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1. 发明授权

US5137875A Hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen 失效
标题翻译：含有含酸水溶液或胶原蛋白的水性分散液
公开(公告)号：US5137875A
公开(公告)日：1992-08-11
申请号：US339765
申请日：1989-04-18
申请人： Makoto Tsunenaga , Naoki Tominaga , Toshio Nishiyama , Toru Yamashita , Mutsumi Fukuyama , Teruo Miyata , Masayasu Furuse
发明人： Makoto Tsunenaga , Naoki Tominaga , Toshio Nishiyama , Toru Yamashita , Mutsumi Fukuyama , Teruo Miyata , Masayasu Furuse
IPC分类号： A61L27/00 , A61F2/00 , A61L27/20 , A61L27/24 , A61L27/50 , C08L5/08 , C08L89/06
CPC分类号： A61L27/20 , A61L27/24 , A61L27/50 , C08L5/08 , C08L89/06 , A61F2310/00365
摘要： A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH.sub.2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.

2. 发明授权

US6153593A Laminin 5 and the formation of basement membrane structure 失效
标题翻译：层粘连蛋白5和基底膜结构的形成
公开(公告)号：US6153593A
公开(公告)日：2000-11-28
申请号：US868600
申请日：1997-06-04
申请人： Robert E. Burgeson , Makoto Tsunenaga , Satoshi Amano , Toshio Nishiyama , Eijiro Adachi , Nobuyuji Shioya
发明人： Robert E. Burgeson , Makoto Tsunenaga , Satoshi Amano , Toshio Nishiyama , Eijiro Adachi , Nobuyuji Shioya
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61L27/22 , A61L27/38 , A61L27/60 , C12N5/00 , C12N5/071 , A01N1/02 , A61F2/10 , C12N5/08
CPC分类号： C12N5/0629 , A61K38/39 , A61L27/227 , A61L27/3813 , A61L27/60 , C12N5/0068 , C12N2501/58 , C12N2533/52 , Y10S623/901
摘要： The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.
摘要翻译：使用层粘连蛋白-5促进基底膜的形成并形成皮肤等同物并改善角质形成细胞片的接枝。

3. 发明授权

US08173705B2 Agent for alleviating wrinkles 有权
标题翻译：减轻皱纹的代理
公开(公告)号：US08173705B2
公开(公告)日：2012-05-08
申请号：US12530841
申请日：2008-03-14
申请人： Makoto Tsunenaga , Mikiko Kaminuma , Masaru Suetsugu , Chika Katagiri
发明人： Makoto Tsunenaga , Mikiko Kaminuma , Masaru Suetsugu , Chika Katagiri
IPC分类号： A61K31/195
CPC分类号： A61K8/44 , A61K8/466 , A61K31/197 , A61Q19/08
摘要： The present invention provides an agent for preventing and alleviating wrinkles which has excellent effects of preventing and alleviating wrinkles formed by decreased barrier function of the skin owing to aging or photo aging, that is graphic wrinkles or linear wrinkles. The agent for preventing and alleviating wrinkles consisting of one or more compounds selected from the group consisting of gamma-aminobutyric acid derivatives represented by the following formula (1) or N,N,N-trimethyl gamma-aminobutyric acid represented by the following formula (3) and salts thereof: wherein R1 and R2 independently represent any of a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a benzyloxycarbonyl group, a cyclohexyl group, a cyclohexanemethyl group, a cyclohexanecarbonyl group, a guanidino group formed with nitrogen atom in the formula (1), an ureido group formed with nitrogen atom in the formula (1), and a group represented by following formula (2). Additionally, R1 and R2 may jointly form a piperidine ring, morpholine ring, or pyrrolidine ring. Both of R1 and R2 are not simultaneously a hydrogen atom.
摘要翻译：本发明提供一种防止和减轻皱纹的试剂，其具有优异的防止和减轻由于老化或照片老化导致的皮肤屏障功能形成的皱纹，即图形皱纹或线状皱纹的效果。用于预防和减轻由一种或多种选自由下式（1）表示的γ-氨基丁酸衍生物或由下式（N）表示的N，N，N-三甲基γ-氨基丁酸组成的组中的化合物组成的皱纹的试剂 3）及其盐：其中R 1和R 2独立地表示氢原子，具有1至3个碳原子的烷基，苄氧基羰基，环己基，环己烷甲基，环己烷羰基，与氮形成的胍基式（1）中的原子，式（1）中由氮原子形成的脲基和由下式（2）表示的基团。此外，R 1和R 2可以共同形成哌啶环，吗啉环或吡咯烷环。 R1和R2两者不同时为氢原子。

4. 发明申请

US20100087535A1 EXTERNAL COMPOSITION FOR SKIN 审中-公开
标题翻译：皮肤外用组合物
公开(公告)号：US20100087535A1
公开(公告)日：2010-04-08
申请号：US12450095
申请日：2008-03-19
申请人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
发明人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
IPC分类号： A61K31/195 , C07C229/26
CPC分类号： A61Q19/007 , A61K8/44 , A61K8/64 , A61K31/197
摘要： A moisturizing agent comprising one or more than one compound selected from the group consisting of lysyl-β-alanine represented by the following general formula (1) and a salt thereof:
摘要翻译：一种保湿剂，其包含一种或多于一种选自下列通式（1）表示的赖氨酰 - 丙氨酸及其盐的化合物：

5. 发明授权

US08871505B2 Artificial skin 有权
标题翻译：人造皮肤
公开(公告)号：US08871505B2
公开(公告)日：2014-10-28
申请号：US13582199
申请日：2011-01-19
申请人： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata , Eijiro Adachi
发明人： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata , Eijiro Adachi
IPC分类号： A61F2/10 , C12N5/071 , A61L27/38 , A61L27/60
CPC分类号： A61K31/4406 , A61F2/105 , A61K8/4926 , A61K8/4946 , A61K8/64 , A61K31/4184 , A61K38/005 , A61K38/07 , A61K2800/782 , A61L27/362 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60 , A61Q19/08
摘要： The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.
摘要翻译：本发明涉及一种生产人造皮肤的方法，包括：将基质金属蛋白酶抑制剂和乙酰肝素酶抑制剂加入到人表皮角质形成细胞和人真皮成纤维细胞的人造皮肤形成培养基中，在人造皮肤形成培养基中培养细胞，并形成人造皮肤。

6. 发明申请

US20120328719A1 EXTERNAL PREPARATION FOR SKIN 审中-公开
标题翻译：外用皮肤制剂
公开(公告)号：US20120328719A1
公开(公告)日：2012-12-27
申请号：US13582588
申请日：2011-01-21
申请人： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata
发明人： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata
IPC分类号： A61K36/38
CPC分类号： A61K45/06 , A61K8/4933 , A61K8/4946 , A61K31/416 , A61K31/4402 , A61K2800/782 , A61Q19/00 , A61K2300/00
摘要： An object of the present invention is to provide prevent or improve decreases in the barrier function and moisture retention function of the skin, and that object is achieved by applying an external preparation for skin that comprises a matrix metalloproteinase inhibitor and a heparanase inhibitor.
摘要翻译：本发明的目的是提供防止或改善皮肤的屏障功能和保湿功能的降低，并且该目的通过应用包含基质金属蛋白酶抑制剂和乙酰肝素酶抑制剂的皮肤外用剂来实现。

7. 发明申请

US20120157388A1 EXTERNAL COMPOSITION FOR SKIN 审中-公开
标题翻译：皮肤外用组合物
公开(公告)号：US20120157388A1
公开(公告)日：2012-06-21
申请号：US13403336
申请日：2012-02-23
申请人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
发明人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
IPC分类号： A61K8/64 , A61P19/00
CPC分类号： A61Q19/007 , A61K8/44 , A61K8/64 , A61K31/197
摘要： A moisturizing agent comprising one or more than one compound selected from the group consisting of lysyl-β-alanine represented by the following general formula (1) and a salt thereof:
摘要翻译：一种保湿剂，其包含一种或多于一种选自下列通式（1）表示的赖氨酰 - 丙氨酸及其盐的化合物：

8. 发明授权

US08138374B2 Composition for external application to skin 有权
标题翻译：外用于皮肤的组合物
公开(公告)号：US08138374B2
公开(公告)日：2012-03-20
申请号：US12449143
申请日：2008-01-24
申请人： Mikiko Kaminuma , Masaru Suetsugu , Nobuhiko Ochiai , Makoto Tsunenaga
发明人： Mikiko Kaminuma , Masaru Suetsugu , Nobuhiko Ochiai , Makoto Tsunenaga
IPC分类号： C07C233/05 , A61K31/16
CPC分类号： A61Q19/08 , A61K8/42 , A61K31/16 , C07C237/06
摘要： The present invention provides a composition for external application to skin containing one type or two or more types of compounds selected from the group consisting of aminoacetoamide compounds represented by the following general formula (1) and salts thereof.
摘要翻译：本发明提供一种皮肤外用组合物，其含有选自下述通式（1）表示的氨基乙酰胺化合物及其盐的一种或两种以上的化合物。

9. 发明申请

US20110065794A1 Wrinkle-preventing and improving composition 审中-公开
标题翻译：防皱，改善成分
公开(公告)号：US20110065794A1
公开(公告)日：2011-03-17
申请号：US12926351
申请日：2010-11-12
申请人： Makoto Tsunenaga , Haruhi Iwaki , Toshii Iida , Mikiko Kaminuma , Masaru Suetsugu , Keiko Takada , Shinji Inomata
发明人： Makoto Tsunenaga , Haruhi Iwaki , Toshii Iida , Mikiko Kaminuma , Masaru Suetsugu , Keiko Takada , Shinji Inomata
IPC分类号： A61K31/197 , A61Q19/08
CPC分类号： A61K8/44 , A61K8/445 , A61Q19/08
摘要： A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.
摘要翻译：一种防皱和改善组合物，其包含一种或多于一种选自下列通式（1）表示的α-氨基酸衍生物及其盐的化合物：其中，R 1表示氢原子，CH 3基或CH 2 OH 基团，R 2和R 3各自独立地表示氢原子，具有1至4个碳的烷基，条件是R 2和R 3不能同时为氢原子，或者R 2和R 3与它们所连接的N原子可以形成环总碳数为4〜6的结构，在这种情况下，所述环结构可任选地含有氧原子作为杂原子，R4表示氢原子，具有1至18个碳原子的烷基，其中当R 1和R 4为氢原子时，不能是R2和R3之一是苄氧基羰基，另一个是氢原子。

10. 发明申请

US20140004210A1 DEGRADATION INHIBITOR OF HYALURONIC ACID, COMPRISING ROSEMARY EXTRACT AND RETINOL ACETATE 审中-公开
标题翻译：含有硫酸的降解抑制剂，包括油性提取物和乙醇胺
公开(公告)号：US20140004210A1
公开(公告)日：2014-01-02
申请号：US13822762
申请日：2012-06-28
申请人： Masato Iino , Nobuhiko Ochiai , Makoto Tsunenaga
发明人： Masato Iino , Nobuhiko Ochiai , Makoto Tsunenaga
IPC分类号： A61K8/97 , A61K8/67 , A61Q19/08
CPC分类号： A61K8/97 , A61K8/671 , A61K2800/782 , A61Q19/007 , A61Q19/08
摘要： The present invention relates to providing a hyaluronidase inhibitor having a good hyaluronidase inhibiting activity. Specifically, the present invention provides with a hyaluronidase inhibitor comprising rosemary extract having a hyaluronidase inhibitory activity, and retinol acetate, which can enhances the hyaluronidase inhibitory activity of rosemary extract.
摘要翻译：本发明涉及提供具有良好的透明质酸酶抑制活性的透明质酸酶抑制剂。具体而言，本发明提供了含有透明质酸酶抑制活性的迷迭香提取物和乙酸视黄醇的透明质酸酶抑制剂，其能够增强迷迭香提取物的透明质酸酶抑制活性。

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