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    • 10. 发明授权
    • Particulate encapsulation of liquid beads
    • 液体珠的颗粒包封
    • US06413548B1
    • 2002-07-02
    • US09568272
    • 2000-05-10
    • Monica A. HamerJames J. MartiWilliam A. Hendrickson
    • Monica A. HamerJames J. MartiWilliam A. Hendrickson
    • A61K914
    • A61K8/11A61K8/25A61K8/676A61K9/501A61K9/5031A61K9/5089A61K2800/412A61Q19/00B01J13/02Y10T428/2984Y10T428/2985Y10T428/2991Y10T428/2998
    • Various materials, including generally non-compatible materials may be provided from a single delivery system by a unique encapsulation system. An encapsulation system is advantageously constructed as a core of aqueous liquid having at least 5% by weight water therein, and an encapsulant surrounding the core to form a stable encapsulated particle, the encapsulant comprising at least one layer of hydrophobic particles in contact with and surrounding the core, the core and hydrophobic particles providing an encapsulated system that has an average weight average particle diameter of from 0.05 to 25 micrometers and can support its own weight. The encapsulation system may be provided by a novel method of manufacture comprising providing a mass of hydrophobic particles having average mass diameter size of between 0.05 and 25 micrometers, providing droplets of an aqueous medium to the mass of particles, gently mixing the fine particles of aqueous medium and the hydrophobic particles to form a stable encapsulant system of droplets of the aqueous medium encapsulated by a shell of particles.
    • 可以通过独特的封装系统从单个递送系统提供各种材料,包括通常不兼容的材料。 封装系统有利地被构造为具有至少5重量%水中的水的含水液体的核心,以及包围核心以形成稳定的包封颗粒的密封剂,所述密封剂包含至少一层与所述疏水性颗粒接触并包围 芯,芯和疏水性颗粒提供具有0.05至25微米的平均重量平均粒径并且可以支撑其自身重量的封装体系。 包封系统可以通过一种新的制造方法提供,包括提供大量平均质量直径尺寸为0.05至25微米的疏水性颗粒,向颗粒物质提供水性介质的液滴,轻轻地将水性微粒 介质和疏水颗粒以形成由颗粒壳包封的水性介质的液滴的稳定的密封剂系统。