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1. 发明授权

US10892573B1 Thin-film connectors for data acquisition system 有权
公开(公告)号：US10892573B1
公开(公告)日：2021-01-12
申请号：US16734729
申请日：2020-01-06
申请人： Verily Life Sciences LLC
发明人： Bo Lu , Annapurna Karicherla , Huanfen Yao
IPC分类号： H01R12/78 , H01R12/79 , H01R12/53 , H01R13/04 , A61N1/375 , H01R13/10
摘要： The present disclosure relates to data acquisition, and in particular to thin film connectors between a lead assembly and a data acquisition system. Particularly, aspects of the present disclosure are directed to a connector that includes a button having a housing and conductive pins extending from a proximal end of the housing through a base plate into a cavity on a distal end of the housing. The connector further includes a thin-film adapter having: (i) a supporting structure, (ii) bond pads formed on the supporting structure, (iii) a cable having conductive traces electrically connected to the bond pads, and (iv) feedthroughs that pass through the supporting structure and are electrically connected with the bond pads. Each conductive pin extends through a feedthrough, and each conductive pin is in electrical connection with one or more conductive traces via each bond pad.

2. 发明申请

US20200330747A1 IMPLANTABLE ELECTRODES COMPRISING MECHANICALLY CONSTRAINED BIOCOMPATIBLE HYDROGELS WITH CONDUCTIVE PASSTHROUGH 审中-公开
公开(公告)号：US20200330747A1
公开(公告)日：2020-10-22
申请号：US16918306
申请日：2020-07-01
申请人： Verily Life Sciences LLC
发明人： Huanfen Yao , Kimberly Kam , Daniel Otts
IPC分类号： A61N1/05 , A61B5/04 , A61B5/00
摘要： Biomaterials, such as hydrogels, can be mechanically secured to an electrode of an implantable device using a non-swellable shell. Hydrogel can be applied to an electrode surface and then mechanically constrained in place by a non-swellable shell. The non-swellable material can be secured to a substrate supporting an electrode or can otherwise surround an electrode and the hydrogel. The non-swellable shell can include openings or passthroughs that allow for electrical conduction across the non-swellable shell. The hydrogel can extend out of the openings to contact adjacent biological tissue. In some cases, an outer layer of hydrogel can surround the non-swellable shell and connected to the inner layer of hydrogel through the openings of the non-swellable shell.

3. 发明申请

US20180132790A1 IMPLANTABLE ELECTRODES COMPRISING MECHANICALLY ANCHORED BIOCOMPATIBLE HYDROGELS 审中-公开
公开(公告)号：US20180132790A1
公开(公告)日：2018-05-17
申请号：US15811766
申请日：2017-11-14
申请人： Verily Life Sciences LLC
发明人： Huanfen Yao , Kimberly Kam , Daniel Otts
IPC分类号： A61B5/00 , A61B5/05 , A61N1/05
CPC分类号： A61B5/6846 , A61B5/05 , A61B2562/046 , A61B2562/125 , A61N1/05 , A61N1/0526 , A61N1/0541 , A61N1/0553
摘要： Biomaterials, such as hydrogels, can be mechanically secured to electrodes of an implantable device, such as electrodes made of noble metals. The hydrogel can be mechanically secured via anchoring features of the electrode. Anchoring features can include apertures, voids, textures, or other patterns created in or on the electrode. The hydrogel can incorporate into the anchoring features to mechanically hold the hydrogel against the electrode. The anchoring features, by being located in or on the electrode, can further increase the surface area of the electrode that is exposed to the hydrogel, which can facilitate the conduction of electrical signals between the electrode and surrounding biological tissue. The substrate supporting the electrode can include additional anchoring features that further assist in mechanically securing the hydrogel.

4. 发明授权

US09743885B1 Method of two-step parylene patterning and etching to release a parylene sandwiched device 有权
公开(公告)号：US09743885B1
公开(公告)日：2017-08-29
申请号：US14302844
申请日：2014-06-12
申请人： Verily Life Sciences LLC
发明人： Huanfen Yao , James Etzkorn , Harvey Ho
IPC分类号： H05K3/30 , A61B5/00 , A61B5/1486 , A61B3/10 , A61B17/00
CPC分类号： A61B5/6821 , A61B3/101 , A61B5/1486 , A61B2017/00526 , A61B2562/028 , A61B2562/12
摘要： An example method involves: forming a first bio-compatible layer that defines a first side of a bio-compatible device; forming a conductive pattern over a portion of the first bio-compatible layer; mounting an electronic component to the electrical contacts; forming a second bio-compatible layer over the first bio-compatible layer, the electronic component, the conductive pattern, wherein the second bio-compatible layer defines a second side of the bio-compatible device; forming a first etch mask to partially cover the second bio-compatible layer, thereby exposing a first portion of the second bio-compatible layer; removing the first portion of the second bio-compatible layer; forming a second etch mask to partially cover the second bio-compatible layer, thereby exposing a second portion of the second bio-compatible layer; and removing the second portion of the second bio-compatible layer.

5. 发明申请

US20180133457A1 IMPLANTABLE ELECTRODES COMPRISING MECHANICALLY CONSTRAINED BIOCOMPATIBLE HYDROGELS WITH CONDUCTIVE PASSTHROUGH 审中-公开
公开(公告)号：US20180133457A1
公开(公告)日：2018-05-17
申请号：US15811774
申请日：2017-11-14
申请人： Verily Life Sciences LLC
发明人： Huanfen Yao , Kimberly Kam , Daniel Otts
IPC分类号： A61N1/05 , A61B5/00
摘要： Biomaterials, such as hydrogels, can be mechanically secured to an electrode of an implantable device using a non-swellable shell. Hydrogel can be applied to an electrode surface and then mechanically constrained in place by a non-swellable shell. The non-swellable material can be secured to a substrate supporting an electrode or can otherwise surround an electrode and the hydrogel. The non-swellable shell can include openings or passthroughs that allow for electrical conduction across the non-swellable shell. The hydrogel can extend out of the openings to contact adjacent biological tissue. In some cases, an outer layer of hydrogel can surround the non-swellable shell and connected to the inner layer of hydrogel through the openings of the non-swellable shell.

6. 发明授权

US09572522B2 Tear fluid conductivity sensor 有权
标题翻译：撕裂流体电导率传感器
公开(公告)号：US09572522B2
公开(公告)日：2017-02-21
申请号：US14136895
申请日：2013-12-20
申请人： Verily Life Sciences LLC
发明人： Zenghe Liu , Huanfen Yao
IPC分类号： A61B5/00 , A61B5/145 , A61B5/053 , A61B5/1468
CPC分类号： A61B5/14507 , A61B3/101 , A61B5/0031 , A61B5/053 , A61B5/1468 , A61B5/6821 , A61B2560/0219 , A61B2562/028 , A61B2562/12
摘要： Disclosed herein is a fluid conductivity sensor that can be used to obtain in-vivo measurements of conductivity of biological fluid samples, for example, to determine osmolarity. The conductivity sensor can be disposed on a substrate that is at least partially embedded within a polymeric material of a body-mountable device. The conductivity sensor can include a frame having a trench formed therein that defines a fluid sample cell. First and second electrodes can be formed on sidewalls of the trench, such that the first and second electrodes are on opposite sides of the fluid sample cell. A controller in the body-mountable device can operate the sensor by applying a voltage to the electrodes and measuring a current through a fluid occupying the fluid sample cell. The body-mountable device may indicate the current measurements wirelessly using an antenna.
摘要翻译：本文公开了一种流体电导率传感器，其可用于获得生物流体样品的导电性的体内测量，例如以确定渗透压。电导率传感器可以设置在至少部分地嵌入在可体内安装的装置的聚合物材料中的基底上。电导率传感器可以包括其中形成有沟槽的框架，其限定流体样本池。第一和第二电极可以形成在沟槽的侧壁上，使得第一和第二电极在流体样品池的相对侧上。身体安装装置中的控制器可以通过向电极施加电压并测量通过占据流体样品池的流体的电流来操作传感器。身体安装设备可以使用天线无线地指示当前测量。

7. 发明授权

US09452260B2 Closed loop control system based on a non-invasive continuous sensor 有权
标题翻译：基于非侵入式连续传感器的闭环控制系统
公开(公告)号：US09452260B2
公开(公告)日：2016-09-27
申请号：US14088280
申请日：2013-11-22
申请人： Verily Life Sciences LLC
发明人： Huanfen Yao
IPC分类号： A61M5/172 , A61B5/145 , G02C7/04 , A61M5/142 , A61B5/00 , A61B10/00
CPC分类号： A61B5/4836 , A61B5/002 , A61B5/0022 , A61B5/14507 , A61B5/14532 , A61B5/1477 , A61B5/4839 , A61B5/6821 , A61B5/742 , A61B2010/0067 , A61B2560/0214 , A61B2562/028 , A61M5/142 , A61M5/14244 , A61M5/1723 , A61M2205/3317 , A61M2205/3561 , A61M2205/3576 , A61M2205/3584 , A61M2205/3592 , A61M2205/6054 , A61M2210/0612 , A61M2230/005 , A61M2230/201 , G02C7/04
摘要： Methods and systems for controlling analyte levels are described. An example method may include receiving a sensor measurement relating to an eye-mountable device. The method also may include determining an analyte concentration based on the one or more sensor measurements, and comparing the analyte concentration to a target analyte concentration. Based on the comparing, the method further may include providing instructions to a drug delivery device, where the instructions are configured to control a drug delivery rate by the drug delivery device.
摘要翻译：描述了用于控制分析物水平的方法和系统。示例性方法可以包括接收与眼睛可安装装置有关的传感器测量。该方法还可以包括基于一个或多个传感器测量确定分析物浓度，并将分析物浓度与目标分析物浓度进行比较。基于比较，该方法还可以包括向药物递送装置提供指令，其中指令被配置为通过药物递送装置控制药物递送速率。

8. 发明申请

US20180104114A1 SMART DIAPER FOR DETECTING AND DIFFERENTIATING FECES AND URINE 审中-公开
公开(公告)号：US20180104114A1
公开(公告)日：2018-04-19
申请号：US15292389
申请日：2016-10-13
申请人： Verily Life Sciences LLC
发明人： Brian Pepin , Huanfen Yao
IPC分类号： A61F13/42 , G01N27/04 , G01N33/493 , G01N33/483
摘要： A diaper sensor for detecting and differentiating feces and urine in a diaper is described. The diaper sensor may include at least one pair of conductive elements positioned within an absorbent region of the diaper. The diaper sensor may also include a transmitter and a control circuit operatively connected to the at least one pair of conductive elements and the transmitter. The diaper sensor may further include a power source operatively connected to the control circuit. The control circuit may measure the conductivity between the at least one pair of conductive elements. The control circuit may also determine whether there is poop or pee present in the diaper using the conductivity. The control circuit may also transmit via the transmitter a signal indicative of whether there is excrement or pee present in the diaper.

9. 发明授权

US09834805B2 Two-layer analyte sensor 有权
公开(公告)号：US09834805B2
公开(公告)日：2017-12-05
申请号：US14138368
申请日：2013-12-23
申请人： Verily Life Sciences LLC
发明人： Zenghe Liu , Huanfen Yao
IPC分类号： G01N27/327 , B05D3/00 , C12Q1/00 , G01N3/50
CPC分类号： C12Q1/006 , G01N3/50
摘要： An analyte sensor and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a sensing membrane having a crosslinked network with an embedded analyte sensing component. In another aspect, the analyte sensor includes a protective membrane adjacent to the surface of the sensing membrane. The protective membrane can be a crosslinked, hydrophilic copolymer having methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have hydrophilic side chains, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks. A method for making the analyte sensor is also disclosed.

10. 发明授权

US11000686B1 Platinum/iridium surface patterning by laser to improve neuromodulation electrode performance 有权
公开(公告)号：US11000686B1
公开(公告)日：2021-05-11
申请号：US16394558
申请日：2019-04-25
申请人： Verily Life Sciences LLC
发明人： Huanfen Yao , Kathy Jackson
IPC分类号： A61N1/36 , H01B1/02 , H05K5/02 , H05K5/00 , B23K26/352 , A61N1/375 , H01B13/00 , C22C5/04
摘要： The present disclosure relates to neuromodulation electrodes, and in particular, to neuromodulation electrodes having a platinum/iridium surface etched with a pattern and methods of laser etching the pattern into the platinum/iridium surface of the neuromodulation electrodes to improve performance of the neuromodulation electrodes. Particularly, aspects are directed to an electrode including a base body having: (i) an interface surface that has an area of less than 50 mm2, and (ii) an alloy including platinum and iridium. The interface surface has a surface topography including: (i) an artificial pattern, and (ii) a surface roughness having an arithmetical mean height (Ra) of greater than 0.8 μm.

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