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1. 发明申请

US20080181972A1 Compositions and Methods for Maintaining, Strengthening, Improving, or Promoting Eye Health 审中-公开
标题翻译：维持，加强，改善或促进眼睛健康的组成和方法
公开(公告)号：US20080181972A1
公开(公告)日：2008-07-31
申请号：US11969239
申请日：2008-01-04
申请人： Valentina Amico , Stephen P. Bartels , Karl Cummins , Daniel Stein
发明人： Valentina Amico , Stephen P. Bartels , Karl Cummins , Daniel Stein
IPC分类号： A61K33/24 , A61K31/385 , A61K31/51 , A61P3/00 , A61P27/02
CPC分类号： A61K31/352 , A23L33/15 , A23L33/16 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/355 , A61K31/375 , A61K31/385 , A61K33/24 , A61K2300/00 , A23V2250/708 , A23V2250/712 , A23V2250/026 , A23V2250/1586 , A23V2250/704
摘要： Compositions for maintaining, strengthening, improving, or promoting eye health comprise α-lipoic acid, ascorbic acid, and α-tocopherol, or pharmaceutical equivalents thereof. The compositions are useful to prevent, stabilize, reverse and/or treat visual acuity loss in subjects having, or being at risk of developing, an ocular disease. The compositions can further comprise one or more other antioxidants, beneficial minerals, and/or nutritional or dietary materials.
摘要翻译：用于维持，加强，改善或促进眼睛健康的组合物包括α-硫辛酸，抗坏血酸和α-生育酚，或其药物等同物。该组合物可用于预防，稳定，逆转和/或治疗患有或有发展为眼部疾病风险的受试者的视力丧失。组合物可进一步包含一种或多种其它抗氧化剂，有益矿物质和/或营养或膳食材料。

2. 发明申请

US20060247436A1 Process for preparing acylphosphanes and derivatives thereof 有权
标题翻译：制备酰基磷烷及其衍生物的方法
公开(公告)号：US20060247436A1
公开(公告)日：2006-11-02
申请号：US10564711
申请日：2004-07-09
申请人： Reinhard Sommerlade , Souad Boulmaaz , Jean-Pierre Wolf , Jens Geier , Hansjorg Grutzmacher , Markus Scherer , Hartmut Schonberg , Daniel Stein , Peter Murer , Stephan Burkhardt
发明人： Reinhard Sommerlade , Souad Boulmaaz , Jean-Pierre Wolf , Jens Geier , Hansjorg Grutzmacher , Markus Scherer , Hartmut Schonberg , Daniel Stein , Peter Murer , Stephan Burkhardt
IPC分类号： C07F9/6533 , C07F9/06 , C07F9/547
CPC分类号： C07F9/5036 , C07F9/5337
摘要： The present invention relates to a new, selective process for the preparation of mono- and bisacylphosphanes of formula (I) n and m are each independently of the other 1 or 2; R1, if n=1, is e.g. phenyl R1, if n=2, is e.g. C1-C18alkylene or phenylene; R2 is e.g. C1-C18alkyl, phenyl or substituted phenyl; R3 is e.g. C1-C18alkyl, by (I) reacting a phosphorous halide of formula IIa or a phosphorous halide oxide of formula (IIb) or a phosphorous halide sulfide of formula (IIc) with an alkali metal in a solvent in the presence of a proton source; (2) subsequent reaction with m acid halides of formula (III) An oxidation step may follow to obtain mono- and bisacylphosphane oxides or mono-and bisacylphosphane sulfides.
摘要翻译：本发明涉及制备式（I）的单 - 和双酰基磷烷的新的选择性方法，n和m各自独立地为1或2; 如果n = 1，则为R 1。苯基R 1，如果n = 2，则为例如。 C 1 -C 18亚烷基或亚苯基; R 2是例如。 C 1 -C 18烷基，苯基或取代的苯基; R 3是例如。通过（I）使式IIa的卤化磷或式（IIb）的卤化磷氧化物或式（IIb）的卤化磷化物或式（Ⅳ） IIc）与碱金属在溶剂中在质子源存在下反应; （2）随后与式（III）的酰卤反应可以进行氧化步骤以获得单酰基和双酰基氧化膦或单酰基和双酰基磷烷硫化物。

3. 发明授权

US08792885B2 Method and system for provisioning a wireless device 失效
标题翻译：用于配置无线设备的方法和系统
公开(公告)号：US08792885B2
公开(公告)日：2014-07-29
申请号：US12060771
申请日：2008-04-01
申请人： Yue Chen , Alan W. Shen , Daniel Stein
发明人： Yue Chen , Alan W. Shen , Daniel Stein
IPC分类号： H04W4/00
CPC分类号： H04W8/265 , H04W8/18
摘要： A method and system for controlling the provisioning of a device with information for accessing services of a wireless service provider via a wireless network is provided. The provisioning system initially stores automatic provisioning information on the device that includes the identification of wireless service providers that have the capability to automatically provision the device. When a user of the device wants to subscribe to a service of a service provider, the provisioning system requests an automatic provisioning service of the service provider to provide information describing available services and information needed to subscribe to those services. When the user selects a service and provides the needed information, the provisioning system retrieves provisioning information for the selected service from the service provider. The provisioning system stores the provisioning information on the device so that the device can then be used to access the selected service of the service provider.
摘要翻译：提供了一种用于通过无线网络控制具有用于访问无线服务提供商的服务的信息的设备的供应的方法和系统。配置系统最初在设备上存储自动配置信息，该信息包括具有自动提供设备能力的无线服务提供商的标识。当设备的用户想要订阅服务提供商的服务时，供应系统请求服务提供商的自动供应服务来提供描述可用服务的信息和订阅这些服务所需的信息。当用户选择服务并提供所需的信息时，供应系统从服务提供商检索所选服务的供应信息。配置系统将配置信息存储在设备上，使得设备然后可以用于访问服务提供商的所选服务。

4. 发明申请

US20080004464A1 Process for Preparing Acylphosphanes and Derivatives Thereof 有权
公开(公告)号：US20080004464A1
公开(公告)日：2008-01-03
申请号：US11667780
申请日：2005-11-14
申请人： Peter Murer , Jean-Pierre Wolf , Stephan Burkhardt , Hansjorg Grutzmacher , Daniel Stein , Kurt Dietliker
发明人： Peter Murer , Jean-Pierre Wolf , Stephan Burkhardt , Hansjorg Grutzmacher , Daniel Stein , Kurt Dietliker
IPC分类号： C07F9/50 , C07C69/66
CPC分类号： G03F7/029 , C07F9/5036 , C07F9/5337 , C07F9/5537 , C07F9/65515 , C07F9/6552
摘要： The invention relates to a process for the preparation of (bis)acylphosphanes of formula I, wherein n and m are each independently of the other 1 or 2; R1 if n=1, is e.g. unsubstituted or substituted C1-C18alkyl or C2-C18alkenyl, or phenyl, R1 if n=2, is e.g. a divalent radical of the monovalent radical defined above; R2 is e.g. C1-C18alkyl, C3-C12cycloalkyl, C2-C18alkenyl, mesityl, phenyl, naphthyl; R3 is one of the radicals defined under R1; the process comprises the steps a) contacting e.g. elemental phosphorous [P]∞, P(Hal)3 with a reducing metal optionally in the presence of a catalyst or an activator in a solvent to obtain metal phosphides Me3P or Me′3P2, wherein Me is an alkali metal and Me′ is an earth alkali metal or to obtain metal polyphosphides b) optionally adding a proton source, optionally in the presence of a catalyst or an activator to obtain metal dihydrogen phosphides MePH2; c) subsequent acylation reaction with m acid halides of formula III or m carboxylic acid esters of formula IV or, in case that in formula I m=1, with one carboxylic ester of formula IV followed by one acid halide of formula III or vice versa, wherein R is the residue of an alcohol and R2 is as defined above; d) alkylation reaction subsequent reaction with an electrophilic agent R1Hal or other electrophilic agents to obtain the compounds of formula I. An oxidation step may follow to obtain mono- and bisacylphosphane oxides or mono- and bisacylphosphane sulfides, which are used as photoinitiators.

5. 发明授权

US08363465B2 High speed low power magnetic devices based on current induced spin-momentum transfer 有权
标题翻译：基于电流感应自旋动量传递的高速低功率磁性装置
公开(公告)号：US08363465B2
公开(公告)日：2013-01-29
申请号：US13041104
申请日：2011-03-04
申请人： Andrew Kent , Daniel Stein , Jean-Marc Beaujour
发明人： Andrew Kent , Daniel Stein , Jean-Marc Beaujour
IPC分类号： G11C11/14
CPC分类号： G11C11/16 , G11C11/161 , G11C11/1673 , G11C11/1675 , G11C11/5607
摘要： A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The mapetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity and/or magnetization direction. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer. The fixed and free magnetic layers may have magnetization directions at a substantially nonzero angle relative to the layer normal. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to read out the information stored in the device.
摘要翻译：一种用于使用自旋极化电流来控制和切换用于存储器单元的磁性装置中的磁区的磁化方向和/或螺旋度的高速和低功率方法。该图解装置包括具有固定磁性螺旋度和/或磁化方向的参考磁性层和具有可变磁性和/或磁化方向的自由磁性层。固定磁性层和自由磁性层优选由非磁性层分离。固定和自由磁性层可以具有相对于层法线基本上非零的角度的磁化方向。可以将电流施加到装置以引起改变装置的磁状态的扭矩，使得其可以用作写入信息的磁存储器。测量取决于装置的磁状态的电阻来读出存储在装置中的信息。

6. 发明申请

US20070249063A1 Biosensors 审中-公开
标题翻译：生物传感器
公开(公告)号：US20070249063A1
公开(公告)日：2007-10-25
申请号：US11214012
申请日：2005-08-30
申请人： Philip Deshong , Douglas English , Daniel Stein , Mridula Kadalbajoo , Fehmi Damkaci
发明人： Philip Deshong , Douglas English , Daniel Stein , Mridula Kadalbajoo , Fehmi Damkaci
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/54346 , G01N33/54326
摘要： Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of the substrate and wherein the ligand preferentially binds to a receptor.
摘要翻译：用于检测生物相互作用的方法，包括施用包含与底物连接的配体的底物，其中配体结合受体并且其中产生信号。还公开了包含底物和配体的生物传感器，其中配体连接到底物的表面，并且其中配体优先与受体结合。

7. 发明授权

US5824098A Patello-femoral joint replacement device and method 失效
标题翻译：髌股关节置换装置及方法
公开(公告)号：US5824098A
公开(公告)日：1998-10-20
申请号：US725394
申请日：1996-10-03
申请人： Daniel Stein
发明人： Daniel Stein
IPC分类号： A61B17/00 , A61B17/15 , A61B17/16 , A61B17/17 , A61F2/00 , A61F2/30 , A61F2/38 , A61F2/46
CPC分类号： A61B17/1728 , A61B17/1764 , A61F2/3877 , A61F2/461 , A61B17/155 , A61B17/1675 , A61B2017/00464 , A61B2017/1602 , A61F2/30767 , A61F2002/30505 , A61F2002/30574 , A61F2002/30616 , A61F2002/30772 , A61F2002/30879 , A61F2002/30884 , A61F2002/30892 , A61F2002/4681 , A61F2220/0025 , A61F2310/00023 , A61F2310/00029 , A61F2310/00449
摘要： A prosthetic system comprising a patellar unit to replace the femoral surface of the patella with a convex prosthesis constructed from a low-friction material and an elongate femoral prosthesis for replacing the trochlear groove without use of bone cement. The femoral prosthesis has a arcuate indentation on its upper surface to accommodate the patellar prosthesis and a lower surface with diverging, protruding vanes. The lower surface and the vanes are made of a biocompatible material that promotes bonding to living bone. The femoral prosthesis is inserted by first driving a guide rod into the distal end of the femur. Then a guide frame is inserted onto the rod to guide an instrument in the cutting of a groove in the trochlear portion of the femur. Then a second guide frame replaces the first guide frame and acts as a template for cutting slots sized to receive the vanes of the prosthesis. Finally, the guide frame and rod are removed, and the prosthesis is slid into the cut groove with the vanes occupying the slots. The prosthesis is fixed in place by an insertable peg with no use of bone cement. Over time the interaction of the bone with the vanes results in tight integration of the prosthesis so that it cannot not be loosened.
摘要翻译：一种假体系统，其包括髌骨单元以用由低摩擦材料和细长股骨假体构成的凸形假体替代髌骨的股骨表面，用于在不使用骨水泥的情况下更换滑车槽。股骨假体在其上表面上具有弓形凹陷以容纳髌骨假体和具有分叉的突出叶片的下表面。下表面和叶片由促进结合活骨的生物相容性材料制成。通过首先将导杆驱动到股骨的远端来插入股骨假体。然后将引导框架插入到杆上以引导器械切割股骨的滑车部分中的凹槽。然后，第二引导框架代替第一引导框架并用作用于切割尺寸适于接纳假体的叶片的狭槽的模板。最后，引导框架和杆被移除，并且假体滑动到切割槽中，叶片占据槽。假体通过可插入的栓固定在适当位置，不使用骨水泥。随着时间的推移，骨骼与叶片的相互作用导致假体的紧密集成，使得它不能松动。

8. 外观设计

USD778375S1 Exercise stretching mat 有权
标题翻译：运动拉伸垫
公开(公告)号：USD778375S1
公开(公告)日：2017-02-07
申请号：US29528426
申请日：2015-05-28
申请人： Daniel Stein
设计人： Daniel Stein

9. 发明授权

US07307876B2 High speed low power annular magnetic devices based on current induced spin-momentum transfer 有权
标题翻译：基于电流感应自旋动量传递的高速低功率环形磁性器件
公开(公告)号：US07307876B2
公开(公告)日：2007-12-11
申请号：US11498303
申请日：2006-08-01
申请人： Andrew Kent , Daniel Stein
发明人： Andrew Kent , Daniel Stein
IPC分类号： G11C11/14
CPC分类号： H01F10/325 , B82Y10/00 , B82Y25/00 , G11C11/161 , G11C11/1673 , G11C11/1675 , G11C11/5607 , H01F10/123 , H01F10/3286 , H01L29/82 , H01L43/08
摘要： A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer, and the reference layer includes an easy axis perpendicular to the reference layer. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to thereby read out the information stored in the device.
摘要翻译：一种用于使用自旋极化电流来控制和切换用于存储器单元的磁性装置中的磁区的磁化方向和/或螺旋度的高速和低功率方法。磁性装置包括具有固定磁性螺旋度和/或磁化方向的参考磁性层和具有可变磁性的自由磁性层。固定磁性层和自由磁性层优选由非磁性层分离，并且参考层包括垂直于参考层的容易轴。可以将电流施加到装置以引起改变装置的磁状态的扭矩，使得其可以用作写入信息的磁存储器。测量取决于装置的磁状态的电阻，从而读出存储在装置中的信息。

10. 发明申请

US20050283027A1 Process for the synthesis of cycloorganylphosphanes and di (alkyli metal/alkaline earth metal)oligophosphanediides 有权
标题翻译：合成环亚烷基磷烷和二（烷基金属/碱土金属）低聚二氧化膦的方法
公开(公告)号：US20050283027A1
公开(公告)日：2005-12-22
申请号：US10535372
申请日：2003-11-24
申请人： Hansjorg Grutzmacher , Jens Geier , Hartmut Schonberg , Markus Scherer , Daniel Stein , Souad Boulmaaz
发明人： Hansjorg Grutzmacher , Jens Geier , Hartmut Schonberg , Markus Scherer , Daniel Stein , Souad Boulmaaz
IPC分类号： C07F9/6564 , C07F9/6568 , C07F9/6596 , C07F9/547
CPC分类号： C07F9/6568 , C07F9/6596
摘要： The invention relates to a process for the preparation of cycloorganylphosphanes of formula 1 (R1P)n by reaction of dihalo(organyl)phosphanes of formula R1PHaI2 with: a) activated zinc in an organic solvent, or with: b) an alkali metal or alkaline earth metal in a non-polar organic solvent in the presence of an activator, wherein R1 is C1-C12alkyl; C3-C12 cycloalkyl, aryl or heteroaryl, Hal is F, Cl, Br or I, and n is a number from 3 to 20. The invention relates also to novel di(alkali metal/alkaline earth metal) oligophosphanediides and to the use thereof in the preparation of organophosphorus compounds.
摘要翻译：本发明涉及通过式R 1的二卤代（有机基）磷烷的反应来制备式1的环氧基磷烷（R 1 P 1）n的方法，其中：a）在有机溶剂中活化的锌，或者在b）碱金属或碱土金属的非极性有机溶剂中，在活化剂存在下，其中 R 1是C 1 -C 12烷基; R 1是C 1 -C 12烷基; C 3 -C 12环烷基，芳基或杂芳基，Hal是F，Cl，Br或I，n是3至20的数。本发明还涉及新型二（碱金属/碱土金属）低聚二氧化膦及其在制备有机磷化合物中的应用。

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