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1. 发明授权

US5776438A External preparation 失效
标题翻译：外部准备
公开(公告)号：US5776438A
公开(公告)日：1998-07-07
申请号：US645681
申请日：1996-05-14
申请人： Wataru Tokue , Kenzo Ito , Naoki Tominaga
发明人： Wataru Tokue , Kenzo Ito , Naoki Tominaga
IPC分类号： A61K8/35 , A61K8/67 , A61Q19/08 , A61K7/42 , A61K31/66
CPC分类号： A61Q19/08 , A61K8/35 , A61K8/678
摘要： An external preparation containing DL-.alpha.-tocopherol 2- L-ascorbic phosphoric diester and/or a salt thereof, and at least one ultraviolet absorbing agent. The cross-linking of collagen is suppressed and an excellent cutaneous aging resisting effect is obtained.
摘要翻译：含有DL-α-生育酚2- L-抗坏血酸磷酸二酯和/或其盐的外用制剂和至少一种紫外线吸收剂。抑制胶原的交联，获得优异的抗皮肤老化效果。

2. 发明申请

US20120183492A1 External Preparation For The Skin 有权
标题翻译：外部皮肤准备
公开(公告)号：US20120183492A1
公开(公告)日：2012-07-19
申请号：US13381107
申请日：2010-06-23
申请人： Naoki Tominaga
发明人： Naoki Tominaga
IPC分类号： A61K8/81 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/8158 , A61K8/86 , A61K2800/28 , A61K2800/594 , A61Q19/08
摘要： An external preparation for skin has a pH value of 2.0-5.0 and comprises: (a) 1.0-7.0 mass % of at least one of the members selected from hydroxy acids, (b) 0-0.1-3.0 mass % of a crosslinked type N,N-dimethylacrylamide-2-acrylamido-2-methylpropane sulfonic acid sodium salt copolymer, and (c) 0-0.1-3.0 mass % of an associating thickener constituted of a compound of the formula (1): R1—{(O—R2)k—OCONH—R3[—NHCOO—(R4—O)n—R5]h}m (1) wherein R1 represents a hydrocarbon group, R2 and R4 represent alkylene groups having 2-4 carbon atoms, which may be identical or different, or a phenylethylene group, R3 represents a hydrocarbon group, which may have a urethane bond, R5 represents a branched chain or secondary hydrocarbon group, m is a number of at least 2, h is a number of at least 1, k is a number within the range of 1-500, and n is a number within the range of 1-200.
摘要翻译：外用的皮肤制剂的pH值为2.0〜5.0，包括：（a）1.0〜7.0质量％的选自羟基酸的成分中的至少一种，（b）交联型的0〜0.1-3.0质量％ N，N-二甲基丙烯酰胺-2-丙烯酰胺基-2-甲基丙磺酸钠盐共聚物，（c）0-0.1-3.0质量％的由式（1）的化合物构成的缔合增稠剂：R1 - {（O -R2）k-OCONH-R3 [-NHCOO-（R4-O）n-R5] h} m（1）其中R1表示烃基，R2和R4表示具有2-4个碳原子的亚烷基，相同或不同的苯基亚乙基，R 3表示可具有氨基甲酸酯键的烃基，R 5表示支链或仲烃基，m为至少2的数，h为至少1的数， k是1-500范围内的数字，n是1-200范围内的数字。

3. 发明申请

US20120022160A1 COMPOSITION FOR EXTERNAL USE ON SKIN 审中-公开
标题翻译：外用于皮肤的组合物
公开(公告)号：US20120022160A1
公开(公告)日：2012-01-26
申请号：US13124114
申请日：2009-10-14
申请人： Kazunobu Suzuki , Naoki Tominaga
发明人： Kazunobu Suzuki , Naoki Tominaga
IPC分类号： A61K8/92 , A61Q19/00 , A61K8/73
CPC分类号： A61K8/44 , A61K8/345 , A61K8/73 , A61K8/8152 , A61K9/0014 , A61Q19/00 , A61Q19/02
摘要： It is intended to provide a cleansing cosmetic composition that quickly removes makeup from the skin, is easily applicable onto the skin without dripping from the hand or running on the face during application, and can freshen the skin because of being washed off thoroughly. The present invention provides a cleansing cosmetic composition comprising: (1) 1 to 15% by mass of silicone oil, (2) 1 to 15% by mass of volatile hydrocarbon oil, (3) 5 to 20% by mass of dihydric glycol, (4) 5 to 40% by mass of polyoxyethylene glyceryl fatty acid ester, and (5) 15 to 88% by mass of water, wherein the weight ratio between the silicone oil (1) and the volatile hydrocarbon oil (2) ((1)/(2)) falls within the range of 0.3 to 3 and the composition has a viscosity of 100 to 500 mPas at 25° C.
摘要翻译：旨在提供一种快速从皮肤上除去化妆品的清洁化妆品组合物，在使用过程中容易适用于皮肤而不会从手上滴落或在脸上跑动，并且可以彻底清洗皮肤，从而使皮肤变得清爽。本发明提供一种清洁化妆品组合物，其含有：（1）1〜15质量％的硅油，（2）1〜15质量％的挥发性烃油，（3）5〜20质量％的二元醇，（4）聚氧乙烯甘油脂肪酸酯5〜40质量％，（5）15〜88质量％的水，其中，硅油（1）与挥发性烃油（2）（（ 1）/（2））在0.3〜3的范围内，组合物在25℃下的粘度为100〜500mPa·s。

4. 发明授权

US5137875A Hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen 失效
标题翻译：含有含酸水溶液或胶原蛋白的水性分散液
公开(公告)号：US5137875A
公开(公告)日：1992-08-11
申请号：US339765
申请日：1989-04-18
申请人： Makoto Tsunenaga , Naoki Tominaga , Toshio Nishiyama , Toru Yamashita , Mutsumi Fukuyama , Teruo Miyata , Masayasu Furuse
发明人： Makoto Tsunenaga , Naoki Tominaga , Toshio Nishiyama , Toru Yamashita , Mutsumi Fukuyama , Teruo Miyata , Masayasu Furuse
IPC分类号： A61L27/00 , A61F2/00 , A61L27/20 , A61L27/24 , A61L27/50 , C08L5/08 , C08L89/06
CPC分类号： A61L27/20 , A61L27/24 , A61L27/50 , C08L5/08 , C08L89/06 , A61F2310/00365
摘要： A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH.sub.2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.

5. 发明授权

US5747049A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US5747049A
公开(公告)日：1998-05-05
申请号：US529601
申请日：1995-09-18
申请人： Naoki Tominaga
发明人： Naoki Tominaga
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/35 , A61K8/46 , A61K31/13 , A61P17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61K8/466 , A61K8/35 , A61Q17/04 , A61Q19/08 , Y10S514/844 , Y10S514/846
摘要： An anti-aging preparation for cutaneous application which prevents cutaneous aging, a collagen cross-linking inhibitory preparation for cutaneous application which inhibits collagen cross-linking occurring predominantly in the dermis to maintain skin elasticity and to prevent wrinkles or sagging, and an anti-UV preparation for cutaneous application which protects the skin from harmful effects caused by of excessive exposure to ultraviolet rays of sunlight are disclosed. The preparation contains one or two aminoethyl compounds represented by formula (I): NH.sub.2 CH.sub.2 CH.sub.2 X (I) wherein X represents --SO.sub.2 H or --SO.sub.2 SH, and preferably contains at least one ultraviolet protective agent.
摘要翻译：用于皮肤应用的抗衰老制剂，其防止皮肤老化，用于皮肤应用的胶原交联抑制剂，其抑制主要在真皮中发生的胶原交联以保持皮肤弹性并防止皱纹或下垂，以及抗紫外线公开了皮肤应用的准备，其保护皮肤免受由于太阳紫外线的过度暴露而引起的有害影响。该制剂含有一个或两个由式（I）表示的氨基乙基化合物：其中X代表-SO2H或-SO2SH的NH2CH2CH2X（Ⅰ），优选含有至少一种紫外线防护剂。

6. 发明授权

US08323629B2 External preparation for the skin 有权
标题翻译：外用皮肤准备
公开(公告)号：US08323629B2
公开(公告)日：2012-12-04
申请号：US13381107
申请日：2010-06-23
申请人： Naoki Tominaga
发明人： Naoki Tominaga
IPC分类号： A61K8/02 , A61K31/74
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/8158 , A61K8/86 , A61K2800/28 , A61K2800/594 , A61Q19/08
摘要： An external preparation for skin has a pH value of 2.0-5.0 and comprises: (a) 1.0-7.0 mass % of at least one of the members selected from α-hydroxy acids, (b) 0.1-3.0 mass % of a crosslinked type N,N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium salt copolymer, and (c) 0.1-3.0 mass % of an associating thickener constituted of a compound of the formula (1): R1—{(O—R2)k—OCONH—R3[—NHCOO—(R4—O)n—R5]h}m (1) wherein R1 represents a hydrocarbon group, R2 and R4 represent alkylene groups having 2-4 carbon atoms, which may be identical or different, or a phenylethylene group, R3 represents a hydrocarbon group, which may have a urethane bond, R5 represents a branched chain or secondary hydrocarbon group, m is a number of at least 2, h is a number of at least 1, k is a number within the range of 1-500, and n is a number within the range of 1-200.
摘要翻译：皮肤外用剂的pH值为2.0-5.0，包括：（a）选自α-羟基酸中的至少一种成分的1.0〜7.0质量％，（b）0.1〜3.0质量％的交联型 N，N-二甲基丙烯酰胺-2-丙烯酰胺基-2-甲基丙磺酸钠盐共聚物，和（c）0.1-3.0质量％由式（1）化合物构成的缔合增稠剂：R1 - {（O-R2） k-OCONH-R3 [-NHCOO-（R4-O）n-R5] h} m（1）其中R1表示烃基，R2和R4表示具有2-4个碳原子的亚烷基，可以相同或不同或苯基亚乙基，R 3表示可以具有氨基甲酸酯键的烃基，R 5表示支链或仲烃基，m为至少2的数，h为至少1的数，k为数字在1-500的范围内，n是1-200范围内的数字。

7. 发明申请

US20060099161A1 Skin preparations for external use 审中-公开
标题翻译：外用皮肤准备
公开(公告)号：US20060099161A1
公开(公告)日：2006-05-11
申请号：US10531737
申请日：2003-10-21
申请人： Toshihiko Nakane , Hirokazu Ishino , Takashi Isa , Nozomi Oguchi , Naoki Tominaga , Yukiko Kamiya
发明人： Toshihiko Nakane , Hirokazu Ishino , Takashi Isa , Nozomi Oguchi , Naoki Tominaga , Yukiko Kamiya
IPC分类号： A61K8/27 , A61K33/06
CPC分类号： A61K8/44 , A61K8/26 , A61K8/90 , A61K2800/42 , A61Q1/12 , A61Q15/00 , A61Q19/00
摘要： A skin treatment composition comprising anti-bacterial zeolite and trisalt ethylenediaminehydroxyethyl triacetate. A skin treatment composition comprising anti-bacterial zeolite and alum and/or dried alum. A skin treatment composition comprising anti-bacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether. The object is to provide a skin treatment composition containing anti-bacterial zeolite that exhibits the effect of preventing discoloration of the skin treatment compositions and/or reducing the degree of discoloration. Another object is to provide a skin treatment composition that is superior in terms of formulation stability and tactile sensation during use. Yet another object is to provide a skin treatment composition having the effect of preventing the skin treatment composition from staining clothing and/or reducing the degree of such staining.
摘要翻译：一种皮肤治疗组合物，其包含抗菌沸石和三乙二胺乙二胺羟乙基。包含抗细菌沸石和明矾和/或干燥的明矾的皮肤处理组合物。包含抗菌沸石和聚氧乙烯聚氧丙烯2-癸基十四烷基醚的皮肤处理组合物。本发明的目的是提供含有抗菌沸石的皮肤处理组合物，其具有防止皮肤处理组合物变色和/或降低变色程度的效果。另一个目的是提供在使用过程中在制剂稳定性和触觉方面优异的皮肤处理组合物。另一个目的是提供具有防止皮肤处理组合物染色衣物和/或降低这种染色程度的效果的皮肤处理组合物。

8. 发明授权

US5407677A Invigorating herbal gel for supple skin 失效
标题翻译：振兴草药凝胶柔软的皮肤
公开(公告)号：US5407677A
公开(公告)日：1995-04-18
申请号：US22476
申请日：1993-02-25
申请人： Naoki Tominaga , Toshio Yoshioka
发明人： Naoki Tominaga , Toshio Yoshioka
IPC分类号： A61K8/30 , A61K8/00 , A61K8/34 , A61K8/72 , A61K8/73 , A61K8/96 , A61K8/97 , A61K36/23 , A61P3/00 , A61P3/06 , A61Q19/00 , A61Q19/06 , H01L21/8247 , A61K7/00
CPC分类号： A61Q19/06 , A61K8/345 , A61K8/73 , A61K8/97 , Y10S514/937 , Y10S514/938
摘要： An herbal composition for the body is provided which promotes lipid metabolism by increasing the activity of a lipid metabolism enzyme in the body, and which has a weight reducing effect. The composition contains at least one component selected from fennel extract, inositol and dextrane sulfate.This composition is preferably employed in the form of an invigorating herbal gel for supple skin which is effective in increasing lipase activity and thus accelerating lipid metabolism.
摘要翻译：提供了一种用于身体的草药组合物，其通过增加身体中的脂质代谢酶的活性而促进脂质代谢，并且具有减轻重量的作用。该组合物含有至少一种选自茴香提取物，肌醇和硫酸葡聚糖的组分。该组合物优选以促进皮肤柔软的草药形式使用，其有效增加脂肪酶活性并因此促进脂质代谢。

9. 发明授权

US6077520A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US6077520A
公开(公告)日：2000-06-20
申请号：US23047
申请日：1998-02-13
申请人： Naoki Tominaga
发明人： Naoki Tominaga
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/35 , A61K8/46 , A61K31/13 , A61P17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61K8/466 , A61K8/35 , A61Q17/04 , A61Q19/08 , Y10S514/844 , Y10S514/846
摘要： An anti-aging preparation for cutaneous application which prevents cutaneous aging, a collagen cross-linking inhibitory preparation for cutaneous application which inhibits collagen cross-linking occurring predominantly in the dermis to maintain skin elasticity and to prevent wrinkles or sagging, and an anti-UV preparation for cutaneous application which protects the skin from harmful effects caused by excessive exposure to ultraviolet rays of sunlight are disclosed. The preparation contains one or two aminoethyl compounds represented by formula (I):NH.sub.2 CH.sub.2 CH.sub.2 X (I)wherein X represents --SO.sub.2 H or --SO.sub.2 SH, and preferably contains at least one ultraviolet protective agent.
摘要翻译：用于皮肤应用的抗衰老制剂，其防止皮肤老化，用于皮肤应用的胶原交联抑制剂，其抑制主要在真皮中发生的胶原交联以保持皮肤弹性并防止皱纹或下垂，以及抗紫外线公开了皮肤应用的准备，其保护皮肤免受过度暴露于太阳紫外线的有害影响。该制剂含有一个或两个由式（I）表示的氨基乙基化合物：其中X代表-SO2H或-SO2SH的NH2CH2CH2X（Ⅰ），优选含有至少一种紫外线防护剂。

10. 发明授权

US5478560A External dermatological composition 失效
标题翻译：外用皮肤组成
公开(公告)号：US5478560A
公开(公告)日：1995-12-26
申请号：US161447
申请日：1993-12-06
申请人： Naoki Tominaga , Ito Kenzo , Yoshimaru Kumano
发明人： Naoki Tominaga , Ito Kenzo , Yoshimaru Kumano
IPC分类号： A61K8/44 , A61K38/04 , A61K38/05 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/44 , A61K38/05 , A61Q19/00 , A61Q19/007 , Y10S514/847
摘要： An external dermatological composition comprising a salt of L-arginine-L-aspartic acid and a pharmacologically acceptable carrier therefor.
摘要翻译：包含L-精氨酸-L-天冬氨酸的盐的外用皮肤病学组合物及其药理学上可接受的载体。

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