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1. 发明授权

US08142759B2 Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof 有权
标题翻译：用于肝纤维化分级的糖分子成像方法及其糖分子成像剂
公开(公告)号：US08142759B2
公开(公告)日：2012-03-27
申请号：US11954221
申请日：2007-12-12
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14
摘要： The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.
摘要翻译：本发明公开了一种用于肝纤维化等级分类的糖分子成像方法及其糖分子成像剂。结合糖分子成像方法进行肝脏靶向的药物可用于区分肝纤维化分级和治疗效果的随访评估。

2. 发明申请

US20090155169A1 Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof 有权
标题翻译：用于肝纤维化分级的糖分子成像方法及其糖分子成像剂
公开(公告)号：US20090155169A1
公开(公告)日：2009-06-18
申请号：US11954221
申请日：2007-12-12
申请人： MEI-HUI WANG , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
发明人： MEI-HUI WANG , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
IPC分类号： A61K51/08 , A61K49/00 , A61K49/14
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14
摘要： The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.
摘要翻译：本发明公开了一种用于肝纤维化等级分类的糖分子成像方法及其糖分子成像剂。结合糖分子成像方法进行肝脏靶向的药物可用于区分肝纤维化分级和治疗效果的随访评估。

3. 发明申请

US20070014718A1 Kits for gastric emptying measurement 审中-公开
标题翻译：胃排空测量试剂盒
公开(公告)号：US20070014718A1
公开(公告)日：2007-01-18
申请号：US11180516
申请日：2005-07-14
申请人： Shui-Cheng Lee , Tung-Chian Chiang , Shiou-Shiow Farn , Mei-Hui Wang
发明人： Shui-Cheng Lee , Tung-Chian Chiang , Shiou-Shiow Farn , Mei-Hui Wang
IPC分类号： A61K51/00 , A61K49/00
CPC分类号： A61K51/1296 , A61K49/0004 , A61K51/1206
摘要： The present invention provides a test meal kits that are used in the diagnosis of gastrointestinal disorders characterized by changes in the rate of gastric emptying; and, with a breath test or a nuclear scintigraphy scan, are used to measure a half-gastric emptying time useful for therapy monitoring of gastrointestinal disorders in clinical.
摘要翻译：本发明提供了一种用于诊断以胃排空率变化为特征的胃肠道疾病的测试餐具，并且通过呼吸试验或核扫描扫描来测量可用于临床上胃肠道疾病的治疗监测的半胃排空时间。

4. 发明授权

US08691189B2 Method of colorectal cancer detection by using radiolabeled anti-GRP78 peptide 有权
标题翻译：通过使用放射性标记抗GRP78肽的结肠直肠癌检测方法
公开(公告)号：US08691189B2
公开(公告)日：2014-04-08
申请号：US13026471
申请日：2011-02-14
申请人： Siao-Syun Guan , Chun-Chia Cheng , Shui-Cheng Lee , Hsien-Ming Wu
发明人： Siao-Syun Guan , Chun-Chia Cheng , Shui-Cheng Lee , Hsien-Ming Wu
IPC分类号： A61K49/04 , A61K49/00 , A61K49/14 , A61K38/08 , C07K7/06
CPC分类号： A61K49/0004 , A61K38/08 , A61K49/14 , A61K51/08 , C07K7/06
摘要： The present disclosure describes techniques used for colorectal cancer detection. Position and distribution of colorectal cancer tumor are detected through nuclear imaging. Alternatively, stage of colorectal cancer is identified by shading value in tumor. Thus, the present disclosure provides a safe and noninvasive clinical method for diagnosing and tracing level and distribution of colorectal cancer before and after treatment.
摘要翻译：本公开描述了用于结肠直肠癌检测的技术。通过核成像检测结直肠癌肿瘤的位置和分布。或者，通过肿瘤中的阴影值鉴定结肠直肠癌的阶段。因此，本公开提供了用于诊断和追踪治疗前后结肠直肠癌水平和分布的安全和无创的临床方法。

5. 发明申请

US20100323374A1 Serum Biomarkers for Diagnosing Liver Fibrosis and Method for Measuring the Same 审中-公开
标题翻译：用于诊断肝纤维化的血清生物标志物及其测量方法
公开(公告)号：US20100323374A1
公开(公告)日：2010-12-23
申请号：US12618882
申请日：2009-11-16
申请人： Chun-Chia Cheng , Shui-Cheng Lee , Shiao-shiun Guan
发明人： Chun-Chia Cheng , Shui-Cheng Lee , Shiao-shiun Guan
IPC分类号： G01N33/53 , G01N33/92 , C07K14/00
CPC分类号： G01N33/6893 , G01N33/576 , G01N2800/085
摘要： Disclosed are serum biomarkers for diagnosing liver fibrosis and methods for measuring the same. The serum biomarkers obtained from human serum include alpha2-macroglobulin (“A2M”), vitamin D binding protein (“VDBP”), apolipoprotein AI (“ApoAI”). The methods involve with immunoassay using specific antibodies to detect the biomarkers, including enzyme-linked immunosorbent assay (“ELISA”), radio immune assay (“RIA”) and flexible multi-analyte profiling (“xMAP”). ELISA, RIA or xMAP is used to measure changes of protein concentration for the specific protein biomarkers in serum for diagnosing liver fibrosis with suffering hepatitis B or C or other liver diseases. The measurement is safe and accurate. The method can be used before and after treatment of liver fibrosis. Thus, it is possible to achieve early diagnosis and treatment advocated in the preventive medicine.
摘要翻译：公开了用于诊断肝纤维化的血清生物标志物及其测量方法。从人血清获得的血清生物标志物包括α2-巨球蛋白（“A2M”），维生素D结合蛋白（“VDBP”），载脂蛋白AI（“ApoAI”）。该方法包括使用特异性抗体进行免疫测定以检测生物标志物，包括酶联免疫吸附测定（“ELISA”），放射免疫测定（“RIA”）和柔性多分析物分析（“xMAP”）。 ELISA，RIA或xMAP用于测量血清中特异性蛋白质生物标志物的蛋白质浓度变化，以诊断患有乙型肝炎或C型肝炎或其他肝脏疾病的肝纤维化。测量安全准确。该方法可用于肝纤维化治疗前后。因此，可以实现预防医学中倡导的早期诊断和治疗。

6. 发明授权

US08551735B2 Method of diagnosing gastric cancer by using human neutrophil peptide 1-3 有权
标题翻译：使用人嗜中性粒细胞肽1-3诊断胃癌的方法
公开(公告)号：US08551735B2
公开(公告)日：2013-10-08
申请号：US12942126
申请日：2010-11-09
申请人： Chun-Chia Cheng , Shui-Cheng Lee
发明人： Chun-Chia Cheng , Shui-Cheng Lee
IPC分类号： C12P21/04
CPC分类号： G01N33/57446 , G01N2333/4721 , G01N2560/00
摘要： Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS). Then, three differential biomarkers, including HNP-1, -2 and -3, are identified (P
摘要翻译：用作诊断和治疗分子探针的人嗜中性粒细胞肽（HNP）1-3可见于胃癌患者的临床组织。在根据本公开的分析过程中，使用胃癌组织对通过基于基质辅助激光解吸电离成像质谱（MALDI-IMS）的蛋白质组学策略来寻找推定的生物标志物。然后，鉴定出三种差异生物标志物（包括HNP-1，-2和-3）（P <0.001），并在胃癌中过表达。最后，Western印迹和免疫组织化学法检测胃癌组织中的蛋白表达。总之，上调蛋白HNP1-3的使用有助于诊断和治疗临床胃癌的敏感性和特异性。

7. 发明申请

US20120115178A1 Method of Diagnosing Gastric Cancer by Using Human Neutrophil Peptide 1-3 有权
标题翻译：使用人中性粒细胞肽诊断胃癌的方法1-3
公开(公告)号：US20120115178A1
公开(公告)日：2012-05-10
申请号：US12942126
申请日：2010-11-09
申请人： Chun-Chia Cheng , Shui-Cheng Lee
发明人： Chun-Chia Cheng , Shui-Cheng Lee
IPC分类号： C12Q1/02
CPC分类号： G01N33/57446 , G01N2333/4721 , G01N2560/00
摘要： Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS). Then, three differential biomarkers, including HNP-1, -2 and -3, are identified (P
摘要翻译：用作诊断和治疗分子探针的人嗜中性粒细胞肽（HNP）1-3可见于胃癌患者的临床组织。在根据本公开的分析过程中，使用胃癌组织对通过基于基质辅助激光解吸电离成像质谱（MALDI-IMS）的蛋白质组学策略来寻找推定的生物标志物。然后，鉴定出三种差异生物标志物（包括HNP-1，-2和-3）（P <0.001），并在胃癌中过表达。最后，Western印迹和免疫组织化学法检测胃癌组织中的蛋白表达。总之，上调蛋白HNP1-3的使用有助于诊断和治疗临床胃癌的敏感性和特异性。

8. 发明申请

US20130109580A1 High-Affinity Peptide Probes for Tumor Biomarker, GRP-78, and Screening Method Thereof 审中-公开
标题翻译：用于肿瘤生物标志物的高亲和力肽探针，GRP-78及其筛选方法
公开(公告)号：US20130109580A1
公开(公告)日：2013-05-02
申请号：US13283704
申请日：2011-10-28
申请人： Chia-Hung Huang , Shui-Cheng Lee , Pei-Tzu Ku , Ker-Jer Huang
发明人： Chia-Hung Huang , Shui-Cheng Lee , Pei-Tzu Ku , Ker-Jer Huang
IPC分类号： C40B30/04 , C40B40/10
CPC分类号： G01N33/57484 , C07K5/0815 , C07K5/1019 , C07K7/06
摘要： Peptide ligands are found. All of the peptide ligands have high-affinity against a tumor biomarker, GRP-78. Phage display library is used for screening out the peptide ligands. The peptide ligands can be labeled with a luminescent or a radioactive material to be used as probes for detecting tumor.
摘要翻译：发现肽配体。所有肽配体对肿瘤生物标志物GRP-78具有高亲和力。噬菌体展示文库用于筛选肽配体。肽配体可以用发光或放射性物质进行标记，以用作检测肿瘤的探针。

9. 发明申请

US20120288442A1 Nuclear Imaging Method Using Molecular Target Detection Agent for Liver Fibrosis 审中-公开
标题翻译：使用分子靶标检测剂进行肝纤维化的核成像方法
公开(公告)号：US20120288442A1
公开(公告)日：2012-11-15
申请号：US13105019
申请日：2011-05-11
申请人： Chun-Chia Cheng , Shui-Cheng Lee , Pei-Chih Ku
发明人： Chun-Chia Cheng , Shui-Cheng Lee , Pei-Chih Ku
IPC分类号： A61K51/10 , A61K49/00
CPC分类号： A61K51/1027 , A61K49/0058
摘要： A method for diagnosing liver fibrosis is provided. A monoclonal antibody and an antagonist of cannabinoid receptor in liver fibrosis cell are labeled. The monoclonal antibody or the antagonist is injected for nuclear imaging. Thus, through the image obtained through the nuclear imaging, liver fibrosis is diagnosed and traced in clinic use for preventive medicine.
摘要翻译：提供了一种诊断肝纤维化的方法。标记肝纤维化细胞中的单克隆抗体和大麻素受体的拮抗剂。注射单克隆抗体或拮抗剂用于核成像。因此，通过核成像获得的图像，肝纤维化在临床使用中被诊断和追踪用于预防医学。

10. 发明申请

US20120207675A1 Method of Colorectal Cancer Detection by Using Radiolabeled Anti-GRP78 Peptide 有权
标题翻译：通过使用放射性标记抗GRP78肽的结肠直肠癌检测方法
公开(公告)号：US20120207675A1
公开(公告)日：2012-08-16
申请号：US13026471
申请日：2011-02-14
申请人： Siao-Syun Guan , Chun-Chia Cheng , Shui-Cheng Lee , Hsien-Ming Wu
发明人： Siao-Syun Guan , Chun-Chia Cheng , Shui-Cheng Lee , Hsien-Ming Wu
IPC分类号： A61K51/08
CPC分类号： A61K49/0004 , A61K38/08 , A61K49/14 , A61K51/08 , C07K7/06
摘要： The present disclosure describes techniques used for colorectal cancer detection. Position and distribution of colorectal cancer tumor are detected through nuclear imaging. Alternatively, stage of colorectal cancer is identified by shading value in tumor. Thus, the present disclosure provides a safe and noninvasive clinical method for diagnosing and tracing level and distribution of colorectal cancer before and after treatment.
摘要翻译：本公开描述了用于结肠直肠癌检测的技术。通过核成像检测结直肠癌肿瘤的位置和分布。或者，通过肿瘤中的阴影值鉴定结肠直肠癌的阶段。因此，本公开提供了一种用于诊断和追踪治疗前后结肠直肠癌水平和分布的安全无创的临床方法。

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