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1. 发明申请

US20130265359A1 INKJET RECORDING DEVICE 有权
标题翻译：喷墨记录装置
公开(公告)号：US20130265359A1
公开(公告)日：2013-10-10
申请号：US13993043
申请日：2011-12-08
申请人： Toyoaki Sugaya , Mitsuru Obata , Hiroya Kimoto , Takashi Muramatsu , Masakazu Date , Akio Maeda
发明人： Toyoaki Sugaya , Mitsuru Obata , Hiroya Kimoto , Takashi Muramatsu , Masakazu Date , Akio Maeda
IPC分类号： B41J11/00
CPC分类号： B41J11/002 , B41J11/009 , B41J13/223
摘要： An inkjet recording device includes an image forming drum, a recording medium supplying section, a recording head which ejects ink onto a recording medium, a first heating unit which heats the recording medium held on the drum before image recording, a second heating unit which heats the drum downstream of the position at which the recording medium is outputted after image recording and upstream of the supplying section, a heating-unit temperature detector, a drum temperature detector, and a heating control section. The heating control section performs heat control of the first heating unit such that the temperature detected by the heating-unit temperature detector falls within a predetermined set temperature range, and performs heat control of the second heating unit such that the temperature detected by the drum temperature detector falls within a predetermined set temperature range.
摘要翻译：喷墨记录装置包括图像形成鼓，记录介质供给部，将墨喷射到记录介质上的记录头，在图像记录之前加热保持在滚筒上的记录介质的第一加热单元，加热第二加热单元在图像记录之后输出记录介质的位置下游的鼓，在供应部分的上游，加热单元温度检测器，滚筒温度检测器和加热控制部分。加热控制部进行第一加热单元的热控制，使得由加热单元温度检测器检测出的温度落在规定的设定温度范围内，进行第二加热单元的热控制，使得由滚筒温度检测到的温度检测器落在预定的设定温度范围内。

2. 发明授权

US08814347B2 Inkjet recording device 有权
标题翻译：喷墨记录装置
公开(公告)号：US08814347B2
公开(公告)日：2014-08-26
申请号：US13993043
申请日：2011-12-08
申请人： Toyoaki Sugaya , Mitsuru Obata , Hiroya Kimoto , Takashi Muramatsu , Masakazu Date , Akio Maeda
发明人： Toyoaki Sugaya , Mitsuru Obata , Hiroya Kimoto , Takashi Muramatsu , Masakazu Date , Akio Maeda
IPC分类号： B41J2/01
CPC分类号： B41J11/002 , B41J11/009 , B41J13/223
摘要： An inkjet recording device includes an image forming drum, a recording medium supplying section, a recording head which ejects ink onto a recording medium, a first heating unit which heats the recording medium held on the drum before image recording, a second heating unit which heats the drum downstream of the position at which the recording medium is outputted after image recording and upstream of the supplying section, a heating-unit temperature detector, a drum temperature detector, and a heating control section. The heating control section performs heat control of the first heating unit such that the temperature detected by the heating-unit temperature detector falls within a predetermined set temperature range, and performs heat control of the second heating unit such that the temperature detected by the drum temperature detector falls within a predetermined set temperature range.
摘要翻译：喷墨记录装置包括图像形成鼓，记录介质供给部，将墨喷射到记录介质上的记录头，在图像记录之前加热保持在滚筒上的记录介质的第一加热单元，加热第二加热单元在图像记录之后输出记录介质的位置下游的鼓，在供应部分的上游，加热单元温度检测器，滚筒温度检测器和加热控制部分。加热控制部进行第一加热单元的热控制，使得由加热单元温度检测器检测出的温度落在规定的设定温度范围内，进行第二加热单元的热控制，使得由滚筒温度检测到的温度检测器落在预定的设定温度范围内。

3. 发明授权

US08288343B2 Activation of endothelial nitric oxide synthase by midkine and uses therefor in effecting vasodilation 有权
标题翻译：通过中期因子激活内皮一氧化氮合酶，并用于实现血管舒张
公开(公告)号：US08288343B2
公开(公告)日：2012-10-16
申请号：US12593277
申请日：2008-03-28
申请人： Mitsuru Horiba , Kenji Kadomatsu , Itsuo Kodama , Takashi Muramatsu , Hisaaki Ishiguro , Hiroharu Takenaka , Arihiro Sumida
发明人： Mitsuru Horiba , Kenji Kadomatsu , Itsuo Kodama , Takashi Muramatsu , Hisaaki Ishiguro , Hiroharu Takenaka , Arihiro Sumida
IPC分类号： A61K38/00 , A61K38/22 , A61K38/16
CPC分类号： C07K14/475 , A61K38/00
摘要： The object is to find a nitric oxide synthase activator, a method for the administration of the activator, and the amount of the activator to be administered. Disclosed is a nitric oxide synthase activator comprising a midkine family protein or a midkine derivative as an active ingredient. Specifically disclosed is a nitric oxide synthase activator which is intended to be administered through the blood, a coronary artery or a vein and which comprises a midkine family protein or a midkine derivative as an active ingredient.
摘要翻译：目的是找到一氧化氮合酶激活剂，给予激活剂的方法和待施用的活化剂的量。公开了包含中期因子家族蛋白或中期因子衍生物作为活性成分的一氧化氮合酶激活剂。具体公开了旨在通过血液，冠状动脉或静脉施用的一氧化氮合酶激活剂，其包含中期因子家族蛋白或中期因子衍生物作为活性成分。

4. 发明授权

US07601348B2 Method of examining colon cancer and colon adenoma 失效
标题翻译：检查结肠癌和结肠腺瘤的方法
公开(公告)号：US07601348B2
公开(公告)日：2009-10-13
申请号：US10568544
申请日：2004-07-09
申请人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
发明人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
IPC分类号： A61K39/395
CPC分类号： G01N33/57419 , G01N2333/91097 , G01N2400/02
摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.
摘要翻译：本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂其中。本发明人发现，GlcNAc-6-磺基转移酶同工酶，糖残基的硫酸化酶在非癌结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织中的分布存在显着差异。此外，本发明人将该发现应用于诊断，并发现通过测定来自患者或粪便样品的组织中GlcNAc-6-硫酸化糖残基的确定范围来特异性检测结肠直肠癌和腺瘤。与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查结肠直肠癌和结直肠腺瘤。

5. 发明申请

US20090215937A1 Aqueous Resin Composition 审中-公开
标题翻译：水性树脂组合物
公开(公告)号：US20090215937A1
公开(公告)日：2009-08-27
申请号：US12224304
申请日：2007-03-07
申请人： Noriyuki Kikuchi , Yasunori Terunuma , Takashi Muramatsu , Mikio Akimoto , Kazuo Nobuchika , Tadashige Nakamoto
发明人： Noriyuki Kikuchi , Yasunori Terunuma , Takashi Muramatsu , Mikio Akimoto , Kazuo Nobuchika , Tadashige Nakamoto
IPC分类号： C08K5/09 , C08F22/00
CPC分类号： C08L23/0869 , C08K5/17 , C08K5/29 , C08K5/54 , C08L33/02 , C08L35/00 , C08L83/04 , C09D123/0869 , C08L2666/06 , C08L83/00 , C08L2666/04
摘要： There is provided a practically useful aqueous resin composition which enables to obtain a coating film is satisfactory not only in corrosion resistance but also in coating adhesion when applied over a metal surface, specifically an aqueous resin composition which enables, in a form of a thin film having a thickness of about 0.1-5 μm, to exhibit various properties practically required for surface treating agents for chromium-free surface-treated steel plates, namely excellent corrosion resistance, adhesion to steel plates, durability against alkaline degreasing agents or solvents which are used for removing a press oil used during press molding, adhesion to an overcoating material which is used for aesthetic purposes, mechanical stability and the like. The aqueous resin composition comprises 100 parts by mass of a copolymer of an α,β-ethylenically unsaturated carboxylic acid and an olefin; and 0.1-10 parts by mass of a carboxylic acid polymer
摘要翻译：提供了一种实用有用的水性树脂组合物，其能够获得涂膜不仅在耐腐蚀性方面也是令人满意的，而且在涂覆在金属表面上时的涂层粘合性，特别是能够以薄膜形式的水性树脂组合物具有约0.1-5μm的厚度，以表现出对于无铬表面处理钢板的表面处理剂实际上需要的各种性能，即优异的耐腐蚀性，对钢板的粘合性，对碱性脱脂剂或溶剂的耐久性用于除去在压制成型期间使用的压榨油，与用于美学目的的外涂层材料的粘合性，机械稳定性等。含水树脂组合物包含100质量份α，β-烯键式不饱和羧酸和烯烃的共聚物; 和0.1-10质量份羧酸聚合物

6. 发明申请

US20090047319A1 Pharmaceutical composition for obstructive vascular disease 审中-公开
标题翻译：阻塞性血管疾病的药物组合物
公开(公告)号：US20090047319A1
公开(公告)日：2009-02-19
申请号：US11921020
申请日：2006-05-24
申请人： Kenji Kadomatsu , Hiroshi Banno , Yoshifumi Takei , Kimihiro Komori , Takashi Muramatsu , Sadatoshi Sakuma
发明人： Kenji Kadomatsu , Hiroshi Banno , Yoshifumi Takei , Kimihiro Komori , Takashi Muramatsu , Sadatoshi Sakuma
IPC分类号： A61K31/7105 , A61P9/00 , A61F2/82
CPC分类号： C12N15/1136 , A61K9/0019 , A61K9/0024 , A61K9/0092 , A61K9/1658 , A61K9/7007 , A61K31/7105 , A61K38/39 , A61K47/42 , A61K47/6957 , A61K49/0032 , A61K49/0054 , A61L27/26 , A61L29/049 , A61L31/041 , C12N2310/14 , C08L89/06
摘要： Provided is the excellent prevention or treatment of a vascular occlusive disease such as vascular restenosis. A pharmaceutical composition for a obstructive vascular disease comprising a nucleic acid construct capable of inhibiting the expression of a midkine gene through RNA interference and a collagen molecule. The use of the nucleic acid construct capable of inhibiting the expression of an MK protein through RNA interference in the presence of the collagen molecule can provide an excellent inhibitory effect on the thickened vascular intima.
摘要翻译：提供了血管闭塞性疾病如血管再狭窄的优异的预防或治疗。一种用于阻塞性血管疾病的药物组合物，其包含能够通过RNA干扰抑制中期因子基因表达的核酸构建体和胶原分子。通过在胶原分子的存在下通过RNA干扰能够抑制MK蛋白表达的核酸构建体的使用可以对增厚的血管内膜提供优异的抑制作用。

7. 发明授权

US07393672B2 DNA coding for endo-β-galactosidase 失效
标题翻译：编码内切β-半乳糖苷酶的DNA
公开(公告)号：US07393672B2
公开(公告)日：2008-07-01
申请号：US11407596
申请日：2006-04-20
申请人： Takashi Muramatsu , Haruko Ogawa , Hisako Muramatsu , Takaaki Kobayashi , Itsuo Yokoyama
发明人： Takashi Muramatsu , Haruko Ogawa , Hisako Muramatsu , Takaaki Kobayashi , Itsuo Yokoyama
IPC分类号： C12N9/38
CPC分类号： A61K39/001 , A61K35/12 , A61K38/00 , C12N9/2471 , C12Y302/01023
摘要： A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of Clostridium perfringens as a template to thereby obtain a fragment of cDNA encoding endo-β-galactosidase, effecting cassette PCR by using the cDNA fragment thus obtained to thereby obtain the 5′-terminal and 3′-terminal domains, and further effecting PCR with the use of primers constructed on the basis of the data acquired above.
摘要翻译：通过分析纯化的内切β-半乳糖苷酶C的部分氨基酸序列，构建其上的引物，利用产气荚膜梭菌的基因组DNA作为模板进行PCR，从而获得cDNA片段，从而获得全长cDNA 编码内切β-半乳糖苷酶，通过使用由此获得的cDNA片段进行盒式PCR，从而获得5'-末端和3'末端结构域，并且使用基于上述获得的数据构建的引物进一步进行PCR 。

8. 发明授权

US06572851B2 Method for suppressing or treating drug-induced nephropathy 失效
标题翻译：抑制或治疗药物性肾病的方法
公开(公告)号：US06572851B2
公开(公告)日：2003-06-03
申请号：US09380882
申请日：1999-12-02
申请人： Takashi Muramatsu , Kenji Kadomatsu , Munehiro Oda , Shinya Ikematsu , Sadatoshi Sakuma
发明人： Takashi Muramatsu , Kenji Kadomatsu , Munehiro Oda , Shinya Ikematsu , Sadatoshi Sakuma
IPC分类号： A61K3800
CPC分类号： A61K38/18
摘要： The present invention provides a novel drug for relieving drug-induced nephropathy and acute hepatopahy containing a midkine (MK) family protein such as pleiotrophin (PTN). The MK family proteins can inhibit nephropathy induced by an antitumor agent or acute hepatopathy caused by carbon tetrachloride and thus effectively relieve drug-induced nephropathy or hepatopathy.
摘要翻译：本发明提供了一种用于缓解药物诱导的肾病和含有中期因子（MK）家族蛋白如多效素（PTN）的急性肝细胞的新型药物。 MK家族蛋白可以抑制由四氯化碳引起的抗肿瘤剂或急性肝病引起的肾病，从而有效缓解药物诱发的肾病或肝病。

9. 发明授权

US06455289B1 Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 有权
标题翻译： N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA
公开(公告)号：US06455289B1
公开(公告)日：2002-09-24
申请号：US09471867
申请日：1999-12-23
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C12N910
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAc&bgr;1-3Gal&bgr;1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, &bgr;1-3 represents a &bgr;1-3 glycosidic linkage, and &bgr;1-4 represents a &bgr;1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性供体位于位于由式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基的6位的羟基：其中GlcNAc表示N-乙酰葡糖胺残基，Gal表示半乳糖残基，β1-3表示 β1-糖苷键，β1-4代表β1-4糖苷键。

10. 发明申请

US20110125075A1 METHOD FOR CONTROL OF ELECTROPORATION APPARATUS 审中-公开
标题翻译：电气设备控制方法
公开(公告)号：US20110125075A1
公开(公告)日：2011-05-26
申请号：US11988832
申请日：2006-07-14
申请人： Yoshifumi Takei , Kenji Kadomatsu , Tatsuya Fujishima , Takashi Muramatsu
发明人： Yoshifumi Takei , Kenji Kadomatsu , Tatsuya Fujishima , Takashi Muramatsu
IPC分类号： A61N1/30 , A01K67/027 , C12Q1/02
CPC分类号： A61N1/327 , A61K31/7088 , A61K38/1866 , A61K48/00 , A61N1/0424 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2320/32 , C12N2320/51 , G01N33/5088
摘要： A method for controlling an electroporation apparatus for use in an animal such as human and a non-human animal, the method comprising a step of applying a voltage to an electrode of the electroporation apparatus placed in/on a biological sample of the animal in the presence of a nucleic acid construct capable of inhibiting the expression of a gene in the animal. In this manner, a nucleic acid construct can be introduced into a cell of a living body with good efficiency.
摘要翻译：一种用于控制动物如人和非人动物的电穿孔装置的方法，所述方法包括向放置在动物生物样品中的电穿孔装置的电极施加电压的步骤能够抑制动物中基因表达的核酸构建体的存在。以这种方式，可以以高效率将核酸构建体引入生物体的细胞。

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