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1. 发明授权

US12076278B2 Method for modifying the refractive index of ocular tissues and applications thereof 有权
$Method for modifying the refractive index of ocular tissues and applications thereof$
公开(公告)号：US12076278B2
公开(公告)日：2024-09-03
申请号：US18198509
申请日：2023-05-17
申请人： University of Rochester
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/008
CPC分类号： A61F9/00827 , A61F9/00834 , A61F2009/00842 , A61F2009/00846 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

2. 发明授权

US10226381B2 Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues 有权
$Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues$
公开(公告)号：US10226381B2
公开(公告)日：2019-03-12
申请号：US15405717
申请日：2017-01-13
申请人： University of Rochester
发明人： Wayne H. Knox , Krystel R. Huxlin , Li Ding
IPC分类号： A61F9/008
摘要： By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.

3. 发明申请

US20170156931A1 MULTI-PHOTON ABSORPTION FOR FEMTOSECOND MICROMACHINING AND REFRACTIVE INDEX MODIFICATION OF TISSUES 审中-公开
公开(公告)号：US20170156931A1
公开(公告)日：2017-06-08
申请号：US15405717
申请日：2017-01-13
申请人： University of Rochester
发明人： Wayne H. Knox , Krystel R. Huxlin , Li Ding
IPC分类号： A61F9/008
CPC分类号： A61F9/00827 , A61F9/008 , A61F9/00804 , A61F9/00829 , A61F2009/00842 , A61F2009/00846 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.

4. 发明申请

US20170035613A1 METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES 审中-公开
标题翻译：修饰眼科组织折射指数的方法
公开(公告)号：US20170035613A1
公开(公告)日：2017-02-09
申请号：US15297560
申请日：2016-10-19
申请人： University of Rochester
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/008
CPC分类号： A61F9/00829 , A61F9/008 , A61F9/00827 , A61F2009/00842 , A61F2009/00851 , A61F2009/0087 , A61F2009/00872 , A61F2009/00897
摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
摘要翻译：一种用于向患者提供视力矫正的方法。该方法包括：（a）测量患者所需的视力矫正度，并确定需要定位在角膜内的折射结构的位置和形状，以部分校正患者的视力; （b）以足够高的强度将飞秒激光脉冲引导和聚焦在角膜内的蓝色光谱区域，以改变焦点区域内的角膜的折射率，但不足以破坏角膜或影响角膜外部的角膜组织焦点区域; 和（c）扫描角膜或透镜体积上的激光脉冲，以在角膜或透镜中提供焦点区域的折射结构。此外，折射结构的特征在于折射率的变化，并且表现出很少或没有散射损失。

5. 发明授权

US11571336B2 Refractive index shaping laser writing process control 有权
$Refractive index shaping laser writing process control$
公开(公告)号：US11571336B2
公开(公告)日：2023-02-07
申请号：US16964477
申请日：2019-01-25
申请人： University of Rochester
发明人： Wayne Knox , Jonathan D. Ellis , Krystel R. Huxlin , Daniel R. Brooks , Kaitlin T. Wozniak
IPC分类号： A61F9/008
摘要： Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes. A real-time process control monitor for detecting emissions from the optical material transmitted through the objective lens at a second wavelength may further be employed while writing the one or more traces.

6. 发明申请

US20210045920A1 METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES AND APPLICATIONS THEREOF 有权
公开(公告)号：US20210045920A1
公开(公告)日：2021-02-18
申请号：US17072286
申请日：2020-10-16
申请人： University of Rochester
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/008
摘要： A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

7. 发明申请

US20140107632A1 METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES 有权
标题翻译：修饰眼科组织折射指数的方法
公开(公告)号：US20140107632A1
公开(公告)日：2014-04-17
申请号：US14109542
申请日：2013-12-17
申请人： UNIVERSITY OF ROCHESTER
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/008
CPC分类号： A61F9/00829 , A61F9/008 , A61F9/00827 , A61F2009/00842 , A61F2009/00851 , A61F2009/0087 , A61F2009/00872 , A61F2009/00897
摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
摘要翻译：一种用于向患者提供视力矫正的方法。该方法包括：（a）测量患者所需的视力矫正度，并确定需要定位在角膜内的折射结构的位置和形状，以部分校正患者的视力; （b）以足够高的强度将飞秒激光脉冲引导和聚焦在角膜内的蓝色光谱区域，以改变焦点区域内的角膜的折射率，但不足以破坏角膜或影响角膜外部的角膜组织焦点区域; 和（c）扫描角膜或透镜体积上的激光脉冲，以在角膜或透镜中提供焦点区域的折射结构。此外，折射结构的特征在于折射率的变化，并且表现出很少或没有散射损失。

8. 发明授权

US08512320B1 Method for modifying the refractive index of ocular tissues 有权
$Method for modifying the refractive index of ocular tissues$
标题翻译：改变眼组织折射率的方法
公开(公告)号：US08512320B1
公开(公告)日：2013-08-20
申请号：US13789755
申请日：2013-03-08
申请人： University of Rochester , Bausch & Lomb Incorporated
发明人： Wayne H. Knox , Krystel R. Huxlin , Jay F. Kunzler , Li Ding
IPC分类号： A61B18/18
CPC分类号： A61F9/00804 , A61F9/008 , A61F9/00829 , A61F2009/00842 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： The invention is directed to a method for correcting vision in a patient by modifying the refractive index of cornea tissue. The method comprises identifying and measuring the degree of vision correction of the patient; and determining the position and type of refractive structures to be written into the cornea tissue of the patient to correct the patient's vision. The refractive structures are written by irradiating select regions of the cornea tissue with focused laser pulses having a wavelength from 400 nm to 900 nm and a pulse energy from 0.01 nJ to 10 nJ. The refractive structures are characterized by a positive change in refractive index in relation to non-irradiated cornea tissue of the patient.
摘要翻译：本发明涉及通过改变角膜组织的折射率来校正患者视力的方法。该方法包括识别和测量患者的视力矫正程度; 以及确定要写入患者的角膜组织中的折射结构的位置和类型以校正患者的视力。通过用波长为400nm至900nm的聚焦激光脉冲和0.01nJ至10nJ的脉冲能量照射角膜组织的选择区域来写入折射结构。折射结构的特征在于与患者的未照射的角膜组织相关的折射率的正变化。

9. 发明申请

US20210052425A1 REFRACTIVE INDEX SHAPING LASER WRITING PROCESS CONTROL 有权
公开(公告)号：US20210052425A1
公开(公告)日：2021-02-25
申请号：US16964477
申请日：2019-01-25
申请人： University of Rochester
发明人： Wayne Knox , Jonathan D. Ellis , Krystel R. Huxlin , Daniel R. Brooks , Kaitlin T. Wozniak
IPC分类号： A61F9/008
摘要： Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes. A real-time process control monitor for detecting emissions from the optical material transmitted through the objective lens at a second wavelength may further be employed while writing the one or more traces.

10. 发明授权

US09492323B2 Method for modifying the refractive index of ocular tissues 有权
$Method for modifying the refractive index of ocular tissues$
公开(公告)号：US09492323B2
公开(公告)日：2016-11-15
申请号：US14109542
申请日：2013-12-17
申请人： UNIVERSITY OF ROCHESTER
发明人： Wayne H. Knox , Krystel R. Huxlin
IPC分类号： A61F9/008
CPC分类号： A61F9/00829 , A61F9/008 , A61F9/00827 , A61F2009/00842 , A61F2009/00851 , A61F2009/0087 , A61F2009/00872 , A61F2009/00897
摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.

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