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1. 发明授权

US09372187B2 Detection method and determination method for detection target 有权
标题翻译：检测目标的检测方法和测定方法
公开(公告)号：US09372187B2
公开(公告)日：2016-06-21
申请号：US12810038
申请日：2008-12-25
申请人： Toshiya Sawai , Eri Oowada , Yasunobu Sato , Hirokazu Nagaoka , Satoru Sugita
发明人： Toshiya Sawai , Eri Oowada , Yasunobu Sato , Hirokazu Nagaoka , Satoru Sugita
IPC分类号： G01N33/533 , G01N33/543
CPC分类号： G01N33/54333 , G01N33/54306
摘要： A detection/determination kit with which a substance to be detected or the amount thereof can be rapidly, inexpensively, and easily detected or determined; and a detection/determination method. The kit, which is for detecting a substance to be detected (50) contained in a specimen, comprises: a first compound (10) comprising a first substance including a stimulus-responsive polymer (11) and, bonded to the first substance, a first antibody (13) against the substance (50); and a second compound (20) comprising a second substance (21) which is hydrophilic and, bonded thereto, a second antibody (23) against the substance (50). The first antibody (13) and second antibody (23) can simultaneously combine with the substance (50) at different sites in the substance (50).
摘要翻译：可以快速，低成本地且容易地检测或确定待检测物质或其量的检测/测定试剂盒; 和检测/确定方法。用于检测样品中所含检测物质（50）的试剂盒包括：第一化合物（10），其包含包含刺激响应性聚合物（11）的第一物质，并且与第一物质结合，针对物质（50）的第一抗体（13）; 和包含第二物质（21）的第二化合物（20），所述第二物质（21）是亲水性的，并且与第二物质（21）键合到针对物质（50）的第二抗体（23）。第一抗体（13）和第二抗体（23）可以与物质（50）中不同部位的物质（50）同时组合。

2. 发明申请

US20110014713A1 DETECTION METHOD AND DETERMINATION METHOD FOR DETECTION TARGET 有权
标题翻译：用于检测目标的检测方法和确定方法
公开(公告)号：US20110014713A1
公开(公告)日：2011-01-20
申请号：US12810038
申请日：2008-12-25
申请人： Toshiya Sawai , Eri Oowada , Yasunobu Sato , Hirokazu Nagaoka , Satoru Sugita
发明人： Toshiya Sawai , Eri Oowada , Yasunobu Sato , Hirokazu Nagaoka , Satoru Sugita
IPC分类号： G01N33/50
CPC分类号： G01N33/54333 , G01N33/54306
摘要： A detection/determination kit with which a substance to be detected or the amount thereof can be rapidly, inexpensively, and easily detected or determined; and a detection/determination method. The kit, which is for detecting a substance to be detected (50) contained in a specimen, comprises: a first compound (10) comprising a first substance including a stimulus-responsive polymer (11) and, bonded to the first substance, a first antibody (13) against the substance (50); and a second compound (20) comprising a second substance (21) which is hydrophilic and, bonded thereto, a second antibody (23) against the substance (50). The first antibody (13) and second antibody (23) can simultaneously combine with the substance (50) at different sites in the substance (50).
摘要翻译：可以快速，低成本地且容易地检测或确定待检测物质或其量的检测/测定试剂盒; 和检测/确定方法。用于检测样品中所含检测物质（50）的试剂盒包括：第一化合物（10），其包含包含刺激响应性聚合物（11）的第一物质，并且与第一物质结合，针对物质（50）的第一抗体（13）; 和包含第二物质（21）的第二化合物（20），所述第二物质（21）是亲水性的，并且与第二物质（21）键合到针对物质（50）的第二抗体（23）。第一抗体（13）和第二抗体（23）可以与物质（50）中不同部位的物质（50）同时组合。

3. 发明授权

US3960863A Pyrido[1,2-a]pyrimidinone derivatives 失效
标题翻译：吡啶{8,1-a {9嘧啶酮衍生物
公开(公告)号：US3960863A
公开(公告)日：1976-06-01
申请号：US583864
申请日：1975-06-05
申请人： Yasunobu Sato , Hiroshi Fujita , ; Hiromu Takagi , Katsuo Kamoshita
发明人： Yasunobu Sato , Hiroshi Fujita , ; Hiromu Takagi , Katsuo Kamoshita
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： 3-[2-(4-PHENYL-1-PIPERAZINYL)ETHYL]-4H-pyrido[1,2-a]pyrimidin-4-one derivatives have central nervous depressant and hypotensive activities and are useful as major tranquillizers.The compounds can be prepared by (a) reacting 2-methyl-3-halogeno (or arylsulfonyloxy or alkylsulfonyloxy)ethyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative with 1-phenylpiperazine derivative or (b) reacting an aminopyridine with 2-[2-(4-phenyl-1-piperazinyl)ethyl]-acetoacetic acid ester.
摘要翻译： 3- [2-（4-苯基-1-哌嗪基）乙基] -4H-吡啶并[1,2-a]嘧啶-4-酮衍生物具有中枢神经抑制剂和降血压活性，可用作主要镇静剂。

4. 发明授权

US4426382A 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use 失效
标题翻译： 4-氨基-6,7-二甲氧基-2-哌嗪基喹唑啉衍生物，其制备和用途
公开(公告)号：US4426382A
公开(公告)日：1984-01-17
申请号：US233679
申请日：1981-02-11
申请人： Yasunobu Sato , Hiroshi Fukumi , Hiroyuki Koike , Hiroshi Nishino
发明人： Yasunobu Sato , Hiroshi Fukumi , Hiroyuki Koike , Hiroshi Nishino
IPC分类号： C07D239/95 , A61K31/505 , C07D403/04
CPC分类号： C07D239/95
摘要： Novel piperazinylquinazoline and homopiperazinylquinazoline compounds which have useful antihypertensive activity and their use including pharmaceutical compositions containing said derivatives as the active antihypertensive component thereof. Said compounds have the following formula. ##STR1## wherein m is 2 or 3 and R is as defined in the specification.
摘要翻译：具有有用的抗高血压活性的新型哌嗪基喹唑啉和高哌嗪基喹唑啉化合物及其用途，包括含有所述衍生物作为其主要抗高血压成分的药物组合物。所述化合物具有下式。其中m为2或3，R如说明书中所定义。

5. 发明授权

US4495188A Acylaminoquinazoline derivatives and a pharmaceutical composition containing them 失效
标题翻译：酰氨基喹唑啉衍生物和含有它们的药物组合物
公开(公告)号：US4495188A
公开(公告)日：1985-01-22
申请号：US324425
申请日：1981-11-24
申请人： Yasunobu Sato , Hiroshi Fukumi , Hiroyuki Koike , Nobuaki Kitahara
发明人： Yasunobu Sato , Hiroshi Fukumi , Hiroyuki Koike , Nobuaki Kitahara
IPC分类号： C07D413/14 , A61K31/505 , A61K31/55 , A61P9/12 , C07D207/16 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14
CPC分类号： C07D207/16
摘要： Acylaminoquinazoline derivatives of formula ##STR1## (in which: R.sup.1 represents a lower alkoxy group, a substituted or unsubstituted lower alkyl group, a cycloalkyl group, a lower alkenyl group, a vinyl group having an optionally substituted phenyl or furyl substituent, an optionally substituted phenyl group, a furyl group, an oxazolyl group, a methylthiooxadiazolyl group or a tetrahydrofuryl group;R.sup.2 represents a hydrogen atom or a lower alkyl group;R.sup.3 represents a lower alkyl group or an optionally substituted phenyl group;R.sup.4 represents a hydrogen atom or an acyloxy-substituted phenyl group;X represents a methylene group or a sulphur atom; andn is 2 or 3)and pharmaceutically acceptable acid addition salts thereof are valuable antihypertensive agents and inhibit the activity of the angiotension I-converting enzyme. They may be prepared by reacting a 4-aminoquinazoline derivative with a carboxylic acid or reactive derivative thereof corresponding to the amide group which it is desired to introduce at the 4- position of said compound of formula (I). The compounds of the invention may be formulated with conventional pharmaceutically acceptable carriers or diluents to provide a pharmaceutical composition.
摘要翻译：式（I）的酰氨基喹唑啉衍生物（其中：R1表示低级烷氧基，取代或未取代的低级烷基，环烷基，低级烯基，具有任意取代的苯基或呋喃基取代基的乙烯基，任选取代的苯基，呋喃基，恶唑基，甲硫基二唑基或四氢呋喃基; R 2表示氢原子或低级烷基; R 3表示低级烷基或任意取代的苯基; R 4表示氢原子或酰氧基取代的苯基; X表示亚甲基或硫原子; n为2或3）及其药学上可接受的酸加成盐是有价值的抗高血压药，并且抑制血管紧张素I转化酶的活性。它们可以通过4-氨基喹唑啉衍生物与其中所需的引入式（I）化合物的4-位的酰胺基的羧酸或其反应性衍生物反应来制备。本发明的化合物可以与常规的药学上可接受的载体或稀释剂配制以提供药物组合物。

6. 发明授权

US4007189A Pyrrolotriazolopyrimidine derivatives and process for the preparation thereof 失效
标题翻译：吡咯并三唑并嘧啶衍生物及其制备方法
公开(公告)号：US4007189A
公开(公告)日：1977-02-08
申请号：US683055
申请日：1976-05-04
申请人： Yasunobu Sato , Hiromu Takagi , Yasuo Shimoji , Seiji Kumakura
发明人： Yasunobu Sato , Hiromu Takagi , Yasuo Shimoji , Seiji Kumakura
IPC分类号： A61K31/505 , A61P9/08 , A61P9/12 , A61P29/00 , C07D487/14
CPC分类号： C07D487/14 , Y10S514/929
摘要： Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R.sup.2 represents an alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group having from 5 to 8 carbon atoms, a phenyl group optionally substituted with one or more halogen atoms or a phenylalkyl group having the formula ##STR2## IN WHICH R.sup.3 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R.sup.4 represents halogen atom, an alkyl group having from 1 to 4 carbon atoms or an alkoxy group having from 1 to 4 carbon atoms, m represents an integer from 0 to 2 and n represents an integer from 0 to 3, and pharmacologically acceptable salts thereof. The compounds are useful as vasodilating or hypotensive agents and may be prepared by reacting triazolopyrimidine derivatives having the formula ##STR3## wherein X.sup.1 and X.sup.2 may be the same or different and each represents a halogen atom and R.sup.1 has the same meaning as defined above with an amine having the formulaR.sup.2 - NH.sub.2wherein R.sup.2 has the same meaning as defined above.
摘要翻译：具有式的吡咯并三唑并嘧啶衍生物，其中R 1表示氢原子或具有1至4个碳原子的烷基，R 2表示具有1至4个碳原子的烷基，具有5至8个碳原子的环烷基，任选被一个或多个卤素原子取代的苯基或具有下式的苯基烷基：其中R 3表示氢原子或具有1至4个碳原子的烷基，R 4表示卤素原子，具有1至 4个碳原子或1〜4个碳原子的烷氧基，m表示0〜2的整数，n表示0〜3的整数，以及其药理学上可接受的盐。这些化合物可用作血管扩张剂或降血压剂，并且可以通过使具有式（I）的三唑并嘧啶衍生物反应来制备，其中X 1和X 2可以相同或不同，并且各自表示卤素原子，并且R 1具有与上述相同的含义，具有式R2-NH2的胺，其中R2具有与上述相同的含义。

7. 发明授权

US4328238A Benzothiazocine and benzothiazonine derivatives and use 失效
标题翻译：苯并噻嗪和苯并噻嗪衍生物和用途
公开(公告)号：US4328238A
公开(公告)日：1982-05-04
申请号：US184096
申请日：1980-09-04
申请人： Yasunobu Sato , Kuniyuki Tomita , Shinsaku Kobayashi
发明人： Yasunobu Sato , Kuniyuki Tomita , Shinsaku Kobayashi
IPC分类号： C07D281/00 , C07D281/18 , A61K31/395 , A61K31/55 , C07D281/10
CPC分类号： C07D281/00 , C07D281/18 , Y10S514/927
摘要： Benzothiazocine and benzothiazonine derivatives of formula (I): ##STR1## in which: R.sup.1, R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom or an alkyl group;X.sup.1 and X.sup.2 are the same or different and each represents a hydrogen atom, an alkyl group, an alkoxy group, an alkanesulphinyl group, an alkanesulphonyl group, a halogen atom, a trifluoromethyl group, a nitro group or a cyano group;n is 1 or 2; andm is 0 or 1 (excluding those compounds wherein:R.sup.1, R.sup.2, R.sup.3, X.sup.1 and X.sup.2 all represent hydrogen atoms;n is 1 and m is 0; and wherein:R.sup.1 and R.sup.2 both represent hydrogen atoms;R.sup.3 represents a hydrogen atom or a methyl group;X.sup.1 represents a chlorine atom at the 9-position;X.sup.2 represents a hydrogen atom;n is 1; andm is 0)and acid addition salts thereof are novel compounds which have been found to suppress gastric secretions and are thus useful in the treatment and prevention of gastric ulcers. Compounds in which m is 0 may be prepared by reacting a corresponding .omega.-substituted thioalkylaniline derivative with a halogen or an active halogen compound and then condensing the product and, if necessary, introducing an alkyl group at the 1-position. Compounds in which m is 1 may be prepared by oxidizing the corresponding compound wherein m is 0.
摘要翻译：式（I）的苯并噻唑啉和苯并噻唑衍生物：其中：R 1，R 2和R 3相同或不同，各自表示氢原子或烷基; X1和X2相同或不同，分别表示氢原子，烷基，烷氧基，烷基亚磺酰基，链烷磺酰基，卤素原子，三氟甲基，硝基或氰基。 n为1或2; 并且m为0或1（不包括其中：R 1，R 2，R 3，X 1和X 2都表示氢原子的那些化合物; n为1且m为0;并且其中：R 1和R 2都表示氢原子; R 3表示氢原子或甲基; X1表示9位的氯原子; X2表示氢原子，n为1，m为0），其酸加成盐为抑制胃分泌物的新化合物，因此可用于治疗和预防胃溃疡。其中m为0的化合物可以通过使相应的ω-取代的硫代烷基苯胺衍生物与卤素或活性卤素化合物反应制备，然后使产物冷凝，如果需要，在1-位引入烷基。 m为1的化合物可以通过氧化其中m为0的相应化合物来制备。

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