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    • 4. 发明授权
    • Pyrimidinedione derivatives and antiarrythmic agents containing the same
    • 嘧啶二酮衍生物和含有它们的抗焦虑剂
    • US5308848A
    • 1994-05-03
    • US927738
    • 1992-08-12
    • Michihiko MiyamotoTsutomu KatakamiNobuya KawauchiTadahito NoboriJoji KamiyaMasaaki Ishii
    • Michihiko MiyamotoTsutomu KatakamiNobuya KawauchiTadahito NoboriJoji KamiyaMasaaki Ishii
    • C07D239/54C07D239/545C07D401/12A61K31/505C07D239/10
    • C07D239/545C07D401/12
    • A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a linking structure comprising an alkyl chain containing two nitrogen atoms. This linking structure is represented by ##STR1## [wherein A is --(CH.sub.2).sub.n --, --CO-- or --O--(CH.sub.2).sub.m --; each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.1 and R.sup.2 may be so linked with each other as to make an alkylene chain and thus form a heterocyclic structure; R.sup.5 is a halogen atom, a hydroxyl group, a lower alkyloxycarbonyl group, a lower alkyloxy group which may be substituted by a lower alkyloxy group, or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.5 may be so linked with R.sup.1 as to make an alkylene chain and thus form a heterocyclic structure; n is 0, 1, 2 or 3 (when R.sup.5 is the hydroxyl group, n.noteq.0); m is 0, 1, 2 or 3; and k is 0, 1, 2 or 3 (however, a compound in which A is --O--(CH.sub.2).sub.m -- and R.sup.5 is the hydroxyl group is excluded from the pyrimidinedione derivative)]. The pyrimidinedione derivative and its acid addition salt are useful for a medical treatment of cardiac arrhythmias.
    • 嘧啶二酮衍生物化合物具有其中苯基部分和嘧啶二酮部分通过包含含有两个氮原子的烷基链的连接结构连接的碱性主链。 该连接结构由表示,其中A是 - (CH 2)n - , - CO-或-O-(CH 2)m - ; R 1和R 2各自独立地为氢原子或可以被羟基取代的低级烷基,或者R 1和R 2可以相互连接形成亚烷基链,从而形成杂环结构; R5是卤素原子,羟基,低级烷氧基羰基,可被低级烷氧基取代的低级烷氧基或可被羟基取代的低级烷基,或R5可以与 R1形成亚烷基链,从而形成杂环结构; n是0,1,2或3(当R5是羟基时,n是等于0); m为0,1,2或3; 并且k为0,1,2或3(然而,其中A为-O-(CH 2)m - 且R 5为羟基的化合物不包括在嘧啶二酮衍生物中]]。 嘧啶二酮衍生物及其酸加成盐可用于治疗心律失常。
    • 9. 发明申请
    • PROCESSOR
    • 处理器
    • US20100011195A1
    • 2010-01-14
    • US12498536
    • 2009-07-07
    • Masaaki Ishii
    • Masaaki Ishii
    • G06F9/38
    • G06F9/3851G06F9/30087G06F9/3009G06F9/3834G06F9/3885
    • A processor includes a plurality of executing sections configured to simultaneously execute instructions for a plurality of threads, an instruction issuing section configured to issue instructions to the plurality of executing sections, and an instruction sync monitoring section configured to, when an instruction-synchronizing instruction is issued to one or more of the plurality of executing sections from the instruction issuing section, monitor completion of execution of the instruction-synchronizing instruction for each of the executing sections, to which the instruction-synchronizing instruction has been issued, thus detecting completion of execution of preceding instructions for the thread to which the instruction-synchronizing instruction belongs. After issuing the instruction-synchronizing instruction, the instruction issuing section stops issuance of succeeding instructions for the thread to which the instruction-synchronizing instruction belongs, until the completion of execution of the preceding instructions for the thread to which the instruction-synchronizing instruction belongs is detected by the instruction sync monitoring section.
    • 处理器包括:多个执行部,被配置为同时执行多个线程的指令;指令发布部,被配置为向多个执行部发出指令;指令同步监视部,被配置为当指令同步指令为 从指令发布部分发出到多个执行部分中的一个或多个执行部分,监视对已经发出指令同步指令的每个执行部分的指令同步指令的执行完成,从而检测执行完成 对于指令同步指令所属的线程的先前指令。 在发出指令同步指令之后,指令发布部分停止向指令同步指令所属的线程发出后续指令,直到对指令同步指令所属的线程的前一条指令的执行完成为止 由指令同步监视部分检测。