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1. 发明申请

US20110165615A1 APPARATUS AND METHODS FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES 有权
标题翻译：装置和组织样品的自动处理和嵌入方法
公开(公告)号：US20110165615A1
公开(公告)日：2011-07-07
申请号：US13047053
申请日：2011-03-14
申请人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
发明人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： G01N1/30 , C12M1/34
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

2. 发明申请

US20090247117A1 CELLULAR TELEPHONE SYSTEM THAT USES POSITION OF A MOBILE UNIT TO MAKE CALL MANAGEMENT DECISIONS 审中-公开
标题翻译：使用移动单元的位置进行呼叫管理决策的蜂窝电话系统
公开(公告)号：US20090247117A1
公开(公告)日：2009-10-01
申请号：US12482759
申请日：2009-06-11
申请人： Everett Dennison , Timothy J. Duffy , Gregory T. Pauley , Scott L. Jones , Albert H. Pharis, JR. , Warren P. Williamson, IV
发明人： Everett Dennison , Timothy J. Duffy , Gregory T. Pauley , Scott L. Jones , Albert H. Pharis, JR. , Warren P. Williamson, IV
IPC分类号： H04M11/04
CPC分类号： H04W4/029 , H04B7/18541 , H04B7/18552 , H04W4/90 , H04W36/32 , H04W64/00 , H04W76/20 , H04W76/50
摘要： A cellular telephone system has call management decisions made based on the exact geographic location of the mobile unit. These call management decisions include billing and taxing decisions, cell site selection, frequency selection and even cellular system selection. The decisions are continuously updated during a call whereby decisions can be made and changed regardless of where a call originated. Cell site location, and even cellular system selection, can be made in a specific manner to best serve the needs of the mobile user, the cellular system as well as the public. It is even possible for a cellular system to locate one or more of its cell sites in the geographic area served by another cellular system. In some cases, cellular systems might even share cell sites.
摘要翻译：蜂窝电话系统具有基于移动单元的确切地理位置进行的呼叫管理决定。这些呼叫管理决策包括计费和税收决定，小区站点选择，频率选择甚至蜂窝系统选择。决定在呼叫期间不断更新，无论呼叫发起于何地，都可以进行决定和更改。蜂窝站点位置，甚至蜂窝系统选择，可以以特定方式进行，以最好地满足移动用户，蜂窝系统以及公众的需求。蜂窝系统甚至可能在由另一蜂窝系统服务的地理区域中定位其一个或多个小区站点。在某些情况下，蜂窝系统甚至可能共享小区站点。

3. 发明授权

US07404792B2 Device to permit offpump beating heart coronary bypass surgery 失效
标题翻译：允许偏心跳动心脏冠状动脉旁路手术的装置
公开(公告)号：US07404792B2
公开(公告)日：2008-07-29
申请号：US10745781
申请日：2003-12-24
申请人： Paul A. Spence , Warren P. Williamson, IV
发明人： Paul A. Spence , Warren P. Williamson, IV
IPC分类号： A61F2/00
CPC分类号： A61B17/0218 , A61B17/00491 , A61B17/02 , A61B17/0206 , A61B17/0293 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/29 , A61B2017/0243 , A61B2017/308
摘要： A system for manipulating and supporting a beating heart during cardiac surgery, including a gross support element for engaging and supporting the heart (the gross support element preferably including a head which is sized and shaped to cradle the myocardium of the left ventricle”), a suspension head configured to exert lifting force on the heart when positioned near the apical region of the heart at a position at least partially overlying the right ventricle, and a releasable attachment element for releasably attaching at least one of the gross support element and the suspension head to the heart. The releasable attachment element can be a mechanical element (such as one or more staples or sutures') or an adhesive such as glue. Alternatively, the system includes a suspension head and a releasable attachment element for releasably attaching it to the heart, but does not include a gross support element.
摘要翻译：一种用于在心脏手术期间操纵和支撑跳动心脏的系统，包括用于接合和支撑心脏的总体支撑元件（总体支撑元件优选地包括头部，其尺寸和形状适于摇动左心室的心肌），悬架头部构造成当至少部分地覆盖右心室的位置处定位在心脏的顶部区域附近时在心脏上施加提升力;以及可释放的附接元件，用于将大体支撑元件和悬架头部中的至少一个可释放地附接到心脏可释放的附接元件可以是机械元件（例如一个或多个缝钉或缝线）或诸如胶的粘合剂。或者，该系统包括悬挂头和可释放的附接元件，用于可释放地将其附接到心脏，但不包括总支撑元件。

4. 再颁专利

USRE40377E1 Means and method of replacing a heart valve in a minimally invasive manner 有权
标题翻译：以微创方式更换心脏瓣膜的方法和方法
公开(公告)号：USRE40377E1
公开(公告)日：2008-06-10
申请号：US10863862
申请日：2004-06-07
申请人： Warren P. Williamson, IV , Paul A. Spence , George T. Christakis , Mark Ortiz
发明人： Warren P. Williamson, IV , Paul A. Spence , George T. Christakis , Mark Ortiz
IPC分类号： A61F2/24
摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners to attach the cuff to the tissue from the inside out. The tool stores a plurality of fasteners and is self-contained whereby a fastener is delivered and placed all from inside a vessel. The fasteners are self-forming whereby they do not need an anvil to be formed. Anchor elements are operated from outside the patient's body to cinch a prosthesis to an anchoring cuff of the valve body. The cuff is releasably mounted on the tool and the tool holds the cuff against tissue and drives the fastener through the cuff and the tissue before folding over the legs of the fastener whereby secure securement between the cuff and the tissue is assured. Fasteners are placed and formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner. Fasteners that are permanently deformed during the process of attaching the cuff are disclosed as are fasteners that are not permanently deformed during the attaching process.
摘要翻译：可以使用微创方法来替换心脏瓣膜，所述方法包括无缝线缝合套，以及紧固件递送工具，其将袖带保持抵靠患者组织，同时递送紧固件以将袖带从内向外附接到组织。该工具存储多个紧固件并且是独立的，由此紧固件全部从容器内部输送和放置。紧固件是自成型的，由此它们不需要形成砧座。锚杆元件从患者身体外部操作，将假体固定到阀体的锚定箍。袖带可释放地安装在工具上，并且工具将袖带保持抵靠组织，并且在折叠紧固件的腿部之前通过袖口和组织驱动紧固件，从而确保袖带和组织之间的牢固固定。紧固件被放置和形成，由此紧固件连续地位于袖带的整个圆周上。公开了一种微创手术方法，并且公开了一种以微创方式修复腹主动脉瘤的方法和工具。在附接袖带的过程中永久变形的紧固件公开为在附接过程中不会永久变形的紧固件。

5. 发明授权

US06884251B2 Apparatus and method for performing an anastomosis 失效
标题翻译：用于进行吻合的装置和方法
公开(公告)号：US06884251B2
公开(公告)日：2005-04-26
申请号：US10384250
申请日：2003-03-06
申请人： Paul A. Spence , Warren P. Williamson, IV , George Christakis , Mark Ortiz , Craig B. Berky , Douglas P. Allen , Matthew J. Huddleston , Delbert Ted Leimbach , Cecil R. Robinson , E. Dale VanHoose , Thomas J. Ward , Marty J. Warnecke
发明人： Paul A. Spence , Warren P. Williamson, IV , George Christakis , Mark Ortiz , Craig B. Berky , Douglas P. Allen , Matthew J. Huddleston , Delbert Ted Leimbach , Cecil R. Robinson , E. Dale VanHoose , Thomas J. Ward , Marty J. Warnecke
IPC分类号： A61B17/11 , A61B17/115 , A61B17/08
CPC分类号： A61B17/11 , A61B17/1152 , A61B2017/1135 , A61B2017/1139
摘要： An anastomosis is performed using a flexible mounting structure mounted on the outside of at least one vessel. Fasteners extend through the vessel and are bent towards the incision to attach the flexible mounting structure to the vessel in a manner that controls the edge of the vessel adjacent to the incision. The mounting structures are oriented on each vessel so fasteners on one mounting structure interdigitate with fasteners on the other mounting structure at the location of contact between the vessels when the two vessels are brought together. This creates two complementary sinusoidal-shaped vessel edges with peaks of one edge being accommodated in the valleys of the other edge. The peak-to-valley orientation forms a sinusoidal-shaped joint which is leak free. The fasteners are spaced so proper pressure is applied to the tissue to promote healing without leaking. Furthermore, the fasteners are sized and shaped to properly engage the tissue and bend in a desired manner. Methods and tools for carrying out the anastomosis according to the invention are also disclosed. Methods for forming the fastener and the tines having the proper characteristics are disclosed. An absorbable ring-shaped stent is also disclosed.
摘要翻译：使用安装在至少一个容器的外部的柔性安装结构进行吻合。紧固件延伸穿过容器并朝向切口弯曲，以将控制与切口相邻的容器边缘的方式将柔性安装结构附接到容器。安装结构被定向在每个容器上，因此当两个容器被接合在一起时，在一个安装结构上的紧固件与另一个安装结构上的紧固件在容器之间的接触位置处相互交错。这产生两个互补的正弦形容器边缘，其中一个边缘的峰值被容纳在另一个边缘的谷部中。峰 - 谷取向形成无泄漏的正弦形接头。紧固件间隔开，以便适当的压力施加到组织以促进愈合而不泄漏。此外，紧固件的尺寸和形状适于适当地接合组织并以期望的方式弯曲。还公开了用于进行根据本发明的吻合的方法和工具。公开了用于形成紧固件和具有适当特性的尖齿的方法。还公开了可吸收的环形支架。

6. 发明授权

US06847822B1 Cellular telephone system that uses position of a mobile unit to make call management decisions 失效
标题翻译：使用移动单元的位置进行呼叫管理决定的蜂窝电话系统
公开(公告)号：US06847822B1
公开(公告)日：2005-01-25
申请号：US09662613
申请日：2000-09-15
申请人： Everett Dennison , Timothy J. Duffy , Gregory T Pauley , Scott L. Jones , Albert H. Pharis, Jr. , Warren P. Williamson, IV
发明人： Everett Dennison , Timothy J. Duffy , Gregory T Pauley , Scott L. Jones , Albert H. Pharis, Jr. , Warren P. Williamson, IV
IPC分类号： H04B7/185 , H04W4/02 , H04W36/32 , H04W76/04 , H04Q7/20
CPC分类号： H04W4/02 , H04B7/18541 , H04B7/18552 , H04W4/90 , H04W36/32 , H04W64/00 , H04W76/20 , H04W76/50
摘要： A cellular telephone system has call management decisions made based on the exact geographic location of the mobile unit. These call management decisions include billing and taxing decisions, cell site selection, frequency selection and even cellular system selection. The decisions are continuously updated during a call whereby decisions can be made and changed regardless of where a call originated. Cell site location, and even cellular system selection, can be made in a specific manner to best serve the needs of the mobile user, the cellular system as well as the public. It is even possible for a cellular system to locate one or more of its cell sites in the geographic area served by another cellular system. In some cases, cellular systems might even share cell sites.
摘要翻译：蜂窝电话系统具有基于移动单元的确切地理位置进行的呼叫管理决定。这些呼叫管理决策包括计费和税收决定，小区站点选择，频率选择甚至蜂窝系统选择。决定在呼叫期间不断更新，无论呼叫发起于何地，都可以进行决定和更改。蜂窝站点位置，甚至蜂窝系统选择，可以以特定的方式进行，以最好地满足移动用户，蜂窝系统以及公众的需要。蜂窝系统甚至可能在由另一蜂窝系统服务的地理区域中定位其一个或多个小区站点。在某些情况下，蜂窝系统甚至可能共享小区站点。

7. 发明授权

US06254617B1 Means and method for performing an anastomosis 失效
标题翻译：用于进行吻合的手段和方法
公开(公告)号：US06254617B1
公开(公告)日：2001-07-03
申请号：US09200796
申请日：1998-11-27
申请人： Paul A. Spence , Warren P. Williamson, IV , George Christakis
发明人： Paul A. Spence , Warren P. Williamson, IV , George Christakis
IPC分类号： A61B1704
CPC分类号： A61B17/1152 , A61B17/11 , A61B2017/1135 , A61B2017/1139 , Y10S623/903
摘要： An anastomosis is performed using a mounting structure mounted on the outside of at least one vessel. The mounting structure includes a flexible mounting structure that is attached to the vessel by a special instrument. A graft vessel is attached to the mounting structure either directly or by means of another mounting structure attached to the graft vessel. Tools for attaching a mounting structure to a vessel are disclosed, and a tool for attaching two mounting structures together is also disclosed. Methods for carrying out the anastomosis according to the invention are also disclosed.
摘要翻译：使用安装在至少一个容器的外部的安装结构进行吻合。安装结构包括通过专用仪器附接到容器的柔性安装结构。移植物容器直接或通过附接到移植血管的另一安装结构附接到安装结构。公开了用于将安装结构附接到容器的工具，并且还公开了用于将两个安装结构连接在一起的工具。还公开了根据本发明的用于进行吻合的方法。

8. 发明授权

US6080173A Tissue punching instrument 有权
标题翻译：组织冲孔仪
公开(公告)号：US6080173A
公开(公告)日：2000-06-27
申请号：US318866
申请日：1999-05-26
申请人： Warren P. Williamson, IV , Craig B. Berky , Paul A. Spence , Mark Ortiz
发明人： Warren P. Williamson, IV , Craig B. Berky , Paul A. Spence , Mark Ortiz
IPC分类号： A61B17/11 , A61B17/32
CPC分类号： A61B17/32053 , A61B2017/1107
摘要： A surgical punch prevents tissue debris associated with punching a hole in a patient's tissue, such as an aorta during an anastomosis procedure, from reentering the patient's bloodstream. The punch includes elements that move the debris away from the cutting site and then capture that debris inside the instrument. The punch also includes means for aligning the punch with the selected site and for atraumatically holding the tissue prior to cutting. Various means for moving the tissue debris and for trapping the tissue debris in the instrument are also disclosed.
摘要翻译：外科手术冲击器防止在吻合过程期间冲击患者组织（例如主动脉）中的孔而与患者血流重新进入相关联的组织碎片。冲头包括将碎屑从切割部位移开的元件，然后捕获仪器内的碎屑。冲头还包括用于将冲头与选定部位对准的装置，并且用于在切割之前无创地保持组织。还公开了用于移动组织碎片和捕获器械中的组织碎片的各种手段。

9. 发明授权

US6076260A Cigar clipper and method 失效
标题翻译：雪茄剪和方法
公开(公告)号：US6076260A
公开(公告)日：2000-06-20
申请号：US982697
申请日：1997-12-02
申请人： Warren P. Williamson, IV
发明人： Warren P. Williamson, IV
IPC分类号： A24F13/26 , A24C5/12
CPC分类号： A24F13/26
摘要： A clipper for cutting an end from a cigar preparatory to smoking the cigar includes a pair of relatively slidable body sections, each of which has an opening at an outer end dimensioned to permit a finger to pass thereinto and a pair of slide rails disposed along the sides. Two opposed cutouts at the inner ends form a body hole, into which extend a pair of opposed blade edges, which each also have opposed cutouts that form a cutting hole. The body sections are slidable between an admitting position for placing the cigar end into the cutting hole and a cutting position wherein the blade cutouts obscure the cutting hole, thereby clipping the end from the cigar. A depression is provided for resting the cigar therein when not being smoked, and finger notches
摘要翻译：用于从雪茄切割末端的裁剪器，其准备吸烟雪茄包括一对相对滑动的主体部分，每个部分在外端具有开口，其尺寸设计成允许手指通过，并且沿着边。在内端的两个相对的切口形成一个主体孔，一个相对的刀片边缘延伸到该孔中，每个边缘也具有形成切割孔的相对的切口。主体部分可在用于将雪茄端放入切割孔的允许位置和切割位置之间滑动，其中刀片切口遮蔽切割孔，从而将雪茄的末端剪切。提供凹陷以在不吸烟时将雪茄放置在其中，并且手指凹口

10. 发明授权

US5817032A Means and method for harvesting and handling tissue samples for biopsy analysis 失效
标题翻译：收集和处理组织样本用于活检分析的方法和方法
公开(公告)号：US5817032A
公开(公告)日：1998-10-06
申请号：US645750
申请日：1996-05-14
申请人： Warren P. Williamson, IV , Stephen P. Whitlach
发明人： Warren P. Williamson, IV , Stephen P. Whitlach
IPC分类号： A61B10/00 , G01N1/31 , G01N1/36 , A61B5/00
CPC分类号： G01N1/36 , A61B10/0096 , G01N2001/315
摘要： A tissue biopsy sample is placed on a tissue trapping and supporting material that can withstand tissue preparation procedures and which can be cut with a microtome. The tissue is immobilized on the material and the material and the tissue are subjected to a process for replacing tissue fluids with wax, and then the tissue and the supporting material are sliced for mounting on slides using a microtome. Harvesting devices and containers using the filter material are disclosed. An automated process is also disclosed. One form of the invention has the tissue trapping and supporting material porous and another form of the invention includes a tissue supporting material that is not easily microtomed.
摘要翻译：将组织活组织检查样品放置在组织捕获和支撑材料上，所述组织捕获和支撑材料可以承受组织制备程序并且可以用切片机切割。将组织固定在材料上，并将材料和组织进行用蜡代替组织液的过程，然后使用切片机将组织和支撑材料切片以安装在载玻片上。公开了使用过滤材料的收获装置和容器。还公开了一种自动化过程。本发明的一种形式具有多孔的组织捕获和支撑材料，本发明的另一种形式包括不容易切片的组织支撑材料。

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