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1. 发明申请

US20180185509A1 AMATOXIN-CONJUGATES WITH IMPROVED LINKAGES 审中-公开
公开(公告)号：US20180185509A1
公开(公告)日：2018-07-05
申请号：US15728170
申请日：2017-10-09
申请人： Werner Simon , Christian Lutz , Christoph Müller , Jan Anderl
发明人： Werner Simon , Christian Lutz , Christoph Müller , Jan Anderl
IPC分类号： A61K47/68 , A61K38/12 , A61K47/64 , A61K47/61 , A61K47/66
CPC分类号： A61K47/6813 , A61K38/12 , A61K47/61 , A61K47/64 , A61K47/66 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6891
摘要： The present disclosure relates to tumour therapy. In one aspect, the present disclosure relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

2. 发明申请

US20140294865A1 AMATOXIN-CONJUGATES WITH IMPROVED LINKAGES 审中-公开
标题翻译：具有改进的链接的AMATOXIN-CONJUGATE
公开(公告)号：US20140294865A1
公开(公告)日：2014-10-02
申请号：US14004183
申请日：2012-03-09
申请人： Werner Simon , Christian Lutz , Christoph Muller , Jan Anderl
发明人： Werner Simon , Christian Lutz , Christoph Muller , Jan Anderl
IPC分类号： A61K47/48 , A61K38/12
CPC分类号： A61K47/6813 , A61K38/12 , A61K47/61 , A61K47/64 , A61K47/66 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6891
摘要： The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
摘要翻译：本发明涉及肿瘤治疗。在一个方面，本发明涉及阿莫地辛和靶结合部分的缀合物，例如，通过某些连接连接的抗体，其可用于治疗癌症。在另一方面，本发明涉及包含这种缀合物的药物组合物。

3. 发明授权

US08142485B2 Bone connection device 有权
标题翻译：骨连接装置
公开(公告)号：US08142485B2
公开(公告)日：2012-03-27
申请号：US12157391
申请日：2008-06-10
申请人： Volker Buhren , Christian Lutz
发明人： Volker Buhren , Christian Lutz
IPC分类号： A61B17/80
CPC分类号： A61B17/8047 , A61B17/8033 , A61B17/8052 , A61B17/8057
摘要： An implantable orthopedic device having a load-bearing element, such as a bone plate, with at least one opening for a fixation element and one insert which can be inserted in an inclined opening in a receptacle in the bore. This insert has an external form that is at least partially complementary to the internal form of the receptacle and a central through-bore for receiving the body of the fixation element such as a bone screw. The insert also provides a locking system for holding the insert in the receptacle, in which the insert exhibits at least one locking mechanism with which conformal locking with the load-bearing element may be achieved.
摘要翻译：一种具有承载元件（例如骨板）的可植入矫形装置，其具有用于固定元件的至少一个开口和可插入孔中的容器中的倾斜开口中的一个插入件。该插入件具有与容器的内部形式至少部分互补的外部形式，以及用于接收诸如骨螺钉的固定元件的主体的中心通孔。插入件还提供用于将插入件保持在插座中的锁定系统，其中插入件表现出至少一个锁定机构，通过该锁定机构可以实现与承载元件的共形锁定。

4. 发明授权

US07841063B2 Deformable element of a steering wheel spindle in the form of a corrugated tube 有权
标题翻译：波纹管形式的方向盘主轴的可变形元件
公开(公告)号：US07841063B2
公开(公告)日：2010-11-30
申请号：US12222161
申请日：2008-08-04
申请人： Christian Lutz
发明人： Christian Lutz
IPC分类号： B21D39/02 , B62D1/16
CPC分类号： B62D1/192 , B21C37/0803 , B21C37/0815 , B21C37/14 , B21C37/157 , B21C37/16 , B21C37/205 , B21D13/02 , B21D15/06 , Y10T29/49826 , Y10T29/49893
摘要： In a method for the production of a corrugated tube from a flat metal sheet, two half shells are formed each extending in a longitudinal direction, and the half shells are provided with corrugations oriented transversely to their longitudinal direction. The two half shells are either disposed in a single sheet metal part longitudinally next to one another or are separate parts. In the case of their formation with two half shells disposed in a common sheet metal part next to one another, the preformed sheet metal part in the region between the two half shells is folded or curved about an axis parallel to the longitudinal directions of the half shells, wherein free longitudinal edges of the half shells are brought into mutual contact and are connected with one another. In the case of the formation of the half shells in the form of separate parts, the two half shells are placed against one another with their longitudinal edges and the longitudinal edges are connected with one another. At least one of the two longitudinal edges, coming into mutual contact, of the subshells is provided with a row of cutouts spaced apart from one another in the longitudinal direction of the subshells. Through the connection of sections of this longitudinal edge, located between the cutouts, together with the other longitudinal edge in the connection region of the two longitudinal edges, a row of openings through the casing of the corrugated tube is formed, which openings are spaced apart in the longitudinal direction of the corrugated tube.
摘要翻译：在从平板状金属板制造波纹管的方法中，形成两个沿纵向方向延伸的半壳体，并且半壳体设置有横向于其纵向方向的波纹。两个半壳体或者彼此纵向放置在单个金属片部件中，或者是分开的部件。在它们形成两个半壳的情况下，彼此相邻地设置在共同的金属板部分中，在两个半壳之间的区域中的预成型的金属板部分围绕平行于半部的纵向方向的轴线折叠或弯曲壳体，其中半壳体的自由纵向边缘彼此相互接触并彼此连接。在以分开的形式形成半壳的情况下，两个半壳彼此相对放置，其纵向边缘和纵向边缘彼此连接。子壳的两个相互接触的两个纵向边缘中的至少一个设置有沿着子壳的纵向方向彼此间隔开的一排切口。通过连接这个纵向边缘的位于切口之间的部分与两个纵向边缘的连接区域中的另一纵向边缘连接，形成穿过波纹管的壳体的一排开口，这些开口被间隔开在波纹管的纵向上。

5. 发明授权

US07766917B2 Extractor for a bone connection element 有权
标题翻译：骨骼连接元件的抽出器
公开(公告)号：US07766917B2
公开(公告)日：2010-08-03
申请号：US11975846
申请日：2007-10-22
申请人： Stefan Kugler , André Gasser , Christian Lutz
发明人： Stefan Kugler , André Gasser , Christian Lutz
IPC分类号： A61B17/58
CPC分类号： A61B17/92 , A61B17/8047 , Y10T29/5393
摘要： An extractor is provided to extract an insert used with a bone connection element such as a bone plate having at least one opening for a bone screw used with the insert. The extractor has an outer hollow sleeve having proximal abutment surface for engaging a surface portion of the bone plate, and an inner bar having a diameter enabling the insertion of the bar into the hollow sleeve. The bar has a threaded leading end to engage the thread of the insert to be extracted. The hollow sleeve has an inner thread and the inner bar has an outer threaded element for engaging the inner thread of the hollow sleeve. The outer threaded element is positioned with respect to the bar in a longitudinal position to enable the threaded locking end to extend beyond the proximal abutment surface of the sleeve to be threaded into the insert.
摘要翻译：提供提取器以提取与骨连接元件（例如骨板）一起使用的插入物，所述骨连接元件具有用于与插入物一起使用的骨螺钉的至少一个开口。提取器具有外部中空套管，其具有用于接合骨板的表面部分的近端邻接表面和具有能够将杆插入中空套筒的直径的内杆。该杆具有螺纹的前端以与插入件的螺纹接合以被拔出。中空套管具有内螺纹，并且内杆具有用于接合中空套筒的内螺纹的外螺纹元件。外螺纹元件相对于杆在纵向位置定位，以使得螺纹锁定端能够延伸超过套筒的近端邻接表面以被拧入插入件中。

6. 发明授权

US07752940B2 Adjustable steering column for a motor vehicle 有权
标题翻译：用于机动车辆的可调节转向柱
公开(公告)号：US07752940B2
公开(公告)日：2010-07-13
申请号：US12068100
申请日：2008-02-01
申请人： Christian Lutz
发明人： Christian Lutz
IPC分类号： B62D1/18
CPC分类号： B62D1/184
摘要： An adjustable steering column for a motor vehicle includes a fixing device, in the opened state of which the steering column is adjustable in at least one displacement direction, and, in the closed state of which the set position of the steering column is fixed in the displacement direction or at least one of the displacement directions, for fixing the set position comprises at least one securement part which includes at least one toothing with teeth, and at least one counter-securement part, which includes at least one counter toothing, with teeth. Viewed in a cross section through the teeth of the securement part and of the counter-securement part, wherein the plane of this cross section is oriented parallel to the displacement direction and parallel to the opening direction, both side flanks of the teeth of the securement part and of the counter-securement part in the closed state of the fixing device form, at least in a section of their extent, inclination angles of less than 20°, preferably less than 12°, with the opening direction.
摘要翻译：用于机动车辆的可调节转向柱包括固定装置，处于打开状态，转向柱在至少一个位移方向上可调节，并且在关闭状态下，转向柱的设定位置被固定在位移方向或位移方向中的至少一个用于固定设定位置包括至少一个固定部件，该固定部件包括至少一个带有齿的齿部，以及至少一个反紧固部件，其包括至少一个反齿条与齿。在通过固定部分和相对固定部分的齿的横截面中观察，其中该横截面的平面平行于位移方向定向并平行于打开方向，固定件的齿的两个侧面在固定装置的关闭状态下的反紧固部分的部分和相对固定部分形成至少在它们的程度的一部分中，与打开方向小于20°，优选小于12°的倾斜角。

7. 发明授权

US07648508B2 Bone plating implants, instruments and methods 有权
标题翻译：骨电镀植入物，仪器和方法
公开(公告)号：US07648508B2
公开(公告)日：2010-01-19
申请号：US10999665
申请日：2004-11-30
申请人： Christian Lutz , Yves Crozet , Rene Wirth
发明人： Christian Lutz , Yves Crozet , Rene Wirth
IPC分类号： A61F5/00
CPC分类号： A61B17/808 , A61B17/02 , A61B17/1728 , A61B17/80 , A61B17/8042 , A61B17/8052 , A61B17/842 , A61B17/88 , A61B90/39 , A61B2017/00238 , A61B2017/0046 , A61B2017/00464 , A61F2/4684 , A61F2002/4658
摘要： Bone plating implants, instruments, systems and methods for fracture fixation are provided. The systems includes the instruments and implants comprising a trial component, handle, aiming block, bone plate, tissue spreader, drill guide, K-wire guide, monoaxial screw-locking inserts, polyaxial screw-locking inserts, cable plugs, K-wires, monoaxial screws and polyaxial screws. The methods include the use of the instruments and implants for either open or minimally invasive fracture fixation surgery.
摘要翻译：骨折固定的骨电镀植入物，仪器，系统和方法。系统包括仪器和植入物，其包括试验部件，手柄，瞄准块，骨板，组织撒布机，钻子引导器，K线引导件，单轴螺钉锁定插入件，多轴螺钉锁定插件，电缆插头，K线，单轴螺钉和多轴螺丝。这些方法包括使用仪器和植入物进行开放或微创骨折固定术。

8. 发明授权

US07387045B2 Adjustable steering column 有权
标题翻译：可调转向柱
公开(公告)号：US07387045B2
公开(公告)日：2008-06-17
申请号：US10720066
申请日：2003-11-25
申请人： Christoph Klukowski , Robert Galehr , Reinhard Bertsch , Reto Umberg , Hubert Breuss , Christian Lutz
发明人： Christoph Klukowski , Robert Galehr , Reinhard Bertsch , Reto Umberg , Hubert Breuss , Christian Lutz
IPC分类号： B62D1/18
CPC分类号： B62D1/184 , B62D1/195
摘要： An adjustable steering column includes a steering spindle (1), a shell unit (3) bearing the steering spindle (1), a console unit (4), stationary on the chassis, with at least one side wall (5), which extends bilaterally along the shell unit (3) and supports the shell unit (3). The steering column also includes a securement device, which can be opened and closed, in the opened state of which the shell unit (3) is adjustable relative to the console unit (4) at least in one adjustment direction, and which has a tension bolt (11) penetrating openings in the shell unit (3) and in the at least one side wall (5). At least for one adjustment direction at least one tilting part (26) is provided acting in this adjustment direction, wherein in a torsion entailed in a deformation of the steering column of at least the segment, located in the proximity of the side wall (5), of the shell unit (3) relative to the side wall (5), an entrainment of the tilting part (26) takes place and clamping edges (36) and clamping faces (35) come to engage one another, whereby the displaceability of the tilting part (26) in this adjustment direction is inhibited.
摘要翻译：可调节的转向柱包括转向轴（1），承载转向主轴（1）的壳单元（3），在底盘上固定的控制台单元（4），至少一个侧壁（5）延伸沿着壳单元（3）双边地并且支撑壳单元（3）。转向柱还包括可以打开和关闭的固定装置，其处于打开状态，壳体单元（3）可相对于控制台单元（4）至少在一个调节方向上可调节，并且其具有张力螺栓（11）穿过壳单元（3）和至少一个侧壁（5）中的开口。至少对于一个调节方向，至少一个倾斜部分（26）被设置成在该调节方向上作用，其中，在位于侧壁（5）附近的至少部分的转向柱的变形中，）相对于侧壁（5）的壳单元（3）中，夹持夹紧边缘（36）和夹紧面（35）彼此接合，从而使可移动性在该调节方向上的倾斜部分（26）被禁止。

9. 发明申请

US20080045969A1 Extractor for a bone connection element 有权
标题翻译：骨骼连接元件的抽出器
公开(公告)号：US20080045969A1
公开(公告)日：2008-02-21
申请号：US11975846
申请日：2007-10-22
申请人： Stefan Kugler , Andre Gasser , Christian Lutz
发明人： Stefan Kugler , Andre Gasser , Christian Lutz
IPC分类号： A61B17/58
CPC分类号： A61B17/92 , A61B17/8047 , Y10T29/5393
摘要： An extractor is provided to extract an insert used with a bone connection element such as a bone plate having at least one opening for a bone screw used with the insert. The extractor has an outer hollow sleeve having proximal abutment surface for engaging a surface portion of the bone plate, and an inner bar having a diameter enabling the insertion of the bar into the hollow sleeve. The bar has a threaded leading end to engage the thread of the insert to be extracted. The hollow sleeve has an inner thread and the inner bar has an outer threaded element for engaging the inner thread of the hollow sleeve. The outer threaded element is positioned with respect to the bar in a longitudinal position to enable the threaded locking end to extend beyond the proximal abutment surface of the sleeve to be threaded into the insert.
摘要翻译：提供提取器以提取与骨连接元件（例如骨板）一起使用的插入物，所述骨连接元件具有用于与插入物一起使用的骨螺钉的至少一个开口。提取器具有外部中空套管，其具有用于接合骨板的表面部分的近端邻接表面和具有能够将杆插入中空套筒的直径的内杆。该杆具有螺纹的前端以与插入件的螺纹接合以被拔出。中空套管具有内螺纹，并且内杆具有用于接合中空套筒的内螺纹的外螺纹元件。外螺纹元件相对于杆在纵向位置定位，以使得螺纹锁定端能够延伸超过套筒的近端邻接表面以被拧入插入件中。

10. 发明授权

US07325467B2 Locking device of a steering column adjustable in at least one adjustment direction 有权
标题翻译：转向柱的锁定装置可在至少一个调节方向上调节
公开(公告)号：US07325467B2
公开(公告)日：2008-02-05
申请号：US10893436
申请日：2004-07-19
申请人： Hubert Breuss , Christoph Klukowski , Christian Lutz
发明人： Hubert Breuss , Christoph Klukowski , Christian Lutz
IPC分类号： B62D1/18
CPC分类号： B62D1/184
摘要： A locking device of a steering column adjustable in at least one adjustment direction (46) comprises at least one locking part (20, 21) associated with the adjustment direction (46) or one of the adjustment directions, at least one counterlocking part (14, 15) associated with this adjustment direction (46) and an openable and closable tensioning arrangement, in the opened state of which first and second toothings (38, 39) of locking parts (20, 21) are spaced apart from first and second countertoothings (40, 41) of the counterlocking part (14, 15), and in the closed state of which the locking part (20, 21) and the counterlocking part (14, 15) engage each other's teeth. The planes (47, 48; 49, 50) of the tips of teeth (42, 43; 44, 45) of the first and second toothings (38, 39) or first and second countertoothings (40, 41) are disposed in a V shape relative to one another and between the teeth (42, 43; 44, 45) of the first and second toothing (38, 39) or the first and second countertoothing (40, 41) is present an offset (v) in the adjustment direction (46), which is a fraction of the distance (a) between successive teeth (42 to 45).
摘要翻译：一种可在至少一个调节方向（46）上调节的转向柱的锁定装置包括至少一个与调节方向（46）或调节方向之一相关联的锁定部分（20,21），至少一个调节方向，所述第一和第二齿轮（38,39）与所述调节方向（46）相关联，以及可打开和可关闭的张紧装置，在所述打开状态下，锁定部分（20,21）的第一和第二齿（38,39）（14,15）的所述锁定部（40,41）中，并且在所述锁定部（20,21）和所述防抱止部（14,15）彼此啮合的关闭状态下。第一和第二齿（38,39）或第一和第二计数器齿（40,41）的齿（42,43,44,45）的尖端的平面（47,48; 49,50）设置在 V形相对于第一和第二齿（38,39）或第一和第二反运送（40,41）的齿（42,43,44,45）之间的偏心（v）在调整方向（46）是连续齿（42〜45）之间距离（a）的一部分。

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