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1. 发明授权

US08216810B2 Multiplex systems, methods, and kits for detecting and identifying nucleic acids 有权
标题翻译：用于检测和鉴定核酸的多重系统，方法和试剂盒
公开(公告)号：US08216810B2
公开(公告)日：2012-07-10
申请号：US10833791
申请日：2004-04-27
申请人： W. Ian Lipkin , Thomas Briese , Gustavo Palacios , Omar Jabado
发明人： W. Ian Lipkin , Thomas Briese , Gustavo Palacios , Omar Jabado
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6837 , C12Q2565/549 , C12Q2565/125 , C12Q2531/113 , C12Q2563/149
摘要： The present invention provides systems and methods for determining the presence or absence of one or more target nucleic acid sequences in a sample. Also provided are kits comprising these systems, and uses of these systems in such applications as determining the presence or absence of at least one target nucleic acid sequence in a sample, detecting microorganism transcripts and host transcripts, differentiating microorganism transcripts from host transcripts, screening blood products, assaying a food product for contamination, assaying a sample for environmental contamination, detecting genetically-modified organisms, biodefense, forensics, and genetic-comparability studies. The present invention further provides a complex that includes a target nucleic acid sequence, a capture nucleic acid, and a reporter nucleic acid.
摘要翻译：本发明提供用于确定样品中一种或多种靶核酸序列的存在或不存在的系统和方法。还提供了包括这些系统的试剂盒，以及这些系统在确定样品中是否存在至少一种靶核酸序列的应用中的用途，检测微生物转录物和宿主转录物，将微生物转录本与宿主转录物区分开来，筛选血液产品，测定食品污染，测定样品的环境污染，检测转基因生物，生物防治，取证和遗传比较研究。本发明还提供了包含靶核酸序列，捕获核酸和报道核酸的复合物。

2. 发明授权

US07582740B2 Methods and kits for detecting SARS-associated coronavirus 失效
标题翻译：检测SARS相关冠状病毒的方法和试剂盒
公开(公告)号：US07582740B2
公开(公告)日：2009-09-01
申请号：US10764075
申请日：2004-01-23
申请人： Thomas Briese , W. Ian Lipkin , Gustavo Palacios , Omar Jabado
发明人： Thomas Briese , W. Ian Lipkin , Gustavo Palacios , Omar Jabado
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/70 , C12Q1/68
CPC分类号： C07H21/04 , C12Q1/686 , C12Q1/701 , Y02A50/451
摘要： The present invention provides a synthetic nucleic acid sequence comprising 10-30 nucleotides of the N gene region and/or the 3′ non-coding region of the SARS-associated coronavirus genome, and a synthetic nucleic acid sequence comprising 10-30 nucleotides of a nucleic acid sequence that is complementary to at least one of those regions. Also provided are compositions comprising the sequences, and uses of the sequences in diagnostic kits. The present invention further provides a primer set for determining the presence or absence of SARS-associated coronavirus in a biological sample, wherein the primer set comprises at least one of the synthetic nucleic acid sequences. Also provided are a composition comprising the primer set, and use of the primer set in a diagnostic kit. Finally, the present invention provides kits and methods for determining the presence or absence of SARS-associated coronavirus in a biological sample.
摘要翻译：本发明提供了包含N基因区域的10-30个核苷酸和/或SARS相关冠状病毒基因组的3'非编码区的合成核酸序列，以及包含10个核苷酸的合成核酸序列，与这些区域中的至少一个互补的核酸序列。还提供了包含序列的组合物，以及诊断试剂盒中序列的用途。本发明还提供了用于确定生物样品中SARS相关冠状病毒存在或不存在的引物组，其中该引物组包含至少一个合成核酸序列。还提供了包含引物组的组合物和在诊断试剂盒中使用引物组。最后，本发明提供用于确定生物样品中SARS相关冠状病毒存在或不存在的试剂盒和方法。

3. 发明申请

US20090275636A1 PICORNAVIRUS AND USES THEREOF 审中-公开
标题翻译： PICORNAVIRUS及其用途
公开(公告)号：US20090275636A1
公开(公告)日：2009-11-05
申请号：US12364301
申请日：2009-02-02
申请人： Thomas Briese , Gustavo Palacios , W. Ian Lipkin , Daryl Lamson
发明人： Thomas Briese , Gustavo Palacios , W. Ian Lipkin , Daryl Lamson
IPC分类号： A61K31/7105 , C12N15/11 , C07K14/00 , C07K16/00 , C12Q1/70
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C12N2770/32721 , C12N2770/32722 , G01N2333/085
摘要： The invention is directed to a a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The invention also relates to antibodies against antigens derived from the picornavirus. The invention also relates to iRNAs which target nucleic acid sequences of the picornavirus. The invention is related to methods for detecting the presence or absence of picornavirus in a subject. The invention is also related to immunogenic compositions for inducing an immune response against picornavirus in a subject.
摘要翻译：本发明涉及与呼吸道感染相关的新分离和鉴定的小核糖核酸病毒的进化枝，以及分离的核酸序列及其肽。本发明还涉及针对来源于小核糖核酸病毒的抗原的抗体。本发明还涉及靶向小核糖核酸病毒核酸序列的iRNA。本发明涉及用于检测受试者中存在或不存在小核糖核酸病毒的方法。本发明还涉及用于在受试者中诱导针对小RNA病毒的免疫应答的免疫原性组合物。

4. 发明申请

US20130072542A1 PISCINE REOVIRUS DIAGNOSTIC COMPOSITIONS 有权
标题翻译： PISCINE REOVIRUS诊断组合物
公开(公告)号：US20130072542A1
公开(公告)日：2013-03-21
申请号：US13499867
申请日：2010-10-04
申请人： W. Ian Lipkin , Gustavo Palacios , Ruth Toril Kongtorp , Edgar Brun
发明人： W. Ian Lipkin , Gustavo Palacios , Ruth Toril Kongtorp , Edgar Brun
IPC分类号： G01N33/53 , A61K31/7088
CPC分类号： A61K39/15 , A61K31/7088 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2720/12022 , C12N2720/12034 , C12N2720/12222 , C12N2720/12234 , G01N33/5308 , Y02A50/403
摘要： The invention is directed to a isolated a Piscine reovirus associated with HSMI in teleosts, and isolated nucleic acids sequences and peptides thereof. The invention also relates to diagnostic antibodies against antigens derived from Piscine re-oviruses. In another aspect, the invention relates to iRNAs which target nucleic acid sequences of Piscine reoviruses. In another aspect, the invention is related to methods for detecting the presence or absence of Piscine reoviruses in an animal.
摘要翻译：本发明涉及在硬骨鱼中与HSMI相关的分离的鱼类呼肠孤病毒，以及分离的核酸序列及其肽。本发明还涉及针对来自鱼类再次病毒的抗原的诊断抗体。另一方面，本发明涉及靶向鱼类呼肠病毒的核酸序列的iRNA。另一方面，本发明涉及用于检测动物中鱼类呼吸道病毒存在或不存在的方法。

5. 发明申请

US20130058968A1 PISCINE REOVIRUS IMMUNOGENIC COMPOSITIONS 有权
标题翻译： PISCINE REOVIRUS免疫组化
公开(公告)号：US20130058968A1
公开(公告)日：2013-03-07
申请号：US13499874
申请日：2010-10-04
申请人： W. Ian Lipkin , Gustavo Palacios , Ruth Toril Kongtorp , Edgar Brun
发明人： W. Ian Lipkin , Gustavo Palacios , Ruth Toril Kongtorp , Edgar Brun
IPC分类号： C07K14/14 , C12N7/04 , A61K39/15 , A61P31/14 , C07H21/00 , C07K16/10
CPC分类号： A61K39/15 , A61K31/7088 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2720/12022 , C12N2720/12034 , C12N2720/12222 , C12N2720/12234 , G01N33/5308 , Y02A50/403
摘要： The invention is directed to immunogenic compositions and methods for inducing an immune response against Piscine reoviruses in an animal. In another aspect, the invention relates to antibodies that bind Piscine reovirus poplypeptides. In yet another aspect, the invention relates to methods for preventing, or reducing PRV infection in an animal.
摘要翻译：本发明涉及免疫原性组合物和用于诱导针对动物中的鱼类呼肠孤病毒的免疫应答的方法。另一方面，本发明涉及结合Piscine呼肠孤病毒多肽的抗体。在另一方面，本发明涉及用于预防或降低动物中PRV感染的方法。

6. 发明授权

US09395356B2 Piscine reovirus immunogenic compositions 有权
标题翻译：鱼类呼肠病毒免疫原性组合物
公开(公告)号：US09395356B2
公开(公告)日：2016-07-19
申请号：US13499874
申请日：2010-10-04
申请人： W. Ian Lipkin , Gustavo Palacios , Ruth T. Kongtorp , Edgar Brun
发明人： W. Ian Lipkin , Gustavo Palacios , Ruth T. Kongtorp , Edgar Brun
IPC分类号： A61K31/713 , A61K39/15 , G01N33/53 , C07K14/005 , C07K16/10 , A61K31/7088 , A61K39/12
CPC分类号： A61K39/15 , A61K31/7088 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2720/12022 , C12N2720/12034 , C12N2720/12222 , C12N2720/12234 , G01N33/5308 , Y02A50/403
摘要： The invention is directed to immunogenic compositions and methods for inducing an immune response against Piscine reoviruses in an animal. In another aspect, the invention relates to antibodies that bind Piscine reovirus poplypeptides. In yet another aspect, the invention relates to methods for preventing, or reducing PRV infection in an animal.
摘要翻译：本发明涉及免疫原性组合物和用于诱导针对动物中的鱼类呼肠孤病毒的免疫应答的方法。另一方面，本发明涉及结合Piscine呼肠孤病毒多肽的抗体。在另一方面，本发明涉及用于预防或降低动物中PRV感染的方法。

7. 发明授权

US09366667B2 Piscine reovirus diagnostic compositions 有权
标题翻译：鱼类呼肠病毒诊断组合物
公开(公告)号：US09366667B2
公开(公告)日：2016-06-14
申请号：US13499867
申请日：2010-10-04
申请人： W. Ian Lipkin , Gustavo Palacios , Ruth Toril Kongtorp , Edgar Brun
发明人： W. Ian Lipkin , Gustavo Palacios , Ruth Toril Kongtorp , Edgar Brun
IPC分类号： G01N33/53 , A61K31/7088 , A61K39/15 , C07K14/005 , C07K16/10 , A61K39/12
CPC分类号： A61K39/15 , A61K31/7088 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2720/12022 , C12N2720/12034 , C12N2720/12222 , C12N2720/12234 , G01N33/5308 , Y02A50/403
摘要： The invention is directed to a isolated a Piscine reovirus associated with HSMI in teleosts, and isolated nucleic acids sequences and peptides thereof. The invention also relates to diagnostic antibodies against antigens derived from Piscine reoviruses. In another aspect, the invention relates to iRNAs which target nucleic acid sequences of Piscine reoviruses. In another aspect, the invention is related to methods for detecting the presence or absence of Piscine reoviruses in an animal.
摘要翻译：本发明涉及在硬骨鱼中与HSMI相关的分离的鱼类呼肠孤病毒，以及分离的核酸序列及其肽。本发明还涉及针对源自Piscine呼肠孤病毒的抗原的诊断抗体。另一方面，本发明涉及靶向鱼类呼肠病毒的核酸序列的iRNA。另一方面，本发明涉及用于检测动物中鱼类呼吸道病毒存在或不存在的方法。

8. 发明申请

US20130071421A1 TURKEY VIRAL HEPATITIS VIRUS AND USES THEREOF 审中-公开
标题翻译：土耳其病毒性肝炎病毒及其用途
公开(公告)号：US20130071421A1
公开(公告)日：2013-03-21
申请号：US13499871
申请日：2010-10-04
申请人： W. Ian Lipkin , Thomas Briese , Kirsi Honkavuori , H.L. Shivaprasad
发明人： W. Ian Lipkin , Thomas Briese , Kirsi Honkavuori , H.L. Shivaprasad
IPC分类号： A61K39/29 , G01N33/576 , A61K31/7088 , C12Q1/70
CPC分类号： A61K39/29 , A61K31/7088 , C12Q1/706 , C12Q1/707 , G01N33/5767
摘要： Isolated a Turkey Viral Hepatitis picomavirus-like viruses associated with Turkey viral hepatitis, and isolated nucleic acid sequences and polypeptides are disclosed. Antibodies against antigens from Turkey Viral Hepatitis picornavirus-like viruses, iRNAs which target nucleic acid sequences of the Turkey Viral Hepatitis picornavirus-like virus, methods for detecting the presence or absence of Turkey Viral Hepatitis picomavirus-like viruses in an animal, and immunogenic compositions for inducing an immune response against Turkey Viral Hepatitis picomavirus-like viruses in an animal are also disclosed.
摘要翻译：分离出一种土耳其与土耳其病毒性肝炎相关的病毒性肝炎皮损病毒样病毒，以及分离的核酸序列和多肽。针对来自土耳其的抗原的抗体病毒性肝炎微小RNA病毒样病毒，靶向土耳其病毒性小RNA病毒样病毒的核酸序列的iRNA，用于检测动物中存在或不存在土耳其病毒性肝炎皮损病毒样病毒的方法和免疫原性组合物用于诱导针对土耳其的免疫应答也公开了动物中的病毒性乙型皮炎病毒样病毒。

9. 发明授权

US06113905A Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases 失效
标题翻译：博尔纳病病毒序列，神经系统疾病的诊断和治疗
公开(公告)号：US06113905A
公开(公告)日：2000-09-05
申请号：US434831
申请日：1995-05-02
申请人： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Anette Schneemann
发明人： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Anette Schneemann
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P25/00 , A61P31/12 , C07K14/08 , A61K39/12 , C07K4/02 , C12Q1/70
CPC分类号： C07K14/005 , A01K2217/05 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2760/00022 , C12N2760/00043 , Y10S435/81
摘要： The present invention presents: genomic nucleotide sequence of Borna disease virus, nucleotide and amino acid sequences of Borna disease virus proteins, recombinant viral proteins, vectors and cells containing the sequences or encoding the proteins, ligand binding to these proteins such as antibodies, and the diagnostic and therapeutic uses of the foregoing.
摘要翻译：本发明提出：博尔那病病毒的基因组核苷酸序列，博尔纳病毒蛋白质的核苷酸和氨基酸序列，重组病毒蛋白质，含有序列或编码蛋白质的载体和细胞，与这些蛋白质如抗体结合的配体，以及诊断和治疗用途。

10. 发明授权

US6077510A Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases 失效
公开(公告)号：US6077510A
公开(公告)日：2000-06-20
申请号：US582776
申请日：1996-01-04
申请人： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Annette Schneemann
发明人： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Annette Schneemann
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61P25/00 , A61P31/12 , C07K14/08 , C07K16/10 , C12M1/00 , C12N7/00 , C12N15/09 , C12N15/40 , C12Q1/68 , G01N33/569 , C07K7/00 , C12Q1/70
CPC分类号： C07K14/005 , A01K2217/05 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2760/00022 , C12N2760/00043 , Y10S435/975
摘要： The present invention presents: genomic nucleotide sequence of Borna disease virus, nucleotide and amino acid sequences of Borna disease virus proteins, recombinant viral proteins, vectors and cells containing the sequences or encoding the proteins, ligand binding to these proteins such as antibodies, and the diagnostic and therapeutic uses of the foregoing.

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