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1. 发明授权

US5323113A NMR probe which includes B1, gradient coils 失效
标题翻译： NMR探头，包括B1，梯度线圈
公开(公告)号：US5323113A
公开(公告)日：1994-06-21
申请号：US30693
申请日：1993-03-12
申请人： David G. Cory , Frank H. Laukien , Werner E. Maas
发明人： David G. Cory , Frank H. Laukien , Werner E. Maas
IPC分类号： G01R33/34 , G01V3/00
CPC分类号： G01R33/34069 , G01R33/34061
摘要： An NMR probe is designed to generate both a homogeneous RF field over the sample volume and, alternatively, a "radial" field comprising two orthogonal gradient fields generated simultaneously in the transverse plane or a linear gradient field. The homogeneous field is generated by means of a known homogeneous coil construction, such as a Helmholtz coil or modified Helmholtz coil. The radial field can be generated by means of an inverted Helmholtz coil, either modified or unmodified, and the linear field can be generated by a Golay type coil, which coils are positioned coaxially with the homogeneous coil. The two coils are connected in parallel to the RF signal generator and switching can be accomplished either by means of an active switch or by detuning one of the coil resonant circuits when the other coil is in use.
摘要翻译： NMR探针被设计成在样本体积上产生均匀的RF场，或者可选地，包括在横向平面中同时产生的两个正交梯度场或线性梯度场的“径向”场。均匀场通过已知的均匀线圈结构产生，例如亥姆霍兹线圈或改进的亥姆霍兹线圈。径向场可以通过反转的亥姆霍兹线圈产生，其被修改或未修改，并且线性场可以由Golay型线圈产生，该线圈与均匀线圈同轴地定位。两个线圈并联连接到RF信号发生器，并且切换可以通过有源开关来实现，或者当使用另一个线圈时使线圈谐振电路中的一个失谐。

2. 发明授权

US5546000A Method for the reduction of radiation damping during signal acqusition in NMR experiments 失效
标题翻译：在NMR实验中，在信号捕获期间降低辐射阻尼的方法
公开(公告)号：US5546000A
公开(公告)日：1996-08-13
申请号：US409641
申请日：1995-03-24
申请人： Werner E. Maas , David G. Cory , Frank H. Laukien
发明人： Werner E. Maas , David G. Cory , Frank H. Laukien
IPC分类号： G01R33/36 , G01R33/20
CPC分类号： G01R33/3671 , G01R33/3628 , G01R33/3621
摘要： A method of reducing radiation damping during free induction decay in NMR measurements of samples having a narrow line width uses the active switching of the quality factor value of the coil circuit of an NMR detection probe. After application of an excitation pulse to the sample, data acquisition is accomplished in periodic samples. The Q of the coil circuit is set to a high value while each sample is being taken, but is reduced significantly in between samples by detuning the coil circuit. Minimization of the high-Q state of the coil circuit and maximization of the difference between the high Q value and the low Q value greatly decrease the detrimental effects of radiation damping on free induction decay. The coil circuit Q is modified automatically by the application of a Q switching signal generated by a controller, such as a computer which controls other aspect of the NMR experiment.
摘要翻译：在具有窄线宽的样品的NMR测量中，在自由感应衰减期间减小辐射阻尼的方法使用NMR检测探针的线圈电路的品质因数值的有效切换。在向样品施加激发脉冲之后，在周期性样品中完成数据采集。线圈电路的Q值被设定为高值，而每个样品被取出，但是通过使线圈电路失谐而在样品之间显着降低。线圈电路的高Q状态的最小化和高Q值与低Q值之差的最大化大大降低了辐射阻尼对自由感应衰减的有害影响。线圈电路Q通过应用由控制器（诸如控制NMR实验的另一方面的计算机）产生的Q开关信号而自动修改。

3. 发明授权

US5521504A Pulse sequence and method for creating a radio-frequency magnetic field gradient with a spatially independent phase for NMR experiments 失效
标题翻译：用于创建具有空间独立相的NMR实验的射频磁场梯度的脉冲序列和方法
公开(公告)号：US5521504A
公开(公告)日：1996-05-28
申请号：US177761
申请日：1994-01-04
申请人： David G. Cory , Frank H. Laukien , Werner E. Maas
发明人： David G. Cory , Frank H. Laukien , Werner E. Maas
IPC分类号： G01R33/46 , G01R33/48 , G01R33/483 , G01V3/00
CPC分类号： G01R33/446 , G01R33/46 , G01R33/4831
摘要： A composite RF pulse is created from a sequence of conventional homogeneous RF pulses and conventional gradient RF pulses and the composite pulse generates a gradient magnetic field with a spatially varying amplitude, but a spatially independent phase. In one embodiment of the invention, the pulse sequence consists of four conventional gradient RF pulses interspersed with two conventional homogeneous RF pulses. In another embodiment of the invention, a conventional gradient RF pulse is combined with a conventional homogeneous RF pulse and the pulse pair is repeated in order to generate an effective magnetic field with a spatially varying amplitude, but a spatially independent phase.
摘要翻译：复合RF脉冲是从传统的均匀RF脉冲序列和常规梯度RF脉冲序列产生的，并且复合脉冲产生具有空间变化幅度但空间上独立相位的梯度磁场。在本发明的一个实施例中，脉冲序列由散布有两个常规均匀RF脉冲的四个常规梯度RF脉冲组成。在本发明的另一个实施例中，传统的梯度RF脉冲与传统的均匀RF脉冲组合，并且重复脉冲对以便产生具有空间变化幅度但空间上独立相位的有效磁场。

4. 发明授权

US5325058A Method for improving selectivity in NMR experiments involving coherence transformation 失效
标题翻译：涉及相干转化的NMR实验中提高选择性的方法
公开(公告)号：US5325058A
公开(公告)日：1994-06-28
申请号：US30511
申请日：1993-03-12
申请人： David G. Cory , Frank H. Laukien , Werner E. Maas
发明人： David G. Cory , Frank H. Laukien , Werner E. Maas
IPC分类号： G01R33/46 , G01V3/00
CPC分类号： G01R33/4608
摘要： Coherence transformation selectivity is improved by using combinations of homogeneous RF pulses and "radial" RF pulses that have a uniform RF field strength throughout the sample, but whose phase (relative to the detection coil phase) has a spatial dependence such that all possible phase differences are equally represented throughout the sample. The use of radial pulses allows the spin coherences in the sample to evolve in spatial waves and the observation, or suppression, of a given coherence can be selected by using a receiver coil which has a predetermined symmetry relative to the symmetry of the spatial wave.
摘要翻译：通过使用在整个样本中具有均匀RF场强的均匀RF脉冲和“径向”RF脉冲的组合，但是其相位（相对于检测线圈相位）具有空间依赖性使得所有可能的相位差在整个样品中同样代表。使用径向脉冲允许样品中的自旋相干在空间波中演化，并且可以通过使用相对于空间波的对称性具有预定对称性的接收器线圈来选择给定相干的观察或抑制。

5. 发明授权

US5532594A Method for suppressing solvent resonance signals in NMR experiments 失效
标题翻译： NMR实验中抑制溶剂共振信号的方法
公开(公告)号：US5532594A
公开(公告)日：1996-07-02
申请号：US223699
申请日：1994-04-06
申请人： David G. Cory , Werner E. Maas
发明人： David G. Cory , Werner E. Maas
IPC分类号： G01R33/46 , G01R33/483 , G01R33/20
CPC分类号： G01R33/4608
摘要： B.sub.1 (RF) gradient echo pulse sequences are combined with frequency-selective pulse sequences to selectively suppress a solvent resonance signal by preventing the formation of an echo for the solvent resonance, while allowing the formation of an echo for the sample resonances under study. The RF gradient pulses may be planar or radial pulses. A pulse sequence for suppressing a solvent resonance signal in NMR experiments comprises a pair of (RF) gradient pulses which sandwich a selective inversion pulse sequence. In accordance with one embodiment of the invention, the RF gradient pulses are anti-symmetric (have opposite phase) and the selective inversion pulse sequence comprises a homogeneous frequency-selective inversion pulse, such as a .pi. pulse, applied in time between the two RF gradient pulses. In accordance with another embodiment of the invention, the RF gradient pulses are symmetric (have the same phase) and the selective inversion pulse sequence comprises a pulse sequence which has an excitation profile with a null at the frequency of the resonance to be suppressed.
摘要翻译： B1（RF）梯度回波脉冲序列与频率选择脉冲序列组合，以通过阻止形成用于溶剂共振的回波而选择性地抑制溶剂共振信号，同时允许形成用于所研究的样品共振的回波。 RF梯度脉冲可以是平面或径向脉冲。在NMR实验中用于抑制溶剂共振信号的脉冲序列包括夹着选择性反转脉冲序列的一对（RF）梯度脉冲。根据本发明的一个实施例，RF梯度脉冲是反对称的（具有相反的相位），并且选择性反转脉冲序列包括均匀的频率选择性反转脉冲，诸如在两个RF之间的时间上施加的pi脉冲梯度脉冲。根据本发明的另一个实施例，RF梯度脉冲是对称的（具有相同的相位），并且选择性反转脉冲序列包括脉冲序列，该脉冲序列具有要抑制的谐振频率处的零点的激励分布。

6. 发明授权

US5317263A Method for creating a z-rotation using radial pulses in NMR experiments involving coherence transformations 失效
标题翻译：在涉及相干转换的NMR实验中使用径向脉冲创建z旋转的方法
公开(公告)号：US5317263A
公开(公告)日：1994-05-31
申请号：US32612
申请日：1993-03-17
申请人： David G. Cory , Werner E. Maas
发明人： David G. Cory , Werner E. Maas
IPC分类号： G01R33/46 , G01V3/00
CPC分类号： G01R33/4608
摘要： A composite RF pulse for NMR experiments is created by applying to a sample a radial pulse followed by a .pi. homogeneous pulse. The radial pulse has a uniform RF field strength throughout the sample and a phase relative to the detection coil phase with a spatial dependence such that all possible phase differences are equally represented throughout the sample. The composite pulse converts the radial RF pulse into a spatially-varying z rotation. The creation of a spatially-varying composite z pulse based on a radial pulse allows for a simple and direct application of a radial pulse in a manner analogous to many known B.sub.0 gradient NMR experiments (such as multiple-quantum filters, quadrature detection, and solvent suppression).
摘要翻译：用于核磁共振实验的复合RF脉冲是通过向样本施加径向脉冲，然后是pi均匀脉冲而产生的。径向脉冲在整个采样中具有均匀的RF场强，并且具有相对于具有空间依赖性的检测线圈相位的相位，使得在整个样本中均等地表示所有可能的相位差。复合脉冲将辐射RF脉冲转换成空间变化的z旋转。基于径向脉冲的空间变化的复合z脉冲的创建允许以类似于许多已知的B0梯度NMR实验（例如多量子滤波器，正交检测和溶剂）的方式简单且直接地施加径向脉冲抑制）。

7. 发明授权

US5539315A NMR probe for cross-polarization measurements 失效
标题翻译：用于交叉极化测量的NMR探针
公开(公告)号：US5539315A
公开(公告)日：1996-07-23
申请号：US410095
申请日：1995-03-24
申请人： David G. Cory , Joel T. Lewandowski , Werner E. Maas
发明人： David G. Cory , Joel T. Lewandowski , Werner E. Maas
IPC分类号： G01R33/34 , G01R33/20
CPC分类号： G01R33/3635 , G01R33/34053 , G01R33/3415 , G01R33/34092
摘要： A nuclear magnetic resonance cross polarization probe uses a dual-coil arrangement in which a single-turn inner coil is surrounded by a solenoid coil. The inner coil is tuned to the frequency of a relatively high Larmor frequency nuclei type, such as proton. The solenoid coil is tuned to a lower Larmor frequency nuclei type. An inner sample region surrounded by the inner coil has a first magnetic field component induced by an electrical signal at the relatively high frequency in the inner coil. An electrical signal at the lower frequency is input to the solenoid coil and results in the generation of a magnetic field alternating at the lower frequency. This field induces a current in the inner coil at the lower frequency that, in turn, induces a magnetic field component in the inner region at the lower frequency. Because the structure of the relatively high magnetic field component and the lower magnetic field component in the inner region are both dictated by the shape of the inner coil, a good spatial matching of the fields is obtained resulting in a good Hartman-Hahn match across the sample volume.
摘要翻译：核磁共振交叉极化探针使用双线圈装置，其中单匝内线圈被电磁线圈包围。内部线圈被调谐到相对较高的拉莫尔频率核型（例如质子）的频率。电磁线圈调谐到较低的拉莫尔频率核型。由内部线圈围绕的内部采样区域具有由内部线圈中较高频率的电信号感应的第一磁场分量。较低频率的电信号被输入到螺线管线圈，并导致在较低频率下交替的磁场的产生。该场以较低频率在内部线圈中感应出电流，这又导致较低频率的内部区域中的磁场分量。由于内部区域的相对较高的磁场分量和较低的磁场分量的结构都是由内部线圈的形状决定的，所以获得了良好的场的空间匹配，从而导致了整个的Hartman-Hahn匹配样品量。

8. 发明授权

US07187176B2 NMR probe circuit with nodal impedance bridge 有权
标题翻译：具有节点阻抗桥的NMR探头电路
公开(公告)号：US07187176B2
公开(公告)日：2007-03-06
申请号：US11053452
申请日：2005-02-08
申请人： Yit Aun Lim , Werner E. Maas
发明人： Yit Aun Lim , Werner E. Maas
IPC分类号： G01V3/00
CPC分类号： G01R33/3635
摘要： A nuclear magnetic resonance (NMR) probe circuit is used with a sample coil tuned to a primary frequency f1. The circuit is arranged to have a plurality of points of electric field minima at the f1 frequency. One or more additional frequencies may be coupled to the circuit at these points, without interaction with f1. The probe circuit also uses an impedance coupled between two of the minima points that affects the frequency response at the additional frequency or frequencies, without affecting the frequency response at f1. The impedance may be made adjustable to allow tuning of the relative frequency resonances.
摘要翻译：使用核磁共振（NMR）探针电路，其中调谐到主频率f 1的样本线圈。电路被布置成在f 1频率具有多个电场最小点。一个或多个附加频率可以在这些点处耦合到电路，而不与f 1 1相互作用。探针电路还使用耦合在两个最小点之间的阻抗来影响附加频率或频率处的频率响应，而不会影响f 1的频率响应。可以使阻抗可调，以便调谐相对频率谐振。

9. 发明授权

US08686729B2 NMR reaction monitoring flow cell 有权
标题翻译： NMR反应监测流通池
公开(公告)号：US08686729B2
公开(公告)日：2014-04-01
申请号：US13181105
申请日：2011-07-12
申请人： Brian Marquez , Michael Fey , Kimberly L. Colson , Robert Krull , Eckhard Bez , Don Piroli , Werner E. Maas
发明人： Brian Marquez , Michael Fey , Kimberly L. Colson , Robert Krull , Eckhard Bez , Don Piroli , Werner E. Maas
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , G01R33/307 , G01R33/31 , G01R33/46
摘要： A monitoring cell, used to perform a measurement in an NMR spectrometer of a reaction fluid produced by a reaction vessel, has a body having inlet and outlet transport coaxial capillaries for transporting the reaction fluid between the body and the reaction vessel. Cooling lines are also positioned coaxially with the transport capillaries to transport cooling liquid between the body and the reaction vessel. The cell further has a hollow sample probe for insertion into the NMR spectrometer and a coupler section that removably connects the sample probe to the body so that the inlet transport capillary extends through the body into the interior of the sample probe and the outlet transport capillary is sealed to the sample probe to allow reaction fluid that enters the sample probe via the inlet transport capillary to exit the sample probe via the outlet transport capillary.
摘要翻译：用于在由反应容器产生的反应流体的NMR光谱仪中进行测量的监测单元具有用于在体和反应容器之间输送反应流体的入口和出口输送同轴毛细管的主体。冷却管线也与运输毛细管同轴地定位，以在主体和反应容器之间输送冷却液体。细胞还具有用于插入NMR光谱仪的中空样品探针和可将样品探针可移除地连接到身体的耦合器部分，使得入口输送毛细管延伸穿过身体进入样品探针的内部，并且出口输送毛细管密封到样品探针，以允许经由入口输送毛细管进入样品探针的反应流体通过出口输送毛细管离开样品探针。

10. 发明授权

US07403007B1 Nuclear magnetic resonance probe with cooled sample coil 有权
标题翻译：具有冷却样品线圈的核磁共振探头
公开(公告)号：US07403007B1
公开(公告)日：2008-07-22
申请号：US11670298
申请日：2007-02-01
申请人： Yit Aun Lim , Eckhard Bez , Xiaozhong Zhang , Werner E. Maas
发明人： Yit Aun Lim , Eckhard Bez , Xiaozhong Zhang , Werner E. Maas
IPC分类号： G01V3/00
CPC分类号： G01R33/3628 , G01R33/34007 , G01R33/34015 , G01R33/34023 , G01R33/3403 , G01R33/34053 , G01R33/3635
摘要： In a nuclear magnetic resonance probe, the sample coil is connected to the RF excitation source via transmission lines that are arranged to generate one or more nodal points at the 1H excitation frequency along their lengths and a balanced magnetic filed profile within the sample coil. Heat exchangers are then connected directly to the inner conductor of the transmission line at these nodal points. The transmission line inner conductors are in direct contact with the sample coil and efficiently cool the coil to cryogenic temperatures without interfering with the 1H resonance or RF profile.
摘要翻译：在核磁共振探针中，采样线圈经由传输线路连接到RF激发源，传输线被布置成沿着它们的长度在<1 / 2H激励频率处产生一个或多个节点，并且平衡磁在样品盘管内的外形。然后，热交换器在这些节点处直接连接到传输线的内导体。传输线内导体与样品线圈直接接触，并有效地将线圈冷却至低温，而不会干扰<1 H“H谐振或RF分布。

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