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1. 发明授权

US06599917B1 Quinuclidine compounds and drugs containing the same as the active ingredient 失效
标题翻译：奎宁环化合物和含有与活性成分相同的药物
公开(公告)号：US06599917B1
公开(公告)日：2003-07-29
申请号：US10088554
申请日：2002-03-19
申请人： Toshimi Okada , Nobuyuki Kurusu , Keigo Tanaka , Kazuki Miyazaki , Daisuke Shinmyo , Hiroyuki Sugumi , Hironori Ikuta , Hironobu Hiyoshi , Takao Saeki , Mamoru Yanagimachi , Masashi Ito
发明人： Toshimi Okada , Nobuyuki Kurusu , Keigo Tanaka , Kazuki Miyazaki , Daisuke Shinmyo , Hiroyuki Sugumi , Hironori Ikuta , Hironobu Hiyoshi , Takao Saeki , Mamoru Yanagimachi , Masashi Ito
IPC分类号： A61K31439
CPC分类号： C07D453/02
摘要： The present invention provides an excellent squalene synthesizing enzyme inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In which R1 represents (1) hydrogen atom or (2) hydroxyl group; HAr represents an aromatic heterocycle which may be substituted with 1 to 3 groups; Ar represents an optionally substituted aromatic ring; W represents a chain represented by (1) —CH2—CH2— which may be substituted, (2) —CH═CH— which may be substituted, (3) —C≡C—, (4) —NH—CO—, (5) —CO—NH—, (6) —NH—CH2—, (7) —CH2—NH—, (8) —CH2—CO—, (9) —CO—CH2—, (10) —NH—S(O)l—, (11) —S(O)l—NH—, (12) —CH2—S(O)— or (13) —S(O)l—CH2— (l denotes 0, 1 or 2); and X represents a chain represented by (1) a single bond, (2) an optionally substituted C1-6 alkylene chain, (3) an optionally substituted C2-6 alkenylene chain, (4) an optionally substituted C2-6 alkynylene chain, (5) a formula —Q— (wherein Q represents oxygen atom, sulfur atom, CO or N(R2) (wherein R2 represents a C1-6 alkyl group or a C1-6 alkoxy group)), (6) —NH—CO—, (7) —CO—NH—, (8) —NH—CH2—, (9) —CH2—NH—, (10) —CH2—CO—, (11) —CO—CH2—, (12) —NH—S(O)m—, (13) —S(O)m—NH—, (14) —CH2—S(O)m—, (15) —S(O)m—CH2— (wherein m denotes 0, 1 or 2) or (16) —(CH2)n—O— (wherein n denotes an integer from 1 to 6).
摘要翻译：本发明提供优良的角鲨烯合成酶抑制剂。具体地说，它提供由下式表示的化合物（I），其盐或它们的水合物。其中R1表示（1）氢原子或（2）羟基; HAr表示可被1〜3个基团取代的芳香族杂环; Ar表示任选取代的芳环; W表示可被取代的（1）-CH 2 -CH 2 - 表示的链，（2）可以被取代的-CH = CH-，（3）-C = C-，（4）-NH-CO-，（5）-CO-NH-，（6）-NH-CH2-，（7）-CH2-NH-，（8）-CH2-CO-，（9）-CO-CH2-，（10）-NH -S（O）1 - ，（11）-S（O）1 -NH-，（12）-CH 2 -S（O） - 或（13）-S（O） 1或2）; 并且X表示由（1）单键表示的链，（2）任选取代的C 1-6亚烷基链，（3）任选取代的C 2-6亚烯基链，（4）任选取代的C 2-6亚炔基链，（5）式-Q-（其中Q表示氧原子，硫原子，CO或N（R2）（其中R2表示C1-6烷基或C1-6烷氧基）），（6）-NH- CO-，（7）-CO-NH-，（8）-NH-CH2-，（9）-CH2-NH-，（10）-CH2-CO-，（11）-CO-CH2-，）-NH-S（O）m - ，（13）-S（O）m -NH-，（14）-CH 2 -S（O）m - ，（15）-S（O）m -CH 2 - 其中m表示0,1或2）或（16） - （CH2）nO-（其中n表示1至6的整数）。

2. 发明授权

US07112593B2 N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient 失效
标题翻译： N-芳基取代环胺衍生物和含有活性成分的药物
公开(公告)号：US07112593B2
公开(公告)日：2006-09-26
申请号：US10470675
申请日：2002-03-27
申请人： Toshimi Okada , Nobuyuki Kurusu , Keigo Tanaka , Seiji Yoshikawa , Daisuke Shinmyo , Nobuhisa Watanabe , Hironori Ikuta , Hironobu Hiyoshi , Takao Saeki , Mamoru Yanagimachi , Masashi Ito
发明人： Toshimi Okada , Nobuyuki Kurusu , Keigo Tanaka , Seiji Yoshikawa , Daisuke Shinmyo , Nobuhisa Watanabe , Hironori Ikuta , Hironobu Hiyoshi , Takao Saeki , Mamoru Yanagimachi , Masashi Ito
IPC分类号： A61K31/44 , C07D453/02
CPC分类号： C07D401/04 , A61K31/435 , A61K31/439 , A61K31/4545 , C07D401/14 , C07D453/04 , C07D491/10
摘要： An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), R1 represents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom. Finally, W represents a chain
摘要翻译：提供了极好的角鲨烯合酶抑制剂。具体地，提供由下式表示的化合物（I），其盐或它们的水合物。在式（I）中，R 1表示任选取代的乙烯基或可被取代的芳环。此外，n是0〜2的整数。此外，X，Y和Z彼此相同或不同，各自表示任选取代的碳原子，或任选取代的氮原子，硫原子或氧原子，以及 Y任选表示单键，当Y表示单键时，X，Y和Z所属的环为5元环。式中，CyA表示可以被取代的5〜14元非芳香族环状氨基或非芳香族环状酰胺基，非芳香族环状氨基或非芳香族环状酰胺基任选具有氧原子或硫原子。最后，W代表一个链

3. 发明申请

US20140187115A1 POLYPHENYLENE SULFIDE FIBER AND NONWOVEN FABRIC 审中-公开
标题翻译：聚苯乙烯纤维和非织造布
公开(公告)号：US20140187115A1
公开(公告)日：2014-07-03
申请号：US14122114
申请日：2012-06-01
申请人： Yohei Nakano , Yoshikazu Yakake , Masashi Ito
发明人： Yohei Nakano , Yoshikazu Yakake , Masashi Ito
IPC分类号： D01F6/76 , D04H1/4326
CPC分类号： D01F6/765 , D01D5/08 , D04H1/4326 , D04H1/44 , D04H1/54 , Y10T442/60 , Y10T442/69
摘要： Provided are a polyphenylene sulfide fiber including a PPS resin as a main component and having both excellent heat resistance and excellent thermal bonding properties, and a nonwoven fabric including the fiber. The polyphenylene sulfide fiber includes polyphenylene sulfide as a main component and having the sum of the crystallinity and the rigid amorphous fraction of 30% to 90%. The crystallinity is preferably not less than 5% and less than 25%. The polyphenylene sulfide fiber is used to form a nonwoven fabric. The nonwoven fabric is preferably produced by consolidation by thermal bonding or mechanical entanglement.
摘要翻译：提供以PPS树脂为主要成分，具有优异的耐热性和优异的热粘合性的聚苯硫醚纤维，以及包含该纤维的无纺布。聚苯硫醚纤维包括聚苯硫醚作为主要成分，其结晶度和刚性非晶部分之和为30％至90％。结晶度优选为5％以上且小于25％。聚苯硫醚纤维用于形成无纺织物。无纺布优选通过热粘合或机械缠结固结而制成。

4. 发明授权

US08735135B2 Transformed strains originated from multidrug efflux protein defective strains and a method for microbial conversion using them 有权
标题翻译：来自多种药物外排蛋白质缺陷菌株的转化菌株和使用它们的微生物转化方法
公开(公告)号：US08735135B2
公开(公告)日：2014-05-27
申请号：US12449868
申请日：2008-02-28
申请人： Tadashi Fujii , Atsushi Ochiai , Masashi Ito , Hiroki Kabumoto , Yoshikazu Fujii , Kazuhiro Machida
发明人： Tadashi Fujii , Atsushi Ochiai , Masashi Ito , Hiroki Kabumoto , Yoshikazu Fujii , Kazuhiro Machida
IPC分类号： C12N1/21 , C12P1/04
CPC分类号： C12P1/04 , C07K14/195 , C12P7/02 , C12P7/62 , C12P13/08 , C12P17/10 , C12P33/06
摘要： Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion system using a transformant which is given by introducing a gene originated from xerogenic organisms. A transformant is prepared by using a host which is defective in a gene encoding a multidrug efflux protein and introducing a gene originated from xerogenic organisms. Use of the transformant results in much effective microbial conversion of a hydrophobic or amphipathic substrate compound into a desired compound. In case, an Escherichia coli is used as the host, the gene encoding a multidrug efflux protein to be defective may be tolC, acrA, acrB and the like.
摘要翻译：公开了一种改善常规生物转化系统中转化效率差的方法，该方法是使用通过引入源自干细胞生物体的基因而给出的转化体。通过使用在编码多药外排蛋白的基因中有缺陷的宿主并引入源自干细胞生物的基因来制备转化体。转化体的使用导致将疏水性或两亲性底物化合物转化为所需化合物的有效微生物转化。如果使用大肠杆菌作为宿主，编码有缺陷的多药外排蛋白的基因可以是toC，acrA，acrB等。

5. 发明申请

US20130001859A1 SHEET CONVEYING APPARATUS, PRINTING APPARATUS, AND PROCESSING APPARATUS 有权
标题翻译：板材输送装置，印刷装置和加工装置
公开(公告)号：US20130001859A1
公开(公告)日：2013-01-03
申请号：US13529229
申请日：2012-06-21
申请人： Noriyuki Sugiyama , Hiroyuki Saito , Atsushi Ikeda , Yasuyuki Hirai , Noriko Sato , Masashi Ito , Fumie Kameyama
发明人： Noriyuki Sugiyama , Hiroyuki Saito , Atsushi Ikeda , Yasuyuki Hirai , Noriko Sato , Masashi Ito , Fumie Kameyama
IPC分类号： B65H5/00 , B65H3/06
CPC分类号： B65H3/0684 , B65H3/34 , B65H3/56 , B65H3/66 , B65H2301/4222 , B65H2403/512 , B65H2405/1134 , B65H2405/1136 , B65H2511/214 , B65H2511/416 , B65H2515/81 , B65H2220/01 , B65H2220/02 , B65H2220/11
摘要： Even in printing apparatus that make use of a plurality of kinds of sheets, the degradation of image quality is reduced. A sheet conveying apparatus includes: a sheet stacking unit; a sheet conveying unit being in contact with the sheet stacked on an uppermost portion, of the stacked sheets, and conveying the sheet; a separation unit separating the sheets into only one sheet of the uppermost portion by a separation slope that abuts a tip portion of the sheet conveyed by the sheet conveying unit; and a guide unit connected to the separation unit and guiding the sheet, in which an angle between the sheet stacking unit and the separation slope is switched to a first angle and a second angle smaller than the first angle by a rotation center of the separation unit provided in a vicinity of a connection portion of the separation unit and the guide unit.
摘要翻译：即使在使用多种片材的打印装置中，也降低了图像质量的劣化。片材输送装置包括：片材堆积单元; 片材输送单元与层叠在最上部的片材接触，并且输送片材; 分离单元，其通过与由所述片材输送单元输送的所述片材的前端部抵接的分离斜面将所述片材分离成仅一片最上部; 以及引导单元，其连接到分离单元并引导片材，其中片材积累单元和分离斜面之间的角度通过分离单元的旋转中心切换到第一角度和小于第一角度的第二角度设置在分离单元和引导单元的连接部分附近。

6. 发明授权

US08142955B2 Fuel cell system, fuel cell vehicle, and operating method for fuel cell system 有权
标题翻译：燃料电池系统，燃料电池车以及燃料电池系统的运行方法
公开(公告)号：US08142955B2
公开(公告)日：2012-03-27
申请号：US12084637
申请日：2006-11-22
申请人： Masashi Ito
发明人： Masashi Ito
IPC分类号： H01M8/22
CPC分类号： H01M8/04089 , B60L11/1883 , B60L11/1892 , B60L11/1898 , H01M4/8647 , H01M8/04126 , H01M8/1023 , H01M8/1032 , H01M8/1039 , H01M2250/20 , Y02E60/521 , Y02T90/32 , Y02T90/34
摘要： A utility supply system supplies a fluid containing an antioxidant of a gaseous phase to a stack of proton-exchange membrane fuel cells, for efficient removal of hydroxyl radicals.
摘要翻译：公用设施供应系统将含有气相抗氧化剂的流体提供给质子交换膜燃料电池堆，以有效地除去羟基。

7. 发明授权

US08071085B2 Primary cultured adipocytes for gene therapy 有权
标题翻译：原代培养的脂肪细胞进行基因治疗
公开(公告)号：US08071085B2
公开(公告)日：2011-12-06
申请号：US12175186
申请日：2008-07-17
申请人： Masashi Ito , Yasushi Saito
发明人： Masashi Ito , Yasushi Saito
IPC分类号： A61K48/00 , C12P21/00 , C12P21/02
CPC分类号： C12N5/0653 , A61K35/12 , C12N2510/00 , C12N2510/02
摘要： The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells. This invention provides cells suitable for gene therapy, which can replace bone marrow cells and liver cells used for conventional ex vivo gene therapy. The present invention established methods for transferring foreign genes into primary cultured adipocytes, which are suitable for ex vivo gene therapy; can be easily collected and implanted; and can be removed after implantation. Specifically, the present invention established these methods that use retroviral vectors. The present invention also established primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells.
摘要翻译：本发明涉及用于基因治疗的原代培养的脂肪细胞，其中脂肪细胞稳定地维持编码在细胞外分泌的蛋白质的外源基因。本发明提供适用于基因治疗的细胞，其可代替用于常规体外基因治疗的骨髓细胞和肝细胞。本发明建立了将外源基因转移到适合离体基因治疗的原代培养脂肪细胞中的方法; 可以轻松收集和植入; 并且可以在植入后去除。具体地，本发明建立了使用逆转录病毒载体的这些方法。本发明还建立了用于基因治疗的原代培养的脂肪细胞，其中脂肪细胞稳定地保持编码在细胞外分泌的蛋白质的外源基因。

8. 发明授权

US08045155B2 Spectroscopic module 失效
标题翻译：光谱模块
公开(公告)号：US08045155B2
公开(公告)日：2011-10-25
申请号：US12377343
申请日：2008-06-05
申请人： Tomofumi Suzuki , Katsumi Shibayama , Takafumi Yokino , Masashi Ito , Helmut Teichmann , Dietmar Hiller , Ulrich Starker
发明人： Tomofumi Suzuki , Katsumi Shibayama , Takafumi Yokino , Masashi Ito , Helmut Teichmann , Dietmar Hiller , Ulrich Starker
IPC分类号： G01J3/26
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/0243 , G01J3/0259 , G01J3/04
摘要： The spectroscopy module is provided with a body portion for transmitting light, a spectroscopic portion for dispersing light made incident from the front plane of the body portion into the body portion to reflect the light on the front plane, a light detecting element having a light detecting portion for detecting the light dispersed and reflected by the spectroscopic portion and electrically connected to a wiring formed on the front plane of the body portion by face-down bonding, and an underfill material filled in the body portion side of the light detecting element to transmit the light. The light detecting element is provided with a light-passing hole through which the light advancing into the spectroscopic portion passes, and a reservoir portion is formed on a rear plane of the body portion side in the light detecting element so as to enclose a light outgoing opening of the light-passing hole.
摘要翻译：光谱模块设置有用于透射光的主体部分，用于将从主体部分的前平面入射的光分散到主体部分中以将光反射到前平面上的光谱部分，具有光检测的光检测元件用于检测由分光部分分散和反射的光并通过面朝下接合与形成在主体部分的前平面上的布线电连接的光;以及填充在光检测元件的主体部分侧的底部填充材料，光。光检测元件设置有通向分光部分的光通过的通光孔，并且在光检测元件中的主体部分侧的后平面上形成储存部分，以便包围光出射打开通光孔。

9. 发明授权

US07799485B2 Fuel cell system and composition for electrode 有权
标题翻译：燃料电池系统及电极组成
公开(公告)号：US07799485B2
公开(公告)日：2010-09-21
申请号：US11571865
申请日：2005-07-07
申请人： Masashi Ito , Takao Maruyama
发明人： Masashi Ito , Takao Maruyama
IPC分类号： H01M4/02 , B01D19/00 , C10L1/24 , C10L1/00
CPC分类号： H01M8/1039 , B60L11/1883 , B60L11/1898 , B60L2240/36 , H01M8/04 , H01M8/1023 , H01M2250/20 , Y02E60/521 , Y02E60/528 , Y02T90/32 , Y02T90/34
摘要： According to the invention, a fuel cell system features a fuel cell (1) having an electrode (5, 6), and an antioxidant residing in or contacting the electrode (5, 6), for inactivating active oxygen.
摘要翻译：根据本发明，燃料电池系统具有燃料电池（1），其具有电极（5,6）以及驻留在电极（5,6）中或与电极接触的抗氧化剂，用于使活性氧失活。

10. 发明申请

US20080050787A1 Method for Manufacturing Optically Active Tetrahydrothiophene Derivative and Method for Crystallization of Optically Active Tetrahydrothiophene-3-Ol 审中-公开
标题翻译：光学活性四氢噻吩衍生物的制备方法和光活性四氢噻吩-3-O的结晶方法
公开(公告)号：US20080050787A1
公开(公告)日：2008-02-28
申请号：US10581366
申请日：2004-12-01
申请人： Hazuki Nagai , Kaname Konuki , Masashi Ito , Tomohiro Sameshima
发明人： Hazuki Nagai , Kaname Konuki , Masashi Ito , Tomohiro Sameshima
IPC分类号： C12P17/00 , C07D333/32
CPC分类号： C12P17/167
摘要： A method for manufacturing (R)-tetrahydrothiophene-3-ol denoted by formula (II): by bioconversion of tetrahydrothiophene-3-one denoted by formula (I): to (R)-tetrahydrothiophene-3-ol denoted by formula (II). It comprises the steps of: (A) incubating the tetrahydrothiophene-3-one denoted by formula (I) in the presence of a strain, or a preparation of a cultured cell thereof, belonging to Penicillium, Aspergillus, or Streptomyces that is capable of said bioconversion; and (B) collecting the (R)-tetrahydrothiophene-3-ol denoted by formula (II) from incubated solution. A method for crystallization of optically active tetrahydrothiophene-3-ol of improved optical purity, characterized by maintaining a solution comprising optically active tetrahydrothiophene-3-ol and organic solvent at equal to or lower than 1° C. to cause optically active tetrahydrothiophene-3-ol to crystallize from said solution, or characterized by adding optically active tetrahydrothiophene-3-ol dropwise to organic solvent at a solution temperature of equal to or lower than 1° C. to cause optically active tetrahydro thiophene-3-ol to crystallize.
摘要翻译：由式（II）表示的（R） - 四氢噻吩-3-醇的制造方法：通过式（I）表示的四氢噻吩-3-酮的生物转化：式（II）表示的（R） - 四氢噻吩-3-醇）。其包括以下步骤：（A）在菌株存在下将式（I）表示的四氢噻吩-3-酮或其培养细胞的制剂，属于青霉属，曲霉属或链霉菌属，其能够说生物转化和（B）从温育溶液中收集由式（II）表示的（R） - 四氢噻吩-3-醇。一种提高光学纯度的光学活性四氢噻吩-3-醇的结晶方法，其特征在于将含有光学活性四氢噻吩-3-醇和有机溶剂的溶液保持在等于或低于1℃，使光学活性的四氢噻吩-3 - 醇从所述溶液中结晶，或者特征在于在等于或低于1℃的溶液温度下将光学活性的四氢噻吩-3-醇滴加到有机溶剂中，使光学活性的四氢噻吩-3-醇结晶。

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