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1. 发明申请

US20110052495A1 USE OF FULLERENES IN PHOTOACOUSTIC IMAGING 有权
标题翻译：在光电成像中使用富勒烯
公开(公告)号：US20110052495A1
公开(公告)日：2011-03-03
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
IPC分类号： A61K49/00 , C12Q1/02 , H04B1/02 , G01S15/89 , B82Y15/00 , B82Y5/00
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译：富勒烯当用电磁辐射照射时产生声波。公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。由材料产生的所得光声效应由至少一个检测器检测。还描述了使用包含富勒烯的材料的光声层析成像系统。

2. 发明申请

US20100208965A1 Method and Apparatus for Tomographic Imaging of Absolute Optical Absorption Coefficient in Turbid Media Using Combined Photoacoustic and Diffusing Light Measurements 审中-公开
标题翻译：用于使用组合光声和漫射光测量的混浊介质中绝对光吸收系数的断层摄影的方法和装置
公开(公告)号：US20100208965A1
公开(公告)日：2010-08-19
申请号：US12668976
申请日：2008-03-05
申请人： Huabei Jiang , Zhen Yuan , Qiang Wang , Lu Yin , Qizhi Zhang
发明人： Huabei Jiang , Zhen Yuan , Qiang Wang , Lu Yin , Qizhi Zhang
IPC分类号： G06K9/00
CPC分类号： A61B5/0073 , A61B5/0095 , A61B5/4528
摘要： Embodiments of the invention pertain to methods for imaging a light absorption coefficient distribution. Embodiments of the subject method can be implemented without knowing the strength of incident light in advance and without requiring careful calibrations in the non-scattering medium. Embodiments of the method can combine conventional photoacoustic tomography (PAT) with diffusing light measurements coupled with an optimization procedure based on the photon diffusion equation. Images of absorbing targets as small as 0.5 mm in diameter embedded in a 50 mm diameter background medium can be quantitatively recovered. Small targets with various optical contrast levels relative to the background can be detected well. Embodiments of the subject reconstruction method can include first obtaining the map of absorbed optical energy density. Embodiments can obtain the map of absorbed optical energy density through a model-based reconstruction algorithm that is based on a finite element solution to the photoacoustic wave equation in frequency domain subject to the radiation or absorbing boundary conditions (BCs). The distribution of optical fluence can then be obtained. Embodiments can obtain the distribution of optical fluence using the photon diffusion equation based optimization procedure. The distribution of optical absorption coefficient can then be recovered from the distribution of optical fluence and the absorbed energy density.
摘要翻译：本发明的实施例涉及用于对光吸收系数分布进行成像的方法。可以在不知道入射光的强度并且不需要在非散射介质中仔细校准的情况下实现本方法的实施例。该方法的实施例可以将传统的光声层析成像（PAT）与基于光子扩散方程的优化过程耦合的扩散光测量结合起来。可以定量地回收直径为50mm的背景介质中直径小于0.5mm的吸收靶的图像。可以很好地检测到具有相对于背景的各种光学对比度水平的小目标。被摄体重建方法的实施例可以包括首先获得吸收的光能密度的图。实施例可以通过基于模型的重建算法获得吸收的光能密度的图，该算法基于经受辐射或吸收边界条件（BC）的频域中的光声波方程的有限元解。然后可以获得光能的分布。实施例可以使用基于光子扩散方程的优化程序获得光能的分布。光吸收系数的分布可以从光能的分布和吸收的能量密度中恢复。

3. 发明授权

US08883124B2 Use of fullerenes in photoacoustic imaging 有权
标题翻译：在光声成像中使用富勒烯
公开(公告)号：US08883124B2
公开(公告)日：2014-11-11
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
IPC分类号： A61B8/00 , G01S15/00 , H04B1/02 , A61K49/00 , A61B5/00 , G01N21/17
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译：富勒烯当用电磁辐射照射时产生声波。公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。由材料产生的所得光声效应由至少一个检测器检测。还描述了使用包含富勒烯的材料的光声层析成像系统。

4. 发明授权

US08361437B2 Multimodal nanoparticles for non-invasive bio-imaging 失效
公开(公告)号：US08361437B2
公开(公告)日：2013-01-29
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
IPC分类号： A61K51/00 , A61K49/06 , A61K49/04
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

5. 发明授权

US07725167B2 Microwave imaging assisted ultrasonically 失效
标题翻译：微波成像辅助超声波
公开(公告)号：US07725167B2
公开(公告)日：2010-05-25
申请号：US11180434
申请日：2005-07-13
申请人： Razvan M. Ciocan , Huabei Jiang
发明人： Razvan M. Ciocan , Huabei Jiang
IPC分类号： A61B5/05 , A61B8/00
CPC分类号： A61B5/05 , A61B5/0035 , A61B5/0037 , A61B5/0507 , A61B8/0825 , A61B8/14 , A61B8/4416
摘要： Disclosed is an apparatus and methodology for imaging objects, more particularly radiologically dense objects. The currently disclosed technology has particular applicability in the medical field as a tool and methodology for investigation of radiologically dense breast tissue of young patients by using microwave energy in concert with an ultrasonic initial investigation of the tissue. The use of an ultrasonic initial investigation operates as an initial evaluation point for the subsequent microwave investigation.
摘要翻译：公开了用于成像对象的装置和方法，更具体地说是辐射密集的物体。目前公开的技术在医学领域中具有特别的适用性，作为通过使用微波能量与组织的超声初始研究相结合来调查年轻患者放射致密乳腺组织的工具和方法。使用超声波初始调查作为随后的微波调查的初始评估点。

6. 发明授权

US07187441B1 Particle analysis system and method 失效
标题翻译：粒子分析系统及方法
公开(公告)号：US07187441B1
公开(公告)日：2007-03-06
申请号：US09297895
申请日：1997-11-07
申请人： Eva Sevick-Muraca , Joseph Pierce , Steven Richter , Rajesh Shinde , Ganesh Balgi , Jeffrey Kao , Huabei Jiang
发明人： Eva Sevick-Muraca , Joseph Pierce , Steven Richter , Rajesh Shinde , Ganesh Balgi , Jeffrey Kao , Huabei Jiang
IPC分类号： G01N21/51
CPC分类号： G01N21/49 , G01N15/0205
摘要： A system (20) and method are disclosed for the self-calibrating, on-line determination of size distribution f(x) and volume fraction φ of a number of particles (P) dispersed in a medium (M) by detecting one or more propagation characteristics of multiply scattered light from the particles (P). The multiply scattered light is re-emitted in response to exposure to a light source (21) configured to provide light at selected wavelengths. The determination includes calculating the isotropic scattering and absorption coefficients for the particles (P) by comparing the incident and detected light to determine a measurement corresponding to the propagation time through the scattering medium (M), and iteratively estimating the size distribution f(x) and volume fraction φ as a function of the coefficients for each of the wavelengths. An estimation approach based on an expected form of the distribution and the mass of the particles is also disclosed. Furthermore, techniques to determine a particle structure factor indicative of particle-to-particle interactions which vary with particle concentration and influence light scattering at high concentrations is disclosed.
摘要翻译：公开了用于自动校准，在线确定分散在介质中的多个颗粒（P）的尺寸分布f（x）和体积分数phi的系统（20）和方法（ M），通过检测来自颗粒（P）的多个散射光的一个或多个传播特性。响应于暴露于被配置为提供所选波长的光的光源（21），多次散射光被重新发射。确定包括通过比较入射光和检测光来计算颗粒（P）的各向同性散射和吸收系数，以确定对应于通过散射介质的传播时间的测量（ M），并且迭代地估计尺寸分布f（x）和体积分数phi作为每个波长的系数的函数。还公开了基于颗粒的分布和质量的预期形式的估计方法。此外，公开了确定指示随着粒子浓度变化并影响高浓度下的光散射的粒子与粒子相互作用的粒子结构因子的技术。

7. 发明申请

US20140029829A1 ENHANCED IMAGE RECONSTRUCTION IN PHOTOACOUSTIC TOMOGRAPHY 有权
标题翻译：光电图像增强图像重构
公开(公告)号：US20140029829A1
公开(公告)日：2014-01-30
申请号：US14009584
申请日：2012-04-06
申请人： Huabei Jiang , Lei Yao
发明人： Huabei Jiang , Lei Yao
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , A61B5/0095 , A61B5/72 , A61B8/13 , A61B8/5207
摘要： Various embodiments of methods and systems are provided for image reconstruction in photoacoustic tomography. In one embodiment, among others, a method includes obtaining photoacoustic time-domain data; reconstructing an image from the photoacoustic time-domain data using total-variation m inimization based photoacoustic tomography reconstruction; and providing the reconstructed image for rendering on a display device. In another embodiment, a system includes a computing device and an image reconstruction program executable in the computing device. The image reconstruction program includes logic that obtains photoacoustic time-domain data; logic that reconstructs an image from the photoacoustic time-domain data using total-variation minimization based photoacoustic tomography reconstruction; and logic that provides the reconstructed image for rendering on a display device.
摘要翻译：方法和系统的各种实施例被提供用于光声层析成像中的图像重建。在一个实施例中，其中包括获得光声时域数据的方法; 使用基于全变量的基于光声层析成像重建的光声时域数据重建图像; 以及提供用于在显示装置上呈现的重建图像。在另一个实施例中，系统包括计算设备和可在计算设备中执行的图像重建程序。图像重建程序包括获得光声时域数据的逻辑; 使用基于总变差最小化的光声层析成像重建从光声时域数据重建图像的逻辑; 以及提供用于在显示设备上呈现的重建图像的逻辑。

8. 发明申请

US20100254911A1 MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING 失效
标题翻译：用于非侵入式生物成像的多模式纳米粒子
公开(公告)号：US20100254911A1
公开(公告)日：2010-10-07
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
IPC分类号： A61K49/06 , A61K49/04
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
摘要翻译：多峰纳米颗粒是含有PAT造影剂和发光成像，X射线成像和/或MRI中的一种或多种的纳米颗粒。多峰纳米颗粒可以具有包含在芯上具有金属涂层的氧化物的介电芯。颗粒可以是金属斑点。多模式纳米颗粒可用于治疗目的，例如肿瘤的消融或中子捕获以及用作成像的造影剂。

9. 发明申请

US20070015993A1 Microwave imaging assisted ultrasonically 失效
标题翻译：微波成像辅助超声波
公开(公告)号：US20070015993A1
公开(公告)日：2007-01-18
申请号：US11180434
申请日：2005-07-13
申请人： Razvan Ciocan , Huabei Jiang
发明人： Razvan Ciocan , Huabei Jiang
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0035 , A61B5/0037 , A61B5/0507 , A61B8/0825 , A61B8/14 , A61B8/4416
摘要： Disclosed is an apparatus and methodology for imaging objects, more particularly radiologically dense objects. The currently disclosed technology has particular applicability in the medical field as a tool and methodology for investigation of radiologically dense breast tissue of young patients by using microwave energy in concert with an ultrasonic initial investigation of the tissue. The use of an ultrasonic initial investigation operates as an initial evaluation point for the subsequent microwave investigation.
摘要翻译：公开了用于成像对象的装置和方法，更具体地说是辐射密集的物体。目前公开的技术在医学领域中具有特别的适用性，作为通过使用微波能量与组织的超声初始研究相结合来调查年轻患者放射致密乳腺组织的工具和方法。使用超声波初始调查作为随后的微波调查的初始评估点。

10. 发明授权

US06480276B1 Enhanced photon-migration methods for particle sizing in concentrated suspensions 失效
标题翻译：在浓缩悬浮液中增强粒子尺寸的光子迁移方法
公开(公告)号：US06480276B1
公开(公告)日：2002-11-12
申请号：US09615914
申请日：2000-07-13
申请人： Huabei Jiang
发明人： Huabei Jiang
IPC分类号： G01N1502
CPC分类号： G01N15/0227 , G01N2015/0693
摘要： A method and apparatus for determining particle size distribution in undiluted suspensions using spectral measurements of transport-scattering co-efficients using continuous photon-migration techniques is provided. Particle size distribution for concentrated suspensions is determined by a regularized inverse algorithm and may be obtained without a priori distribution function assumptions.
摘要翻译：提供了使用连续光子迁移技术的传输散射系数的光谱测量来确定未稀释悬浮液中的粒度分布的方法和装置。浓缩悬浮液的粒度分布由正则化逆算法确定，可以在没有先验分布函数假设的情况下获得。

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