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1. 发明授权

US09095629B2 Magnetic nanostructures as theranostic agents 有权
标题翻译：磁性纳米结构作为主要药剂
公开(公告)号：US09095629B2
公开(公告)日：2015-08-04
申请号：US13505167
申请日：2010-11-01
申请人： Vinayak P. Dravid , Saurabh Sharma , Tadanori Tomita , Kirsten L. Viola , William L. Klein
发明人： Vinayak P. Dravid , Saurabh Sharma , Tadanori Tomita , Kirsten L. Viola , William L. Klein
IPC分类号： H01F1/00 , A61K41/00 , A61K49/18 , A61K47/48 , B82Y5/00
CPC分类号： A61K47/6923 , A61K41/0052 , A61K47/6865 , A61K49/1833 , A61K49/186 , A61K49/1875 , A61N2/004 , B82Y5/00
摘要： The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.
摘要翻译：本发明涉及作为诊断剂的磁性纳米结构，其作为诊断和治疗剂提供双重功能。特别地，本发明涉及包含磁性纳米结构的组合物及其作为癌症（例如成神经管细胞瘤）和阿尔茨海默氏病以及相关疾病和病症的靶向治疗剂的用途。

2. 发明申请

US20120308657A1 MAGNETIC NANOSTRUCTURES AS THERANOSTIC AGENTS 有权
标题翻译：磁性纳米结构作为治疗剂
公开(公告)号：US20120308657A1
公开(公告)日：2012-12-06
申请号：US13505167
申请日：2010-11-01
申请人： Vinayak P. Dravid , Saurabh Sharma , Tadanori Tomita , Kirsten L. Viola , William L. Klein
发明人： Vinayak P. Dravid , Saurabh Sharma , Tadanori Tomita , Kirsten L. Viola , William L. Klein
IPC分类号： A61K39/395 , A61K49/06 , A61N2/10 , A61B5/055 , A61K9/14 , A61P35/00 , B82Y5/00
CPC分类号： A61K47/6923 , A61K41/0052 , A61K47/6865 , A61K49/1833 , A61K49/186 , A61K49/1875 , A61N2/004 , B82Y5/00
摘要： The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.
摘要翻译：本发明涉及作为诊断剂的磁性纳米结构，其作为诊断和治疗剂提供双重功能。特别地，本发明涉及包含磁性纳米结构的组合物及其作为癌症（例如成神经管细胞瘤）和阿尔茨海默氏病以及相关疾病和病症的靶向治疗剂的用途。

3. 发明授权

US08337813B2 Contrast agents 有权
标题翻译：对比剂
公开(公告)号：US08337813B2
公开(公告)日：2012-12-25
申请号：US12210829
申请日：2008-09-15
申请人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
IPC分类号： A61B5/055
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译：本发明一般涉及多模式磁共振成像（MRI）造影剂。特别地，本发明提供了构造成操纵周围水质子旋转的纵向（T1）和横向（T2）弛豫时间的MRI造影剂。

4. 发明申请

US20110036169A1 Scanning Near-Field Ultrasound Holography 有权
标题翻译：扫描近场超声全息术
公开(公告)号：US20110036169A1
公开(公告)日：2011-02-17
申请号：US12886929
申请日：2010-09-21
申请人： Gajendra Shekhawat , Vinayak P. Dravid
发明人： Gajendra Shekhawat , Vinayak P. Dravid
IPC分类号： G01N29/04 , G01Q60/24
CPC分类号： G01N29/265 , G01N29/0663 , G01N29/0681 , G01N29/069 , G01N2291/0232 , G01N2291/02827 , G01N2291/0427 , G01Q60/32 , G03H3/00
摘要： A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations at a sample surface. As such, it overcomes the spatial resolution limitations of conventional phase-resolved acoustic microscopy (i.e. holography) by eliminating the need for far-field acoustic lenses.
摘要翻译：高空间分辨率相敏技术采用扫描近场超声全息（SNFUH）方法，用于在样品表面上成像弹性以及粘弹性变化。 SNFUH使用近场方法测量样品表面超声波振荡的时间分辨变化。因此，它通过消除对远场声透镜的需要来克服常规相分离声学显微镜（即全息术）的空间分辨率限制。

5. 发明授权

US5665277A Nanoparticle synthesis apparatus and method 失效
标题翻译：纳米微粒合成装置及方法
公开(公告)号：US5665277A
公开(公告)日：1997-09-09
申请号：US557304
申请日：1995-11-14
申请人： D. Lynn Johnson , Vinayak P. Dravid , Mao-Hua Teng , Jonathon J. Host , Jinha Hwang , Brian R. Elliott
发明人： D. Lynn Johnson , Vinayak P. Dravid , Mao-Hua Teng , Jonathon J. Host , Jinha Hwang , Brian R. Elliott
IPC分类号： B01J13/02 , B01J13/04 , B22F1/00 , B22F9/12 , B22F9/14 , C01B13/20 , C01B21/06 , C01B31/30 , C01B35/04 , B05B17/04
CPC分类号： B82Y30/00 , B01J13/02 , B01J13/04 , B22F1/0018 , B22F1/0088 , B22F9/12 , B22F9/14 , C01B13/20 , C01B21/06 , C01B31/30 , C01B35/04 , B01J2219/0822 , C01P2004/51 , C01P2004/64 , C01P2004/80 , Y10S423/40 , Y10S977/773 , Y10S977/843 , Y10S977/844 , Y10S977/845 , Y10S977/896 , Y10S977/901
摘要： Method and apparatus for making nanoparticles of a material having a diameter of 100 nanometers or less wherein the material to be formed into nanoparticles is evaporated to form a vapor plume therein, a non-reactive entrainment gaseous atmosphere suitable for evaporation conditions is introduced to a first chamber, a gaseous jet is directed through the vapor plume in a direction to carry nanoparticles formed by quenching of the vapor plume through a flow restriction orifice between the first chamber and a second chamber downstream of the first chamber, recirculation of the gaseous jet and nanoparticles entrained therein from the second chamber to the first chamber is substantially prevented to thereby provide a second stage of the gaseous jet downstream of the orifice and substantially isolated from said first chamber for flow to the second chamber, and collecting the nanoparticles from the second stage of said gaseous jet in a collection chamber downstream from the orifice. The nanoparticles can be reacted in an aerosol reactor chamber located downstream of the orifice under a variety of reaction conditions without adversely affecting the evaporation conditons present in the first chamber.
摘要翻译：用于制造直径为100纳米或更小的材料的纳米颗粒的方法和装置，其中待形成纳米颗粒的材料被蒸发以在其中形成蒸汽羽流，适合于蒸发条件的非反应性夹带气态气体被引入第一气体射流沿着蒸气羽流的方向被引导通过在第一腔室和第一腔室下游的第二腔室之间的流动限制孔板骤冷蒸汽羽流而形成的纳米颗粒，气态射流和纳米颗粒的再循环基本上防止了从第二腔室夹带到第一腔室中的气态射流的第二阶段，并且基本上与所述第一腔室隔离，以流动到第二腔室，并从第二腔室的第二阶段收集纳米颗粒所述气体射流在孔口下游的收集室中。纳米颗粒可以在多种反应条件下在位于孔口下游的气溶胶反应器室中反应，而不会不利地影响第一室中存在的蒸发条件。

6. 发明申请

US20110036170A1 Scanning Near Field Thermoelastic Acoustic Holography (SNFTAH) 有权
标题翻译：扫描近场热弹性声全息（SNFTAH）
公开(公告)号：US20110036170A1
公开(公告)日：2011-02-17
申请号：US12896282
申请日：2010-10-01
申请人： Gajendra S. Shekhawat , Vinayak P. Dravid
发明人： Gajendra S. Shekhawat , Vinayak P. Dravid
IPC分类号： G01N29/04
CPC分类号： G01N29/0663 , G01N29/0681 , G01N29/2418 , G01N29/265 , G01N2291/0231 , G01N2291/0232 , G01N2291/02827 , G01N2291/0427 , G01Q60/32 , G03H3/00
摘要： A system and method for analyzing a sample is described. The system may include, for example, a light source and a scanning probe microscope probe. The light source may generate a coherent laser beam that is modulated by a waveform of a lower frequency. The modulated laser beam is absorbed by the sample causing thermally induced expansion and resulting in an excitation of acoustic waves. The probe is locally deployed near the sample and detects, in real time, perturbations in the excited acoustic waves to detect surface and buried structures of the sample.
摘要翻译：描述用于分析样品的系统和方法。该系统可以包括例如光源和扫描探针显微镜探针。光源可以产生由较低频率的波形调制的相干激光束。调制的激光束被样品吸收，引起热诱导的膨胀并导致声波的激发。探头本地部署在样品附近，并实时检测激发的声波中的扰动，以检测样品的表面和掩埋结构。

7. 发明授权

US07722928B2 Nanolithography methods and products therefor and produced thereby 有权
标题翻译：纳米光刻方法和产品，由此生产
公开(公告)号：US07722928B2
公开(公告)日：2010-05-25
申请号：US11100483
申请日：2005-04-07
申请人： Chad A. Mirkin , Seunghun Hong , Vinayak P. Dravid
发明人： Chad A. Mirkin , Seunghun Hong , Vinayak P. Dravid
IPC分类号： B05D5/00 , B05D1/36 , B05D7/24 , B01J19/08 , C12Q1/68 , C12P19/34
CPC分类号： G03F7/0002 , B05D1/007 , B05D1/185 , B05D1/26 , B82B3/00 , G01Q80/00 , G03F7/165 , Y10S977/85 , Y10S977/857 , Y10S977/86 , Y10S977/862 , Y10S977/863 , Y10S977/878 , Y10S977/882 , Y10S977/884 , Y10S977/885 , Y10S977/886
摘要： In one aspect, a method of nanolithography is provided using a driving force to control the movement of a deposition compound from a scanning probe microscope tip to a substrate. Another aspect of the invention provides a tip for use in nanolithography having an internal cavity and an aperture restricting movement of a deposition compound from the tip to the substrate. The rate and extent of movement of the deposition compound through the aperture is controlled by a driving force.
摘要翻译：一方面，使用驱动力来提供纳米光刻的方法，以控制沉积化合物从扫描探针显微镜尖端到基底的移动。本发明的另一方面提供了一种用于纳米光刻的尖端，其具有内腔和限制沉积化合物从尖端到基底的运动的孔。沉积化合物通过孔的运动速度和程度由驱动力控制。

8. 发明授权

US5618475A Evaporator apparatus and method for making nanoparticles 失效
标题翻译：蒸发器及其制造方法
公开(公告)号：US5618475A
公开(公告)日：1997-04-08
申请号：US557206
申请日：1995-11-14
申请人： D. Lynn Johnson , Vinayak P. Dravid
发明人： D. Lynn Johnson , Vinayak P. Dravid
IPC分类号： B01J13/02 , B01J13/04 , B22F1/00 , B22F9/12 , B22F9/14 , C01B13/20 , C01B21/06 , C01B31/30 , C01B35/04 , B29B9/00
CPC分类号： B82Y30/00 , B01J13/02 , B01J13/04 , B22F1/0018 , B22F1/0088 , B22F9/12 , B22F9/14 , C01B13/20 , C01B21/06 , C01B31/30 , C01B35/04 , B01J2219/0822 , C01P2004/51 , C01P2004/64 , C01P2004/80 , Y10S423/40 , Y10S977/773 , Y10S977/843 , Y10S977/844 , Y10S977/845 , Y10S977/896 , Y10S977/901
摘要： Nanoparticles of a material less than about 100 nm in diameter are made by evaporating the material in an evaporation chamber residing in an entrainment chamber having a gaseous atmosphere therein. The evaporator is disposed in but isolated from the entrainment chamber, except for a gaseous jet discharge opening. A carrier gas is introduced to the evaporation chamber to carry vapor of the material in the evaporation chamber through the discharge opening into the entrainment chamber as a gaseous jet. The gaseous jet entrains the gaseous atmosphere for quenching the vapor to form nanoparticles. Solid material is supplied at a feedrate to a supply opening of the evaporation chamber, melted at an end region remote from the supply opening, and evaporated at the end region at an evaporation rate equal to the feed rate of the solid material. First and second metals having different vapor pressures can be supplied to respective first and second evaporation chambers and their vapors collected in a common vapor collection chamber having the discharge opening therein. The carrier gas is introduced to the vapor collection chamber to carry the metal vapors together through the discharge opening as a gaseous jet into the entrainment chamber where nanoparticles comprising the two metals are formed.
摘要翻译：直径小于约100nm的材料的纳米颗粒通过在其中具有气体气氛的夹带室中的蒸发室中蒸发掉材料来制备。除了气体喷射排出口之外，蒸发器设置在与夹带室隔离的位置。将载气引入蒸发室以将蒸发室中的材料的蒸气通过排放口带入作为气体射流的夹带室。气态气流夹带气态气体以猝灭蒸气形成纳米颗粒。固体材料以进给速度供给到蒸发室的供应开口，在远离供应开口的端部区域熔化，并以与固体材料的进料速率相等的蒸发速率在端部区域蒸发。可以将具有不同蒸汽压的第一和第二金属供应到相应的第一和第二蒸发室，并且其蒸气被收集在其中具有排放口的公共蒸气收集室中。载气被引入蒸气收集室，以将金属蒸气作为气体射流通过排放口输送到夹带室中，其中形成了包含两种金属的纳米颗粒。

9. 发明授权

US08647814B2 Method of making nanopatterns and nanostructures and nanopatterned functional oxide materials 有权
标题翻译：制备纳米图案和纳米结构和纳米图案化功能氧化物材料的方法
公开(公告)号：US08647814B2
公开(公告)日：2014-02-11
申请号：US11805546
申请日：2007-05-23
申请人： Vinayak P. Dravid , Suresh K. Donthu , Zixiao Pan
发明人： Vinayak P. Dravid , Suresh K. Donthu , Zixiao Pan
IPC分类号： G03C5/00 , B44C1/17
CPC分类号： G03F7/405 , H01L21/0272 , H01L21/0277 , H01L21/31144
摘要： Method for nanopatterning of inorganic materials, such as ceramic (e.g. metal oxide) materials, and organic materials, such as polymer materials, on a variety of substrates to form nanopatterns and/or nanostructures with control of dimensions and location, all without the need for etching the materials and without the need for re-alignment between multiple patterning steps in forming nanostructures, such as heterostructures comprising multiple materials. The method involves patterning a resist-coated substrate using electron beam lithography, removing a portion of the resist to provide a patterned resist-coated substrate, and spin coating the patterned resist-coated substrate with a liquid precursor, such as a sol precursor, of the inorganic or organic material. The remaining resist is removed and the spin coated substrate is heated at an elevated temperature to crystallize the deposited precursor material.
摘要翻译：无机材料如陶瓷（例如金属氧化物）材料和有机材料（例如聚合物材料）在各种基底上的纳米图案化方法，以形成具有尺寸和位置控制的纳米图案和/或纳米结构，所有这些都不需要蚀刻材料并且不需要在形成纳米结构的多个图案化步骤之间进行重新对准，例如包括多种材料的异质结构。该方法包括使用电子束平版印刷图案化抗蚀剂涂覆的基底，去除抗蚀剂的一部分以提供图案化的抗蚀剂涂覆的基底，并用液体前体如溶胶前体旋涂涂敷图案化的抗蚀剂涂覆的基底，无机或有机材料。除去剩余的抗蚀剂，并将旋转涂覆的基材在升高的温度下加热以使沉积的前体材料结晶。

10. 发明申请

US20130108554A1 CONTRAST AGENTS 审中-公开
公开(公告)号：US20130108554A1
公开(公告)日：2013-05-02
申请号：US13720160
申请日：2012-12-19
申请人： Elise A. Schultz Sikma , Mohammed Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammed Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
IPC分类号： A61K49/14 , A61K49/18
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.

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