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1. 发明授权

US06714811B1 Method and apparatus for monitoring heart rate 有权
标题翻译：监测心率的方法和装置
公开(公告)号：US06714811B1
公开(公告)日：2004-03-30
申请号：US09452659
申请日：1999-12-01
申请人： Vasant Padmanabhan , Karen A. Stone , Walter H. Olson , Kevin T. Ousdigian
发明人： Vasant Padmanabhan , Karen A. Stone , Walter H. Olson , Kevin T. Ousdigian
IPC分类号： A61B504
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/11 , A61B2560/0431
摘要： A monitoring device for implant in a patient's body. The device is provided with a physiologic sensor generating output signals, which signals are stored as numerical values. The device defines first monitoring periods limited to time periods during successive nights during which the patient is likely to be asleep, stores the numerical values generated during the first monitoring periods in a memory and calculates values reflecting general levels of the numerical values during the first monitoring periods. The device may also or alternatively define second monitoring periods limited to time periods during successive daytime and store numerical values generated during the second monitoring periods. The physiologic sensor may be an electrogram amplifier or other sensor indicative of metabolic demand for oxygenated blood, such as an activity sensor. The calculated values reflecting general levels of the numerical values generated during the monitoring periods may be average values, such as mean values or over-all total values, depending upon the sensor employed.
摘要翻译：一种用于植入患者体内的监测装置。该装置设置有生成输出信号的生理传感器，该信号被存储为数值。该装置定义了限制在患者可能睡着的连续夜晚的时间段的第一监测时段，将在第一监测周期期间产生的数值存储在存储器中，并且计算反映在第一监测期间的数值的一般水平的值时期。设备还可以或者替代地定义限制在连续白天期间的时间段的第二监视周期，并且存储在第二监视周期期间生成的数值。生理传感器可以是电描记放大器或指示氧合血液的代谢需求的其它传感器，例如活性传感器。反映在监测期间产生的数值的一般水平的计算值可以是平均值，例如平均值或全部总值，这取决于所使用的传感器。

2. 发明授权

US06438407B1 Method and apparatus for monitoring physiologic parameters conjunction with a treatment 有权
标题翻译：用于监测与治疗结合的生理参数的方法和装置
公开(公告)号：US06438407B1
公开(公告)日：2002-08-20
申请号：US09528627
申请日：2000-03-20
申请人： Kevin T. Ousdigian , Karen A. Stone , Vasant Padmanabhan
发明人： Kevin T. Ousdigian , Karen A. Stone , Vasant Padmanabhan
IPC分类号： A61B504
CPC分类号： A61N1/37247
摘要： A system including an implantable medical device and an associated external device, in which the implantable device is adapted to monitor a physiologic parameter and includes a telemetry system for transmitting information to and receiving information from the external device, including information regarding the measured physiological parameter and in which wherein the external device includes a telemetry system for receiving information from the implanted device and for transmitting information to the implanted device and is provided with a mechanism for receiving information indicative of occurrences of significant therapeutic events and is further provided with a display system which combines information received from the implantable device related to the monitored physiologic parameter with the information of therapeutic significance and for displays the combined information in a time-scaled display in which the measured physiologic parameter is displayed along a common time scale with indications of occurrences of the significant therapy related events. The implantable device may also include a mechanism for delivering a therapy; and the mechanism in the external device for receiving information indicative of occurrences of significant therapeutic events may receive information regarding changes in the therapy delivered by the implantable device. The mechanism in the external device for receiving information indicative of occurrences of significant therapeutic events may also or in addition receive information indicative of changes in the therapy delivered by a physician, e.g. changes in a drug therapy.
摘要翻译：一种包括可植入医疗装置和相关联的外部装置的系统，其中所述可植入装置适于监测生理参数，并且包括用于向所述外部装置发送信息并从外部装置接收信息的遥测系统，所述遥测系统包括关于所测量的生理参数的信息，其中所述外部设备包括用于从所述植入设备接收信息并用于向所述植入设备发送信息的遥测系统，并且设置有用于接收指示重要治疗事件发生的信息的机构，并且还具有显示系统，所述显示系统将从与所监视的生理参数相关的可植入装置接收的信息与具有治疗意义的信息组合，并且以按照公共时间尺度显示测量的生理参数的时间尺度显示中的组合信息显示有明显的治疗相关事件的发生。可植入装置还可以包括用于递送治疗的机构; 并且用于接收指示重大治疗事件发生的信息的外部设备中的机制可以接收关于由可植入装置递送的治疗变化的信息。用于接收指示重大治疗事件发生的信息的外部设备中的机制还可以或另外接收指示由医师传递的治疗变化的信息，例如，药物治疗的变化。

3. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

4. 发明授权

US06718204B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US06718204B2
公开(公告)日：2004-04-06
申请号：US09918224
申请日：2001-07-30
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N108
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

5. 发明授权

US08170663B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US08170663B2
公开(公告)日：2012-05-01
申请号：US11687282
申请日：2007-03-16
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

6. 发明授权

US6045513A Implantable medical device for tracking patient functional status 失效
公开(公告)号：US6045513A
公开(公告)日：2000-04-04
申请号：US78221
申请日：1998-05-13
申请人： Karen A. Stone , Vasant Padmanabhan
发明人： Karen A. Stone , Vasant Padmanabhan
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0402 , A61B5/11 , A61B5/02
CPC分类号： A61B5/0031 , A61B5/1118 , A61B5/7232
摘要： An implantable medical device determines activity levels over a set of time periods, preferably on the order of seconds, minutes and hours and a display is enabled for days or weeks at recorded activity levels over a range of dates. This enables physician review of patient functional status. Additional physiologic data can be recorded along with the activity data, and this too may be reported out from the implanted device to a medical communications system for alarm purposes, titrating drugs or other monitoring tasks.

7. 发明授权

US06280409B1 Medical for tracking patient functional status 有权
标题翻译：跟踪患者功能状态的方法
公开(公告)号：US06280409B1
公开(公告)日：2001-08-28
申请号：US09408469
申请日：1999-09-28
申请人： Karen A. Stone , Vasant Padmanabhan
发明人： Karen A. Stone , Vasant Padmanabhan
IPC分类号： A61M500
CPC分类号： A61B5/0031 , A61B5/1118 , A61B5/7232
摘要： An implantable medical device determines activity levels over a set of time periods, preferably on the order of seconds, minutes and hours and a display is enabled for days or weeks at recorded activity levels over a range of dates. This enables physical review of patient functional status. Additional physiologic data can be recorded along with the activity data, and this too may be reported out from the implanted device to a medical communications system for alarm purposes, filtrating drugs or other monitoring tasks.
摘要翻译：可植入医疗设备确定一组时间段内的活动水平，优选地以秒，分钟和小时的顺序，并且在日期范围内记录的活动水平显示数天或数周。这使得能够对患者功能状态进行实质检查。另外的生理数据可以与活动数据一起记录，并且这也可以从植入装置报告给用于报警目的的医疗通信系统，过滤药物或其他监测任务。

8. 发明授权

US6102874A Implantable medical device for tracking patient functional status 有权
标题翻译：用于跟踪患者功能状态的植入式医疗装置
公开(公告)号：US6102874A
公开(公告)日：2000-08-15
申请号：US487561
申请日：2000-01-19
申请人： Karen A. Stone , Vasant Padmanabhan
发明人： Karen A. Stone , Vasant Padmanabhan
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0402 , A61B5/11
CPC分类号： A61B5/0031 , A61B5/1118 , A61B5/7232
摘要： An implantable medical device determines activity levels over a set of time periods, preferably on the order of seconds, minutes and hours and a display is enabled for days or weeks at recorded activity levels over a range of dates. This enables physician review of patient functional status. Additional physiologic data can be recorded along with the activity data, and this too may be reported out from the implanted device to a medical communications system for alarm purposes, titrating drugs or other monitoring tasks.
摘要翻译：可植入医疗设备确定一组时间段内的活动水平，优选地以秒，分钟和小时的顺序，并且在日期范围内记录的活动水平显示数天或数周。这使得医师能够检查患者的功能状态。另外的生理数据可以与活动数据一起记录，并且这也可以从植入装置报告给用于报警目的的医疗通信系统，滴定药物或其他监测任务。

9. 发明授权

US07076298B2 Method and apparatus for prevention of arrhythmia clusters using overdrive pacing 有权
公开(公告)号：US07076298B2
公开(公告)日：2006-07-11
申请号：US10171231
申请日：2002-06-14
申请人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
发明人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： An implantable medical device that includes a microprocessor that characterizes cardiac activity of a patient to enable the implantable medical device to deliver therapy in response to an identified arrhythmia event. A monitor/controller monitors the characterized cardiac activity and the delivered therapy, and controls activation of triggered overdrive pacing subsequent to the delivered therapy.

10. 发明授权

US06508771B1 Method and apparatus for monitoring heart rate 有权
标题翻译：监测心率的方法和装置
公开(公告)号：US06508771B1
公开(公告)日：2003-01-21
申请号：US09452533
申请日：1999-12-01
申请人： Vasant Padmanabhan , Walter H. Olson
发明人： Vasant Padmanabhan , Walter H. Olson
IPC分类号： A61B50468
CPC分类号： A61N1/3702 , A61N1/3925
摘要： An implantable monitoring device for monitoring a patient's heart rate variability over time. The device includes a cardiac electrogram amplifier, a sensing electrode coupled to an input of the amplifier, timing circuitry, processing circutry and a memory. The timing circuitry defines successive monitoring periods each extending over a period of hours, the monitoring periods together extending at least over a period of weeks and also defines successive shorter time periods during each monitoring period. The memory stores heart intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods. The processing circuitry calculates median intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods and calculates standard deviations of the median intervals calculated during each monitoring period. The processing circuitry may also reject heart intervals occurring during tachyarrhythmias and calculate median intervals based only on heart intervals not rejected.
摘要翻译：一种可植入监测装置，用于随时间监测患者的心率变异性。该装置包括心电图放大器，耦合到放大器的输入的感测电极，定时电路，处理循环和存储器。定时电路定义了连续的监视周期，每个监视周期都在几个小时内延伸，监视周期至少延长了几周，并且还在每个监视周期内定义了连续较短的时间段。存储器存储在较短时间段期间由放大器感测的患者心脏的去极化之间的心脏间隔。处理电路计算在较短时间段期间由放大器感测到的患者心脏的去极化之间的中间间隔，并计算在每个监测期间计算的中位数间隔的标准偏差。处理电路还可以排除在快速性心律失常期间发生的心脏间隔，并且仅基于未被拒绝的心脏间隔计算中位数间隔。

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