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1. 发明授权

US07602501B2 Interferometric synthetic aperture microscopy 有权
标题翻译：干涉合成孔径显微镜
公开(公告)号：US07602501B2
公开(公告)日：2009-10-13
申请号：US11775572
申请日：2007-07-10
申请人： Tyler S. Ralston , Daniel L. Marks , Paul Scott Carney , Stephen A. Boppart
发明人： Tyler S. Ralston , Daniel L. Marks , Paul Scott Carney , Stephen A. Boppart
IPC分类号： G01B11/02
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measured data to structure of an object to allow solution of an inverse scattering problem based upon the interference signal so that a three-dimensional structure of the sample may be inferred in near real time.
摘要翻译：样品三维成像的方法和装置。提供源于由时间依赖光谱表征的基本上准直的光束的光束。光束聚焦在特征为沿着光束的传播轴的固定位移的平面中，并且来自样本的散射光与从基本上准直的光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。派生前向散射模型将测量数据与对象的结构相关联，以允许基于干扰信号解决反散射问题，从而可以近似实时推断样本的三维结构。

2. 发明申请

US20080140341A1 Interferometric Synthetic Aperture Microscopy 有权
标题翻译：干涉合成孔径显微镜
公开(公告)号：US20080140341A1
公开(公告)日：2008-06-12
申请号：US11775572
申请日：2007-07-10
申请人： Tyler S. Ralston , Daniel L. Marks , Paul Scott Carney , Stephen A. Boppart
发明人： Tyler S. Ralston , Daniel L. Marks , Paul Scott Carney , Stephen A. Boppart
IPC分类号： G01B11/24 , G06F15/00
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measured data to structure of an object to allow solution of an inverse scattering problem based upon the interference signal so that a three-dimensional structure of the sample may be inferred in near real time
摘要翻译：样品三维成像的方法和装置。提供源于由时间依赖光谱表征的基本上准直的光束的光束。光束聚焦在特征为沿着光束的传播轴的固定位移的平面中，并且来自样本的散射光与从基本上准直的光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。派生前向散射模型将测量数据与对象的结构相关联，以便基于干扰信号解决反散射问题，从而可以近似实时推断样本的三维结构

3. 发明申请

US20090086216A1 Partially Coherent Illumination For Inverse Scattering Full-Field Interferometric Synthetic Aperture Microscopy 有权
标题翻译：部分相干照明用于反向散射全场干涉合成孔径显微镜
公开(公告)号：US20090086216A1
公开(公告)日：2009-04-02
申请号：US12131390
申请日：2008-06-02
申请人： Daniel L. Marks , Brynmor J. Davis , Stephen A. Boppart , Paul Scott Carney
发明人： Daniel L. Marks , Brynmor J. Davis , Stephen A. Boppart , Paul Scott Carney
IPC分类号： G01B11/02 , G02B21/00
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of light characterized by partial spatial coherence. The beam is focused onto a sample and scattered light from the sample is superposed with a reference beam derived from the source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measurement data to structure of an object to allow solutions of an inverse scattering problem, based upon the interference signal so that a three-dimensional structure of the same may be inferred. The partial spatial coherence of the source, which may be fixed or variable, may advantageously provide for rejection of multiple scattering artifacts and thus improve image quality.
摘要翻译：样品三维成像的方法和装置。提供了源于以部分空间相干为特征的光束的源。光束被聚焦到样本上，并且来自样本的散射光与从光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。导出将测量数据与对象的结构相关联的前向散射模型，以便基于干扰信号来反演散射问题的解，从而可以推断出该三维结构。可以是固定的或可变的源的部分空间相干性可以有利地提供多个散射假象的抑制，从而提高图像质量。

4. 发明授权

US07643155B2 Partially coherent illumination for inverse scattering full-field interferometric synthetic aperture microscopy 有权
标题翻译：反向散射全场干涉合成孔径显微镜的部分相干照明
公开(公告)号：US07643155B2
公开(公告)日：2010-01-05
申请号：US12131390
申请日：2008-06-02
申请人： Daniel L. Marks , Brynmor J. Davis , Stephen A. Boppart , Paul Scott Carney
发明人： Daniel L. Marks , Brynmor J. Davis , Stephen A. Boppart , Paul Scott Carney
IPC分类号： G01B11/02
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of light characterized by partial spatial coherence. The beam is focused onto a sample and scattered light from the sample is superposed with a reference beam derived from the source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measurement data to structure of an object to allow solutions of an inverse scattering problem, based upon the interference signal so that a three-dimensional structure of the same may be inferred. The partial spatial coherence of the source, which may be fixed or variable, may advantageously provide for rejection of multiple scattering artifacts and thus improve image quality.
摘要翻译：样品三维成像的方法和装置。提供了源于以部分空间相干为特征的光束的源。光束被聚焦到样本上，并且来自样本的散射光与从光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。导出将测量数据与对象的结构相关联的前向散射模型，以便基于干扰信号来反演散射问题的解，从而可以推断出该三维结构。可以是固定的或可变的源的部分空间相干性可以有利地提供多个散射假象的抑制，从而提高图像质量。

5. 发明授权

US08300228B2 Matched pulse stimulated raman scattering 有权
标题翻译：匹配脉冲刺激拉曼散射
公开(公告)号：US08300228B2
公开(公告)日：2012-10-30
申请号：US12582168
申请日：2009-10-20
申请人： Daniel L. Marks , Joseph B. Geddes, III , Stephen A. Boppart
发明人： Daniel L. Marks , Joseph B. Geddes, III , Stephen A. Boppart
IPC分类号： G01B9/02
CPC分类号： G01J3/44 , G01J3/10 , G01J3/4531 , G01J9/02
摘要： Methods and apparatus for selectively driving the vibrations of normal modes of a target molecule into coherence using stimulated Raman scattering. In concert, many vibrations produce a larger anti-Stokes signal than a single vibration. The same illumination does not drive other molecules to have coherent vibrations, so these molecules produce a weaker signal. Target and confounder molecules can be distinguished by pulses that drive many vibrations coherently, with applications in coherent Raman microspectroscopy.
摘要翻译：使用受激拉曼散射选择性地将目标分子的正常模式的振动驱动到相干性的方法和装置。在一致的情况下，许多振动产生比单个振动更大的反斯托克斯信号。相同的照明不会驱使其他分子具有相干的振动，所以这些分子产生较弱的信号。目标和混杂分子可以通过相干拉曼光谱中应用的脉冲来区分。

6. 发明授权

US07586618B2 Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering 有权
标题翻译：在相干斯托克斯和反斯托克斯拉曼散射中区分非谐振四波混频噪声
公开(公告)号：US07586618B2
公开(公告)日：2009-09-08
申请号：US11068739
申请日：2005-02-28
申请人： Daniel L. Marks , Stephen A. Boppart
发明人： Daniel L. Marks , Stephen A. Boppart
IPC分类号： G01J3/45
CPC分类号： G01N21/65 , B33Y80/00 , G01J3/4412 , G01N2021/653 , G01N2021/656
摘要： A method of examining a sample comprises exposing the sample to a pump pulse of electromagnetic radiation for a first period of time, exposing the sample to a stimulant pulse of electromagnetic radiation for a second period of time which overlaps in time with at least a portion of the first exposing, to produce a signal pulse of electromagnetic radiation for a third period of time, and interfering the signal pulse with a reference pulse of electromagnetic radiation, to determine which portions of the signal pulse were produced during the exposing of the sample to the stimulant pulse. The first and third periods of time are each greater than the second period of time.
摘要翻译：检查样品的方法包括将样品暴露于第一时间段的电磁辐射的泵脉冲，将样品暴露于电磁辐射的刺激脉冲持续第二时间段，时间上与至少一部分时间重叠第一次曝光，以产生第三时间段的电磁辐射的信号脉冲，并用电磁辐射的参考脉冲干扰信号脉冲，以确定信号脉冲的哪些部分在样品暴露于兴奋脉冲。第一和第三个时间段都大于第二个时间段。

7. 发明授权

US07623908B2 Nonlinear interferometric vibrational imaging 有权
标题翻译：非线性干涉振动成像
公开(公告)号：US07623908B2
公开(公告)日：2009-11-24
申请号：US10717437
申请日：2003-11-19
申请人： Stephen A. Boppart , Daniel L. Marks
发明人： Stephen A. Boppart , Daniel L. Marks
IPC分类号： A61B6/00
CPC分类号： G01N21/4795 , B33Y80/00 , G01J3/44 , G01N21/65 , G01N2021/653 , G01N2021/656
摘要： A method of examining a sample, which includes: exposing a reference to a first set of electromagnetic radiation, to form a second set of electromagnetic radiation scattered from the reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation. The first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.
摘要翻译：一种检查样本的方法，其包括：暴露对第一组电磁辐射的参考，以形成从参考物散射的第二组电磁辐射; 将样品暴露于第三组电磁辐射以形成从样品散射的第四组电磁辐射; 并且干扰第二组电磁辐射和第四组电磁辐射。从源头产生第一组和第三组电磁辐射; 所述第二组电磁辐射的至少一部分具有与所述第一组电磁辐射的频率不同的频率; 并且第四组电磁辐射的至少一部分具有与第三组电磁辐射不同的频率。

8. 发明授权

US07450243B2 Volumetric endoscopic coherence microscopy using a coherent fiber bundle 有权
公开(公告)号：US07450243B2
公开(公告)日：2008-11-11
申请号：US11656892
申请日：2007-01-23
申请人： Daniel L. Marks , Stephen A. Boppart
发明人： Daniel L. Marks , Stephen A. Boppart
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0086 , A61B5/6852 , G02B6/06 , G02B21/0056 , G02B21/0064 , G02B27/58
摘要： Methods for employing coherent bundles of optical fibers, whether single- or multi-mode, for optical coherence tomography or optical coherence microscopy. Either a substantially monochromatic source or a broadband source is spatially decohered and/or spatially filtered prior to coupling into the fiber bundle for illumination of a sample. A scatter signal from features disposed beneath the surface of the sample is interfered with a reference signal derived, at either end of the fiber bundle, from the identical source of illumination.

9. 发明授权

US08218152B1 Group refractive index reconstruction with broadband interferometric confocal microscopy 有权
$Group refractive index reconstruction with broadband interferometric confocal microscopy$
标题翻译：宽带干涉共聚焦显微镜组折射率重建
公开(公告)号：US08218152B1
公开(公告)日：2012-07-10
申请号：US12326974
申请日：2008-12-03
申请人： Daniel L. Marks , Stephen A. Boppart , Adam M. Zysk , Simon C. Schlachter
发明人： Daniel L. Marks , Stephen A. Boppart , Adam M. Zysk , Simon C. Schlachter
IPC分类号： G01B11/02
CPC分类号： A61B5/0068 , A61B5/0075 , G01B9/02091 , G01N21/45 , G01N2021/1787 , G02B21/0056
摘要： A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical aperture microscope embedded into an interferometer and a spectrometric means, whereby spectral interferograms are analyzed to compute optical path delay of the beam traversing the sample as the sample is translated through the focus of an interrogating light beam. A determination of group refractive index may serve to disambiguate phase ambiguity in a measurement of refractive index at a specified wavelength. Spatial resolution of object characterization in three dimensions is achieved by imaging the object from multiple viewpoints.
摘要翻译：用于样品的组折射率的微观测量和成像的系统和方法。该方法利用嵌入干涉仪和光谱测量装置的宽带共焦高数值孔径显微镜，分析光谱干涉图以计算当样品通过询问光束的焦点平移时穿过样品的光束的光程延迟。组折射率的确定可以用于消除在特定波长处的折射率测量中的相位模糊度。通过从多个视点对对象进行成像，实现三维对象表征的空间分辨率。

10. 发明申请

US20100208252A1 Matched Pulse Stimulated Raman Scattering 有权
标题翻译：匹配脉冲刺激拉曼散射
公开(公告)号：US20100208252A1
公开(公告)日：2010-08-19
申请号：US12582168
申请日：2009-10-20
申请人： Daniel L. Marks , Joseph B. Geddes, III , Stephen A. Boppart
发明人： Daniel L. Marks , Joseph B. Geddes, III , Stephen A. Boppart
IPC分类号： G01J3/44 , G01J3/45
CPC分类号： G01J3/44 , G01J3/10 , G01J3/4531 , G01J9/02
摘要： Methods and apparatus for selectively driving the vibrations of normal modes of a target molecule into coherence using stimulated Raman scattering. In concert, many vibrations produce a larger anti-Stokes signal than a single vibration. The same illumination does not drive other molecules to have coherent vibrations, so these molecules produce a weaker signal. Target and confounder molecules can be distinguished by pulses that drive many vibrations coherently, with applications in coherent Raman microspectroscopy.
摘要翻译：使用受激拉曼散射选择性地将目标分子的正常模式的振动驱动到相干性的方法和装置。在一致的情况下，许多振动产生比单个振动更大的反斯托克斯信号。相同的照明不会驱使其他分子具有相干的振动，所以这些分子产生较弱的信号。目标和混杂分子可以通过相干拉曼光谱中应用的脉冲来区分。

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