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1. 发明申请

US20110052495A1 USE OF FULLERENES IN PHOTOACOUSTIC IMAGING 有权
标题翻译：在光电成像中使用富勒烯
公开(公告)号：US20110052495A1
公开(公告)日：2011-03-03
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
IPC分类号： A61K49/00 , C12Q1/02 , H04B1/02 , G01S15/89 , B82Y15/00 , B82Y5/00
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译：富勒烯当用电磁辐射照射时产生声波。公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。由材料产生的所得光声效应由至少一个检测器检测。还描述了使用包含富勒烯的材料的光声层析成像系统。

2. 发明授权

US08883124B2 Use of fullerenes in photoacoustic imaging 有权
标题翻译：在光声成像中使用富勒烯
公开(公告)号：US08883124B2
公开(公告)日：2014-11-11
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
IPC分类号： A61B8/00 , G01S15/00 , H04B1/02 , A61K49/00 , A61B5/00 , G01N21/17
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译：富勒烯当用电磁辐射照射时产生声波。公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。由材料产生的所得光声效应由至少一个检测器检测。还描述了使用包含富勒烯的材料的光声层析成像系统。

3. 发明申请

US20100254911A1 MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING 失效
标题翻译：用于非侵入式生物成像的多模式纳米粒子
公开(公告)号：US20100254911A1
公开(公告)日：2010-10-07
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
IPC分类号： A61K49/06 , A61K49/04
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
摘要翻译：多峰纳米颗粒是含有PAT造影剂和发光成像，X射线成像和/或MRI中的一种或多种的纳米颗粒。多峰纳米颗粒可以具有包含在芯上具有金属涂层的氧化物的介电芯。颗粒可以是金属斑点。多模式纳米颗粒可用于治疗目的，例如肿瘤的消融或中子捕获以及用作成像的造影剂。

4. 发明授权

US08361437B2 Multimodal nanoparticles for non-invasive bio-imaging 失效
公开(公告)号：US08361437B2
公开(公告)日：2013-01-29
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
IPC分类号： A61K51/00 , A61K49/06 , A61K49/04
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

5. 发明申请

US20100208965A1 Method and Apparatus for Tomographic Imaging of Absolute Optical Absorption Coefficient in Turbid Media Using Combined Photoacoustic and Diffusing Light Measurements 审中-公开
标题翻译：用于使用组合光声和漫射光测量的混浊介质中绝对光吸收系数的断层摄影的方法和装置
公开(公告)号：US20100208965A1
公开(公告)日：2010-08-19
申请号：US12668976
申请日：2008-03-05
申请人： Huabei Jiang , Zhen Yuan , Qiang Wang , Lu Yin , Qizhi Zhang
发明人： Huabei Jiang , Zhen Yuan , Qiang Wang , Lu Yin , Qizhi Zhang
IPC分类号： G06K9/00
CPC分类号： A61B5/0073 , A61B5/0095 , A61B5/4528
摘要： Embodiments of the invention pertain to methods for imaging a light absorption coefficient distribution. Embodiments of the subject method can be implemented without knowing the strength of incident light in advance and without requiring careful calibrations in the non-scattering medium. Embodiments of the method can combine conventional photoacoustic tomography (PAT) with diffusing light measurements coupled with an optimization procedure based on the photon diffusion equation. Images of absorbing targets as small as 0.5 mm in diameter embedded in a 50 mm diameter background medium can be quantitatively recovered. Small targets with various optical contrast levels relative to the background can be detected well. Embodiments of the subject reconstruction method can include first obtaining the map of absorbed optical energy density. Embodiments can obtain the map of absorbed optical energy density through a model-based reconstruction algorithm that is based on a finite element solution to the photoacoustic wave equation in frequency domain subject to the radiation or absorbing boundary conditions (BCs). The distribution of optical fluence can then be obtained. Embodiments can obtain the distribution of optical fluence using the photon diffusion equation based optimization procedure. The distribution of optical absorption coefficient can then be recovered from the distribution of optical fluence and the absorbed energy density.
摘要翻译：本发明的实施例涉及用于对光吸收系数分布进行成像的方法。可以在不知道入射光的强度并且不需要在非散射介质中仔细校准的情况下实现本方法的实施例。该方法的实施例可以将传统的光声层析成像（PAT）与基于光子扩散方程的优化过程耦合的扩散光测量结合起来。可以定量地回收直径为50mm的背景介质中直径小于0.5mm的吸收靶的图像。可以很好地检测到具有相对于背景的各种光学对比度水平的小目标。被摄体重建方法的实施例可以包括首先获得吸收的光能密度的图。实施例可以通过基于模型的重建算法获得吸收的光能密度的图，该算法基于经受辐射或吸收边界条件（BC）的频域中的光声波方程的有限元解。然后可以获得光能的分布。实施例可以使用基于光子扩散方程的优化程序获得光能的分布。光吸收系数的分布可以从光能的分布和吸收的能量密度中恢复。

6. 发明授权

US07941203B2 Multimodality imaging system 有权
标题翻译：多模态成像系统
公开(公告)号：US07941203B2
公开(公告)日：2011-05-10
申请号：US11903324
申请日：2007-09-21
申请人： Quanlu Zheng , Tie Gao , Jiadi Li , Kai Liu , Qingze Yu , Baowei Xu , Haitao Mu , Qizhi Zhang , Xinghua Zhao
发明人： Quanlu Zheng , Tie Gao , Jiadi Li , Kai Liu , Qingze Yu , Baowei Xu , Haitao Mu , Qizhi Zhang , Xinghua Zhao
IPC分类号： A61B5/05
CPC分类号： A61B6/5276 , A61B6/032 , A61B6/0457 , A61B6/4417
摘要： A multimodality imaging system, comprising: a first imaging system for forming a first image; a second imaging system for forming a second image; and a rotating device on which the first imaging system and the second imaging system are fixed so that the first imaging system and the second imaging system are selectively rotated to a scanning position.
摘要翻译：一种多模态成像系统，包括：用于形成第一图像的第一成像系统; 用于形成第二图像的第二成像系统; 以及旋转装置，其上固定有第一成像系统和第二成像系统，使得第一成像系统和第二成像系统选择性地旋转到扫描位置。

7. 发明申请

US20080081985A1 Multimodality imaging system 有权
标题翻译：多模态成像系统
公开(公告)号：US20080081985A1
公开(公告)日：2008-04-03
申请号：US11903324
申请日：2007-09-21
申请人： Quanlu Zheng , Tie Gao , Jiadi Li , Kai Liu , Qingze Yu , Baowei Xu , Haitao Mu , Qizhi Zhang , Xinghua Zhao
发明人： Quanlu Zheng , Tie Gao , Jiadi Li , Kai Liu , Qingze Yu , Baowei Xu , Haitao Mu , Qizhi Zhang , Xinghua Zhao
IPC分类号： A61B5/00
CPC分类号： A61B6/5276 , A61B6/032 , A61B6/0457 , A61B6/4417
摘要： A multimodality imaging system, comprising: a first imaging system for forming a first image; a second imaging system for forming a second image; and a rotating device on which the first imaging system and the second imaging system are fixed so that the first imaging system and the second imaging system are selectively rotated to a scanning position.
摘要翻译：一种多模态成像系统，包括：用于形成第一图像的第一成像系统; 用于形成第二图像的第二成像系统; 以及旋转装置，其上固定有第一成像系统和第二成像系统，使得第一成像系统和第二成像系统选择性地旋转到扫描位置。

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