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1. 发明授权

US07850663B2 Medicament microdevice delivery system, cartridge and method of use 有权
标题翻译：药物微装置输送系统，药筒和使用方法
公开(公告)号：US07850663B2
公开(公告)日：2010-12-14
申请号：US10858447
申请日：2004-06-01
申请人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
发明人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2205/075 , B05B11/061 , B05B11/062
摘要： A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
摘要翻译：用于皮内递送重构粉末状药物的方法和装置。该装置包括与微型装置例如流体连通的腔室。微型抛光机或一个或多个微针。含有粉末状药物的药筒可以位于所述腔室内。至少一个可爆破膜在壳体内保持粉末状药物。该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重构粉末状药物并递送重组的药物通过微型装置到皮肤的皮肤区域。

2. 发明授权

US08251958B2 Medicament microdevice delivery system, cartridge and method of use 有权
标题翻译：药物微装置输送系统，药筒和使用方法
公开(公告)号：US08251958B2
公开(公告)日：2012-08-28
申请号：US12965278
申请日：2010-12-10
申请人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
发明人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
IPC分类号： A61M5/00 , A61M37/00 , A61M31/00
CPC分类号： A61M37/0015 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2205/075 , B05B11/061 , B05B11/062
摘要： A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
摘要翻译：用于皮内递送重组药物的方法和装置。该装置包括与微型装置例如流体连通的腔室。微型抛光机或一个或多个微针。容纳药物的药筒可以位于所述腔室内。至少一个可爆破膜在壳体内保持药物。该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重建药物并将重组的药物通过皮肤的皮肤区域的微型装置。

3. 发明申请

US20110251546A1 MEDICAMENT MICRODEVICE DELIVERY SYSTEM, CARTRIDGE AND METHOD OF USE 有权
标题翻译：药物MICRODEVICE传递系统，盒子和使用方法
公开(公告)号：US20110251546A1
公开(公告)日：2011-10-13
申请号：US12965278
申请日：2010-12-10
申请人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
发明人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
IPC分类号： A61M5/31 , A61M37/00
CPC分类号： A61M37/0015 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2205/075 , B05B11/061 , B05B11/062
摘要： A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
摘要翻译：用于皮内递送重组药物的方法和装置。该装置包括与微型装置例如流体连通的腔室。微型抛光机或一个或多个微针。容纳药物的药筒可以位于所述腔室内。至少一个可爆破的膜在壳体内保持药物。该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重建药物并将重组的药物通过皮肤的皮肤区域的微型装置。

4. 发明授权

US06644309B2 Medicament respiratory delivery device and method 有权
公开(公告)号：US06644309B2
公开(公告)日：2003-11-11
申请号：US09950369
申请日：2001-09-10
申请人： Robert A. Casper , John M. Snow , David L. Gardner , Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Christopher J. Knors
发明人： Robert A. Casper , John M. Snow , David L. Gardner , Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Christopher J. Knors
IPC分类号： A61M1500
CPC分类号： B05B11/061 , A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0081 , A61M15/08 , A61M2202/04 , A61M2202/064 , A61M2205/073 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.

5. 发明授权

US07051734B2 Medicament respiratory delivery device and method 有权
公开(公告)号：US07051734B2
公开(公告)日：2006-05-30
申请号：US10685187
申请日：2003-10-14
申请人： Robert A. Casper , John M. Snow , David L. Gardner , Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Christopher J. Knors
发明人： Robert A. Casper , John M. Snow , David L. Gardner , Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Christopher J. Knors
IPC分类号： A61M15/00 , A61M16/00 , A61M15/08
CPC分类号： B05B11/061 , A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0081 , A61M15/08 , A61M2202/04 , A61M2202/064 , A61M2205/073 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.

6. 发明授权

US07896836B2 Valved delivery device and method 有权
标题翻译：输送装置及方法
公开(公告)号：US07896836B2
公开(公告)日：2011-03-01
申请号：US11279471
申请日：2006-04-12
申请人： Vincent J. Sullivan , Anjana Bhuta Wills
发明人： Vincent J. Sullivan , Anjana Bhuta Wills
IPC分类号： A61M37/00 , A61M5/315
CPC分类号： A61M5/2448 , A61M5/19 , A61M5/2459 , A61M5/3137 , A61M5/31501 , A61M5/31515 , A61M5/344 , A61M5/347 , A61M5/484 , A61M2005/3128 , A61M2005/3139 , A61M2005/31516
摘要： A valved medicament delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament delivery device of this invention may be utilized to deliver a controlled unit dose of a medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.
摘要翻译：一种带阀的药物输送装置，包括具有包括同轴对齐的入口和出口的腔室的壳体，位于腔室内的药剂盒，其具有穿过其中的通道，以及膜密封具有小于10个大气压的爆破压力的通道，手动致动的流体输送装置具有与腔室流体连通的出口和位于流体输送装置的出口和腔室入口之间的手动致动的阀，用于在压力下将流体输送到阀。本发明的药物输送装置可以用于通过首先对压力输送装置中的压力室施加压力来递送受控单位剂量的药物，然后打开瓣膜以打开膜并通过室出口。

7. 发明授权

US06929005B2 Medicament respiratory delivery device, cartridge and method of making same 有权
标题翻译：药物呼吸装置，药筒及其制造方法
公开(公告)号：US06929005B2
公开(公告)日：2005-08-16
申请号：US09879517
申请日：2001-06-12
申请人： Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Michael W. Trull , Christopher J. Knors
发明人： Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Michael W. Trull , Christopher J. Knors
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M15/00 , B05B11/06
CPC分类号： A61M15/0028 , A61M11/002 , A61M11/003 , A61M11/02 , A61M15/0025 , A61M15/0031 , A61M15/0033 , A61M15/004 , A61M15/0041 , A61M15/0068 , A61M2202/064 , A61M2205/075 , A61M2207/00 , B05B11/061 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet. The method of forming the cartridge includes stretching out and bending a membrane to one end of the cartridge, preferably by heat bonding, filling the cartridge with a medicament and sealing the opposed end preferably with a second burstable membrane by stretching out a membrane over a convex surface and heat bonding.
摘要翻译：一种药物呼吸递送装置，包括具有腔室，大体上与腔室同轴对准的入口和出口的壳体，其中所述腔室包括药剂盒，所述药剂盒具有主体，该主体包括大体上圆柱形的通道，该通道延伸穿过所述药筒的相对端，壳体的入口和出口具有薄的可爆破的聚烯烃膜，其具有介于盒的端部之间拉伸的介于1.2和10个大气压之间的爆破压力，使得输送到入口的流体破裂膜，夹带在盒通道内的药剂通过出口将其输送到患者的呼吸系统。形成盒的方法包括：将膜延伸出并弯曲到盒的一端，优选通过热粘合，用药物填充盒，并优选用第二可爆膜密封相对端，通过在凸起表面和热粘合。

8. 发明授权

US07644562B2 Method of making a cartridge for a medicament respiratory delivery device 有权
标题翻译：制造用于药物呼吸输送装置的药筒的方法
公开(公告)号：US07644562B2
公开(公告)日：2010-01-12
申请号：US11083751
申请日：2005-03-18
申请人： Vincent J. Sullivan , Lawrence A. Monahan , Christopher J. Knors , Anjana Bhuta Wills , Michael W. Trull
发明人： Vincent J. Sullivan , Lawrence A. Monahan , Christopher J. Knors , Anjana Bhuta Wills , Michael W. Trull
IPC分类号： B65B7/28
CPC分类号： B05B11/061 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2207/00 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet. The method of forming the cartridge includes stretching out and bending a membrane to one end of the cartridge, preferably by heat bonding, filling the cartridge with a medicament and sealing the opposed end preferably with a second burstable membrane by stretching out a membrane over a convex surface and heat bonding.
摘要翻译：一种药物呼吸递送装置，包括具有腔室，大体上与腔室同轴对准的入口和出口的壳体，其中所述腔室包括药剂盒，所述药剂盒具有主体，该主体包括大体上圆柱形的通道，该通道延伸穿过所述药筒的相对端，壳体的入口和出口具有薄的可爆破的聚烯烃膜，其具有介于盒的端部之间拉伸的介于1.2和10个大气压之间的爆破压力，使得输送到入口的流体破裂膜，夹带在盒通道内的药剂通过出口将其输送到患者的呼吸系统。形成盒的方法包括：将膜延伸出并弯曲到盒的一端，优选通过热粘合，用药物填充盒，并优选用第二可爆膜密封相对端，通过在凸起表面和热粘合。

9. 发明授权

US07270127B2 Medicament respiratory delivery device 有权
标题翻译：药物呼吸装置
公开(公告)号：US07270127B2
公开(公告)日：2007-09-18
申请号：US10233863
申请日：2002-09-03
申请人： Artis R. Lockhart , Vincent J. Sullivan , Lawrence A. Monahan , Anjana Bhuta Wills
发明人： Artis R. Lockhart , Vincent J. Sullivan , Lawrence A. Monahan , Anjana Bhuta Wills
IPC分类号： A61M15/00
CPC分类号： B05B11/061 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/003 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2207/00 , B05B11/062
摘要： A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.
摘要翻译：一种药物呼吸输送装置，包括由相对的热成型聚合物片材形成的壳体，所述壳体在其间形成有腔室，所述腔室具有封装在所述片材之间的药剂盒，与通过所述药筒的通道对准的入口具有可刺穿的封闭件和与所述通道对准的出口出口具有可爆破的膜。该装置包括形成为片材之间的泡罩的压力致动器和具有弓形致动器部分的穿孔元件和在致动压力致动器时刺穿可刺破的封闭件的轴，将压力下的流体输送到药筒通道，膜并表达药物。

10. 发明授权

US06443152B1 Medicament respiratory delivery device 有权
公开(公告)号：US06443152B1
公开(公告)日：2002-09-03
申请号：US09879714
申请日：2001-06-12
申请人： Artis R. Lockhart , Vincent J. Sullivan , Lawrence A. Monahan , Anjana Bhuta Wills
发明人： Artis R. Lockhart , Vincent J. Sullivan , Lawrence A. Monahan , Anjana Bhuta Wills
IPC分类号： A61M1600
CPC分类号： B05B11/061 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/003 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2207/00 , B05B11/062
摘要： A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.

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