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1. 发明申请

US20070127172A1 ON DEMAND CIRCUIT FUNCTION EXECUTION EMPLOYING OPTICAL SENSING 失效
标题翻译：使用光电传感器的需求电路功能执行
公开(公告)号：US20070127172A1
公开(公告)日：2007-06-07
申请号：US11275058
申请日：2005-12-06
申请人： Wagdi Abadeer , James Adkisson , Jeffrey Brown , Kiran Chatty , Robert Gauthier , Michael Hauser , Jed Rankin , William Tonti
发明人： Wagdi Abadeer , James Adkisson , Jeffrey Brown , Kiran Chatty , Robert Gauthier , Michael Hauser , Jed Rankin , William Tonti
IPC分类号： H02H9/00
CPC分类号： H01L23/5256 , H01L23/525 , H01L27/14609 , H01L2924/0002 , H01L2924/00
摘要： Disclosed is a method of executing an electrical function, such as a fusing operation, by activation through a chip embedded photodiode through spectrally selected external light activation, and corresponding structure and circuit. The present invention is based on having incident light with specific intensity/wave length characteristics, in conjunction with additional circuit elements to an integrated circuit, perform the implementation of repairs, i.e., replacing failing circuit elements with redundant ones for yield and/or reliability. Also to perform disconnection of ESD protection device from input pad once the packaged chip is placed in system. No additional pins on the package are necessary.
摘要翻译：公开了通过光谱选择的外部光激活通过芯片嵌入式光电二极管的激活以及相应的结构和电路来执行诸如定影操作之类的电功能的方法。本发明基于将具有特定强度/波长特性的入射光结合到集成电路的附加电路元件，执行维修的实现，即用冗余电路替换故障电路元件以获得和/或可靠性。一旦封装的芯片放置在系统中，也可以将ESD保护装置从输入焊盘断开。不需要额外的引脚。

2. 发明申请

US20100145223A1 Peripheral Reticular Pigmentary Change and Age-Related Macular Degeneration 审中-公开
标题翻译：周围网状色素变化和年龄相关性黄斑变性
公开(公告)号：US20100145223A1
公开(公告)日：2010-06-10
申请号：US12617256
申请日：2009-11-12
申请人： Eric A. Postel , R. Keith Shuler , Jennifer Vaughn Caldwell , Michael Hauser , Silke Schmidt
发明人： Eric A. Postel , R. Keith Shuler , Jennifer Vaughn Caldwell , Michael Hauser , Silke Schmidt
IPC分类号： A61B3/14 , A61F9/00 , A61B3/10
CPC分类号： A61K31/00
摘要： Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotypes of 160 non-carriers. Of 34 phenotypic features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P-value 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. The association of CFH Y402H polymorphism with PRPC suggests that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula; peripheral retinal changes should also be included in grading methods. PRPC may be used as a surrogate of a high-risk genotype and may be used for diagnostic, therapeutic, and research purposes.
摘要翻译：检查956例年龄相关性黄斑变性病例显示，补体因子H变体（Y402H，C等位基因rs1061170）增加了外周网状色素变化的发展风险。将CF9Y402H变体的796个载体的AMD表型与160个非载体的AMD表型进行比较。在分析的34个表型特征中，只有周围网状色素变化（PRPC）与该CFH变体相关（P值0.0006）。 AMD病例与PRPC的比例与剂量反应方式与CFH风险C等位基因数量相关。 CFH Y402H多态性与PRPC的关联表明AMD的变化并不局限于黄斑。目前AMD分级方法仅评估黄斑; 周边视网膜变化也应包括在分级方法中。 PRPC可以用作高风险基因型的替代物，并且可以用于诊断，治疗和研究目的。

3. 发明申请

US20060068428A1 Identification of genetic markers associated with parkinson disease 审中-公开
标题翻译：鉴定与帕金森病有关的遗传标记
公开(公告)号：US20060068428A1
公开(公告)日：2006-03-30
申请号：US11216660
申请日：2005-08-31
申请人： Jeffery Vance , Yi-Ju Li , Margaret Pericak-Vance , Eden Martin , William Scott , Michael Hauser , Jeffrey Stajich , Sofia Oliveira , Joelle van der Walt
发明人： Jeffery Vance , Yi-Ju Li , Margaret Pericak-Vance , Eden Martin , William Scott , Michael Hauser , Jeffrey Stajich , Sofia Oliveira , Joelle van der Walt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.
摘要翻译：本发明提供用于筛选帕金森病受试者的方法和组合物，用于增加帕金森病发展的风险和/或发展中的帕金森病的早期或更晚年龄，包括检测与帕金森病相关的遗传标记物的存在。

4. 发明申请

US20110217334A1 HYPOALLERGENIC MOLECULES 有权
标题翻译： HYPOALLERGENIC分子
公开(公告)号：US20110217334A1
公开(公告)日：2011-09-08
申请号：US12674195
申请日：2008-06-30
申请人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号： A61K39/35 , C07K14/415 , C12N15/63 , C07H21/00 , A61P37/08
CPC分类号： C07K14/415
摘要： The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v Ia.
摘要翻译：本发明涉及由Bet v 1a或与Bet v Ia具有至少40％同一性的变应原组成的低变应原性分子，其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其与Bet v Ia具有至少40％同一性的变应原的相应区域。

5. 发明申请

US20110183340A1 Phenotype-Genotype Relationship in Age-Related Macular Degeneration 审中-公开
标题翻译：年龄相关性黄斑变性中的表型 - 基因型关系
公开(公告)号：US20110183340A1
公开(公告)日：2011-07-28
申请号：US13036780
申请日：2011-02-28
申请人： R. Keith Shuler, JR. , Eric A. Postel , Jennifer Caldwell , Silke Schmidt , Michael Hauser
发明人： R. Keith Shuler, JR. , Eric A. Postel , Jennifer Caldwell , Silke Schmidt , Michael Hauser
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N2800/164
摘要： Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs 10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.
摘要翻译：具有LOC387715（rs 10490924）变体的年龄相关性黄斑变性（AMD）病例具有较高的新生血管性AMD风险。对于两种变体，AMD均为纯合子的个体可能具有较早发生新生血管性AMD的风险。确定这种变体的存在表明疾病可能采取哪条路径以及哪种营养，补充或药物是适当的。

6. 发明申请

US20090263801A1 Phenotype-Genotype Relationship in Age-Related Macular Degeneration 审中-公开
标题翻译：年龄相关性黄斑变性中的表型 - 基因型关系
公开(公告)号：US20090263801A1
公开(公告)日：2009-10-22
申请号：US12348167
申请日：2009-01-02
申请人： R. Keith Shuler, JR. , Eric A. Postel , Jennifer Caldwell , Silke Schmidt , Michael Hauser
发明人： R. Keith Shuler, JR. , Eric A. Postel , Jennifer Caldwell , Silke Schmidt , Michael Hauser
IPC分类号： C12Q1/68 , G01N33/535 , C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N2800/164
摘要： Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.
摘要翻译：具有LOC387715（rs10490924）变体的年龄相关性黄斑变性（AMD）病例具有较高的新生血管性AMD的风险。对于两种变体，AMD均为纯合子的个体可能具有较早发生新生血管性AMD的风险。确定这种变体的存在表明疾病可能采取哪条路径以及哪种营养，补充或药物是适当的。

7. 发明申请

US20070295558A1 DEVICE FOR LUBRICATING CONTRA-SLIDING PARTS 审中-公开
标题翻译：用于润滑防滑部件的装置
公开(公告)号：US20070295558A1
公开(公告)日：2007-12-27
申请号：US11743731
申请日：2007-05-03
申请人： Ralf Lottgen , Michael Hauser , Jens Thing
发明人： Ralf Lottgen , Michael Hauser , Jens Thing
IPC分类号： F16C1/24 , F16N3/00
CPC分类号： B23Q11/124
摘要： A device for lubricating contra-sliding parts of a tool device having a drive for effecting the sliding operation, wherein the device has a lubricant dispensing device for the moving parts, which lubricant dispensing device can be actuated by means of the same drive. A method for lubricating contra-sliding parts of a tool device having a drive for effecting the sliding operation, wherein a lubricating pulse is triggered by the following method steps: measuring of the path covered in the operating phase of the sliding parts, recording of the individual path lengths by means of a counter, comparison of the total actual path length with a total path length after which a lubricating pulse is intended to be triggered, and triggering of a lubricating pulse by the same drive for the sliding parts after the cumulative total path length has been reached.
摘要翻译：一种用于润滑具有用于进行滑动操作的驱动器的工具装置的反滑部件的装置，其中所述装置具有用于所述运动部件的润滑剂分配装置，所述润滑剂分配装置可以通过相同的驱动器来致动。一种用于润滑具有用于进行滑动操作的驱动装置的工具装置的反滑动部件的方法，其中通过以下方法步骤触发润滑脉冲：测量滑动部件的操作阶段所覆盖的路径，记录通过计数器的单个路径长度，总实际路径长度与旨在触发润滑脉冲的总路径长度的比较，以及在累积总数之后通过相同的驱动器触发滑动部件的润滑脉冲路径长度已达到。

8. 发明授权

US09091649B2 Integrated droplet actuator for gel; electrophoresis and molecular analysis 有权
标题翻译：凝胶液滴致动器电泳和分子分析
公开(公告)号：US09091649B2
公开(公告)日：2015-07-28
申请号：US13508300
申请日：2010-11-08
申请人： Michael G. Pollack , Vijay Srinivasan , Zhishan Hua , Hon Lung Chu , Michael Hauser , Allen Eckhardt
发明人： Michael G. Pollack , Vijay Srinivasan , Zhishan Hua , Hon Lung Chu , Michael Hauser , Allen Eckhardt
IPC分类号： G01N27/447 , B01L7/00 , B01L3/00
CPC分类号： G01N27/44743 , B01L3/502715 , B01L3/502792 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2300/088 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/043 , B01L2400/0457 , B01L2400/046 , G01N27/44791
摘要： The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. The integrated liquid handling operations may be used to prepare and deliver samples to the electrophoresis gel, capture and subsequently process products of the electrophoresis gel or perform additional assays on the same sample materials which are analyzed by gel electrophoresis. In one embodiment, one or more molecular assays, such as nucleic acid (e.g., DNA) quantification by real-time PCR, and one or more sample processing operations such as sample dilution is performed on a droplet actuator integrated with an electrophoresis gel. In one embodiment, an electrophoresis gel may be integrated on the top substrate of the droplet actuator.
摘要翻译：本发明涉及液滴致动器装置以及用于将凝胶电泳分析与分析前样品或分析后处理以及其它分子分析方法相集成的方法。使用数字微流体技术，液滴致动器装置和本发明的方法提供了在单个集成装置上执行凝胶电泳和液体处理操作的能力。集成的液体处理操作可以用于制备并将样品递送到电泳凝胶，捕获并随后处理电泳凝胶的产物，或在通过凝胶电泳分析的相同样品材料上进行附加测定。在一个实施方案中，在与电泳凝胶结合的液滴致动器上进行一个或多个分子测定，例如通过实时PCR的核酸（例如DNA）定量和一个或多个样品处理操作，例如样品稀释。在一个实施方案中，电泳凝胶可以集成在液滴致动器的顶部基底上。

9. 发明授权

US09040054B2 Hypoallergenic molecules 有权
标题翻译：低过敏分子
公开(公告)号：US09040054B2
公开(公告)日：2015-05-26
申请号：US12674195
申请日：2008-06-30
申请人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号： A61K36/00 , A61K39/00 , A61K39/35 , A61K39/36 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K14/415
CPC分类号： C07K14/415
摘要： The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.
摘要翻译：本发明涉及由Bet v 1a或与Bet v Ia具有至少40％同一性的变应原组成的低变应原性分子，其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其与Bet v 1a具有至少40％同一性的变应原的相应区域。

10. 发明申请

US20140242668A1 POLYSACCHARIDE LYASES 审中-公开
标题翻译：多糖盐
公开(公告)号：US20140242668A1
公开(公告)日：2014-08-28
申请号：US14131593
申请日：2012-07-09
申请人： Michael Wallner , Michael Hauser , Gabriele Gadermaier , Martin Himly , Fatima Ferreira
发明人： Michael Wallner , Michael Hauser , Gabriele Gadermaier , Martin Himly , Fatima Ferreira
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C12Y402/02
摘要： The present invention relates to a variant of a mature polysaccharide lyase having a beta helix structure, wherein said variant comprises an N- and/or C-terminal truncation and consists essentially of at least 90% of the beta helix structure of the mature polysaccharide lyase.
摘要翻译：本发明涉及具有β螺旋结构的成熟多糖裂解酶的变体，其中所述变体包含N-和/或C-末端截短并且基本上由至少90％的成熟多糖裂解酶的β螺旋结构组成。

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