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1. 发明申请

US20080241063A1 Combination set of Meta-Iodobenzyl guanidine freezing crystal and making method thereof and method for making a radioactive iodine marker 审中-公开
标题翻译：组合甲基碘苄胍冷冻结晶及其制备方法和制备放射性碘标记物的方法
公开(公告)号：US20080241063A1
公开(公告)日：2008-10-02
申请号：US11727996
申请日：2007-03-29
申请人： Tsai-Yueh Luo , Te-Sheng Liang , Chang-Mau Shing , Shiou-Shiow Farn , Wuu-Jyh Lin , Haw-Jan Chen
发明人： Tsai-Yueh Luo , Te-Sheng Liang , Chang-Mau Shing , Shiou-Shiow Farn , Wuu-Jyh Lin , Haw-Jan Chen
IPC分类号： A61K51/00 , C07C279/02
CPC分类号： A61K51/0406 , A61K51/1282 , C07C279/06
摘要： The present invention relates to a combination set of meta-iodobenzyl guanidine (MIBG) freezing crystal and making method thereof and method of radioactive marker for making. The combination set of freezing crystal includes a first container having freezing crystal and a second container having sodium acetate buffer solution. The method for making a combination set of freezing crystal includes the steps of mixing (meta-iodobenzyl guanidine)2·sulfuric acid and ammonium sulfate into first non-pyrogenic injection water; getting a first container having freezing crystal after freezing and drying; and getting a second container having the sodium acetate buffer solution after sterilizing. The method of radioactive marker for making includes the steps of adding radioactive iodine ion into freezing crystal to react and adding sodium acetate buffer solution to get radioactive MIBG solution. The present invention adjusts agent easily and is instant to use so the radioactive iodine marker don't lose activity easily before using it.
摘要翻译：本发明涉及一种间碘碘苄基胍（MIBG）冷冻结晶的组合及其制备方法和放射性标记物的制备方法。冷冻结晶组合包括具有冷冻晶体的第一容器和具有乙酸钠缓冲溶液的第二容器。制备冷冻结晶组合的方法包括将（间碘碘苄基胍）亚磺酸和硫酸铵混合到第一非致热性注射水中的步骤; 在冷冻和干燥后得到具有冷冻晶体的第一容器; 并在灭菌后得到具有乙酸钠缓冲溶液的第二容器。放射性标记物的制备方法包括将放射性碘离子加入冷冻结晶反应并加入乙酸钠缓冲溶液，得到放射性MIBG溶液的步骤。本发明容易调节剂并且即时使用，所以放射性碘标记物在使用前不容易失去活性。

2. 发明申请

US20070258885A1 Device for concentrating Technetium-99m pertechnetate and method thereof 审中-公开
标题翻译：用于浓缩锝-99m高锝酸盐的装置及其方法
公开(公告)号：US20070258885A1
公开(公告)日：2007-11-08
申请号：US11429194
申请日：2006-05-08
申请人： Tsai-Yueh Luo , Ai-Ren Lo , Wuu-Jyh Lin , Tseng-Chung Huang , Bor-Tsung Hsieh , Ching-Jun Liou
发明人： Tsai-Yueh Luo , Ai-Ren Lo , Wuu-Jyh Lin , Tseng-Chung Huang , Bor-Tsung Hsieh , Ching-Jun Liou
IPC分类号： A61N5/00 , A61K51/00
CPC分类号： G21G4/08 , A61K51/1282 , G21H5/02
摘要： A device for concentrating 99mTc pertechnetate and a method thereof are disclosed. The device includes a concentration device, a control device and a central processing unit. The concentration device is for concentrating 99mTc pertechnetate, the control device connects with each members of the concentration device, and the central processing unit is used for saving an automatic control program. The automatic control program is run by the central processing unit so as to detect and monitor weight as well as activity of the concentrated 99mTc pertechnetate. Due to the automatical control, the concentration quality and production efficiency of the 99mTc pertechnetate are improved. Moreover, the radiation dose received by users is reduced.
摘要翻译：公开了一种用于浓缩超高锝酸盐99m Tc的装置及其方法。该装置包括集中装置，控制装置和中央处理装置。浓缩装置用于浓缩高碘酸钠99m Tc，控制装置与浓缩装置的每个构件连接，中央处理单元用于保存自动控制程序。自动控制程序由中央处理单元运行，以便检测和监测浓缩的99m Tc高温酸盐的重量以及活性。由于自动控制，提高了99m Tc高锝酸盐的浓度质量和生产效率。此外，用户接收的辐射剂量减少。

3. 发明授权

US08142759B2 Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof 有权
标题翻译：用于肝纤维化分级的糖分子成像方法及其糖分子成像剂
公开(公告)号：US08142759B2
公开(公告)日：2012-03-27
申请号：US11954221
申请日：2007-12-12
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14
摘要： The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.
摘要翻译：本发明公开了一种用于肝纤维化等级分类的糖分子成像方法及其糖分子成像剂。结合糖分子成像方法进行肝脏靶向的药物可用于区分肝纤维化分级和治疗效果的随访评估。

4. 发明申请

US20090155169A1 Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof 有权
标题翻译：用于肝纤维化分级的糖分子成像方法及其糖分子成像剂
公开(公告)号：US20090155169A1
公开(公告)日：2009-06-18
申请号：US11954221
申请日：2007-12-12
申请人： MEI-HUI WANG , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
发明人： MEI-HUI WANG , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
IPC分类号： A61K51/08 , A61K49/00 , A61K49/14
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14
摘要： The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.
摘要翻译：本发明公开了一种用于肝纤维化等级分类的糖分子成像方法及其糖分子成像剂。结合糖分子成像方法进行肝脏靶向的药物可用于区分肝纤维化分级和治疗效果的随访评估。

5. 发明申请

US20160113884A1 Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 有权
标题翻译：辐射敏感性纳米粒子和化疗药物辐射敏感性共聚物载体的制备方法
公开(公告)号：US20160113884A1
公开(公告)日：2016-04-28
申请号：US14522583
申请日：2014-10-24
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
IPC分类号： A61K9/51 , A61K31/704
CPC分类号： A61K9/5146 , A61K9/5192 , A61K31/704
摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.
摘要翻译：用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒，在质子治疗期间质子穿透组织。质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强杀死肿瘤的癌细胞。

6. 发明授权

US08043584B2 Method of recycling Cd-112 isotope 有权
公开(公告)号：US08043584B2
公开(公告)日：2011-10-25
申请号：US11812984
申请日：2007-06-22
申请人： Wuu-Jyh Lin , Song-Un Tang
发明人： Wuu-Jyh Lin , Song-Un Tang
IPC分类号： C22B17/00
CPC分类号： C01G11/00
摘要： Cd-112 isotope is recycled from a Cd-112 chemical separated solution or a remainder of an electroplating solution having a Cd-112 target. The present invention recycles Cd-112 isotope with a low cost, a high purity and a high recycle rate. The recycled Cd-112 isotope can be easily stored. And, the Cd-112 isotope can be used as an imaging agent in nuclear medicine.

7. 发明授权

US08007730B2 Synthetic method and automation device for fluorine-18-ACETATE 有权
标题翻译：氟-18-ACETATE的合成方法和自动化装置
公开(公告)号：US08007730B2
公开(公告)日：2011-08-30
申请号：US12478787
申请日：2009-06-05
申请人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
发明人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
IPC分类号： G21C1/00 , G05B1/00 , G05D16/00 , B01J19/00
CPC分类号： B01J19/004
摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
摘要翻译：用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。操作非常简单，可以有效提高生产效率。

8. 发明申请

US20100216207A1 Apparatus and method for growing algae by ionizing radiation 审中-公开
标题翻译：通过电离辐射生长藻类的装置和方法
公开(公告)号：US20100216207A1
公开(公告)日：2010-08-26
申请号：US11979097
申请日：2007-10-30
申请人： Yean-Chang Chen , Kuan-Yin Chen , Chia-Chieh Chen , Bin Lin , Hsueh-Hsuan Liu , Meng-Chou Lee , Wuu-Jyh Lin , Ying-Kai Fu , Lie-Hang Shen , Wen-Song Hwang , Ming-Chao Kuo , Wei-Hsi Chen , Te-Hsing Wu
发明人： Yean-Chang Chen , Kuan-Yin Chen , Chia-Chieh Chen , Bin Lin , Hsueh-Hsuan Liu , Meng-Chou Lee , Wuu-Jyh Lin , Ying-Kai Fu , Lie-Hang Shen , Wen-Song Hwang , Ming-Chao Kuo , Wei-Hsi Chen , Te-Hsing Wu
IPC分类号： C12N13/00 , C12M1/12
CPC分类号： C12N1/36 , A01G33/00 , C12N1/12 , C12N13/00 , Y02A40/88
摘要： An apparatus is disclosed for growing algae by ionizing radiation. The apparatus includes a container for containing medium for the growth of algae, a filter disposed in the container, a 3-dimensional rack disposed in the container, an adherent element wound on the 3-dimension rack so that spores of the algae can be planted in the adherent element, a radiation element disposed in the container for irradiating the spores and a timepiece connected to the radiation element.
摘要翻译：公开了通过电离辐射来生长藻类的装置。该装置包括用于容纳藻类生长的容器的容器，设置在容器中的过滤器，设置在容器中的3维齿条，缠绕在3维齿条上的粘附元件，以便能种植藻类的孢子在粘合元件中，设置在容器中用于照射孢子的辐射元件和连接到辐射元件的钟表。

9. 发明申请

US20080041719A1 Circulated cooled target 有权
标题翻译：循环冷却目标
公开(公告)号：US20080041719A1
公开(公告)日：2008-02-21
申请号：US11500936
申请日：2006-08-09
申请人： Wuu-Jyh Lin , Mao-Hsung Chang , Ping-Yen Huang , Jenn-Tzong Chen , Ting-Shien Duh , Dow-Che Chen , Kuo-Yuan Chu
发明人： Wuu-Jyh Lin , Mao-Hsung Chang , Ping-Yen Huang , Jenn-Tzong Chen , Ting-Shien Duh , Dow-Che Chen , Kuo-Yuan Chu
IPC分类号： C23C14/00
CPC分类号： H01J37/3497 , H01J37/3435
摘要： A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.
摘要翻译：液体和气体不断地被填充到目标的靶室中。然后液体和气体流过室并流出。通过这样做，目标被有效地冷却下来。

10. 发明授权

US09040017B2 Liver-receptor imaging injection, dispensing method and pharmaceutical composition thereof 有权
标题翻译：肝 - 受体成像注射，分配方法及其药物组合物
公开(公告)号：US09040017B2
公开(公告)日：2015-05-26
申请号：US13243225
申请日：2011-09-23
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Hung-Man Yu , Chuan-Yi Chien , Ping-Yen Wang
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Hung-Man Yu , Chuan-Yi Chien , Ping-Yen Wang
IPC分类号： A61K51/04 , A61K51/06
CPC分类号： A61K51/0491 , A61K51/0406 , A61K51/0497 , A61K51/065
摘要： The present invention is related to a pharmaceutical composition for a liver-receptor imaging injection, the pharmaceutical composition including a bi-functional compound which has a ASGPR specificity, wherein the bi-functional compound includes a backbone of alpha-amino acid (or the derivatives thereof) and a poly-galactosamine chain (or a poly-lactose chain) connected to the alpha-amino acid. Thereby, the pharmaceutical composition can quantify potential of liver storage ability and evaluate severity of the course of liver disease. A liver-receptor imaging injection using the same and the one-step dispensing method thereof are also provided to improve defects of iodine-labeled and overcome disadvantages of the reduced labeling-yield and the instability after autoclave sterilization.
摘要翻译：本发明涉及一种肝 - 受体成像注射用药物组合物，该药物组合物包含具有ASGPR特异性的双功能化合物，其中双官能化合物包括α-氨基酸（或其衍生物）和与α-氨基酸连接的聚半乳糖胺链（或聚乳糖链）。因此，药物组合物可以量化肝脏储存能力的潜力并评估肝脏疾病过程的严重程度。还提供使用其的肝受体成像注射器及其一步式分配方法，以改善碘标记的缺陷，克服降压标记产率和高压灭菌后的不稳定性的缺点。

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