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1. 发明授权

US4390719A 1-Methyl-2-chlorocyclopropanecarboxylic acid and its ester 失效
标题翻译： 1-甲基-2-氯环丙烷羧酸及其酯
公开(公告)号：US4390719A
公开(公告)日：1983-06-28
申请号：US280356
申请日：1981-07-06
申请人： Werner Schwarze , Axel Kleemann , Wolfgang Leuchtenberger
发明人： Werner Schwarze , Axel Kleemann , Wolfgang Leuchtenberger
IPC分类号： B01J23/00 , C07B61/00 , C07C51/00 , C07C61/15 , C07C67/00 , C07C69/74
CPC分类号： C07C61/15 , C07C69/74
摘要： 1-Methyl-2-chlorocyclopropanecarboxylic acid and its lower esters are produced by the selective hydrogenating dechlorination of the corresponding 1-methyl-2,2-dichlorocyclopropane compounds. The new materials can be used as intermediate products for the production of pesticides and medicines.
摘要翻译：通过选择性氢化相应的1-甲基-2,2-二氯环丙烷化合物的脱氯产生1-甲基-2-氯环丙烷羧酸及其低级酯。新材料可用作生产农药和药品的中间产品。

2. 发明授权

US4772749A Process for the recovery of malic acid 失效
标题翻译：回收苹果酸的方法
公开(公告)号：US4772749A
公开(公告)日：1988-09-20
申请号：US563983
申请日：1983-12-21
申请人： Michael Karrenbauer , Axel Kleemann , Wolfgang Leuchtenberger , Rudi Moerck
发明人： Michael Karrenbauer , Axel Kleemann , Wolfgang Leuchtenberger , Rudi Moerck
IPC分类号： C07C59/245 , C07C51/00 , C07C51/42 , C07C67/00 , C12P7/46
CPC分类号： C12P7/46
摘要： The reaction mixture obtained in the enzymatic reaction of fumaric acid to form L-malic acid contains the L-malic acid and unreacted fumaric acid as their salts. To recover pure solutions of L-malic acid the reaction mixture is treated at 50.degree. to 150.degree. C. with cation exchangers. The eluate after concentration to 30 to 80 weight % content of L-malic acid is filtered. The pure L-malic acid is recovered by evaporating the solutions, in a given case after treatment with activated carbon.
摘要翻译：在富马酸的酶促反应中获得的形成L-苹果酸的反应混合物含有L-苹果酸和未反应的富马酸作为其盐。为了回收L-苹果酸的纯溶液，将反应混合物用阳离子交换剂在50-150℃下处理。过滤浓缩至30〜80重量％L-苹果酸含量的洗脱液。通过蒸发溶液来回收纯L-苹果酸，在给定情况下用活性炭处理后。

3. 发明授权

US4313894A Process for the production of 3-cyanopropionamide 失效
标题翻译： 3-氰基丙酰胺的制备方法
公开(公告)号：US4313894A
公开(公告)日：1982-02-02
申请号：US206897
申请日：1980-11-14
申请人： Axel Kleemann , Wolfgang Leuchtenberger , Jurgen Martens , Horst Weigel
发明人： Axel Kleemann , Wolfgang Leuchtenberger , Jurgen Martens , Horst Weigel
IPC分类号： C07C255/27 , A61K31/16 , C07C20060101 , C07C67/00 , C07C253/00 , C07C120/02
CPC分类号： C07C253/10
摘要： 3-Cyanopropionamide is produced by adding hydrocyanic acid on acrylamide in the presence of an aprotic organic solvent and an alkali metal cyanide at a temperature between 20.degree. and 150.degree. C. 3-cyanopropionamide is an important intermediate product for the production of pyrrolidone or 4-aminobutyramide.
摘要翻译：在非质子有机溶剂和碱金属氰化物的存在下，在20〜150℃的温度下，在丙烯酰胺上加入氢氰酸，生成3-氰基丙酰胺。3-氰基丙酰胺是生产吡咯烷酮或4 - 氨基丁酰胺。

4. 发明授权

US4827029A Process for the isolation of L-amino acids 失效
标题翻译： L-氨基酸分离方法
公开(公告)号：US4827029A
公开(公告)日：1989-05-02
申请号：US146637
申请日：1988-01-21
申请人： Axel Kleemann , Kurt Klostermann , Wolfgang Leuchtenberger , Rudi E. Moerck , Michael Karrenbauer
发明人： Axel Kleemann , Kurt Klostermann , Wolfgang Leuchtenberger , Rudi E. Moerck , Michael Karrenbauer
IPC分类号： B01J39/26 , C07C227/34 , C07C227/40 , C07C229/02 , C07C319/28 , C07C323/58 , C12P13/04 , C07C99/12
CPC分类号： C12P13/04
摘要： L-amino acids present in cleavage solutions obtained in the acylase-catalyzed cleavage of N-acetyl-D,L-amino acids are isolated by use of a strongly acidic ion exchanger in H+ form. First, the mother liquor from a previous treatment cycle is fed to the ion exchanger, and then the cleavage solution and finally the wash water and the discharge from the ion exchanger which is pH-controlled is analyzed into an "effluent water fraction", an "N-acetyl-D-amino acid fraction" and an "L-amino acid fraction". The last fraction is adjusted by addition of fresh cleavage solution to a pH of between 4.0 and 6.0, and from the mixture which is thus obtained the L-amino acid is isolated by crystallization. The mother liquor which is obtained is recycled back into a subsequent treatment cycle.
摘要翻译：通过使用H +形式的强酸性离子交换剂分离存在于酰基转移酶催化的N-乙酰基-D，L-氨基酸切割中获得的切割溶液中的L-氨基酸。首先，将来自先前处理循环的母液进料到离子交换器中，然后将分离溶液，最后洗涤水和从pH离子交换器排出的pH值控制分析为“流出水分数”， “N-乙酰基-D-氨基酸级分”和“L-氨基酸级分”。通过将新鲜裂解溶液加入至4.0至6.0的pH来调节最后的级分，并且由此得到的混合物通过结晶分离L-氨基酸。将获得的母液循环回到随后的处理循环中。

5. 发明授权

US4175188A Process for the production of 1,2,4-triazin-5-one derivatives 失效
标题翻译：制备1,2,4-三嗪-5-酮衍生物的方法
公开(公告)号：US4175188A
公开(公告)日：1979-11-20
申请号：US924062
申请日：1978-07-12
申请人： Herbert Klenk , Werner Schwarze , Wolfgang Leuchtenberger
发明人： Herbert Klenk , Werner Schwarze , Wolfgang Leuchtenberger
IPC分类号： C07D253/06 , A01N43/707 , C07D253/075
CPC分类号： C07D253/075 , A01N43/707
摘要： 1,2,4-triazin-5-one compounds of the general formula (I) ##STR1## where R is ##STR2## are prepared by reacting a compound of general formula (II) ##STR3## in which R is defined above with either (a) a tertiary alcohol of general formula (III)HO--R' (III) in which R' is a t-alkyl group having 4 to 18 carbon atoms, especially t-amyl or t-octyl or preferably t-butyl or(b) an alkene of general formula (IV) ##STR4## in which R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms and wherein preferably R.sub.1 and R.sub.2 are hydrogen and R.sub.3 and R.sub.4 each are methyl to form an .alpha.-ketocarboxylic acid amide of general formula (V) ##STR5## and this, in a given case after previous saponification to the free acid, condensed with thiocarbohydrazide ##STR6## to form a 1,2,4-triazin-5-one compound of general formula (VI) ##STR7## and then the mercapto group is methylated.
摘要翻译：通式（I）的化合物通过使通式（II）的化合物（II）的化合物在其中R定义如上：（a）通式（III）的叔醇HO-R'（III），其中R'是具有4至18个碳原子的叔烷基，特别是叔戊基或t- 辛基或优选叔丁基或（b）通式（IV）的烯烃其中R 1和R 2相同或不同，为氢或烷基，且R 3和R 4相同或不同并且其中每种情况下的烷基可以是1至15个碳原子，并且其中优选地，R 1和R 2是氢，并且R 3和R 4各自是甲基，形成通式（V）的α-酮羧酸酰胺。并且在给定情况下，在先前皂化成游离酸后，与硫代碳酰肼“IMAGE”缩合形成通式（VI）的化合物VI（VI），然后巯基是甲基 ted。

6. 发明授权

US4007222A Process for the production of 2-chlorocaproic acids 失效
标题翻译：生产2-氯己酸的方法
公开(公告)号：US4007222A
公开(公告)日：1977-02-08
申请号：US607051
申请日：1975-08-22
申请人： Heinz Haschke , Wolfgang Leuchtenberger , Gerd Schreyer , Werner Schwarze
发明人： Heinz Haschke , Wolfgang Leuchtenberger , Gerd Schreyer , Werner Schwarze
IPC分类号： C07C53/19 , C07B9/00
CPC分类号： C07C53/19
摘要： 2-Chloro-n-caproic acid and 6-substituted 2-chloro-n-caproic acids are produced from n-caproic acid or 6-substituted n-caproic acids are chlorinated in the presence of sulfur halides and phosphorus halides at elevated temperatures using for each mole of caproic acid there is used up to about 1.2 mole of chlorine and as catalyst at least one compound of the group of sulfur chlorides, sulfur bromides, phosphorus chloride and phosphorus bromide at a temperature of about 110.degree. to 130 .degree. C.
摘要翻译： 2-氯 - 正己酸和6-取代的2-氯正己酸由正己酸生成，或6-取代的正己酸在高温下在卤化硫和卤化磷存在下氯化，使用对于每摩尔的己酸，在约110-130℃的温度下使用多至约1.2摩尔氯，并且使用至少一种硫化氯，硫化溴，氯化磷和溴化磷的化合物作为催化剂。

7. 发明授权

US5431933A Animal feed supplement based on a fermentation broth amino acid, a process for its production and its use 失效
标题翻译：基于发酵液氨基酸的动物饲料添加剂，其生产和使用的过程
公开(公告)号：US5431933A
公开(公告)日：1995-07-11
申请号：US946069
申请日：1992-09-17
申请人： Wolfram Binder , Heinz Friedrich , Hermann Lotter , Herbert Tanner , Henning Holldorff , Wolfgang Leuchtenberger
发明人： Wolfram Binder , Heinz Friedrich , Hermann Lotter , Herbert Tanner , Henning Holldorff , Wolfgang Leuchtenberger
IPC分类号： A23K1/00 , A23K1/16 , C12P13/04 , C12P13/08 , A23J3/20
CPC分类号： C12P13/04 , A23K20/142 , C12P13/08
摘要： An animal feed supplement and processes for its production which provide an inexpensive, not excessively hygroscopic or sticky supplement amino acid whose content should be standardizable. The animal feed supplement is based on a fermentation broth and contains the predominant proportion of its contents, optionally with the exclusion of part of the biomass. The biomass is preferably present in an amount of at most 10% by weight in the dry state. Proteins are preferably present in a maximum amount of 10% by weight. For the production, the sugar content is adjusted to a maximum of 4 g/l during fermentation, at least towards the end thereof, and at least part of the biomass is optionally removed during the working up.
摘要翻译：一种动物饲料补充剂及其生产方法，其提供廉价，不过度吸湿或粘稠的补充氨基酸，其含量应该是可标准化的。动物饲料补充剂基于发酵液，并且含有其主要比例的内容物，任选地排除了部分生物质。在干燥状态下，生物量优选以至多10重量％的量存在。蛋白质优选以最大量为10重量％存在。为了生产，发酵过程中至少在其末端将糖含量调节至最高达4g / l，并且在加工期间任选地除去至少部分生物质。

8. 发明授权

US5118619A Method for the fermentative production of L-isoleucine from D,L-.alpha.-hydroxybutyrate 失效
标题翻译：从D，L-α-羟基丁酸发酵生产L-异亮氨酸的方法
公开(公告)号：US5118619A
公开(公告)日：1992-06-02
申请号：US59438
申请日：1987-06-08
申请人： Elisabeth Scheer , Hermann Sahm , Lothar Eggeling , Manfred Kircher , Wolfgang Leuchtenberger
发明人： Elisabeth Scheer , Hermann Sahm , Lothar Eggeling , Manfred Kircher , Wolfgang Leuchtenberger
IPC分类号： C12N1/20 , C12P13/06 , C12P41/00 , C12R1/13 , C12R1/15
CPC分类号： C12R1/15 , C12P13/06 , Y10S435/84 , Y10S435/843
摘要： A method for the fermentative production of L-isoleucine from D,L-.alpha.-hydroxybutyrate by means of mutants of the genus Corynbecaterium which utilize D-lactate.
摘要翻译：一种通过使用D-乳酸的Corynbecaterium属的突变体从D，L-α-羟基丁酸发酵生产L-异亮氨酸的方法。

9. 发明授权

US4877734A Microbiologically produced .alpha.-acetylamino cinnamic acid acylase, method of its production and its use 失效
标题翻译：微生物生产的α-乙酰氨基肉桂酸酰基转移酶，其生产方法及其应用
公开(公告)号：US4877734A
公开(公告)日：1989-10-31
申请号：US66492
申请日：1987-06-26
申请人： Maria-Regina Kula , Werner Hummel , Horst Schutte , Wolfgang Leuchtenberger
发明人： Maria-Regina Kula , Werner Hummel , Horst Schutte , Wolfgang Leuchtenberger
IPC分类号： C12N9/80 , C12P13/04 , C12R1/13
CPC分类号： C12P13/04 , C12N9/80 , Y10S435/84
摘要： A microbiologically produced .alpha.-acetylamino cinnamic acid acylase and a method for its production from Brevibacterium species NCIB 12246 or NCIB 12247. The new enzyme can be used as constituent of a coupled enzyme system for enzymatic conversions which run via the intermediary stage .alpha.-imino-.beta.-phenylpropionic acid or phenylpyruvic acid.
摘要翻译：微生物产生的α-乙酰氨基肉桂酸酰基转移酶及其从短杆菌属物种NCIB 12246或NCIB 12247生产的方法。该新酶可以用作通过中间阶段α-亚氨基转移酶进行的酶转化的偶联酶系统的组分， β-苯基丙酸或苯基丙酮酸。

10. 发明授权

US4824781A Microbiologically produced d(-)-mandelate-dehydrogenase process for obtaining it and its use 失效
标题翻译：微生物生产的d（ - ） - 扁桃酸脱氢酶方法获得它及其用途
公开(公告)号：US4824781A
公开(公告)日：1989-04-25
申请号：US917440
申请日：1986-10-10
申请人： Werner Hummel , Horst Schutte , Maria-Regina Kula , Wolfgang Leuchtenberger
发明人： Werner Hummel , Horst Schutte , Maria-Regina Kula , Wolfgang Leuchtenberger
IPC分类号： C12N9/04 , C12P7/42 , C12R1/225
CPC分类号： C12N9/0006 , C12P7/42 , Y10S435/853
摘要： The subject matter of the invention is a new D(-)-mandelate-dehydrogenase and obtaining it from Lactobacillus curvatus DSM 20019 (obtainable from the German Collection of Microorganisms). The new enzyme can be used for the enzymatic conversion of D(-)-mandelic acid and various other D-2-hydroxycarboxylic acids into the corresponding 2-ketocarboxylic acids or from benzoyl formate and various other 2-ketocarboxylic acids conversion to the corresponding D-2-hydroxycarboxylic acids.
摘要翻译：本发明的主题是新的D（ - ） - 扁桃酸脱氢酶，并从曲霉DSM 20019获得（可从德国微生物收集库获得）。该新酶可用于将D（ - ） - 扁桃酸和各种其他D-2-羟基羧酸酶促转化成相应的2-酮羧酸或甲酸甲苯酯和各种其他2-酮羧酸转化为相应的D -2-羟基羧酸。

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