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    • 1. 发明授权
    • Cyclic peptides and medicinal use thereof
    • 环状肽及其药用
    • US06511961B1
    • 2003-01-28
    • US09341435
    • 1999-07-09
    • Toshiya TakahashiNobuo SaitoHideyuki TakeshigeToshiaki TanakaMie Kainoh
    • Toshiya TakahashiNobuo SaitoHideyuki TakeshigeToshiaki TanakaMie Kainoh
    • A61K3800
    • C07K7/06A61K38/00C07K7/54C07K7/64C07K14/70542C07K14/7055
    • Novel cyclic peptides having VLA-4 adhesion inhibiting activity, and their application as therapeutic agents for inflammatory disease, for example allergic inflammatory disease, or hepatitis. Cyclic peptides represented by formula (I) where A and F may be the same or different, and are both selected from L- or D-form Cys, homo-Cys, Pen and Mpr, or both from the group comprising Asp, Glu, Aad, Dpr, Dab and Orn, B is selected from L-or D-form Ala, Ala(t-Bu), Val, Leu, Ile, aIle, Abu, Nle, Nva, Tle, Cha, Chg, Phe, Phg, Trp, Ala(3-Bzt), Ala(1-Naph), Ala(2-Naph), Ala(2-Pyr), Ala(2-Qui), His, Thi, Ala(4-Thz), 2-Abz, Pro, homo-Pro and Tic, C is selected from L-form Asp analogues, Gle analogues, Aad analogues, Asn analogues, Gln analogues, Ser, Ser(OMe), homo-Ser, Dpr, Dab, Orn, Met, Met)O), Met(O2), aIle, Nle, Nva, Chg, Phg, Tyr and Tle, D is selected from L- or D-form Tyr, Ser, homo-Ser, Leu, Ile, AIle, Nle, Nva, Chg, Cha, Val, Ala(t-Bu), Abu, Tle, Ala, Phg, homo-Phe, Phe, Ala(2-Naph), Ala(2-Pyr), Ala(3-Bzt), Ala(1-Naph), Ala(2-Qui), Thi, Ala(4-Thz), 2-Abz, Trp and His, E is selected from L- or D-form Leu, Ile, aIle, Nle, Nva, Chg, Cha, Tle, Phg, homo-Phe, Ala(2-Naph), Ala(2-Pyr), Ala(3-Bzt, Ala(1-Naph), Ala(2-Qui), Thi, Ala(4-Thz), 2-Abz and His, G represents a disulphide bond or amide bond, R1 represents hydrogen or an acyl group, and R2 is hydrogen or an alkyl group, or salts thereof, and to their use in treating inflammatory diseases.
    • 具有VLA-4粘附抑制活性的新型环肽及其作为炎症性疾病例如过敏性炎性疾病或肝炎的治疗剂的应用。 由式(I)表示的环肽,其中A和F可以相同或不同,并且均选自L-或D-型Cys,homo-Cys,Pen和Mpr,或二者均为Asp,Glu, Aad,Dpr,Dab和Orn,B选自L-型或D-型Ala,Ala(t-Bu),Val,Leu,Ile,aIle,Abu,Nle,Nva,Tle,Cha,Chg,Phe,Phg ,Trp,Ala(3-Bzt),Ala(1-Naph),Ala(2-Naph),Ala(2-Pyr),Ala(2-Qui),His,Thi,Ala(4-Thz) -Abz,Pro,homo-Pro和Tic,C选自L型Asp类似物,Gle类似物,Aad类似物,Asn类似物,Gln类似物,Ser,Ser(OMe),homo-Ser,Dpr,Dab,Orn, Met,Met)O),Met(O 2),aIle,Nle,Nva,Chg,Phg,Tyr和Tle,D选自L-或D型Tyr,Ser,homo-Ser,Leu,Ile, Nle,Nva,Chg,Cha,Val,Ala(t-Bu),Abu,Tle,Ala,Phg,hom-Phe,Phe,Ala(2-Naph),Ala(2-Pyr),Ala(3-Bzt ),Ala(1-Naph),Ala(2-Qui),Thi,Ala(4-Thz),2-Abz,Trp和His,E选自L-或D-型Leu,Ile,aIle,Nle ,Nva,Chg,Cha,Tle,Phg,hom-Phe,Ala(2-Naph),Ala(2-Pyr), Ala(3-Bzt,Ala(1-Naph),Ala(2-Qui),Thi,Ala(4-Thz),2-Abz和His,G表示二硫键或酰胺键,R1表示氢或酰基 并且R 2是氢或烷基,或其盐,以及它们在治疗炎性疾病中的用途。
    • 3. 发明授权
    • Data string storage device and method of storing and retrieving data
strings
    • 数据串存储设备和数据串的存储和检索方法
    • US5129074A
    • 1992-07-07
    • US409672
    • 1989-09-20
    • Takashi KikuchiHiroshi FukutaNobuo SaitoOichi Atoda
    • Takashi KikuchiHiroshi FukutaNobuo SaitoOichi Atoda
    • G06F9/44G06F17/30
    • G06F8/313G06F17/30
    • A data storage device for storing data strings each including units of data has a plurality of memory sections each for storing therein a table, a plurality of processor elements one provided for each of the tables and a controlling unit having an internal memory in which data strings are stored. The table contains a plurality of records each including a unit of data, a first index data representative of the number of units of data of a data string which the unit of data constitutes and a second index data unique to each individual data string. The processor elements access in parallel their associated tables under control of the control unit for data storage and data retrieval. The first and index data are generated by the controller for the purpose of data storage. For retrieval of data strings: a key data string is divided into units of data; retrieval keys are produced each from a combination of one of the divided units of data and a third index data representing the number of units of data of the key data string; second index data are retrieved in parallel in the tables of the data storage device with the retrieval keys so that a single second index data common to all of the retrieved second index data is found among them; and a data string corresponding to the found common second index data is outputted from the internal memory of the storage device.
    • 一种用于存储包括数据单元的数据串的数据存储装置具有多个存储部分,每个存储部分用于在其中存储表格,为每个表格提供多个处理器元件,以及具有内部存储器的控制单元,其中数据串 被存储。 该表包含多个记录,每个记录包括数据单元,表示数据单元构成的数据串的数据单元数的第一索引数据和每个单独数据串唯一的第二索引数据。 处理器元件在用于数据存储和数据检索的控制单元的控制下并行访问其相关联的表。 第一和索引数据由控制器生成,用于数据存储。 用于检索数据串:一个关键数据串被分为数据单元; 从分割的数据单元之一的组合和表示密钥数据串的数据单元数的第三索引数据产生检索密钥; 在具有检索关键字的数据存储装置的表中并行地检索第二索引数据,使得在其中找到所有检索到的第二索引数据共同的单个第二索引数据; 并且从存储装置的内部存储器输出与所找到的公共第二索引数据相对应的数据串。
    • 6. 发明申请
    • Instrument for measuring a refractive power
    • 用于测量屈光力的仪器
    • US20080309875A1
    • 2008-12-18
    • US12157336
    • 2008-06-10
    • Nobuo SaitoYasuhide TakahashiKenichi TakahashiYuuichi Kimura
    • Nobuo SaitoYasuhide TakahashiKenichi TakahashiYuuichi Kimura
    • A61B3/103
    • A61B3/103
    • An instrument for measuring a refractive power includes a target, a target projecting unit, a measurement light projecting unit, a light receiving unit, a unit for performing a normal refractive power measurement, a judgment unit, and a unit for performing a high-speed refractive power measurement. The unit for performing a normal refractive power measurement measures a normal refractive power of an examined eye based on received light data. The judgment unit judges reliability of the received light data or the refractive power measurement. The unit for performing a high-speed refractive power measurement measures a refractive power of the examined eye faster than the unit for performing a normal refractive power measurement in response to a judgment result of the judgment unit.
    • 用于测量屈光度的仪器包括目标,目标投影单元,测量光投射单元,光接收单元,用于执行正常屈光力测量的单元,判断单元和用于执行高速 屈光度测量。 用于执行正常屈光力测量的单元基于接收到的光数据测量被检眼的正常屈光度。 判断单元判断所接收的光数据的屈光力测量的可靠性。 用于执行高速屈光力测量的单元响应于判断单元的判断结果,比用于执行正常屈光力测量的单元更快地测量检查眼睛的屈光度。
    • 8. 发明授权
    • Halogen-free flame resisting synthetic resin composition
    • 无卤阻燃合成树脂组合物
    • US4879332A
    • 1989-11-07
    • US183760
    • 1988-04-05
    • Nobuo SaitoMitsuo Noda
    • Nobuo SaitoMitsuo Noda
    • C08K3/22C08K3/34C08K3/36C08L101/00
    • C08K3/22C08K3/36
    • The present invention relates to a self-fire distinguishable halogen-free flame resisting synthetic resin composition obtained by adding 0.5 to 15 parts by weight of synthetic silicate (also called "hydrated silicic acid" or "wet silica") to 100 parts by weight of a mixture comprising 70 to 30 parts by weight of at least one thermoplastic synthetic resin and 30 to 70 parts by weight of magnesium hydroxide or aluminum hydroxide having an average particle size of 0.1 to 10 .mu.m.This composition is white semitranslucent unlike the one containing carbon black according to the prior art, so that it is suitable for decorative use including floor materials and wall covering materials.
    • PCT No.PCT / JP87 / 00593 Sec。 371日期:1988年4月5日 102(e)日期1988年4月5日PCT提交1987年8月7日PCT公布。 出版物WO88 / 00959 日本特开昭通1988年2月11日发明内容本发明涉及通过加入0.5〜15重量份的合成硅酸盐(也称为“水合硅酸”或“湿二氧化硅”)得到的自发区别的无卤阻燃合成树脂组合物, )至100重量份的混合物,其包含70至30重量份的至少一种热塑性合成树脂和30至70重量份的平均粒径为0.1至10微米的氢氧化镁或氢氧化铝。 与现有技术中含有炭黑的组合物相比,该组合物是白色半透明的,因此适用于包括地板材料和墙面材料在内的装饰用途。