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1. 发明申请

US20150047422A1 INTRODUCING SAMPLES INTO SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：将样品引入超临界流体色谱系统
公开(公告)号：US20150047422A1
公开(公告)日：2015-02-19
申请号：US14383239
申请日：2013-03-05
申请人： Waters Technologies Corporation
发明人： Emily J. Berg , Joshua A. Shreve , James E. Usowicz , Douglas P. Wittmer , Aaron Lebeau
IPC分类号： B01D15/14 , G01N30/28 , B01D15/40
CPC分类号： B01D15/14 , B01D15/40 , G01N30/16 , G01N30/20 , G01N30/28 , G01N2030/201 , G01N2030/202 , G01N2030/207 , G01N30/32
摘要： A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection.
摘要翻译：超临界流体色谱系统设置有用于将样品引入流动相流体流的注射阀子系统。喷射阀子系统包括辅助阀和喷射阀。辅助和注入阀的操作以减少样品注入期间发生的样品携带和系统压力扰动的方式进行协调。

2. 发明授权

US11554331B2 Method and apparatus for minimizing the chromatographic band distortion of a back pressure regulator 有权
公开(公告)号：US11554331B2
公开(公告)日：2023-01-17
申请号：US15930683
申请日：2020-05-13
申请人： Waters Technologies Corporation
发明人： Michael O. Fogwill , Joseph D. Michienzi , Joshua A. Shreve , Scott Kelley , Emily J. Berg
IPC分类号： B01D15/14 , B01D15/16 , B01D15/40 , G01N30/32 , F16K1/38 , F16K25/00 , F15B13/02 , F15B13/04
摘要： The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band distortion effects.

3. 发明授权

US09764251B2 Introducing samples into supercritical fluid chromatography systems 有权
公开(公告)号：US09764251B2
公开(公告)日：2017-09-19
申请号：US14383239
申请日：2013-03-05
申请人： Waters Technologies Corporation
发明人： Emily J. Berg , Joshua A. Shreve , James E. Usowicz , Douglas P. Wittmer , Aaron Lebeau
IPC分类号： G01N1/00 , B01D15/14 , B01D15/40 , G01N30/20 , G01N30/16 , G01N30/28
CPC分类号： B01D15/14 , B01D15/40 , G01N30/16 , G01N30/20 , G01N30/28 , G01N2030/201 , G01N2030/202 , G01N2030/207 , G01N30/32
摘要： A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection.

4. 发明申请

US20150042089A1 HIGH PRESSURE FITTING FOR A LIQUID CHROMATOGRAPHY SYSTEM 审中-公开
标题翻译：液相色谱系统的高压配件
公开(公告)号：US20150042089A1
公开(公告)日：2015-02-12
申请号：US14382850
申请日：2013-02-01
申请人： Waters Technologies Corporation
发明人： Kurt D. Joudrey , Sylvain Cormier , James Usowicz , Emily J. Berg , Christopher Seith
IPC分类号： F16L19/06 , G01N30/60
CPC分类号： F16L19/061 , G01N30/6026
摘要： A fitting for coupling fluidic paths, such as high pressure fluidic paths in liquid chromatography systems, includes a compression nut, a tube assembly and a compression member. The compression nut has a threaded outer surface to engage a threaded bore of a receiving port and the tube assembly has an outer surface and an end face to contact a sealing surface of the receiving port. The compression member is pre-staked to the outer surface of the tube assembly at a predetermined distance from the end face and has a tapered surface to engage a surface of the receiving port. The predetermined distance permits the tube assembly to be inserted into the receiving port so that the end face makes contact with the sealing surface without the tapered surface engaging a surface of the receiving port and so that the threaded outer surface of the compression nut engages the threaded bore.
摘要翻译：用于耦合流体路径（例如液相色谱系统中的高压流体路径）的配件包括压缩螺母，管组件和压缩构件。压缩螺母具有螺纹外表面以接合接收端口的螺纹孔，并且管组件具有外表面和端面以接触接收端口的密封表面。压缩构件预先固定在距离端面一预定距离的管组件的外表面上，并且具有锥形表面以接合接收端口的表面。预定距离允许管组件插入到接收端口中，使得端面与密封表面接触，而锥形表面接合接收端口的表面，并且使得压缩螺母的螺纹外表面接合螺纹孔。

5. 发明授权

US11707809B2 Method and apparatus for high pressure sealing 有权
公开(公告)号：US11707809B2
公开(公告)日：2023-07-25
申请号：US15930701
申请日：2020-05-13
申请人： Waters Technologies Corporation
发明人： Emily J. Berg , Joshua A. Shreve
IPC分类号： B23P19/02 , F16B37/04 , F16J15/02 , F16J15/06
CPC分类号： B23P19/02 , F16B37/04 , F16J15/022 , F16J15/061
摘要： The present technology generally relates to devices, systems and methods for providing robust sealing between surfaces in a pressurized system, such as a chromatography system. In particular, the devices, systems and methods relate to compliant and resilient parts that can be reused and/or reinstalled while providing a pressure tight sealing surface even within a high pressure environment (e.g., 1000 psi or greater).

6. 发明授权

US10792589B2 Gas liquid separator for chromatography applications 有权
公开(公告)号：US10792589B2
公开(公告)日：2020-10-06
申请号：US15791622
申请日：2017-10-24
申请人： Waters Technologies Corporation
发明人： Emily J. Berg , Joshua A. Shreve , Edwin H. Denecke
IPC分类号： B01D15/40 , B01D15/16 , B01D19/00 , B01D15/10 , G01N30/84
摘要： Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet. The fluid mixture inlet and the gas and liquid outlets are in fluid communication with the chamber. A fluid mixture received at the fluid mixture inlet diffuses inside the chamber and is separated into a liquid and a gas. The separated liquid is gravity-fed to the liquid outlet. The gas liquid separators have reduced dispersion and increased liquid recovery in comparison to conventional gas liquid separators used for chromatographic separations. The reduced dispersion yields an improvement in the shape of chromatographic peaks.

7. 发明申请

US20180111060A1 GAS LIQUID SEPARATOR FOR CHROMATOGRAPHY APPLICATIONS 审中-公开
公开(公告)号：US20180111060A1
公开(公告)日：2018-04-26
申请号：US15791622
申请日：2017-10-24
申请人： Waters Technologies Corporation
发明人： Emily J. Berg , Joshua A. Shreve , Edwin H. Denecke
IPC分类号： B01D15/40 , B01D15/16
CPC分类号： B01D15/40 , B01D15/10 , B01D15/161 , B01D15/163 , B01D19/0005 , B01D19/0021 , B01D19/0042 , B01D19/0057 , B01D19/0063 , B01D2257/504 , G01N30/84
摘要： Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet. The fluid mixture inlet and the gas and liquid outlets are in fluid communication with the chamber. A fluid mixture received at the fluid mixture inlet diffuses inside the chamber and is separated into a liquid and a gas. The separated liquid is gravity-fed to the liquid outlet. The gas liquid separators have reduced dispersion and increased liquid recovery in comparison to conventional gas liquid separators used for chromatographic separations. The reduced dispersion yields an improvement in the shape of chromatographic peaks.

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