸耳必须遵循的路径才能打开。为了打开气锁的外部门，操作者必须缩回联锁销。缩回联锁销的动作也打开互锁/排气阀，允许互锁中的压力快速排出。

5. 发明授权

US09523250B2 Mixing tank and method of use 有权
标题翻译：混合罐和使用方法
公开(公告)号：US09523250B2
公开(公告)日：2016-12-20
申请号：US13298693
申请日：2011-11-17
申请人： Danny Ness , Robert Bartlett
发明人： Danny Ness , Robert Bartlett
IPC分类号： E21B21/06
CPC分类号： E21B21/062
摘要： A method of transmitting a fluid into an oil well bore including the steps of providing a frame supporting a vessel, the vessel having an interior, upper and lower end portions, a conically shaped side wall, and an outlet for discharging the fluid from the vessel. Further including the steps of adding a viscous polymeric material to the vessel interior, placing a discharge pipe having a vertical section below the vessel wherein the discharge pipe is in communication with the outlet, placing a positive displacement pump within the discharge pipe wherein the pump transmits fluid from the outlet into the discharge pipe downstream of the vertical pipe section, and selectively transmitting fluid to either the vessel interior (for recirculating) or into the well. Air is added to the discharge flow line downstream of the pump. Preferably, the vessel contains a flexible bladder/bag that holds the material to be pumped.
摘要翻译：一种将流体传送到油井的方法，包括以下步骤：提供支撑容器的框架，所述容器具有内部，上下端部，圆锥形侧壁和用于从容器排出流体的出口。还包括以下步骤：将粘性聚合材料添加到容器内部，将排放管放置在容器下方具有垂直部分的排放管，其中排放管与出口连通，将排出管中的容积泵放置在排出管内，流体从出口进入垂直管段下游的排放管，并且选择性地将流体传送到容器内部（用于再循环）或进入井中。空气被添加到泵的下游的排出流动管线。优选地，容器包含保持待泵送材料的柔性气囊/袋。

6. 发明授权

US07071222B2 Preparation containing a combination of 5-methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and N-(4-trifluoromethylphenyl)2-cyano-3-hydroxycrotonic acid amide 有权
标题翻译：含有5-甲基异恶唑-4-羧酸 - （4-三氟甲基） - 苯胺和N-（4-三氟甲基苯基）-2-氰基-3-羟基巴豆酸酰胺
公开(公告)号：US07071222B2
公开(公告)日：2006-07-04
申请号：US09101672
申请日：1997-03-07
申请人： Robert Bartlett , Johann Then
发明人： Robert Bartlett , Johann Then
IPC分类号： A61K31/42 , A61K31/275
CPC分类号： C07D261/18 , A61K31/42 , A61K31/275 , A61K2300/00
摘要： A solid composition comprising 5-methyl-4′-trifluoromethyl-4-isoxazole carboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonic acid amide, suitable for treatment of immunological and cancerous diseases.
摘要翻译：包含5-甲基-4'-三氟甲基-4-异恶唑甲酰苯胺和N-（4-三氟甲基苯基）-2-氰基-3-羟基巴豆酸酰胺的固体组合物，适用于治疗免疫学和癌性疾病。

7. 发明授权

US06251645B1 DEAH-box proteins 有权
标题翻译： DEAH盒蛋白
公开(公告)号：US06251645B1
公开(公告)日：2001-06-26
申请号：US09338546
申请日：1999-06-23
申请人： Bernd Kirschbaum , Stefan Muellner , Robert Bartlett
发明人： Bernd Kirschbaum , Stefan Muellner , Robert Bartlett
IPC分类号： C12N900
CPC分类号： C12Q1/6886 , A61K38/00 , C07K14/47 , C12N9/90 , C12Q1/68 , C12Q1/6823 , C12Q2600/156 , C12Q2521/301
摘要： The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases. The invention also relates to DNA sequences encoding such proteins. It is demonstrated that such proteins bind ATP and nucleic acid and possess helicase and ATPase activities. This invention further relates to processes for preparation of such proteins and their use in pharmacologically relevant test systems and therapeutic applications.
摘要翻译：本发明涉及与其他已知的解旋酶显示结构相似性的新型DEAH盒蛋白的鉴定和分子生物学和生物化学表征。本发明还涉及编码这种蛋白质的DNA序列。证明这些蛋白质结合ATP和核酸并具有解旋酶和ATP酶活性。本发明还涉及制备这些蛋白质的方法及其在药理学相关的测试系统和治疗应用中的用途。

8. 发明授权

US06248365B1 Use of complement inhibitors for the preparation of a pharmaceutical for the prophylaxis and therapy of inflammatory intestinal and skin disorders as well as purpura 失效
标题翻译：使用补体抑制剂制备用于预防和治疗炎性肠和皮肤病以及紫癜的药物
公开(公告)号：US06248365B1
公开(公告)日：2001-06-19
申请号：US08087058
申请日：1993-07-07
申请人： Jürgen Römisch , Eric-Paul Pâques , Robert Bartlett , Gerhard Dickneite
发明人： Jürgen Römisch , Eric-Paul Pâques , Robert Bartlett , Gerhard Dickneite
IPC分类号： A61K3516
CPC分类号： A61K38/57 , A61K38/1709 , A61K38/4873
摘要： The invention relates to the use of complement inhibitors, especially of C1 inactivator or of factors I or H, for the preparation of a pharmaceutical and for the prophylaxis and therapy of chronic inflammatory intestinal disorders, inflammatory skin disorders and purpura.
摘要翻译：本发明涉及补体抑制剂，特别是C1灭活剂或I或H因子用于制备药物和预防和治疗慢性炎症性肠病，炎性皮肤病和紫癜的用途。

9. 发明授权

US5780592A Compositions comprising lipoproteins and crotonamide derivatives 失效
标题翻译：包含脂蛋白和巴豆酰胺衍生物的组合物
公开(公告)号：US5780592A
公开(公告)日：1998-07-14
申请号：US761335
申请日：1996-12-10
申请人： Stefan Mullner , Axel Hofmann , Karin Saar , Hans-Ulrich Schorlemmer , Robert Bartlett
发明人： Stefan Mullner , Axel Hofmann , Karin Saar , Hans-Ulrich Schorlemmer , Robert Bartlett
IPC分类号： A61K38/00 , A61K31/275 , A61K31/44 , A61K38/17 , A61P1/00 , A61P1/16 , A61P3/06 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07C255/23 , C07K14/47 , C07K19/00 , C07K1/00 , A61K31/42
CPC分类号： A61K38/1709
摘要： A composition comprising lipoproteins and a compound of the formula I ##STR1## stereoisomeric form or salt thereof, suitable for the treatment of immunological disorders, cancer or in transplantation.
摘要翻译：一种包含脂蛋白和式I化合物（I）立体异构形式或其盐的组合物，其适用于治疗免疫疾病，癌症或移植。

10. 发明授权

US09027596B2 Method and apparatus for handling oil and gas well drilling fluids 有权
标题翻译：油气井钻井液处理方法及设备
公开(公告)号：US09027596B2
公开(公告)日：2015-05-12
申请号：US13490409
申请日：2012-06-06
申请人： Daniel W. Ness , Robert Bartlett
发明人： Daniel W. Ness , Robert Bartlett
IPC分类号： F17D1/00 , F17D1/08 , B65D25/00 , E21B21/01
CPC分类号： F17D1/08 , B65D25/00 , B65D88/022 , B65D88/12 , B65D88/54 , B65D90/02 , B65D90/20 , E21B21/01 , Y10T137/598 , Y10T137/86187 , Y10T137/8622 , Y10T137/863
摘要： A fluids management apparatus is disclosed herein that enables management of multiple volumes of different fluids when drilling and/or producing oil and/or gas with an oil and gas well drilling platform. The apparatus includes a structural, transportable frame that has upper and lower reservoir sections, each with a plurality of tanks for holding fluid. The upper reservoir section is easily lifted and transported, such as by crane. A docking station on the lower reservoir section is receptive of the upper reservoir section. A piping system enables a selected fluid volume contained in a tank of the upper reservoir section to be selectively transmitted to a selected tank of the lower reservoir section. The lower reservoir section has its own piping system that enables a user to withdraw fluid from any selected one of its tanks.
摘要翻译：本文公开了一种流体管理装置，其能够在用油气井钻井平台钻井和/或生产油和/或气时能够管理多体积的不同流体。该装置包括具有上部和下部储存器部分的每个具有用于保持流体的多个罐的结构的可运输框架。上部储罐部分可以通过起重机容易地提升和运输。下部储罐部分的对接站可接受上部储存部分。管道系统使得包含在上储存部分的罐中的选定流体体积能够选择性地传递到下储存部分的选定罐。下储存器部分具有其自己的管道系统，其使得用户能够从其任何一个罐中抽取流体。

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