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1. 发明授权

US06605257B1 Micro array manufacturing apparatus 失效
标题翻译：微阵列制造装置
公开(公告)号：US06605257B1
公开(公告)日：2003-08-12
申请号：US09634875
申请日：2000-08-07
申请人： Touji Nakazawa , Akihiro Iimura , Hideo Tashiro , Tokuji Kitsunai , Yoshihide Hayashizaki
发明人： Touji Nakazawa , Akihiro Iimura , Hideo Tashiro , Tokuji Kitsunai , Yoshihide Hayashizaki
IPC分类号： B01L302
CPC分类号： B01L3/0251 , B01J19/0046 , B01J2219/00364 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00677 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , B01L3/0244 , B01L3/0255 , B82Y30/00 , C40B60/14 , G01N2035/1037 , Y10T436/2575
摘要： A present micro array manufacturing apparatus includes a substrate placement portion 11 on which a plurality of substrates can be arranged, a tighter plate 12 for storing a solution including a living body sample, a solution storing member 52 for taking in the solution from the tighter plate 12 and storing the solution therein, and a needle 51 which can be inserted into the solution storing member 52 to allow the solution stored in the solution storing member 52 to adhere onto each of the substrates by a given quantity, wherein the solution storing member 52 and needle 51 are moved in directions where they approach and part away from the substrates to thereby form spots on the substrates. And, the individual operations of the solution storing member 52 and needle 51 are carried out by single drive means 32.
摘要翻译：本发明的微阵列制造装置包括：基板配置部11，能够配置多个基板的基板配置部11;用于存储包含生物体样品的溶液的更紧密的板12;从更紧的板取出溶液的溶液存储部件52 12，将溶液保存在其中，将针51插入到溶液收容部件52中，使存储在溶液储存部件52中的溶液以规定量附着在各基板上，其中，溶液收容部件52 并且针51在它们接近并远离基板的方向上移动，从而在基板上形成点。并且，溶液储存构件52和针51的各个操作由单个驱动装置32执行。

2. 发明授权

US06855541B2 Kit used for fabricating an integrated biomolecule sensor 失效
标题翻译：用于制造集成生物分子传感器的试剂盒
公开(公告)号：US06855541B2
公开(公告)日：2005-02-15
申请号：US10676241
申请日：2003-10-01
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
IPC分类号： G01N33/53 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/58 , G01N37/00 , C12M1/34
CPC分类号： G01N21/6452 , C12Q1/6816 , C12Q1/6837 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N2021/6484 , G01N2021/772 , Y10S435/808 , Y10S435/81 , C12Q2565/601 , C12Q2565/518 , C12Q2563/107
摘要： This invention provides a kit used for fabricating an integrated biomolecule sensor. The kit includes an optical fiber bundle unit, which holds the proximal ends of the plurality of optical fibers together with the end-face arranged substantially in the same plane and oriented substantially in the same direction, a plate with wells for holding solutions containing probe polymers with different base sequences, and an auxiliary plate having holes, which corresponds to the wells of the plate respectively. According to this invention, researchers and other people can easily fabricate the integrated biomolecule under individual requirements without need of expensive equipment.
摘要翻译：本发明提供了用于制造集成生物分子传感器的试剂盒。该套件包括光纤束单元，该光纤束单元将多个光纤的近端保持在一起，并将端面基本上布置在相同的平面上并且基本上沿相同的方向定向，具有用于保持含有探针聚合物的溶液的孔的平板具有不同的碱基序列和具有孔的辅助板，其分别对应于板的孔。根据本发明，研究人员和其他人可以根据个人需求轻松制造整合的生物分子，而不需要昂贵的设备。

3. 发明申请

US20060035220A1 Substrate for biomolecule microarray, process for producing the same, biomolecule microarray and method of collecting data on biomolecule microarray 审中-公开
标题翻译：用于生物分子微阵列的底物，其制备方法，生物分子微阵列和收集生物分子微阵列数据的方法
公开(公告)号：US20060035220A1
公开(公告)日：2006-02-16
申请号：US10494517
申请日：2002-11-21
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Kaori Honda
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Kaori Honda
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A biomolecular microarray substrate having a spot for fixing a biomolecular probe on a surface thereof. The spot of light-reflecting layer is present between the biomolecular probe-fixing spot and the substrate surface. A method of manufacturing the biomolecular microarray substrate. A biomolecular microarray having a biomolecular probe-fixing spot in which a biomolecular probe is fixed by a biomolecular probe-fixing spot having the biomolecular microarray substrate. A data collection method for biomolecular arrays. Fluorescently labeled target biomolecules is interacted with a biomolecular microarray having, on a substrate surface, biomolecular probe-fixing spots that fix biomolecular probes on light-reflecting layer spots; excitation light is directed onto the biomolecular microarray obtained and reflected light and fluorescence are simultaneously measured from the biomolecular microarray; a biomolecular probe-fixing spot present on a light-reflecting layer spot is specified from differences in the intensity of the light reflecting off of the biomolecular microarray; and fluorescence data are obtained from within the scope of the specified spot. Alternatively, light is directed onto the biomolecular microarray obtained and reflected light is measured from the biomolecular microarray; a biomolecular probe-fixing spot having a light-reflecting layer spot is specified from differences in the intensity of the light reflecting off of the biomolecular microarray; excitation light is directed only onto the scope of the specified biomolecular probe-fixing spot and measuring the fluorescence; and fluorescence data are obtained from the scope of the specified spot.
摘要翻译：生物分子微阵列基板，其表面上具有用于固定生物分子探针的斑点。光反射层的光点存在于生物分子探针固定点和基片表面之间。制造生物分子微阵列基板的方法。具有生物分子探针固定点的生物分子微阵列，其中生物分子探针通过具有生物分子微阵列基底的生物分子探针固定点固定。生物分子阵列的数据采集方法。荧光标记的目标生物分子与生物分子微阵列相互作用，其在衬底表面上具有将生物分子探针固定在光反射层点上的生物分子探针固定点; 激发光被引导到获得的生物分子微阵列上，并从生物分子微阵列同时测量反射光和荧光; 存在于光反射层点上的生物分子探针固定点由生物分子微阵列反射光的强度的差异来确定; 并且在指定斑点的范围内获得荧光数据。或者，将光引导到获得的生物分子微阵列上，并从生物分子微阵列测量反射光; 具有光反射层点的生物分子探针固定点由生物分子微阵列的反射光强度的差异来确定; 激发光仅指向指定的生物分子探针固定点的范围并测量荧光; 并且从指定斑点的范围获得荧光数据。

4. 发明申请

US20070037155A1 Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction 失效
标题翻译：用于生物分子微阵列的基质，生物分子微阵列，促进相互作用的装置和方法以及检测相互作用的方法
公开(公告)号：US20070037155A1
公开(公告)日：2007-02-15
申请号：US10560584
申请日：2004-06-09
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , G01N21/253 , G01N21/6428 , G01N33/5438 , G01N2021/6482
摘要： The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. The biomolecule microarray comprises the above substrate and a biomolecule and the biomolecule is immobilized on at least the flat surface for spotting on the substrate. The device of promoting interaction between biomolecules comprises a biomolecule microarray having one or more biomolecule-immobilized spots on a substrate, an electrode provided so as to face the surface having the biomolecule-immobilized spots of the microarray, and a power source for applying an electric field between the microarray and the electrode. The method of promoting interaction between biomolecules employing the above device. The method of detecting interaction between biomolecules. Provided are a substrate having biomolecule immobilization regions of prescribed shape on a biomolecule microarray, and means by which the interaction of biomolecules is rapidly conducted, the interaction of trace quantities of sample is promoted, and the interaction is detected and analyzed rapidly and with high sensitivity.
摘要翻译：用于生物分子微阵列的底物具有用于固定生物分子的一个或多个斑点。用于固定生物分子的点从基板的表面突出，并且具有用于在其顶部上点样的平坦表面，至少在突出的点部分周围的基板的表面，突出的点部分的侧表面和平坦表面用于点样由导电物质组成。或者，用于固定生物分子的斑点从基板的表面突出，并且具有用于在其顶部上斑点的平坦表面，突出的点部分彼此相邻，通过突出的斑点部分的侧表面，并且至少横向突出点部分的表面和用于点样的平坦表面由导电物质组成。生物分子微阵列包括上述底物和生物分子，生物分子至少固定在平坦表面上以便在基底上进行点样。促进生物分子之间的相互作用的装置包括在基底上具有一个或多个生物分子固定斑点的生物分子微阵列，设置成面对具有微阵列的生物分子固定点的表面的电极，以及用于施加电微阵列和电极之间的场。促进使用上述装置的生物分子之间相互作用的方法。检测生物分子之间相互作用的方法。提供了一种在生物分子微阵列上具有规定形状的生物分子固定区的底物，以及快速进行生物分子相互作用的手段，促进了微量样品的相互作用，并快速，高灵敏度地检测和分析了相互作用。

5. 发明授权

US06844185B2 Integrated biomolecule sensor, method and apparatus for fabricating the sensor, and method and apparatus for detecting biomolecules using the sensor 失效
标题翻译：集成生物分子传感器，用于制造传感器的方法和装置，以及使用传感器检测生物分子的方法和装置
公开(公告)号：US06844185B2
公开(公告)日：2005-01-18
申请号：US09962434
申请日：2001-09-25
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
IPC分类号： G01N33/53 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/58 , G01N37/00 , C12M1/34
CPC分类号： G01N21/6452 , C12Q1/6816 , C12Q1/6837 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N2021/6484 , G01N2021/772 , Y10S435/808 , Y10S435/81 , C12Q2565/601 , C12Q2565/518 , C12Q2563/107
摘要： An integrated biomolecule sensor comprising a plurality of optical fibers whose proximal ends are held together with the end-faces arranged substantially in the same plane and oriented substantially in the same direction and which have probe polymers with different base sequences bound to the core end-face at their distal ends. The method and apparatus for fabricating the integrated biomolecule sensor, and the method and apparatus for detecting biomolecules using the integrated biomolecule sensor are also disclosed. Researchers can make their own sensors best suited for individual requirements, and detect the presence of target biomolecules quickly, without need of expensive equipment.
摘要翻译：一种集成的生物分子传感器，包括多个光纤，其近端保持在一起，端面基本上布置在相同的平面上并且基本上沿相同的方向取向，并且具有不同的碱基序列的探针聚合物结合到芯的端面在他们的远端。还公开了用于制造集成生物分子传感器的方法和装置，以及使用该集成生物分子传感器检测生物分子的方法和装置。研究人员可以使自己的传感器最适合个人需求，并快速检测目标生物分子的存在，而无需昂贵的设备。

6. 发明授权

US07541195B2 Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction 失效
标题翻译：用于生物分子微阵列的基质，生物分子微阵列，促进相互作用的装置和方法以及检测相互作用的方法
公开(公告)号：US07541195B2
公开(公告)日：2009-06-02
申请号：US10560584
申请日：2004-06-09
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
IPC分类号： G01N33/543
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , G01N21/253 , G01N21/6428 , G01N33/5438 , G01N2021/6482
摘要： The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. The biomolecule microarray comprises the above substrate and a biomolecule and the biomolecule is immobilized on at least the flat surface for spotting on the substrate. The device of promoting interaction between biomolecules comprises a biomolecule microarray having one or more biomolecule-immobilized spots on a substrate, an electrode provided so as to face the surface having the biomolecule-immobilized spots of the microarray, and a power source for applying an electric field between the microarray and the electrode. The method of promoting interaction between biomolecules employing the above device. The method of detecting interaction between biomolecules. Provided are a substrate having biomolecule immobilization regions of prescribed shape on a biomolecule microarray, and means by which the interaction of biomolecules is rapidly conducted, the interaction of trace quantities of sample is promoted, and the interaction is detected and analyzed rapidly and with high sensitivity.
摘要翻译：用于生物分子微阵列的底物具有用于固定生物分子的一个或多个斑点。用于固定生物分子的点从基板的表面突出，并且具有用于在其顶部上点样的平坦表面，至少在突出的点部分周围的基板的表面，突出的点部分的侧表面和平坦表面用于点样由导电物质组成。或者，用于固定生物分子的斑点从基板的表面突出，并且具有用于在其顶部上斑点的平坦表面，突出的点部分彼此相邻，通过突出的斑点部分的侧表面，并且至少横向突出点部分的表面和用于点样的平坦表面由导电物质组成。生物分子微阵列包括上述底物和生物分子，生物分子至少固定在平坦表面上以便在基底上进行点样。促进生物分子之间的相互作用的装置包括在基底上具有一个或多个生物分子固定斑点的生物分子微阵列，设置成面对具有微阵列的生物分子固定点的表面的电极，以及用于施加电微阵列和电极之间的场。促进使用上述装置的生物分子之间相互作用的方法。检测生物分子之间相互作用的方法。提供了一种在生物分子微阵列上具有规定形状的生物分子固定区的底物，以及快速进行生物分子相互作用的手段，促进了微量样品的相互作用，并快速，高灵敏度地检测和分析了相互作用。

7. 发明申请

US20090232704A1 Multiple-Sample Automatic Processing System and Multiple-Sample Automatic Processing Method 审中-公开
标题翻译：多样本自动处理系统和多样本自动处理方法
公开(公告)号：US20090232704A1
公开(公告)日：2009-09-17
申请号：US11887612
申请日：2006-02-08
申请人： Naoshi Dohmae , Hiroshi Nakayama , Tokuji Kitsunai
发明人： Naoshi Dohmae , Hiroshi Nakayama , Tokuji Kitsunai
IPC分类号： G01N33/48
CPC分类号： G01N35/1065 , G01N35/0092 , G01N35/1072
摘要： A system completely automates process steps to reduce contamination, enables quantification of products, and reduces the defective ratio. Sample containers are transported on a unit by unit basis, each unit consisting of a predetermined number of containers, and supplied to the individual dispensing/aspiration apparatuses and each reaction bath. In order to ensure quantification and reliability of the reaction/processing of the sample, a reaction monitoring sensor is provided, and the sample containers are affixed with barcodes to identify the samples. Samples determined through monitoring to be defective are returned to a predetermined step site where reaction/processing is performed again.
摘要翻译：系统完全自动化过程步骤以减少污染，能够量化产品，并降低缺陷率。样品容器以单位为单位运输，每个单位由预定数量的容器组成，并供应到单独的分配/抽吸装置和每个反应浴。为了确保样品的反应/处理的定量和可靠性，提供反应监测传感器，并将样品容器固定有条形码以鉴定样品。通过监视确定为缺陷的样品返回到再次进行反应/处理的预定步骤。

8. 发明授权

US4075062A Throw-in type colorimeter 失效
标题翻译：投入式色度计
公开(公告)号：US4075062A
公开(公告)日：1978-02-21
申请号：US693758
申请日：1976-06-08
申请人： Takehiko Shibata , Tadahiko Ando , Tokuji Kitsunai , Norio Kamiyama , Yoshifumi Oikawa
发明人： Takehiko Shibata , Tadahiko Ando , Tokuji Kitsunai , Norio Kamiyama , Yoshifumi Oikawa
IPC分类号： G01J3/50 , G01J3/51 , G01N21/15 , G01N21/27 , G01N21/85 , C12K1/00 , G01N21/26
CPC分类号： G01N21/8507 , Y10S435/808 , Y10S435/812 , Y10S435/839 , Y10S435/942
摘要： The present invention relates to a throw-in type colorimeter having a defoaming mechanism comprising a double-cylinder whereby it is possible to very easily detect the optical density of the solution to be examined, and more particularly to a thrown-in type colorimeter equipped with a defoaming device in which a downward flow is created in a cylinder by means of the liquid level column difference in the inlet of the cylinder to let the bubbles in the solution escape upwardly therefrom and also equipped with an upward solution flow passage to provide a communicating passage between the outer and inner cylinders to form a down flow in the outer cylinder and drive the remaining bubbles out of the solution in the outer cylinder by the twice reversed flow while removing the bubbles residing in the measuring chamber by the agitated solution flow.
摘要翻译：本发明涉及一种具有包括双气缸的消泡机构的投入式色度计，由此可以非常容易地检测待检测溶液的光密度，更具体地说，涉及一种配备有消泡装置，其中通过气缸入口中的液位柱差在气缸中产生向下的流动，以使溶液中的气泡从其中向上逸出，并且还配备有向上的溶液流动通道，以提供连通在外筒和内筒之间形成通道，以在外筒中形成向下的流动，并且通过两次反转的流动将剩余气泡从外筒中的溶液驱出，同时通过搅动的溶液流除去驻留在测量室中的气泡。

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