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1. 发明授权

US11104878B2 Lactic acid bacteria capable of controlling blood sugar and use thereof 有权
公开(公告)号：US11104878B2
公开(公告)日：2021-08-31
申请号：US16303320
申请日：2016-09-07
申请人： University-Industry Cooperation Group of Kyung Hee University
发明人： Dong Hyun Kim , Myung Joo Han , Su Min Lim , Sang Yun Lee
IPC分类号： C12N1/20 , A23L33/135 , A61P1/16 , A61P3/04 , A61P3/10 , A61P29/00 , A61P1/04 , A61K35/00 , C12R1/225
摘要： A Lactobacillus species strain isolated from kimchi or human feces is described. The particular Bacillus species strain described is highly safe by being isolated from kimchi or human feces and has various functionalities, such as excellent blood sugar control activity, anti-obesity activity, blood cholesterol-lowering activity, blood neutral lipid-lowering activity, arteriosclerosis-inhibiting activity or inflammation-inhibiting activity. Accordingly, the particular Bacillus species strain described can be used as a useful food and drug material for preventing, alleviating or treating a metabolic syndrome including diabetes, obesity, fatty liver, glycosuria, hyperlipidemia, cardiovascular disease, hypertension, arteriosclerosis and/or diabetes, an inflammatory disease, and the like.

2. 发明申请

US20150306158A1 LACTIC ACID BACTERIA CAPABLE OF PREVENTING AND/OR TREATING SENESCENCE AND DEMENTIA 审中-公开
标题翻译：可预防和/或治疗感冒和感染的酸性细菌
公开(公告)号：US20150306158A1
公开(公告)日：2015-10-29
申请号：US14421714
申请日：2013-08-16
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人： Dong-Hyun Kim , Myung Joo Han , Il-Hoon Jung , Myung-Ah Jung
IPC分类号： A61K35/747 , C12R1/225 , C12R1/25
CPC分类号： A61K35/747 , A23L33/135 , A61K2035/11 , C12N1/20 , C12R1/225 , C12R1/25
摘要： The present invention provides a novel lactic acid bacterium having antioxidant and anti-aging functions and a dementia alleviation effect, and more specifically, provides Lactobacillus pentosus var. plantarum C29 KCCM11291P and Lactobacillus curvatus C3 KCCM430009. In addition, the present invention provides an antioxidant and anti-aging pharmaceutical composition and a dietary supplement containing the Lactobacillus pentosus var. plantarum C29 KCCM11291P or Lactobacillus curvatus C3 KCCM430009 of the present invention as an active ingredient, and a composition for preventing or treating dementia and a dietary supplement for preventing or alleviating dementia, containing Lactobacillus pentosus var. plantarum C29 KCCM11291P or Lactobacillus curvatus C3 KCCM430009 as an active ingredient. Additionally, the present invention provides a composition for preventing or treating dementia, containg a fermentation composition, as an active ingredient, fermented by Lactobacullus pentosus var. plantarum C29 KCCM11291P or Lactobacillus curvatus C3 KCCM430009.
摘要翻译：本发明提供了具有抗氧化和抗衰老功能和痴呆减轻作用的新型乳酸菌，更具体地说，提供了戊糖乳酸杆菌（Lactobacillus pentosus var。植物乳杆菌C29KCCM11291P和曲霉菌C3CCCM430009。另外，本发明提供了抗氧化剂和抗老化药物组合物和含有戊糖乳杆菌变种的膳食补充剂。本发明的植物油C29KCCM11291P或曲霉菌C3KCCM430009作为活性成分，以及用于预防或治疗痴呆的组合物和用于预防或缓解含有戊糖乳杆菌变种的痴呆的膳食补充剂。植物乳杆菌C29KCCM11291P或曲霉菌C3CCCM430009作为活性成分。另外，本发明提供了一种用于预防或治疗痴呆的组合物，其包含发酵组合物作为活性成分，由乳酸杆菌变种乳杆菌发酵。植物乳杆菌C29KCCM11291P或曲霉菌C3CCCM430009。

3. 发明授权

US12036253B2 Lactic acid bacteria and use thereof 有权
公开(公告)号：US12036253B2
公开(公告)日：2024-07-16
申请号：US18065497
申请日：2022-12-13
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY , NAVIPHARM CO. LTD
发明人： Dong-Hyun Kim , Myung Joo Han
IPC分类号： A61K35/747 , A61K35/00 , A61K35/745 , A61P3/04 , A61P19/10 , A61P25/24 , C12N1/20 , C12R1/25
CPC分类号： A61K35/745 , A61K35/747 , A61P3/04 , A61P19/10 , A61P25/24 , C12N1/20 , A61K2035/115 , C12R2001/25
摘要： The present invention relates to Lactobacillus plantarum NK3 and Bifidobacterium longum NK49, which are novel lactic acid bacteria and, more particularly, to a composition comprising novel lactic acid bacteria useful for prevention and treatment of inflammatory diseases.

4. 发明授权

US11771725B2 有权
公开(公告)号：US11771725B2
公开(公告)日：2023-10-03
申请号：US17455328
申请日：2021-11-17
申请人： University-Industry Cooperation Group of Kyung Hee University , Navipharm Co, Ltd
发明人： Dong Hyun Kim , Myung Joo Han
IPC分类号： A61K35/747 , A23L33/135 , A61K36/48 , C12N1/20 , A61P25/28 , A61K35/745 , C12R1/25 , C12R1/225 , A61K35/00
CPC分类号： A61K35/747 , A23L33/135 , A61K35/745 , A61K36/48 , A61P25/28 , C12N1/205 , A23V2002/00 , A23V2400/151 , A23V2400/169 , A61K2035/115 , C12R2001/225 , C12R2001/25
摘要： The present invention provides novel Lactobacillus sp. strains, novel Bifidobacterium sp. strains, or lactic acid bacteria mixtures thereof, which are isolated from kimchi or human feces. A certain Lactobacillus sp. strain or certain Bifidobacterium sp. strain according to the present invention is isolated from kimchi or human feces, and thus is highly safe, and has various physiological activities such as antioxidant activity, β-glucuronidase inhibitory activity, lipopolysaccharide (LPS) production inhibitory activity or tight junction protein expression-inducing activity. Accordingly, a certain Lactobacillus sp. strain, certain Bifidobacterium sp. strain or mixture thereof according to the present invention may be used as a functional food or medicinal material useful for the prevention, alleviation or treatment of intestinal damage, liver injury, allergic disease, inflammatory disease, or obesity.

5. 发明授权

US11554146B2 Lactic acid bacteria and use thereof 有权
公开(公告)号：US11554146B2
公开(公告)日：2023-01-17
申请号：US16760689
申请日：2018-04-19
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY , NAVIPHARM CO. LTD
发明人： Dong-Hyun Kim , Myung Joo Han
IPC分类号： A61K35/747 , A61K35/745 , A61K35/00 , C12R1/25
摘要： The present invention relates to Lactobacillus plantarum NK3 and Bifidobacterium longum NK49, which are novel lactic acid bacteria and, more particularly, to a composition comprising novel lactic acid bacteria useful for prevention and treatment of inflammatory diseases.

6. 发明授权

US11963988B2 Lactic acid bacteria and use thereof 有权
公开(公告)号：US11963988B2
公开(公告)日：2024-04-23
申请号：US17714955
申请日：2022-04-06
申请人： University-Industry Cooperation Group of Kyung Hee University , Navipharm Co., Ltd.
发明人： Dong Hyun Kim , Myung Joo Han
IPC分类号： A61K35/745 , A23L33/00 , A23L33/125 , A23L33/135 , A61K35/747 , A61P1/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61K35/00
CPC分类号： A61K35/747 , A23L33/125 , A23L33/135 , A23L33/40 , A61K35/745 , A61P1/00 , A61P25/22 , A61P25/24 , A61P25/28 , A23V2002/00 , A23V2400/533 , A61K2035/11
摘要： The present invention relates to the novel lactic acid bacteria Lactobacillus mucosae and Bifidobacterium longum, and specifically, to a composition comprising the novel lactic acid bacteria, the composition enabling the inhibition of the expression of the p16 protein, which is an aging factor, and the inhibition of inflammatory factors, thereby being useful in preventing and treating memory impairment, learning disabilities or mental disorders, and in preventing and treating inflammatory diseases.

7. 发明申请

US20220370523A1 NOVEL LACTIC ACID BACTERIA AND USE THEREOF 有权
公开(公告)号：US20220370523A1
公开(公告)日：2022-11-24
申请号：US17714955
申请日：2022-04-06
申请人： University-Industry Cooperation Group of Kyung Hee University , Navipharm Co., Ltd.
发明人： Dong Hyun Kim , Myung Joo Han
IPC分类号： A61K35/747 , A23L33/125 , A23L33/135 , A23L33/00 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61K35/745
摘要： The present invention relates to the novel lactic acid bacteria Lactobacillus mucosae and Bifidobacterium longum, and specifically, to a composition comprising the novel lactic acid bacteria, the composition enabling the inhibition of the expression of the p16 protein, which is an aging factor, and the inhibition of inflammatory factors, thereby being useful in preventing and treating memory impairment, learning disabilities or mental disorders, and in preventing and treating inflammatory diseases.

8. 发明授权

US11202811B2 Lactobacillus having various functions, and use thereof 有权
公开(公告)号：US11202811B2
公开(公告)日：2021-12-21
申请号：US15759915
申请日：2016-09-07
申请人： University-Industry Cooperation Group of Kyung Hee University , Navipharm Co, Ltd
发明人： Dong Hyun Kim , Myung Joo Han
IPC分类号： A61K35/747 , A23L33/135 , A61K36/48 , C12N1/20 , A61P25/28 , A61K35/745 , C12R1/25 , C12R1/225 , A61K35/00
摘要： The present invention provides novel Lactobacillus sp. strains, novel Bifidobacterium sp. strains, or lactic acid bacteria mixtures thereof, which are isolated from kimchi or human feces. A certain Lactobacillus sp. strain or certain Bifidobacterium sp. strain according to the present invention is isolated from kimchi or human feces, and thus is highly safe, and has various physiological activities such as antioxidant activity, β-glucuronidase inhibitory activity, lipopolysaccharide (LPS) production inhibitory activity or tight junction protein expression-inducing activity. Accordingly, a certain Lactobacillus sp. strain, certain Bifidobacterium sp. strain or mixture thereof according to the present invention may be used as a functional food or medicinal material useful for the prevention, alleviation or treatment of intestinal damage, liver injury, allergic disease, inflammatory disease, or obesity.

9. 发明申请

US20210145902A1 NOVEL LACTIC ACID BACTERIA AND USE THEREOF 有权
公开(公告)号：US20210145902A1
公开(公告)日：2021-05-20
申请号：US16765834
申请日：2018-11-20
申请人： University-Industry Cooperation Group of Kyung Hee University
发明人： Dong Hyun Kim , Myung Joo Han
IPC分类号： A61K35/747 , A61K35/745 , A61P25/24 , A61P25/22 , A61P25/28 , A61P1/00 , A23L33/135 , A23L33/125 , A23L33/00
摘要： The present invention relates to the novel lactic acid bacteria Lactobacillus mucosae and Bifidobacterium longum, and specifically, to a composition comprising the novel lactic acid bacteria, the composition enabling the inhibition of the expression of the p16 protein, which is an aging factor, and the inhibition of inflammatory factors, thereby being useful in preventing and treating memory impairment, learning disabilities or mental disorders, and in preventing and treating inflammatory diseases.

10. 发明授权

US10751381B2 Composition for preventing, relieving or treating colitis, containing complex extracts 有权
公开(公告)号：US10751381B2
公开(公告)日：2020-08-25
申请号：US16216093
申请日：2018-12-11
申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人： Dong Hyun Kim , Myung Joo Han
IPC分类号： A61K36/8964 , A23L2/02 , A23L2/52 , A23L7/10 , A23L33/105 , A23L13/40 , A23L23/00 , A61K36/718 , A61K31/7048
摘要： The present invention relates to a novel use of an Anemarrhena asphodeloides Bunge extract, and the like, and a Rhizoma Coptidis extract, and the like, and specifically, provides a composition for preventing, relieving, or treating colitis, including, as active ingredients: one or more selected from the Anemarrhena asphodeloides Bunge extract, a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract, mangiferin, a pharmaceutically acceptable salt of mangiferin, neomangiferin, or a pharmaceutically acceptable salt of neomangiferin; and one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract.

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