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1. 发明授权

US09737455B2 Apparatus and method for wound treatment employing periodic sub-atmospheric pressure 有权
公开(公告)号：US09737455B2
公开(公告)日：2017-08-22
申请号：US14082951
申请日：2013-11-18
申请人： Wake Forest University Health Sciences
发明人： Louis C Argenta , Michael J Morykwas , Lawrence X Webb
IPC分类号： A61M35/00 , A61M1/00 , A61H7/00 , A61F13/00 , A61F13/02 , A61B5/00 , A61L15/16 , A61K9/70
CPC分类号： A61H7/001 , A61M1/0037 , A61M1/0088
摘要： A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.

2. 发明授权

US10076318B2 Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage 有权
公开(公告)号：US10076318B2
公开(公告)日：2018-09-18
申请号：US14626313
申请日：2015-02-19
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人： Louis C Argenta , David L Carroll , Nicole H Levi , Michael J Morykwas , James Eric Jordan , William D Wagner , Jie Liu
IPC分类号： A61B17/00 , A61M1/00 , A61B90/00 , A61B17/30 , A61F13/00
CPC分类号： A61B17/00234 , A61B90/06 , A61B2017/00243 , A61B2017/306 , A61B2090/064 , A61F13/00068 , A61F2013/0028 , A61M1/0031 , A61M1/0037 , A61M1/0088 , A61M2210/1082 , A61M2210/125
摘要： A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.

3. 发明申请

US20160193106A1 TISSUE REPAIR DEVICES UTILIZING SELF-ASSEMBLED MATERIALS 审中-公开
标题翻译：组织修复设备利用自组装材料
公开(公告)号：US20160193106A1
公开(公告)日：2016-07-07
申请号：US14911906
申请日：2013-08-20
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人： William D Wagner , Nicole Levi , Rui Wang , Louis C Argenta , Michael J Morykwas
IPC分类号： A61H9/00 , A61L31/04 , A61L31/06 , A61L31/14
CPC分类号： A61H9/0057 , A61L27/26 , A61L27/50 , A61L27/56 , A61L31/042 , A61L31/047 , A61L31/06 , A61L31/146 , A61L2300/236 , A61L2300/252 , A61L2300/606 , A61L2400/06 , A61L2420/02 , A61L2420/06 , A61L2430/20 , A61M1/0088 , C08L89/00 , C08L5/08
摘要： Porous self-assembling biomaterials comprising silk-fibroin and hyaluronic acid and methods for preparing such biomaterials are disclosed. Devices employing the porous self-assembling biomaterials are also provided.
摘要翻译：公开了包含丝心蛋白和透明质酸的多孔自组装生物材料和制备这种生物材料的方法。还提供了使用多孔自组装生物材料的装置。

4. 发明授权

US10632235B2 Devices and methods for treating spinal cord tissue 有权
公开(公告)号：US10632235B2
公开(公告)日：2020-04-28
申请号：US15700667
申请日：2017-09-11
申请人： Wake Forest University Health Sciences
发明人： Louis C Argenta , David L Carroll , Nicole H Levi , Jie Liu , Michael J Morykwas , Stephen Tatter , William D Wagner
IPC分类号： A61M1/00 , A61F13/00
CPC分类号： A61M1/0088 , A61F13/00021 , A61M1/0023 , A61M2210/1003
摘要： The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.

5. 发明授权

US09050136B2 External fixation assembly and method of use 有权
标题翻译：外固定装配及使用方法
公开(公告)号：US09050136B2
公开(公告)日：2015-06-09
申请号：US13896750
申请日：2013-05-17
申请人： Wake Forest University Health Sciences
发明人： Lawrence X Webb , Louis C Argenta , Michael J Morykwas
IPC分类号： A61F5/04 , A61B17/60 , A61B17/66 , A61B17/86 , A61B17/00
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
摘要翻译：外部固定组件包括插入患者骨骼中的多个中空销。每个销具有内孔和从孔延伸穿过销壁延伸的多个孔。销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。

6. 发明授权

US08764794B2 Device and method for treating central nervous system pathology 有权
标题翻译：用于治疗中枢神经系统病理学的装置和方法
公开(公告)号：US08764794B2
公开(公告)日：2014-07-01
申请号：US13622009
申请日：2012-09-18
申请人： Wake Forest University Health Sciences
发明人： Louis C Argenta , David L Carroll , Nicole H Levi , Michael J Morykwas , Stephen B Tatter , William D Wagner , Jie Liu
IPC分类号： A61B17/08
CPC分类号： A61M1/0088 , A61H7/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/56 , A61M2207/00 , A61M2210/0693 , B29C47/0076 , B29C64/112 , B29C67/202 , B29K2089/00 , B29K2995/006 , B29L2031/753 , C08L67/04 , C08L5/08
摘要： The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.
摘要翻译：本发明一般涉及一种用于治疗中枢神经系统的组织的装置和方法，更具体地但不排他地涉及用于治疗脑组织的装置和方法。

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