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1. 发明授权

US06273856B1 Apparatus and methods for METS measurement by accelerometer and minute ventilation sensors 有权
标题翻译：通过加速度计和分钟通气传感器进行METS测量的装置和方法
公开(公告)号：US06273856B1
公开(公告)日：2001-08-14
申请号：US09421017
申请日：1999-10-19
申请人： Weimin Sun , Bruce R. Jones , Donald L. Hopper , Wyatt K. Stahl
发明人： Weimin Sun , Bruce R. Jones , Donald L. Hopper , Wyatt K. Stahl
IPC分类号： A61B500
CPC分类号： A61N1/36585
摘要： Exertion levels of a patient are measured by monitoring signals from adaptive-rate sensors such as an accelerometer and or a minute ventilation sensor; sensor data is collected for conversion into metabolic equivalent measurements. The data obtained can be used to evaluate patient physical activity levels and can be used to assess the patient's condition and change pacing therapy or other treatments accordingly. An automatic adjustment of the adaptive-rate pacing therapy may be based on the activity levels detected by the metabolic equivalent measurements made by the pacemaker.
摘要翻译：通过监测来自自适应速率传感器（例如加速度计和/或分钟通气传感器）的信号来测量患者的消耗水平; 收集传感器数据以转化为代谢等效测量。获得的数据可用于评估患者的身体活动水平，并可用于相应地评估患者的状况和改变起搏治疗或其他治疗。自适应起搏治疗的自动调整可以基于由起搏器进行的代谢等效测量检测到的活动水平。

2. 发明授权

US08019418B2 Self-calibrating rate-adaptive pacemaker 有权
标题翻译：自校准速率自适应起搏器
公开(公告)号：US08019418B2
公开(公告)日：2011-09-13
申请号：US12507414
申请日：2009-07-22
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.
摘要翻译：一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

3. 发明申请

US20090287270A1 SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER 有权
标题翻译：自校准率自适应贴片机
公开(公告)号：US20090287270A1
公开(公告)日：2009-11-19
申请号：US12507414
申请日：2009-07-22
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.
摘要翻译：一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

4. 发明授权

US08494632B2 Self-calibrating rate-adaptive pacemaker 失效
公开(公告)号：US08494632B2
公开(公告)日：2013-07-23
申请号：US13230563
申请日：2011-09-12
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

5. 发明授权

US06459929B1 Implantable cardiac rhythm management device for assessing status of CHF patients 有权
标题翻译：用于评估CHF患者状态的植入式心律管理装置
公开(公告)号：US06459929B1
公开(公告)日：2002-10-01
申请号：US09547519
申请日：2000-04-12
申请人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
发明人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
IPC分类号： A61B50205
CPC分类号： A61N1/36585 , A61N1/3627
摘要： A method and apparatus for providing congestive heart failure therapy status. An electronic device, preferably a cardiac rhythm management device, capable of measuring transthoracic impedance and for sensing a level of physical activity is implanted in a patient. The transthoracic impedance signal is processed to obtain an estimate of the subject's minute ventilation, respiratory rate, tidal volume, inspiratory rate and expiratory rate. From accelerometer measured activity, an estimate is obtained of oxygen uptake, carbon dioxide production and work rate. Ratios of tidal volume to respiratory rate, tidal volume to inspiratory time, tidal volume to expiratory time, heart rate to minute ventilation, respiratory rate to minute ventilation, tidal volume to minute ventilation, minute ventilation to oxygen uptake, minute ventilation to carbon dioxide production, minute ventilation to work rate, heart rate to work rate, oxygen uptake to heart rate and other ratios are meaningful status indicators for assessing the efficacy of particular therapy regimens to CHF patients.
摘要翻译：一种用于提供充血性心力衰竭治疗状态的方法和装置。将能够测量经胸阻抗并感测身体活动水平的电子设备，优选心脏节律管理装置植入患者体内。处理经胸阻抗信号，以获得受试者的分钟通气量，呼吸频率，潮气量，吸气率和呼气率的估计。从加速度计测量的活动，得到氧气摄取，二氧化碳生产和工作率的估计。潮气量对呼吸频率，潮气量吸气时间，潮气量与呼气时间，心率与分钟通气量的比例，呼吸频率到每分钟通气量，潮气量到分钟通气量，分钟通气至吸氧量，分钟通气至二氧化碳生成，分钟通气到工作率，心率到工作率，氧摄取对心率和其他比例是评估特定治疗方案对CHF患者的疗效的有意义的状态指标。

6. 发明授权

US06275727B1 Implantable cardiac rhythm management device for assessing status of CHF patients 有权
标题翻译：用于评估CHF患者状态的植入式心律管理装置
公开(公告)号：US06275727B1
公开(公告)日：2001-08-14
申请号：US09434009
申请日：1999-11-04
申请人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
发明人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
IPC分类号： A61B504
CPC分类号： A61N1/36585 , A61N1/3627
摘要： A method and apparatus for providing congestive heart failure therapy status. An electronic device, preferably a cardiac rhythm management device, capable of measuring transthoracic impedance and for sensing a level of physical activity is implanted in a patient. The transthoracic impedance signal is processed to obtain an estimate of the subject's minute ventilation, respiratory rate and tidal volume. From accelerometer measured activity, an estimate is obtained of oxygen uptake and carbon dioxide production. Ratios of tidal volume to respiratory rate, tidal volume to inspiratory time, minute ventilation to carbon dioxide production and oxygen uptake to heart rate are meaningftil status indicators for assessing the efficacy of particular therapy regimens to CHF patients.
摘要翻译：一种用于提供充血性心力衰竭治疗状态的方法和装置。将能够测量经胸阻抗并感测身体活动水平的电子设备，优选心脏节律管理装置植入患者体内。经胸廓阻抗信号被处理以获得受试者的分钟通气量，呼吸频率和潮气量的估计值。从加速度计测量的活动，得到氧气摄取和二氧化碳生产的估计。潮气量与呼吸频率的比值，潮气量吸气时间，二氧化碳产生的分钟通气量和对心率的氧吸收是评估特定治疗方案对CHF患者的疗效的意义状态指标。

7. 发明授权

US08639324B2 Respiratory parameters for arrhythmia detection and therapy 有权
标题翻译：心律失常检测和治疗的呼吸参数
公开(公告)号：US08639324B2
公开(公告)日：2014-01-28
申请号：US13353515
申请日：2012-01-19
申请人： Efdal Elferri , Randall L. McPherson , Donald L. Hopper , Gary T. Seim , James O. Gilkerson , Dan Li , David L. Perschbacher
发明人： Efdal Elferri , Randall L. McPherson , Donald L. Hopper , Gary T. Seim , James O. Gilkerson , Dan Li , David L. Perschbacher
IPC分类号： A61B5/0205 , A61N1/365 , A61N1/39
CPC分类号： A61N1/36585 , A61B5/0464 , A61B5/0538 , A61B5/0809 , A61B5/091 , A61B5/686 , A61N1/3962
摘要： An implantable or ambulatory medical device can include a cardiac signal sensing circuit configured to provide a sensed cardiac depolarization signal of a heart of a subject, a respiration sensing circuit configured to provide a signal representative of respiration of the subject, and a control circuit communicatively coupled to the cardiac signal sensing circuit and the respiration circuit. The control circuit includes a tachyarrhythmia detection circuit configured to determine heart rate using the depolarization signal, determine a respiration parameter of the subject using the respiration signal, calculate a ratio using the determined heart rate and the determined respiration parameter, generate an indication of tachyarrhythmia when the calculated ratio satisfies a specified detection ratio threshold value, and provide the indication of tachyarrhythmia to a user or process.
摘要翻译：植入式或动态医疗装置可以包括心脏信号感测电路，该心脏信号感测电路被配置为提供受检者的心脏的感测的心脏去极化信号，被配置为提供代表对象呼吸的信号的呼吸感测电路，以及通信耦合的控制电路到心脏信号感测电路和呼吸电路。控制电路包括快速性心律失常检测电路，其被配置为使用去极化信号来确定心率，使用呼吸信号确定受试者的呼吸参数，使用所确定的心率和确定的呼吸参数来计算比率，产生快速性心律失常的指示，所计算的比率满足规定的检测率阈值，并向用户或过程提供快速性心律失常的指示。

8. 发明授权

US08538525B2 Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device 有权
标题翻译：通过植入式心脏装置的代谢反应检测的心肺功能状态评估
公开(公告)号：US08538525B2
公开(公告)日：2013-09-17
申请号：US13371705
申请日：2012-02-13
申请人： Donald L. Hopper , Bruce Wilkoff , Richard Morris
发明人： Donald L. Hopper , Bruce Wilkoff , Richard Morris
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient's functional status.
摘要翻译：可植入心脏装置被配置和编程以通过评估患者的分钟通气反应来评估患者的心肺功能。这种评估可以通过计算每分钟通气量的增加变化与测量活动水平的增量变化的比例来计算每分钟通气响应斜率来进行。然后将分钟通气反应斜率与正常范围进行比较，以评估患者的功能状态。

9. 发明申请

US20090082823A1 Variable shortening of AV delay for treatment of cardiac disease 有权
标题翻译： AV延迟可变缩短治疗心脏病
公开(公告)号：US20090082823A1
公开(公告)日：2009-03-26
申请号：US11903758
申请日：2007-09-25
申请人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
摘要翻译：用于递送心室起搏的可植入起搏装置可以被配置为以模拟运动的方式间歇地和可变地减小在心房触发起搏模式中使用的AV延迟间隔。该设备可以被编程为根据定义的进入和退出条件间歇地切换到可变地缩短的AV延迟模式。

10. 发明申请

US20080281370A1 APPARATUS AND METHOD FOR HEART FAILURE INDICATION BASED ON HEART RATE, ONSET AND TACHYARRHYTHMIA 有权
标题翻译：基于心率，ONSET和TACHYARRHYTHMIA的心脏失效指征的装置和方法
公开(公告)号：US20080281370A1
公开(公告)日：2008-11-13
申请号：US11744952
申请日：2007-05-07
申请人： Yayun Lin , Shelley M. Cazares , Donald L. Hopper
发明人： Yayun Lin , Shelley M. Cazares , Donald L. Hopper
IPC分类号： A61N1/02
CPC分类号： A61N1/3702 , A61B5/02028 , A61B5/02405 , A61B5/0464 , A61N1/3627 , A61N1/36592
摘要： An indication of an actual or potential heart failure condition is computed. One example includes monitoring a first heart rate preceding a first onset of a first sinus tachyarrhythmia episode. Upon detecting the first sinus tachyarrhythmia episode, the indication is automatically provided using information about the first heart rate and how quickly the first onset occurs.
摘要翻译：计算出实际或潜在的心力衰竭状况的指示。一个例子包括监测在第一次窦性心律失常发作的第一次发作之前的第一心率。在检测到第一窦性心律失常发作时，使用关于第一心率的信息以及第一次发作发生的速度自动提供指示。

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