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    • 4. 发明授权
    • Spatially resolved spin resonance detection
    • 空间分辨的自旋共振检测
    • US06693426B1
    • 2004-02-17
    • US10071563
    • 2002-02-09
    • Xiao Dong XiangGang WangHaitao YangGerald F. Dionne
    • Xiao Dong XiangGang WangHaitao YangGerald F. Dionne
    • G01V300
    • G01N24/10G01N24/006Y10T436/24
    • Methods for spatially resolve spin resonance detection in a sample of material, with a resolution as small as 0.5 &mgr;m-1 mm. In one embodiment, a coupler having at least one pair of degenerate orthogonal modes provides an evanescent input signal along one coupler axis to the sample, to which a magnetic field is applied, and senses a spin interaction signal along another coupler axis. In another embodiment, an evanescent input signal is applied to the sample along one of two identical transmission line resonators, and a difference of the two resonator signals provides a spin interaction signal. In another embodiment, a polarized laser beam provides an evanescent input signal to the sample, and the spin interaction signal is sensed according to a second beam polarization direction. Certain ferromagnetic or ferrimagnetic molecules, such as YIG, can be used to tag selected chemical and biological molecules, using spatially resolved spin resonance detection for interrogation.
    • 在材料样品中空间分辨自旋共振检测的方法,分辨率小至0.5 mum-1 mm。 在一个实施例中,具有至少一对简并正交模式的耦合器提供沿着一个耦合器轴线向被施加磁场的样本的消逝输入信号,并且沿另一个耦合器轴线感测自旋相互作用信号。 在另一个实施例中,沿着两个相同的传输线谐振器中的一个将消逝的输入信号施加到样本,并且两个谐振器信号的差提供自旋相互作用信号。 在另一个实施例中,偏振激光束向样本提供消逝的输入信号,并且根据第二光束偏振方向感测自旋相互作用信号。 某些铁磁或亚铁磁分子,如YIG,可用于标记选定的化学和生物分子,使用空间分辨的自旋共振检测进行询问。
    • 8. 发明授权
    • Magnetic resonance imaging contrast system
    • 磁共振成像对比系统
    • US06924150B1
    • 2005-08-02
    • US10124203
    • 2002-04-17
    • Xiao Dong XiangGerald F. DionneHaitao Yang
    • Xiao Dong XiangGerald F. DionneHaitao Yang
    • G01N24/00G01N24/10A61B5/055A61B8/00G01N25/18G01R33/00G01V3/00
    • G01N24/10G01N24/006Y10T436/24
    • A method for improving the magnetic resonance imaging contrast of a selected portion of a sample. A selected ferrimagnetic constituent is associated with the sample portion, by molecular or biological attachment or by some other means, so that the sample portion is distinguished from other adjacent portions of the sample that do not have the selected ferrimagnetic constituent associated therewith. Alternatively, the sample portion is suspected, but not yet confirmed, to have the selected ferrimagnetic constituent associated with it. Ferromagnetic resonance imaging is performed on the sample portion, and at least one resonance frequency ω0 of the sample portion is provided. At least one material parameter of the sample portion is measured at or near the frequency ω0, with enhanced imaging contrast relative to adjacent portions of the sample that do not have the selected ferrimagnetic constituent in association. Alternatively, the measured value is compared with a corresponding reference value for the selected ferrimagnetic constituent. If (and only if) the measured and corresponding reference values substantially agree, the selected ferrimagnetic constituent is present in association with the selected sample portion. Other parameters of the selected ferrimagnetic consituent can also be measured.
    • 一种用于改善所选部分样品的磁共振成像对比度的方法。 选择的亚铁磁性成分通过分子或生物附着或通过某种其他方式与样品部分相关联,使得样品部分与样品中没有与其相关联的选择的亚铁磁性成分的其它相邻部分区分开。 或者,怀疑但尚未确认样品部分具有与其相关联的所选择的亚铁磁性成分。 对样品部分进行铁磁共振成像,并且提供样品部分的至少一个共振频率ω0。 样品部分的至少一个材料参数在频率ω0处或附近被测量,相对于没有关联的选择的亚铁磁性成分的样品的相邻部分,具有增强的成像对比度。 或者,将测量值与所选择的亚铁磁性成分的相应参考值进行比较。 如果(且仅当)测量的和相应的参考值基本一致,则所选择的亚铁磁成分与选择的样品部分相关联地存在。 也可以测量所选铁氧体成分的其它参数。