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1. 发明申请

US20070148746A1 PROCESS FOR THE ENZYMATIC SYNTHESIS OF TRIGLYCERIDES 审中-公开
标题翻译：合成酶的合成方法
公开(公告)号：US20070148746A1
公开(公告)日：2007-06-28
申请号：US11565696
申请日：2006-12-01
申请人： ULRICH SCHOERKEN , Carolin Meyer , Peter Horlacher , Sabine Both
发明人： ULRICH SCHOERKEN , Carolin Meyer , Peter Horlacher , Sabine Both
IPC分类号： C12P7/64 , C07C57/02
CPC分类号： C12P7/6472 , C12P7/6454
摘要： The invention relates to a process for the enzymatic synthesis of esters of polyunsaturated, short-chain or sensitive fatty acids with a high triglyceride content, which is made up of an enzymatic synthesis of the mixture of triglycerides and partial glycerides starting from free fatty acid, methyl or ethyl esters and glycerol, a subsequent selective enzymatic back-hydrolysis of the partial glycerides to fatty acid and glycerol and distillation-based separation of the triglycerides, and to the triglyceride-rich ester mixtures obtainable by this process. The process is preferably carried out as a one-pot process in the same reactor and in the presence of the same enzyme.
摘要翻译：本发明涉及一种用于酶促合成具有高甘油三酯含量的多不饱和，短链或敏感脂肪酸酯的方法，其由甘油三酯和偏甘油酯从游离脂肪酸开始的混合物的酶合成，甲基或乙酯和甘油，随后将部分甘油酯选择性酶促回水解成脂肪酸和甘油，并且基于蒸馏的甘油三酸酯分离，以及通过该方法可获得的富含甘油三酯的酯混合物。该方法优选在同一反应器中和在相同酶存在下作为一锅法进行。

2. 发明授权

US07981641B2 Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes 有权
标题翻译：在酶存在下生产不饱和脂肪酸甘油三酸酯的方法
公开(公告)号：US07981641B2
公开(公告)日：2011-07-19
申请号：US12061005
申请日：2008-04-02
申请人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C12P7/64 , C08L91/00
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form their triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸进行酶催化生产甘油三酸酯的方法，其中（a）在固定化酶存在下，多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中反应形成其甘油三酸酯的方法是通过加入来自弱碱性盐，络合剂和离子交换剂的添加剂和/或加入弱碱性盐和/或以溶剂或气体的形式加入夹带剂和/或添加甘油结合吸附剂和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）除去剩余的脂肪酸和/或其中的C 1-4烷基酯从甘油三酯通过蒸馏，精制或提取。

3. 发明申请

US20080182304A1 PROCESSES FOR THE PRODUCTION OF TRIGLYCERIDES OF UNSATURATED FATTY ACIDS IN THE PRESENCE OF ENZYMES 有权
标题翻译：在酶的存在下生产不饱和脂肪酸的三聚氰胺的方法
公开(公告)号：US20080182304A1
公开(公告)日：2008-07-31
申请号：US12061005
申请日：2008-04-02
申请人： ULRICH SCHOERKEN , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： ULRICH SCHOERKEN , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C12P7/64
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form heir triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸酶催化生产甘油三酸酯的方法，其中（a）多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中的存在下反应，通过从弱碱性盐，络合剂和离子交换剂组中加入添加剂和/或加入弱碱性盐和/或加入溶剂形式的夹带剂来加速形成继承甘油三酯的固定化酶或甘油结合吸附剂的气体和/或加成物和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）剩余的脂肪酸和/或通过蒸馏，精制或萃取，从甘油三酯中除去C 1-4烷基酯。

4. 发明申请

US20050233426A1 Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes 审中-公开
标题翻译：在酶存在下生产不饱和脂肪酸甘油三酸酯的方法
公开(公告)号：US20050233426A1
公开(公告)日：2005-10-20
申请号：US11093410
申请日：2005-03-30
申请人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C11C3/06 , C11C3/10 , C12P7/64
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form their triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸酶催化生产甘油三酸酯的方法，其中（a）多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中的存在下反应，通过从弱碱性盐，络合剂和离子交换剂组中加入添加剂和/或加入弱碱性盐和/或以溶剂形式加入夹带剂来加速形成它们的甘油三酯的固定化酶或甘油结合吸附剂的气体和/或加成物和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）剩余的脂肪酸和/或通过蒸馏，精制或萃取，从甘油三酯中除去C 1-4烷基酯。

5. 发明申请

US20050233427A1 Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes 审中-公开
标题翻译：在酶存在下生产不饱和脂肪酸甘油三酸酯的方法
公开(公告)号：US20050233427A1
公开(公告)日：2005-10-20
申请号：US11093534
申请日：2005-03-30
申请人： Ulrich Schoerken , Carolin Meyer , Sabine Both , Peter Horlacher
发明人： Ulrich Schoerken , Carolin Meyer , Sabine Both , Peter Horlacher
IPC分类号： C11C1/04 , C11C3/06 , C11C3/10 , C12P7/64
CPC分类号： C12P7/6472 , C11C3/06
摘要： Processes for the enzyme-catalyzed synthesis of triglycerides containing polyunsaturated fatty acids in which the synthesis is preceded by a pre-hydrolysis in which (a) C1-4 alkyl esters of polyunsaturated fatty acids are completely or partly hydrolyzed in vacuo with continuous addition of water or are partly hydrolyzed in several stages without vacuum, (b) after the hydrolysis, the water is removed by separation or distillation and (c) the synthesis of the polyunsaturated fatty acids with glycerol in vacuo in the presence of an enzyme to form their triglycerides is carried out under low-water conditions, (d) the enzymes are removed from the triglyceride by separation or filtration and (e) the remaining fatty acids and/or possible residues of C1-4 alkyl esters are removed from the triglyceride by distillation or refining; the pre-hydrolysis and the subsequent synthesis preferably being carried out as a one-pot process in the same reactor and in the presence of the same enzyme.
摘要翻译：用于酶催化合成含有多不饱和脂肪酸的甘油三酯的方法，其中合成之前是预水解，其中（a）多不饱和脂肪酸的C 1-4烷基酯是完全或部分在不加入水的情况下在真空中水解或在几个阶段内没有真空部分水解，（b）水解后，通过分离或蒸馏除去水，和（c）在真空中合成甘油的多不饱和脂肪酸在低水条件下进行酶的形成甘油三酯的存在，（d）通过分离或过滤从甘油三酯中除去酶，和（e）C 1的剩余脂肪酸和/或可能的残基通过蒸馏或精制从甘油三酯中除去-4.0烷基酯; 预水解和随后的合成优选在相同的反应器中和在相同的酶的存在下作为一锅法进行。

6. 发明申请

US20050255570A1 Method for producing conjugated linoleic acid 失效
标题翻译：共轭亚油酸的制备方法
公开(公告)号：US20050255570A1
公开(公告)日：2005-11-17
申请号：US10516987
申请日：2003-05-28
申请人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
发明人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
IPC分类号： C12P7/64 , C12R1/05
CPC分类号： C12P7/6427
摘要： Processes for preparing conjugated linoleic acid are described wherein a conjugated linoleic acid lower alkyl ester is subjected to hydrolysis in the presence of an enzyme to form a hydrolyzate comprising a conjugated linoleic acid and a lower alkanol, wherein at least a portion of the lower alkanol is continuously removed; the hydrolyzate is separated into an organic phase and an aqueous/alcoholic phase; and the conjugated linoleic acid is separated from the organic phase.
摘要翻译：描述制备共轭亚油酸的方法，其中共轭亚油酸低级烷基酯在酶存在下进行水解以形成包含共轭亚油酸和低级链烷醇的水解产物，其中至少一部分低级烷醇为连续删除将水解产物分离成有机相和水相/醇相; 共轭亚油酸与有机相分离。

7. 发明授权

US07138256B2 Processes for preparing conjugated linoleic acid from conjugated linoleic acid esters 失效
标题翻译：从共轭亚油酸酯制备共轭亚油酸的方法
公开(公告)号：US07138256B2
公开(公告)日：2006-11-21
申请号：US10516987
申请日：2003-05-28
申请人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
发明人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
IPC分类号： C12P7/64
CPC分类号： C12P7/6427
摘要： Processes for preparing conjugated linoleic acid are described wherein a conjugated linoleic acid lower alkyl ester is subjected to hydrolysis in the presence of an enzyme to form a hydrolyzate comprising a conjugated linoleic acid and a lower alkanol, wherein at least a portion of the lower alkanol is continuously removed; the hydrolyzate is separated into an organic phase and an aqueous/alcoholic phase; and the conjugated linoleic acid is separated from the organic phase.
摘要翻译：描述制备共轭亚油酸的方法，其中共轭亚油酸低级烷基酯在酶存在下进行水解以形成包含共轭亚油酸和低级链烷醇的水解产物，其中至少一部分低级烷醇为连续删除将水解产物分离成有机相和水相/醇相; 共轭亚油酸与有机相分离。

8. 发明申请

US20060057689A1 Method for producing c4-c12 fatty acids 审中-公开
标题翻译：生产c4-c12脂肪酸的方法
公开(公告)号：US20060057689A1
公开(公告)日：2006-03-16
申请号：US10513812
申请日：2003-04-29
申请人： Ralf Otto , Georg Fieg , Sabine Both , Ulrich Schoerken , Levent Yueksel , Ingomar Mrozek , Carolin Meyer , Norbert Klein , Albrecht Weiss
发明人： Ralf Otto , Georg Fieg , Sabine Both , Ulrich Schoerken , Levent Yueksel , Ingomar Mrozek , Carolin Meyer , Norbert Klein , Albrecht Weiss
IPC分类号： C12P7/64 , C12P7/40
CPC分类号： C12P7/6418 , C12P7/40
摘要： Processes for preparing fatty acids are described wherein a C4-C12 fatty acid methyl ester is subjected to hydrolysis in the presence of an enzyme to form an organic phase comprising a C4-C12 fatty acid and an aqueous phase comprising methanol, wherein at least a portion of the methanol is continuously removed; and the organic phase is subsequently separated from the aqueous phase, and optionally, where the organic phase further comprises an unhydrolyzed portion of the C4-C12 fatty acid methyl ester, the unhydrolyzed portion of the C4-C12 fatty acid methyl ester is separated from the C4-C12 fatty acid.
摘要翻译：描述了制备脂肪酸的方法，其中在酶的存在下使C 4 -C 12脂肪酸甲酯进行水解以形成包含C 脂肪酸和包含甲醇的水相，其中至少部分甲醇被连续除去; 随后将有机相与水相分离，任选地，当有机相进一步包含C 6-14脂肪酸甲酯的未水解部分时，将C 4 -C 12脂肪酸甲酯的未水解部分与C 4 -C 12脂肪酸甲酯分离 >脂肪酸。

9. 发明授权

US09079845B2 Process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil 有权
标题翻译：从粗妥尔油中获得脂肪酸烷基酯，松香酸和甾醇的方法
公开(公告)号：US09079845B2
公开(公告)日：2015-07-14
申请号：US10546426
申请日：2004-02-20
申请人： Setsuo Sato , Henrique Jorge Sousa Sales , Hercules Peloggia , Peter Kempers , Sabine Both , Ulrich Schoerken , Thomas Wolf
发明人： Setsuo Sato , Henrique Jorge Sousa Sales , Hercules Peloggia , Peter Kempers , Sabine Both , Ulrich Schoerken , Thomas Wolf
IPC分类号： C09F7/00 , C07J9/00 , C07J51/00 , C07C51/43 , C07C51/42 , C07C51/44 , C07C67/08 , C07C67/54 , C07J75/00 , C11B13/00 , C11C1/10 , C11C3/00 , C12P7/62 , C12P7/64
CPC分类号： C07C51/42 , C07C51/44 , C07C67/08 , C07C67/54 , C07J9/00 , C07J51/00 , C07J75/00 , C11B13/005 , C11C1/10 , C11C3/003 , C12P7/62 , C12P7/649 , Y02E50/13 , Y02W30/74 , C07C57/26 , C07C61/29 , C07C69/24 , C07C69/58 , C07C69/52 , C07C69/587
摘要： The disclosed invention refers to a process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil (CTO), which is characterized by the following steps: (a) reacting the free fatty acids present in the CTO with lower alcohols; (b) esterifying the sterols in the CTO with boric acid or transesterifying the sterols with a catalyst; (c) separating the fatty acid lower alkyl esters and rosin acids from the remaining sterol borate esters or sterol esters of fatty acids to produce a stream of sterol esters; (d) separating the fatty acid alkyl esters from the rosin acids to produce a first stream of fatty acid alky esters and a second stream of rosin acids; and (e) converting the sterol esters into the free sterols to produce a third stream of free sterols.
摘要翻译：所公开的发明涉及从粗妥质油（CTO）获得脂肪酸烷基酯，松香酸和甾醇的方法，其特征在于以下步骤：（a）使CTO中存在的游离脂肪酸与低级醇反应; （b）用硼酸酯化CTO中的甾醇或用催化剂酯交换甾醇; （c）将脂肪酸低级烷基酯和松香酸与剩余的硼酸酯或脂肪酸甾醇酯分离出来产生一种甾醇酯; （d）将脂肪酸烷基酯与松香酸分离以产生第一个脂肪酸烷基物流和第二个松香酸流; 和（e）将甾醇酯转化成游离甾醇以产生第三游离甾醇流。

10. 发明申请

US20080045606A1 Production and Use of Monoglycerides 有权
标题翻译：单酸甘油酯的生产和使用
公开(公告)号：US20080045606A1
公开(公告)日：2008-02-21
申请号：US11813939
申请日：2006-01-10
申请人： Ulrich Schoerken , Sabine Both , Frank Bongardt , Diana Stuhlmann
发明人： Ulrich Schoerken , Sabine Both , Frank Bongardt , Diana Stuhlmann
IPC分类号： A61K47/12 , A61P43/00 , A61Q99/00 , C12P7/64
CPC分类号： C10L1/191 , A61K47/44 , C10L10/08 , C10M129/76 , C10M2207/289 , C12P7/6445 , C12P7/6472 , C12P7/649 , Y02E50/13
摘要： A higher-yielding process for the production of monoglycerides in which triglycerides are enzymatically reacted with a catalytic amount of an esterase, preferably lipase, that has been activated by the addition of alkaline salts, in the presence of linear or branched alcohols containing 1 to 8 carbon atoms, then the esterase may be deactivated and it and the remaining alcohol removed, with the monoglycerides thus produced useful in lubricants, fuel additives, and emulsifying constituents in foods, and cosmetic and/or pharmaceutical formulations.
摘要翻译：用于生产甘油三酸酯的较高产量的方法，其中甘油三酸酯在催化量的酯酶（优选脂肪酶）中酶催化，其通过加入碱性盐在含有1至8个的直链或支链醇的存在下活化碳原子，那么酯酶可以失活，并且其和除去的剩余的醇与由此产生的单酸甘油酯可用于食品中的润滑剂，燃料添加剂和乳化成分，以及化妆品和/或药物制剂。

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