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1. 发明授权

US4873261A Pharmaceutical composition for treating ulcerative large intestinal disease 失效
标题翻译：用于治疗溃疡性大肠疾病的药物组合物
公开(公告)号：US4873261A
公开(公告)日：1989-10-10
申请号：US154205
申请日：1988-02-10
申请人： Wasei Miyazaki , Yasuhiko Inoue
发明人： Wasei Miyazaki , Yasuhiko Inoue
IPC分类号： A61K31/34 , A61K31/365 , A61P1/00 , A61P1/04 , C07D307/94 , C07D493/04
CPC分类号： A61K31/34 , A61K31/365 , Y10S514/925
摘要： A method for treating ulcerative large intestinal diseases with a pharmcautical composition containing, as the active ingredient, a sesquiterpene compound or a salt thereof.

2. 发明授权

US4545988A Urokinase-plasmin complex adsorbable by fibrin and process for preparing same 失效
标题翻译：由纤维蛋白吸附的尿激酶 - 纤溶酶复合物及其制备方法
公开(公告)号：US4545988A
公开(公告)日：1985-10-08
申请号：US683024
申请日：1984-12-18
申请人： Yasuo Nakayama , Wasei Miyazaki , Masanao Shinohara
发明人： Yasuo Nakayama , Wasei Miyazaki , Masanao Shinohara
IPC分类号： C12N9/68 , A61K38/00 , A61K38/46 , A61K38/48 , A61K47/48 , A61P7/02 , C12N9/72 , A61K37/54 , C12N9/96
CPC分类号： C12N9/6462 , A61K47/48238 , C12Y304/21073 , A61K38/00
摘要： This invention provides a urokinase complex adsorbable by fibrin characterized in that it comprises heavy chain of high molecular weight urokinase as coupled with heavy chain of plasmin by one or more S-S bonds and a process for preparing the same.
摘要翻译：本发明提供一种由纤维蛋白吸附的尿激酶复合物，其特征在于，其包含与一种或多种S-S键连接的纤溶酶重链的高分子量尿激酶重链及其制备方法。

3. 发明授权

US4217345A 3-0-(.beta.-D-Glucuronopyranosyl)-soyasapogenol B 失效
标题翻译： 3-0-（β-D-葡萄糖醛酸吡喃糖基） - 间叶皂甙B
公开(公告)号：US4217345A
公开(公告)日：1980-08-12
申请号：US25518
申请日：1979-03-30
申请人： Masanao Shinohara , Yoshimasa Nakano , Hirotsugu Kaise , Taketoshi Izawa , Wasei Miyazaki
发明人： Masanao Shinohara , Yoshimasa Nakano , Hirotsugu Kaise , Taketoshi Izawa , Wasei Miyazaki
IPC分类号： C07J63/00 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K36/48 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/00 , C07H15/256 , C12P7/00 , C12P19/56 , C07H15/20 , C07H15/24
CPC分类号： C12R1/645 , C07H15/256 , C12P19/56 , Y10S514/885
摘要： 3-0-(.beta.-D-Glucuronopyranosyl)-soyasapogenol B represented by the formula (I): ##STR1## and salts thereof and process for preparing the same are disclosed. The compound represented by the formula (I) and salts thereof have anticomplementary activity and are useful as therapeutic agents for autoimmune diseases, collagen diseases, and rheumatic diseases.
摘要翻译：公开了由式（I）表示的3-0-（β-D-葡萄糖醛酸吡喃糖基） - 邻磺基苯甲酸：其中，其盐及其制备方法。由式（I）表示的化合物及其盐具有抗补体活性，可用作自身免疫性疾病，胶原性疾病和风湿性疾病的治疗剂。

4. 发明授权

US4536391A Process for preparing urokinase complex 失效
标题翻译：制备尿激酶复合物的方法
公开(公告)号：US4536391A
公开(公告)日：1985-08-20
申请号：US551841
申请日：1983-11-15
申请人： Wasei Miyazaki , Tsuneo Sato , Yasuo Nakayama , Tadao Sato
发明人： Wasei Miyazaki , Tsuneo Sato , Yasuo Nakayama , Tadao Sato
IPC分类号： A61K38/00 , C07D207/44 , C07D207/452 , C07D207/46 , C12N9/72 , C12N11/06 , A61K37/48 , A61K37/00 , C07G7/00
CPC分类号： C07D207/452 , C07D207/46 , C12N11/06 , C12N9/6462 , C12Y304/21073 , A61K38/00
摘要： This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula ##STR1## wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and l, m and n are each 0 or 1 provided that l, m and n are not 0 at the same time.The complex is useful as a thrombolytic agent.
摘要翻译：本发明提供了一种制备纤维蛋白可吸附的蛋白质 - 尿激酶复合物的方法，其特征在于在由下式表示的蛋白质偶联试剂存在下使由纤维蛋白可吸附的蛋白质与尿激酶反应，其中R是亚苯基或亚环烷基，A较低亚烷基，B是可以被低级烷硫基或苯基 - 低级烷硫基取代的低级亚烷基，l，m和n各自为0或1，条件是l，m和n不同时为0。该复合物可用作溶栓剂。

5. 发明授权

US4229466A Sesquiterpene derivatives having anti-complementary activity 失效
标题翻译：倍半萜衍生物具有抗互补活性
公开(公告)号：US4229466A
公开(公告)日：1980-10-21
申请号：US906300
申请日：1978-05-15
申请人： Wasei Miyazaki , Hirotsugu Kaise , Yoshimasa Nakano , Taketoshi Izawa , Yasuo Oshiro , Masanao Shinohara
发明人： Wasei Miyazaki , Hirotsugu Kaise , Yoshimasa Nakano , Taketoshi Izawa , Yasuo Oshiro , Masanao Shinohara
IPC分类号： C07D307/94 , C07D493/10 , C07D493/20 , C12P17/04 , A61K31/335 , A61K31/34 , C07D307/77 , C07D307/92
CPC分类号： C07D307/94 , C07D493/10 , C12P17/04
摘要： A sesquiterpene derivative expressed by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a formyl group, a hydroxymethyl group, a hydroxyl group, a carboxyl group, a lower alkanoyloxymethyl group, or a group of the formula --CH.dbd.CR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8, which may be the same or different, each represents a hydrogen atom, a cyano group, a lower alkoxycarbonyl group or a carboxyl group, or R.sup.2 and R.sup.3 may combine to form a lactone ring of the formula ##STR2## in which R.sup.9 represents a hydrogen atom or a hydroxyl group; R.sup.4 and R.sup.6, which may be the same or different, each represents a hydroxyl group or a lower alkanoyloxy group; R.sup.5 represents a hydrogen atom; R.sup.4 and R.sup.5 may together form an oxo group (.dbd.O); and R.sup.4 and R.sup.6 may combine to form a lower alkylidenedioxy group, the pharmaceutically acceptable salts thereof, processes for the production of the compounds of the general formula (I) and the salts thereof, pharmaceutical composition containing the compounds of the general formula (I) and the salts thereof, and method of use of the compounds of the general formula (I) and the salts thereof.
摘要翻译：由通式（I）表示的倍半萜衍生物：其中R 1表示氢原子，低级烷基或低级烷酰基; R2和R3可以相同或不同，分别表示甲酰基，羟甲基，羟基，羧基，低级烷酰氧基甲基或式-CH = CR7R8的基团，其中R7和R8 可以相同或不同，各自表示氢原子，氰基，低级烷氧基羰基或羧基，或者R 2和R 3可以结合形成式“IMAGE”的内酯环，其中R 9表示氢原子或羟基; R 4和R 6可以相同或不同，分别表示羟基或低级烷酰氧基; R5代表氢原子; R4和R5可以一起形成氧代基（= O）; 并且R4和R6可以结合形成低级亚烷基二氧基，其药学上可接受的盐，通式（I）化合物及其盐的制备方法，含有通式（I）化合物的药物组合物，及其盐，以及通式（I）的化合物及其盐的使用方法。

6. 发明授权

US4831053A Composition for prophylaxis and therapy of hepatitis 失效
标题翻译：预防和治疗肝炎的组合物
公开(公告)号：US4831053A
公开(公告)日：1989-05-16
申请号：US81581
申请日：1987-08-03
申请人： Masanao Shinohara , Hirotsugu Kaise , Yoshimasa Nakano , Taketoshi Izawa , Yasuo Oshiro , Wasei Miyazaki
发明人： Masanao Shinohara , Hirotsugu Kaise , Yoshimasa Nakano , Taketoshi Izawa , Yasuo Oshiro , Wasei Miyazaki
IPC分类号： C07D307/94 , A61K31/34 , A61K31/365 , A61P1/16 , C07D493/10
CPC分类号： A61K31/34 , Y10S514/892
摘要： A prophylactic or therapeutic composition for hepatitis is disclosed comprising a prophylactically or therapeutically effective amount of a sesquiterpene compound represented by the formula (I) or (II) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient, and a pharmaceutically acceptable carrier.
摘要翻译：公开了一种用于肝炎的预防或治疗组合物，其包含预防或治疗有效量的由式（I）或（II）表示的倍半萜烯化合物或其药学上可接受的盐作为活性成分和药学上可接受的载体。

7. 发明授权

US06954700B2 Efficacy of biological state and action affecting biological state, judging apparatus, judging system, judging program and recording medium holding the program 失效
标题翻译：生物状态和影响生物状态的作用，判断装置，判断系统，判断程序和记录媒体的功效
公开(公告)号：US06954700B2
公开(公告)日：2005-10-11
申请号：US10474507
申请日：2002-04-25
申请人： Gesshi Higashida , Toshiyuki Shimizu , Tiejun Miao , Wasei Miyazaki , Hideyuki Asaoka
发明人： Gesshi Higashida , Toshiyuki Shimizu , Tiejun Miao , Wasei Miyazaki , Hideyuki Asaoka
IPC分类号： G06F19/00 , G06F15/18
CPC分类号： G16H50/50 , G06F19/00 , Y10S706/924 , Y10T436/25875
摘要： A method of judging a biological state comprising using: (1) correlation and/or symmetry between Lyapunov exponent and entropy; and/or (2) Higuchi fractal dimension, wherein the Lyapunov exponent, entropy and Higuchi fractal dimension are indices that can express chaotic nature and derived from time series data of biological signals from a subject.
摘要翻译：一种判断生物状态的方法，包括：（1）Lyapunov指数和熵的相关性和/或对称性; 和/或（2）Higuchi分形维数，其中Lyapunov指数，熵和Higuchi分形维数是可以表达混沌性质并且来自受试者的生物信号的时间序列数据的指标。

8. 发明授权

US4371524A Anticomplementary agents comprising soyasapogenol B compounds 失效
标题翻译：包含大豆皂甙元B化合物的抗互补剂
公开(公告)号：US4371524A
公开(公告)日：1983-02-01
申请号：US241294
申请日：1981-03-06
申请人： Masanao Shinohara , Yoshimasa Nakano , Hirotsugu Kaise , Taketoshi Izawa , Wasei Miyazaki
发明人： Masanao Shinohara , Yoshimasa Nakano , Hirotsugu Kaise , Taketoshi Izawa , Wasei Miyazaki
IPC分类号： C07H15/256 , A61K31/70
CPC分类号： C07H15/256
摘要： A pharmaceutical composition having an anticomplementary activity comprising a therapeutically effective amount of at least one soyasapogenol B compound represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group represented by the formula: ##STR2## wherein R.sup.2 represents a hydrogen atom or a hydroxymethyl group, R.sup.3 represents a hydrogen atom or a rhamnopyranosyl group, and R.sup.4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.
摘要翻译：一种具有抗补体活性的药物组合物，其包含治疗有效量的由通式（I）表示的至少一种大豆皂草酚B化合物：其中R 1表示氢原子或由下式表示的基团：其中R2表示氢原子或羟甲基，R3表示氢原子或鼠李糖吡喃糖基，R4表示氢原子或碳原子数1〜6的烷基或其药学上可接受的盐和药学上可接受的载体。

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