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1. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

2. 发明授权

US07076298B2 Method and apparatus for prevention of arrhythmia clusters using overdrive pacing 有权
公开(公告)号：US07076298B2
公开(公告)日：2006-07-11
申请号：US10171231
申请日：2002-06-14
申请人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
发明人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： An implantable medical device that includes a microprocessor that characterizes cardiac activity of a patient to enable the implantable medical device to deliver therapy in response to an identified arrhythmia event. A monitor/controller monitors the characterized cardiac activity and the delivered therapy, and controls activation of triggered overdrive pacing subsequent to the delivered therapy.

3. 发明授权

US06714811B1 Method and apparatus for monitoring heart rate 有权
标题翻译：监测心率的方法和装置
公开(公告)号：US06714811B1
公开(公告)日：2004-03-30
申请号：US09452659
申请日：1999-12-01
申请人： Vasant Padmanabhan , Karen A. Stone , Walter H. Olson , Kevin T. Ousdigian
发明人： Vasant Padmanabhan , Karen A. Stone , Walter H. Olson , Kevin T. Ousdigian
IPC分类号： A61B504
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/11 , A61B2560/0431
摘要： A monitoring device for implant in a patient's body. The device is provided with a physiologic sensor generating output signals, which signals are stored as numerical values. The device defines first monitoring periods limited to time periods during successive nights during which the patient is likely to be asleep, stores the numerical values generated during the first monitoring periods in a memory and calculates values reflecting general levels of the numerical values during the first monitoring periods. The device may also or alternatively define second monitoring periods limited to time periods during successive daytime and store numerical values generated during the second monitoring periods. The physiologic sensor may be an electrogram amplifier or other sensor indicative of metabolic demand for oxygenated blood, such as an activity sensor. The calculated values reflecting general levels of the numerical values generated during the monitoring periods may be average values, such as mean values or over-all total values, depending upon the sensor employed.
摘要翻译：一种用于植入患者体内的监测装置。该装置设置有生成输出信号的生理传感器，该信号被存储为数值。该装置定义了限制在患者可能睡着的连续夜晚的时间段的第一监测时段，将在第一监测周期期间产生的数值存储在存储器中，并且计算反映在第一监测期间的数值的一般水平的值时期。设备还可以或者替代地定义限制在连续白天期间的时间段的第二监视周期，并且存储在第二监视周期期间生成的数值。生理传感器可以是电描记放大器或指示氧合血液的代谢需求的其它传感器，例如活性传感器。反映在监测期间产生的数值的一般水平的计算值可以是平均值，例如平均值或全部总值，这取决于所使用的传感器。

4. 发明授权

US06508771B1 Method and apparatus for monitoring heart rate 有权
标题翻译：监测心率的方法和装置
公开(公告)号：US06508771B1
公开(公告)日：2003-01-21
申请号：US09452533
申请日：1999-12-01
申请人： Vasant Padmanabhan , Walter H. Olson
发明人： Vasant Padmanabhan , Walter H. Olson
IPC分类号： A61B50468
CPC分类号： A61N1/3702 , A61N1/3925
摘要： An implantable monitoring device for monitoring a patient's heart rate variability over time. The device includes a cardiac electrogram amplifier, a sensing electrode coupled to an input of the amplifier, timing circuitry, processing circutry and a memory. The timing circuitry defines successive monitoring periods each extending over a period of hours, the monitoring periods together extending at least over a period of weeks and also defines successive shorter time periods during each monitoring period. The memory stores heart intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods. The processing circuitry calculates median intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods and calculates standard deviations of the median intervals calculated during each monitoring period. The processing circuitry may also reject heart intervals occurring during tachyarrhythmias and calculate median intervals based only on heart intervals not rejected.
摘要翻译：一种可植入监测装置，用于随时间监测患者的心率变异性。该装置包括心电图放大器，耦合到放大器的输入的感测电极，定时电路，处理循环和存储器。定时电路定义了连续的监视周期，每个监视周期都在几个小时内延伸，监视周期至少延长了几周，并且还在每个监视周期内定义了连续较短的时间段。存储器存储在较短时间段期间由放大器感测的患者心脏的去极化之间的心脏间隔。处理电路计算在较短时间段期间由放大器感测到的患者心脏的去极化之间的中间间隔，并计算在每个监测期间计算的中位数间隔的标准偏差。处理电路还可以排除在快速性心律失常期间发生的心脏间隔，并且仅基于未被拒绝的心脏间隔计算中位数间隔。

5. 发明授权

US08013133B2 Genetic modification of targeted regions of the cardiac conduction system 有权
标题翻译：心脏传导系统目标区域的遗传修饰
公开(公告)号：US08013133B2
公开(公告)日：2011-09-06
申请号：US10423595
申请日：2003-04-25
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K48/00 , C12N15/00 , C07H21/02
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143
摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
摘要翻译：公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

6. 发明授权

US06178350B1 Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 有权
标题翻译：用于诊断和治疗心律失常的优先规则方法和装置
公开(公告)号：US06178350B1
公开(公告)日：2001-01-23
申请号：US09487189
申请日：2000-01-19
申请人： Walter H. Olson , Jeffrey M. Gillberg
发明人： Walter H. Olson , Jeffrey M. Gillberg
IPC分类号： A61N1362
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable anti-tachyarrhythmia device which delivers anti-tachyarrhythmia therapies to a patient's heart in response to detection of tachyarrhythmias. The device defines first criteria indicating the presence of atrial tachycardia and second criteria indicating the presence of atrial fibrillation, and compares the time elapsed since the either the first or second criteria were initially met to a defined time duration. In response to the defined duration having passed and either of the first or second criteria being met, the device triggers delivery of an appropriate anti-tachyarrhythmia therapy. The timer is reset on detection of termination of atrial tachyarrhythmia, but not on failure of the first and second criteria to be met. The first and second criteria are defined such that they can not be concurrently met.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于快速性心律失常的检测而向患者的心脏递送抗快速性心律失常疗法。该装置定义了指示心房心动过速存在的第一标准和指示心房纤维性颤动的存在的第二标准，并且比较了从第一或第二标准开始满足到限定的持续时间之后经过的时间。响应于已经通过的限定的持续时间并满足第一或第二标准中的任一个，该装置触发适当的抗快速性心律失常治疗的递送。在检测到心房性心律失常终止时，定时器复位，但不符合第一和第二标准的失败。第一和第二个标准被定义为不能同时满足。

7. 发明授权

US6141581A Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 有权
公开(公告)号：US6141581A
公开(公告)日：2000-10-31
申请号：US160064
申请日：1998-09-24
申请人： Walter H. Olson , William F. Kaemmerer , Mark L. Brown
发明人： Walter H. Olson , William F. Kaemmerer , Mark L. Brown
IPC分类号： A61N1/365 , A61N1/362 , A61B5/0452
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable antiarrhythmia device which detects and classifies arrhythmias of the human heart, and delivers appropriate therapy. The device employs a method of arrhythmia classification based on a set of prioritized rules, each of the rules defining a plurality of criteria based upon characteristics of sensed depolarizations of heart tissue, each rule being met when the criteria associated with the rule are met. Some rules, when met, trigger delivery of antiarrhythmia therapy. Other rules, when met, inhibit delivery of antiarrhythmia therapy. The rules may be met simultaneously, and if so, the highest priority rule governs the behavior of the device.

8. 发明授权

US5545186A Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 失效
标题翻译：用于诊断和治疗心律失常的优先规则方法和装置
公开(公告)号：US5545186A
公开(公告)日：1996-08-13
申请号：US413570
申请日：1995-03-30
申请人： Walter H. Olson , William F. Kaemmerer
发明人： Walter H. Olson , William F. Kaemmerer
IPC分类号： A61N1/365 , A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable antiarrhythmia device which detects and classifies arrhythmias of the human heart, and delivers appropriate therapy. The device employs a method of arrhythmia classification based on a set of prioritized rules, each of the rules defining a plurality of criteria based upon characteristics of sensed depolarizations of heart tissue, each role being met when the criteria associated with the role are met. Some rules, when met, trigger delivery of antiarrhythmia therapy. Other rules, when met, inhibit delivery of antiarrhythmia therapy. The rules may be met simultaneously, and if so, the highest priority rule governs the behavior of the device.
摘要翻译：一种可植入的抗心律失常装置，用于检测和分类人心脏的心律失常，并提供适当的治疗。该装置采用基于一组优先规则的心律失常分类方法，每个规则基于感测到的心脏组织的去极化的特征来定义多个标准，当满足与角色相关联的标准时，满足每个作用。一些规则，当遇到时，触发了抗心律失常治疗的传递。遇到其他规则时，抑制抗心律失常治疗。可以同时满足规则，如果是，则最高优先级规则控制设备的行为。

9. 发明授权

US4535774A Stroke volume controlled pacer 失效
标题翻译：中风量控制起搏器
公开(公告)号：US4535774A
公开(公告)日：1985-08-20
申请号：US509573
申请日：1983-06-30
申请人： Walter H. Olson
发明人： Walter H. Olson
IPC分类号： A61N1/362 , A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A rate responsive pacer which paces the heart at a rate dependent on detected variations in the stroke volume of the heart.
摘要翻译：速率响应起搏器，其速度取决于检测到的心脏搏动体积变化的速率。

10. 发明申请

US20120109240A1 AUTOMATIC ADJUSTMENT OF ARRHYTHMIA DETECTION PARAMETERS 审中-公开
标题翻译：自动调整ARRHYTHMIA检测参数
公开(公告)号：US20120109240A1
公开(公告)日：2012-05-03
申请号：US12915877
申请日：2010-10-29
申请人： Xiaohong Zhou , Robert Stadler , Bruce D. Gunderson , Walter H. Olson
发明人： Xiaohong Zhou , Robert Stadler , Bruce D. Gunderson , Walter H. Olson
IPC分类号： A61N1/39 , A61N1/365
CPC分类号： A61N1/3706 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61N1/3621
摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).
摘要翻译：用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

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