专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080039638A1 Asymmetric Hydrogenation of Alkennes Using Chiral Iridium Complexes 有权
标题翻译：使用手性铱配合物对Alkennes的不对称氢化
公开(公告)号：US20080039638A1
公开(公告)日：2008-02-14
申请号：US11793729
申请日：2005-12-20
申请人： Werner Bonrath , Frederik Menges , Thomas Netscher , Andreas Pfaltz , Bettina Wustenberg
发明人： Werner Bonrath , Frederik Menges , Thomas Netscher , Andreas Pfaltz , Bettina Wustenberg
IPC分类号： C07C45/62 , C07C5/03 , C07C67/303 , C07D311/72
CPC分类号： C07D311/72 , C07B53/00 , C07C29/172 , C07C45/30 , C07C45/62 , C07C67/303 , C07C47/02 , C07C49/04 , C07C69/24 , C07C31/125
摘要： The invention relates to the (stereoselective) hydrogenation of carbon-carbon double bonds in compounds having at least one such bond, e.g., isoprenoids, non-cyclic sesquiterpenes, tocomonoenols, tocodienols, tocotrienols or derivatives thereof, as well as to the (stereoselective) hydrogenation of parts/extracts of plant oils containing such tocotrienols or derivatives thereof, in the presence of a chiral Ir complex as the catalyst, whereby preferably one stereoisomer is manufactured in an excess.
摘要翻译：本发明涉及具有至少一个这种键的化合物中的碳 - 碳双键的（立体选择性）氢化，例如类异戊二烯，非环倍半萜烯，对羟基烯醇，苯环醇，生育三烯酚或其衍生物，以及（立体选择性）在手性Ir配合物作为催化剂的存在下氢化含有这种生育三烯酚或其衍生物的植物油的部分/提取物，由此优选制备过量的一种立体异构体。

2. 发明授权

US08426617B2 Asymmetric hydrogenation of alkenes using chiral iridium complexes 有权
标题翻译：使用手性铱络合物对烯烃的不对称氢化
公开(公告)号：US08426617B2
公开(公告)日：2013-04-23
申请号：US11793729
申请日：2005-12-20
申请人： Werner Bonrath , Frederik Menges , Thomas Netscher , Andreas Pfaltz , Bettina Wustenberg
发明人： Werner Bonrath , Frederik Menges , Thomas Netscher , Andreas Pfaltz , Bettina Wustenberg
IPC分类号： C07D311/00
CPC分类号： C07D311/72 , C07B53/00 , C07C29/172 , C07C45/30 , C07C45/62 , C07C67/303 , C07C47/02 , C07C49/04 , C07C69/24 , C07C31/125
摘要： The invention relates to the (stereoselective) hydrogenation of carbon-carbon double bonds in compounds having at least one such bond, e.g., isoprenoids, non-cyclic sesquiterpenes, tocomonoenols, tocodienols, tocotrienols or derivatives thereof, as well as to the (stereoselective) hydrogenation of parts/extracts of plant oils containing such tocotrienols or derivatives thereof, in the presence of a chiral Ir complex as the catalyst, whereby preferably one stereoisomer is manufactured in an excess.
摘要翻译：本发明涉及具有至少一个这种键的化合物中的碳 - 碳双键的（立体选择性）氢化，例如类异戊二烯，非环倍半萜烯，对羟基烯醇，苯环醇，生育三烯酚或其衍生物，以及（立体选择性）在手性Ir配合物作为催化剂的存在下氢化含有这种生育三烯酚或其衍生物的植物油的部分/提取物，由此优选制备过量的一种立体异构体。

3. 发明授权

US06498256B2 Phosphinite-oxazolines and metal complexes thereof 有权
标题翻译：磷腈 - 恶唑啉及其金属络合物
公开(公告)号：US06498256B2
公开(公告)日：2002-12-24
申请号：US09955981
申请日：2001-09-20
申请人： Andreas Pfaltz , Joerg R. Blankenstein , Frederik Menges
发明人： Andreas Pfaltz , Joerg R. Blankenstein , Frederik Menges
IPC分类号： C07D26310
CPC分类号： C07D263/16 , C07B53/00 , C07C233/18 , C07D263/14 , C07F9/653 , C07F15/0033
摘要： Compounds of formulae I and Ia, wherein X1 is secondary phosphino; R3 is hydrogen, a hydrocarbon radical having from 1 to 20 carbon atoms, a heterohydrocarbon radical, bonded via a carbon atom, having from 2 to 20 atoms and at least one hetero atom selected from the group O, S and NR, or ferrocenyl; R is H or C1-C4alkyl; each R4 individually or both R4 together are a hydrocarbon radical having from 1 to 20 carbon atoms; and R01 and R02 are each independently of the other a hydrogen atom or a hydrocarbon radical having from 1 to 20 carbon atoms, are chiral ligands for metal complexes with metals of sub-groups I and VII, which are catalysts for asymmetric addition reactions, for example of hydrogen, to prochiral unsaturated organic compounds.
摘要翻译：式I和Ia的化合物，其中X 1是仲膦基; R3是氢，具有1至20个碳原子的烃基，通过碳原子结合的具有2至20个原子和至少一个选自O，S和NR的杂原子的杂烃基，或二茂铁基; R是H或C 1 -C 4烷基; 每个R 4单独或两个R 4一起是具有1至20个碳原子的烃基; 和R 01和R 02各自独立地为氢原子或具有1至20个碳原子的烃基，是与作为非对称加成反应的催化剂的分组I和VII的金属的金属络合物的手性配体，其用于氢的实例，为前手性不饱和有机化合物。

4. 发明授权

US06632954B2 Phosphinite-oxazolines and metal complexes 有权
标题翻译：磷腈 - 恶唑啉和金属络合物
公开(公告)号：US06632954B2
公开(公告)日：2003-10-14
申请号：US10082116
申请日：2002-02-26
申请人： Andreas Pfaltz , Joerg R. Blankenstein , Frederik Menges
发明人： Andreas Pfaltz , Joerg R. Blankenstein , Frederik Menges
IPC分类号： C07F108
CPC分类号： C07D263/16 , C07B53/00 , C07C233/18 , C07D263/14 , C07F9/653 , C07F15/0033
摘要： Compounds of formulae I and Ia, wherein X1 is secondary phosphino; R3 is hydrogen, a hydrocarbon radical having from 1 to 20 carbon atoms, a heterohydrocarbon radical, bonded via a carbon atom, having from 2 to 20 atoms and at least one hetero atom selected from the group O, S and NR, or ferrocenyl; R is H or C1-C4alkyl; each R4 individually or both R4 together are a hydrocarbon radical having from 1 to 20 carbon atoms; and R01 and R02 are each independently of the other a hydrogen atom or a hydrocarbon radical having from 1 to 20 carbon atoms, are chiral ligands for metal complexes with metals of sub-groups I and VIII, which are catalysts for asymmetric addition reactions, for example of hydrogen, to prochiral unsaturated organic compounds.
摘要翻译：式I和Ia的化合物，其中是仲膦基; R 2是氢，具有1至20个碳原子的烃基，通过碳原子结合的杂烃基，具有2至20个原子和至少一个杂原子选自O，S和NR基团的原子，或二茂铁基; R是H或C PDAT> 1 -C 单独地或每个R 4 一起是具有1至20个碳原子的烃基; 和R 01 和R 02 各自独立地为氢原子或具有1至20个碳原子是与次级I和VIII族金属的金属络合物的手性配体，它们是用于不对称加成反应的催化剂，例如氢，用于前手性不饱和有机化合物。

5. 发明授权

US08415488B2 Bidentate secondary phosphine oxide chiral ligands for use in asymmetric addition reactions 失效
标题翻译：用于不对称加成反应的二齿次膦氧化物手性配体
公开(公告)号：US08415488B2
公开(公告)日：2013-04-09
申请号：US12734726
申请日：2008-11-14
申请人： Benoît Pugin , Heidi Landert , Björn Gschwend , Andreas Pfaltz , Felix Spindler
发明人： Benoît Pugin , Heidi Landert , Björn Gschwend , Andreas Pfaltz , Felix Spindler
IPC分类号： C07D333/62
CPC分类号： C07F9/65517 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C213/02 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5018 , C07F9/5022 , C07F9/655354 , C07C69/34 , C07C69/732 , C07C69/675 , C07C217/08 , C07C233/47
摘要： Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(═O)HR1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*(O)HR1 is bonded to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; and R1 is a hydrocarbon radical, a C-bonded heterohydrocarbon radical or a ferrocenyl radical, with the proviso that R1 is an achiral ferrocenyl radical when Q is an achiral ferrocenyl base skeleton. Metal complexes of these ligands in a molar ratio of ligand to metal of about 1.3:1 to 0.9:1 are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：主要以一种对映体或纯对映异构体形式的混合物形式的式I化合物，其中次膦是C键，仲膦基的仲膦-PQ *（= O）HR1（I） P（R）2; 其中R各自独立地为烃基或杂烃基; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C 1 -C 4亚烷基骨架，其中碱基骨架的仲膦基直接键合到碳原子，或者在环状基骨架的情况下，直接与碳原子或C 1 -C 4 - 亚烷基直接键合，并且其中的基础骨架将P手性基团-P *（O）HR1键合到碳原子，使得磷原子通过1至7个碳链连接，任选被来自O，S，N，Fe或Si基团的杂原子中断; P *是手性磷原子; 并且R 1是烃基，C键合的杂烃基或二茂铁基，条件是当Q是非手性二茂铁基时，R 1是非手性二茂铁基。配体与金属的摩尔比约为1.3:1至0.9:1的这些配体的金属络合物是用于不对称加成反应，特别是氢化的均相催化剂。

6. 发明申请

US20110118482A1 BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS 有权
标题翻译：用于催化不对称添加反应的双歧杆菌配体
公开(公告)号：US20110118482A1
公开(公告)日：2011-05-19
申请号：US12734696
申请日：2008-11-14
申请人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Bjõrn Gschwend , Andreas Pfaltz , Felix Spindler
发明人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Bjõrn Gschwend , Andreas Pfaltz , Felix Spindler
IPC分类号： C07F9/6553 , C07F15/00 , C07F17/02 , C07F9/28 , C07F9/655 , C07C67/00 , C07C227/16
CPC分类号： C07F13/005 , B01J31/1875 , B01J31/2291 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/655354 , C07F17/02 , C07C69/34 , C07C69/732 , C07C69/675 , C07C233/47
摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group Z1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*R0R1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; R0 is methyl or hydroxyl, and R0 is methyl when Z1 is the —P*R0R1 group; and R1 is a C-bonded optically enriched or optically pure chiral, mono- or polycyclic, nonaromatic hydrocarbon or heterohydrocarbon radical which has 3 to 12 ring atoms and 1 to 4 rings and which has a stereogenic carbon atom at least in the a position to the P—C bond; Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：主要为一种非对映体或纯非对映体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C1-C4-亚烷基骨架，其中，基骨架中的次膦基Z1直接键合或在环状基团骨架的情况下直接与碳原子或C 1 -C 4 - 亚烷基直接键合，并且其中的基础骨架中，P手性基团-P * R0R1直接键合到碳上或者在环状基骨架的情况下，直接连接到碳原子上，或者通过C1-C4-亚烷基与碳原子连接，使得磷原子通过1至7个任选被杂原子中断的碳链原子连接由O，S，N，Fe或Si组成; P *是手性磷原子; R 0是甲基或羟基，当Z 1是-P * R 0 R 1基团时，R 0是甲基; 并且R 1是C-键合的光学富集或光学纯的手性，单或多环，非芳族烃或杂烃基，其具有3至12个环原子和1至4个环，并且其具有立体碳原子至少在 P-C键; 这些配体的金属络合物是用于不对称加成反应的均相催化剂，特别是氢化。

7. 发明申请

US20090171114A1 Chiral Ligands Used in Transition Metal Catysts for Asymmetric Addition Reactions Especially Hydrogenation 有权
标题翻译：用于非对称加成反应的过渡金属催化剂中的手性配体特别是氢化
公开(公告)号：US20090171114A1
公开(公告)日：2009-07-02
申请号：US12227574
申请日：2007-05-23
申请人： Andreas Pfaltz , Yann Ribourdouille , Xiangdong Feng , Balamurugan Ramalingam , Benoit Pugin , Felix Spindler
发明人： Andreas Pfaltz , Yann Ribourdouille , Xiangdong Feng , Balamurugan Ramalingam , Benoit Pugin , Felix Spindler
IPC分类号： C07C69/34 , C07F15/02 , C07F9/53 , B01J31/18
CPC分类号： C07F9/5022 , B01J31/1875 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C51/36 , C07C67/303 , C07C213/02 , C07C231/12 , C07F15/008 , C07F17/02 , C07C57/30 , C07C69/675 , C07C69/732 , C07C69/34 , C07C217/08 , C07C233/47
摘要： Ligands of the formula (I) secondary phosphine-Q-P(═O)HR1 (I) in the form of mixtures of diastereomers or pure diastereomers, in which secondary phosphine is a secondary phosphine group with hydrocarbon radicals or heterohydrocarbon radicals as substituents; Q is a bivalent bisaryl or bisheteroaryl radical with an axial chiral centre to which the two phosphorus atoms are bonded in the ortho positions to the bisaryl or bisheteroaryl bridge bond, or Q is a bivalent ferrocenyl radical with a planar chiral centre or without a planar chiral centre, to which the phosphorus atom of the secondary phosphine is bonded directly or via a C1-C4-carbon chain to a cyclopentadienyl ring, the —P*(═O)HR1 group is bonded either on the same cyclopentadienyl ring in ortho position to the bonded secondary phosphine or on the other cyclopentadienyl ring; P* is a chiral phosphorus atom, and R1 is a hydrocarbon radical, a heterohydrocarbon radical or a ferrocenyl radical, where R1 is a ferrocenyl radical with a planar chiral centre when Q is a ferrocenyl radical without a planar chiral centre. Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：式（I）以非对映异构体或纯非对映异构体混合物形式的仲膦-Q-P（-O）HR1（I）的配体，其中次膦是具有烃基或杂烃基作为取代基的仲膦基; Q是具有轴向手性中心的二价双芳基或双杂芳基，其中两个磷原子与双芳基或双杂芳基桥键的邻位键合，或Q是具有平面手性中心或不具有平面手性的二价二茂铁基中心，仲膦的磷原子直接或通过C1-C4-碳键连接到环戊二烯基环上，-P *（ - O）HR 1基团在邻位相邻的环戊二烯基环上键合到键合的次膦或在另一个环戊二烯基环上; P *是手性磷原子，R1是烃基，杂烃基或二茂铁基，其中当Q是没有平面手性中心的二茂铁基时，R 1是具有平面手性中心的二茂铁基。这些配体的金属络合物是用于不对称加成反应的均相催化剂，特别是氢化。

8. 发明授权

US08450501B2 Bidentate chiral ligands for use in catalytic asymmetric addition reactions 有权
标题翻译：用于催化不对称加成反应的双齿手性配体
公开(公告)号：US08450501B2
公开(公告)日：2013-05-28
申请号：US12734696
申请日：2008-11-14
申请人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Björn Gschwend , Andreas Pfaltz , Felix Spindler
发明人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Björn Gschwend , Andreas Pfaltz , Felix Spindler
IPC分类号： C07D333/26
CPC分类号： C07F13/005 , B01J31/1875 , B01J31/2291 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/655354 , C07F17/02 , C07C69/34 , C07C69/732 , C07C69/675 , C07C233/47
摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton.
摘要翻译：主要为一种非对映体或纯非对映体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性芳族基骨架，二价，非手性二茂铁基骨架，任选取代的二价环烷烃或杂环烷骨架，或C 1 -C 4亚烷基骨架。

9. 发明授权

US08288566B2 Enantioselective synthesis of γ-amino-αβ-unsaturated carboxylic acid derivatives 失效
标题翻译： γ-氨基-α和bgr-不饱和羧酸衍生物的对映选择性合成
公开(公告)号：US08288566B2
公开(公告)日：2012-10-16
申请号：US13128972
申请日：2009-11-16
申请人： Murat Acemoglu , Andreas Pfaltz , Claude Schaerer
发明人： Murat Acemoglu , Andreas Pfaltz , Claude Schaerer
IPC分类号： C07D209/48 , C07C271/06
CPC分类号： C07C227/32 , C07B2200/07 , C07C229/30 , C07C231/18 , C07C237/16 , C07C271/12 , C07C271/24 , C07C2601/14 , C07D209/48 , C07F9/4015
摘要： Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
摘要翻译：提供了用于制备具有式II，III，VII和VIII的γ-氨基-α，β-不饱和羧酸衍生物的对映选择性钯催化方法：

10. 发明授权

US07435840B2 Method for producing orthometalated and orthosubstituted metallocenes 失效
标题翻译：生产原位金属和原位取代金属茂的方法
公开(公告)号：US07435840B2
公开(公告)日：2008-10-14
申请号：US10582404
申请日：2004-12-10
申请人： Andreas Pfaltz , Matthias Lotz , Marc Schönleber , Benoît Pugin , Martin Kesselgruber , Marc Thommen
发明人： Andreas Pfaltz , Matthias Lotz , Marc Schönleber , Benoît Pugin , Martin Kesselgruber , Marc Thommen
IPC分类号： C07F15/00 , B01J31/00
CPC分类号： C07F9/65848 , C07F17/02
摘要： The invention relates to compounds having a structural element of formula (I) in an aromatic hydrocarbon ring, wherein: M represents —Li, —MgX3, (C1-C18-Alkyl)3Sn—, —ZnX3 or —B(O—C1-C4-Alkyl)2; X1 and X2, independent of one another, represent O or N, and C-bound hydrocarbon radicals or heterohydrocarbon radicals are bound to the free bonds of the O and N atoms; group —C═C—, together with C atoms, forms a hydrocarbon aromatic compound and represents X3 Cl, Br or I. The inventive compounds are easily obtained by directly substituting the hydrogen in the ortho position to the P atom with metalation reagents. The metal atoms can then be substituted by a reactive electrophilic compound. The group —P(X1—)(X2—) - - - -(BH3)0,1 can then be converted into a secondary phosphine group. The inventive method enables the production of monophosphines and diphosphines even on a large scale, which are valuable ligands for metal complexes serving as catalysts for, e.g. enantioselective hydrogenations.
摘要翻译：本发明涉及在芳族烃环中具有式（I）结构元件的化合物，其中：M表示-Li，-MgX 3，（C 1 -C 3）烷基）3-Sn-，-ZnX 3或-B（OC 1 -C 3） 4 - 烷基）2 然后可以转化成次膦基。本发明的方法甚至可以大量生产单膦和二膦，这是用作金属络合物的有价值的配体，用作催化剂。对映选择性氢化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式