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1. 发明授权

US06919349B2 Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient 失效
标题翻译：含有与活性成分相同的螺环化合物和粘附分子抑制剂
公开(公告)号：US06919349B2
公开(公告)日：2005-07-19
申请号：US10381367
申请日：2001-09-25
申请人： Toshiya Takahashi , Takeshi Ishigaki , Miyuki Funahashi , Koji Taniguchi , Masayuki Kaneko , Mie Kainoh , Hiroyuki Meguro
发明人： Toshiya Takahashi , Takeshi Ishigaki , Miyuki Funahashi , Koji Taniguchi , Masayuki Kaneko , Mie Kainoh , Hiroyuki Meguro
IPC分类号： A61P1/04 , A61P1/16 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/10 , A61K31/438
CPC分类号： C07D471/10
摘要： Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):
摘要翻译：公开了新的螺衍生物及其医疗用途，特别是作为可用于治疗炎性疾病的粘附分子抑制剂。根据本发明的螺衍生物具有例如由下式（31）表示的化学结构：

2. 发明授权

US06511961B1 Cyclic peptides and medicinal use thereof 失效
标题翻译：环状肽及其药用
公开(公告)号：US06511961B1
公开(公告)日：2003-01-28
申请号：US09341435
申请日：1999-07-09
申请人： Toshiya Takahashi , Nobuo Saito , Hideyuki Takeshige , Toshiaki Tanaka , Mie Kainoh
发明人： Toshiya Takahashi , Nobuo Saito , Hideyuki Takeshige , Toshiaki Tanaka , Mie Kainoh
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K7/54 , C07K7/64 , C07K14/70542 , C07K14/7055
摘要： Novel cyclic peptides having VLA-4 adhesion inhibiting activity, and their application as therapeutic agents for inflammatory disease, for example allergic inflammatory disease, or hepatitis. Cyclic peptides represented by formula (I) where A and F may be the same or different, and are both selected from L- or D-form Cys, homo-Cys, Pen and Mpr, or both from the group comprising Asp, Glu, Aad, Dpr, Dab and Orn, B is selected from L-or D-form Ala, Ala(t-Bu), Val, Leu, Ile, aIle, Abu, Nle, Nva, Tle, Cha, Chg, Phe, Phg, Trp, Ala(3-Bzt), Ala(1-Naph), Ala(2-Naph), Ala(2-Pyr), Ala(2-Qui), His, Thi, Ala(4-Thz), 2-Abz, Pro, homo-Pro and Tic, C is selected from L-form Asp analogues, Gle analogues, Aad analogues, Asn analogues, Gln analogues, Ser, Ser(OMe), homo-Ser, Dpr, Dab, Orn, Met, Met)O), Met(O2), aIle, Nle, Nva, Chg, Phg, Tyr and Tle, D is selected from L- or D-form Tyr, Ser, homo-Ser, Leu, Ile, AIle, Nle, Nva, Chg, Cha, Val, Ala(t-Bu), Abu, Tle, Ala, Phg, homo-Phe, Phe, Ala(2-Naph), Ala(2-Pyr), Ala(3-Bzt), Ala(1-Naph), Ala(2-Qui), Thi, Ala(4-Thz), 2-Abz, Trp and His, E is selected from L- or D-form Leu, Ile, aIle, Nle, Nva, Chg, Cha, Tle, Phg, homo-Phe, Ala(2-Naph), Ala(2-Pyr), Ala(3-Bzt, Ala(1-Naph), Ala(2-Qui), Thi, Ala(4-Thz), 2-Abz and His, G represents a disulphide bond or amide bond, R1 represents hydrogen or an acyl group, and R2 is hydrogen or an alkyl group, or salts thereof, and to their use in treating inflammatory diseases.
摘要翻译：具有VLA-4粘附抑制活性的新型环肽及其作为炎症性疾病例如过敏性炎性疾病或肝炎的治疗剂的应用。由式（I）表示的环肽，其中A和F可以相同或不同，并且均选自L-或D-型Cys，homo-Cys，Pen和Mpr，或二者均为Asp，Glu， Aad，Dpr，Dab和Orn，B选自L-型或D-型Ala，Ala（t-Bu），Val，Leu，Ile，aIle，Abu，Nle，Nva，Tle，Cha，Chg，Phe，Phg ，Trp，Ala（3-Bzt），Ala（1-Naph），Ala（2-Naph），Ala（2-Pyr），Ala（2-Qui），His，Thi，Ala（4-Thz） -Abz，Pro，homo-Pro和Tic，C选自L型Asp类似物，Gle类似物，Aad类似物，Asn类似物，Gln类似物，Ser，Ser（OMe），homo-Ser，Dpr，Dab，Orn， Met，Met）O），Met（O 2），aIle，Nle，Nva，Chg，Phg，Tyr和Tle，D选自L-或D型Tyr，Ser，homo-Ser，Leu，Ile， Nle，Nva，Chg，Cha，Val，Ala（t-Bu），Abu，Tle，Ala，Phg，hom-Phe，Phe，Ala（2-Naph），Ala（2-Pyr），Ala（3-Bzt ），Ala（1-Naph），Ala（2-Qui），Thi，Ala（4-Thz），2-Abz，Trp和His，E选自L-或D-型Leu，Ile，aIle，Nle ，Nva，Chg，Cha，Tle，Phg，hom-Phe，Ala（2-Naph），Ala（2-Pyr）， Ala（3-Bzt，Ala（1-Naph），Ala（2-Qui），Thi，Ala（4-Thz），2-Abz和His，G表示二硫键或酰胺键，R1表示氢或酰基并且R 2是氢或烷基，或其盐，以及它们在治疗炎性疾病中的用途。

3. 发明授权

US06492364B1 Triazolo and derivatives as chemokine inhibitors 失效
标题翻译：三氮唑和衍生物作为趋化因子抑制剂
公开(公告)号：US06492364B1
公开(公告)日：2002-12-10
申请号：US09601620
申请日：2000-09-22
申请人： Toshiya Takahashi , Takayuki Imaoka , Noriko Mori , Masayuki Kaneko , Koh Tanida , Yuichi Torii
发明人： Toshiya Takahashi , Takayuki Imaoka , Noriko Mori , Masayuki Kaneko , Koh Tanida , Yuichi Torii
IPC分类号： A61K3153
CPC分类号： A61K31/437 , A61K31/4545 , A61K31/497 , C07D471/04 , Y02P20/582
摘要： Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These are useful as therapeutic agents for allergic diseases such as bronchial asthma and atopic dermatitis; therapeutic agents for inflammatory diseases such as chronic rheumatoid arthritis; therapeutic agents for autoimmune diseases such as ulcerative colitis and nephritis; and as anti-AIDS drugs.
摘要翻译：由下式表示的新型三唑衍生物及其药学上可接受的盐，以及含有与有效成分相同的趋化因子抑制剂。这些可用作过敏性疾病如支气管哮喘和特应性皮炎的治疗剂; 用于炎性疾病如慢性类风湿性关节炎的治疗剂; 自身免疫疾病如溃疡性结肠炎和肾炎的治疗剂; 并作为抗艾滋病药物。

4. 发明授权

US08637220B2 Actinic ray-sensitive or radiation-sensitive resin composition, and resist film and pattern forming method using the composition 有权
标题翻译：光敏感或辐射敏感性树脂组合物，以及使用该组合物的抗蚀剂膜和图案形成方法
公开(公告)号：US08637220B2
公开(公告)日：2014-01-28
申请号：US13172025
申请日：2011-06-29
申请人： Tomotaka Tsuchimura , Hideaki Tsubaki , Toshiya Takahashi
发明人： Tomotaka Tsuchimura , Hideaki Tsubaki , Toshiya Takahashi
IPC分类号： G03F7/004 , G03F7/039
CPC分类号： G03F7/0045 , G03F7/0382 , G03F7/0392 , G03F7/0397 , G03F7/2041 , Y10S430/106 , Y10S430/111
摘要： An actinic ray-sensitive or radiation-sensitive resin composition comprising (A) a guanidine compound having a logP value of 1.2 or more, and (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation.
摘要翻译：一种光化射线敏感或辐射敏感性树脂组合物，其包含（A）logP值为1.2以上的胍化合物，和（B）在用光化射线或辐射照射时能够产生酸的化合物。

5. 发明授权

US08563681B2 Process for producing fine polyphenylene sulfide resin particles, fine polyphenylene sulfide resin particles, and dispersion thereof 有权
标题翻译：微聚苯硫醚树脂颗粒的制造方法，聚苯硫醚树脂微粒及其分散体
公开(公告)号：US08563681B2
公开(公告)日：2013-10-22
申请号：US12933635
申请日：2009-03-23
申请人： Kei Makita , Takae Ono , Toshiya Takahashi , Hiroaki Akasaka , Tomohiro Sakane
发明人： Kei Makita , Takae Ono , Toshiya Takahashi , Hiroaki Akasaka , Tomohiro Sakane
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： C08J3/14 , C08J3/03 , C08J2381/02 , C08J2381/04 , Y10T428/2982
摘要： This invention provides a process for producing fine PPS resin particles and dispersion thereof by industrially applicable simple operation. This invention further provides very fine PPS resin particles, and furthermore provides fine PPS resin particles uniform in particle size. This invention is a process for producing fine polyphenylene sulfide resin particles comprising the following steps (a) and (b); (a) a step of heating a polyphenylene sulfide resin in an organic solvent, for obtaining a solution with the polyphenylene sulfide resin dissolved therein (dissolution step) (b) a step of flushing-cooling the aforementioned solution, for precipitating the fine particles of the polyphenylene sulfide resin (precipitation step).
摘要翻译：本发明提供通过工业上简单的操作制造PPS树脂微粒及其分散体的方法。本发明还提供非常细的PPS树脂颗粒，并且还提供粒度均匀的PPS树脂颗粒。本发明是一种生产精细聚苯硫醚树脂颗粒的方法，包括以下步骤（a）和（b）。（a）在有机溶剂中加热聚苯硫醚树脂以获得溶解有聚苯硫醚树脂的溶液的步骤（溶解步骤）（b）将上述溶液冲洗冷却的步骤，使聚苯硫醚树脂（沉淀步骤）。

6. 发明申请

US20120237771A1 PROCESS FOR PRODUCTION OF POLYAMIDEIMIDE RESIN MICROPARTICLES, AND POLYAMIDEIMIDE RESIN MICROPARTICLES 有权
标题翻译：聚酰胺树脂微生物生产工艺和聚酰胺树脂微生物
公开(公告)号：US20120237771A1
公开(公告)日：2012-09-20
申请号：US13508200
申请日：2010-10-06
申请人： Hiroaki Akasaka , Takae Ono , Toshiya Takahashi
发明人： Hiroaki Akasaka , Takae Ono , Toshiya Takahashi
IPC分类号： C08G73/14
CPC分类号： C08J3/14 , C08G73/14 , C08J2379/08 , Y10T428/2982
摘要： A process for producing fine particles of polyamide-imide resin includes a dissolution step and a precipitation step wherein the dissolution step is selected from steps (a1) and (b1); (a1) polyamide-imide resin is dissolved in an organic solvent to prepare a polyamide-imide resin solution A1 having a polyamide-imide resin content of less than 5 mass %; and (b1) polyamide-imide resin is dissolved in an organic solvent to prepare a polyamide-imide resin solution B1 having a polyamide-imide resin content of less than 10 mass %, and the precipitation step is selected from (a2) the polyamide-imide resin solution A1 is added to a solvent that is virtually free from surface active agents and able to precipitate fine particles of the polyamide-imide resin to cause precipitation of fine particles of the polyamide-imide resin, and (b2) the polyamide-imide resin solution B1 is subjected to flash crystallization to cause precipitation of fine particles of the polyamide-imide resin.
摘要翻译：制备聚酰胺酰亚胺树脂微粒的方法包括溶解步骤和沉淀步骤，其中溶解步骤选自步骤（a1）和（b1）; （a1）聚酰胺酰亚胺树脂溶解在有机溶剂中，制备聚酰胺 - 酰亚胺树脂含量小于5质量％的聚酰胺 - 酰亚胺树脂溶液A1; 和（b1）聚酰胺酰亚胺树脂溶解在有机溶剂中，制备聚酰胺 - 酰亚胺树脂含量小于10质量％的聚酰胺 - 酰亚胺树脂溶液B1，沉淀步骤选自（a2）聚酰胺 - 将酰亚胺树脂溶液A1加入到基本上不含表面活性剂的溶剂中，并能够使聚酰胺 - 酰亚胺树脂的细颗粒沉淀，使聚酰胺 - 酰亚胺树脂的细颗粒沉淀，和（b2）聚酰胺 - 酰亚胺树脂溶液B1进行闪光结晶，使聚酰胺 - 酰亚胺树脂的微粒析出。

7. 发明授权

US08045003B2 Onboard display device, vehicle, display method, image display program and recording medium 有权
标题翻译：车载显示装置，车辆，显示方法，图像显示程序和记录介质
公开(公告)号：US08045003B2
公开(公告)日：2011-10-25
申请号：US10598090
申请日：2005-02-18
申请人： Hitoshi Nohno , Megumi Itoh , Toshiya Takahashi , Takeshi Yamamoto , Aki Miake , Mitsukazu Okuda , Takeshi Doi
发明人： Hitoshi Nohno , Megumi Itoh , Toshiya Takahashi , Takeshi Yamamoto , Aki Miake , Mitsukazu Okuda , Takeshi Doi
IPC分类号： H04N7/18 , H04N5/225 , G06K9/00 , G09G5/00
CPC分类号： B60K37/02 , B60K2350/1072 , B60K2350/1088 , B60K2350/2013 , B60R1/00 , B60R2300/105 , B60R2300/207 , B60R2300/302 , B60R2300/306 , B60R2300/70
摘要： A display screen of an onboard display device is disposed so that a speedometer is displayed in front of a driver of a vehicle. When a right-turn instruction is detected, a blinker is displayed and a rightward rear view image outside the vehicle is displayed on the right side of the display screen. When a left-turn instruction is detected, a blinker is displayed and a leftward rear view image outside the vehicle is displayed on the left side of the display screen. Displaying the image in different positions of the display screen according to the right or the left turn instruction facilitates an intuitive determination of a meaning of the image and makes it easier to drive the vehicle.
摘要翻译：车载显示装置的显示画面被设置为使车速表在车辆驾驶员的前方显示。当检测到右转指示时，显示闪烁灯，并且车辆外部的右后视图像显示在显示屏的右侧。当检测到左转指令时，显示闪烁灯，并且在显示屏左侧显示车辆外部的左后视图。根据右转或左转指示在显示屏的不同位置显示图像有助于直观地确定图像的含义，并且使得驾驶车辆变得更容易。

8. 发明授权

US07951274B2 Diamond electrode, method for producing same, and electrolytic cell 有权
标题翻译：金刚石电极，其制造方法和电解槽
公开(公告)号：US07951274B2
公开(公告)日：2011-05-31
申请号：US12093087
申请日：2006-10-25
申请人： Shigeru Yoshida , Katsuhito Yoshida , Toshiya Takahashi , Takahisa Iguchi , Fuminori Higuchi
发明人： Shigeru Yoshida , Katsuhito Yoshida , Toshiya Takahashi , Takahisa Iguchi , Fuminori Higuchi
IPC分类号： C25B11/12 , C25B11/02 , C25B11/03 , C25B11/04 , C25B11/06
CPC分类号： C02F1/46109 , C02F1/4672 , C02F2001/46133 , C02F2201/46115 , C25B1/13 , C25B11/03 , C25B11/0421 , C25B11/0447 , C25D17/10
摘要： A diamond electrode includes a conductive silicon substrate having a plurality of pores. The diamond electrode also includes a conductive diamond covering the conductive silicon substrate. The inner wall surfaces of the plurality of pores are at an angle of 60° to 85° with respect to a substrate of the conductive silicon substrate.
摘要翻译：金刚石电极包括具有多个孔的导电硅衬底。金刚石电极还包括覆盖导电硅衬底的导电金刚石。多个孔的内壁面相对于导电性硅基板的基板成60°〜85°的角度。

9. 发明授权

US07835854B2 Condition detection and display system, condition detection and display method, control program for condition detection and display system, and storage medium storing the control program 有权
标题翻译：条件检测和显示系统，状态检测和显示方法，状态检测和显示系统的控制程序以及存储控制程序的存储介质
公开(公告)号：US07835854B2
公开(公告)日：2010-11-16
申请号：US10598094
申请日：2005-02-15
申请人： Takeshi Yamamoto , Aki Miake , Toshiya Takahashi , Megumi Itoh , Mitsukazu Okuda , Takeshi Doi
发明人： Takeshi Yamamoto , Aki Miake , Toshiya Takahashi , Megumi Itoh , Mitsukazu Okuda , Takeshi Doi
IPC分类号： G08G1/16
CPC分类号： B60C23/0401 , B60K31/18 , B60K2350/2013 , B60L2250/16 , B60R1/00 , B60R11/0235 , B60R11/04 , B60R2300/105 , B60R2300/207 , B60R2300/301 , B60R2300/302 , B60R2300/305 , G08G1/166 , G08G1/167
摘要： In a condition detection and display system (100), an omnidirectional camera (1), internal condition sensors (3), external condition sensors (4), and others detect a condition of a vehicle and surroundings around the vehicle, image data which is a detection result obtained by the aforesaid members and contains an image of the vehicle is selected from an image database (6), and the selected image data is displayed on a liquid crystal panel (7) at a position close to a display of a speedometer.
摘要翻译：在条件检测和显示系统（100）中，全方位摄像机（1），内部状态传感器（3），外部状况传感器（4）等检测车辆周围的车辆和周围环境的状况，从图像数据库（6）中选择由上述构件获得并包含车辆图像的检测结果，并且将所选择的图像数据显示在靠近车速表显示的位置的液晶面板（7）上。

10. 发明授权

US07729514B2 Display device, vehicle, method for displaying, program for displaying and recording medium of same 失效
标题翻译：显示装置，车辆，显示方法，显示和记录介质的程序
公开(公告)号：US07729514B2
公开(公告)日：2010-06-01
申请号：US11570052
申请日：2005-06-02
申请人： Megumi Itoh , Toshiya Takahashi , Shinichirou Ota , Aki Miake , Takeshi Yamamoto , Keiichiro Sato
发明人： Megumi Itoh , Toshiya Takahashi , Shinichirou Ota , Aki Miake , Takeshi Yamamoto , Keiichiro Sato
IPC分类号： G06K9/00
CPC分类号： B60K37/02 , B60K2350/1064 , B60K2350/1072 , B60K2350/2008 , B60K2350/2017 , G01D7/002 , G01D7/04
摘要： A display section displays a speedometer having a substantially circular shape on an outer circumference of which a speed scale is provided. Then, that point on the outer circumference of the speedometer which indicates a speed at a moment is calculated. Further a speed that is attained at a given time period (e.g. 0.5 second) after the moment if the speed is increased at an acceleration at the moment is calculated. An arc-shaped pointer is displayed, the arc-shaped pointer passing (i) the calculated point of the speed scale, (ii) a middle point between the calculated point of the speed scale and a center of the speedometer, and (iii) the center of the speedometer. With this arrangement, a display device displaying the speedometer allows a driver to easily recognize the speed and an amount of a change therein (i.e. acceleration).
摘要翻译：显示部分在其外周上显示具有大致圆形形状的速度计，其外周设有速度刻度。然后，计算表示该时刻的速度的车速表的外周的该点。此外，计算在此时的速度以此时的加速度增加之后在给定时间段（例如0.5秒）之后获得的速度。显示弧形指针，弧形指针通过（i）速度刻度的计算点，（ii）速度刻度的计算点和速度计的中心之间的中点，以及（iii）车速表的中心。通过这种布置，显示车速表的显示装置允许驾驶员容易地识别速度和其中的变化量（即加速度）。

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