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1. 发明授权

US6156555A Method of preparing an enzyme participating in C-terminal amidation 失效
标题翻译：制备参与C-末端酰胺化的酶的方法
公开(公告)号：US6156555A
公开(公告)日：2000-12-05
申请号：US172120
申请日：1998-10-14
申请人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
发明人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
IPC分类号： C07K1/107 , C12N9/02 , C12N15/53 , C12N15/60 , C12N9/48 , C12N9/14 , C12N9/78 , C12N9/80 , C12N15/00
CPC分类号： C12N9/0071 , C07K1/107 , C12Y114/17003 , Y10S435/814 , Y10S435/815
摘要： A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal .alpha.-hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of 25 to 40.degree. C. and a molecular weight of about 25 kDa or about 36 kDa, and metal ions and ascorbic acid act as a cofactor. A purified enzyme-II is obtained that participates in C-terminal amidation by acting on the peptide C-terminal .alpha.-hydroxyglycine adduct to produce a C-terminal amidated compound. The enzyme has an optimum pH of about 5 to 6, an optimum temperature of 15 to 35.degree. C. and a molecular weight of about 40 kDa or about 43 kDa. Enzyme-I does not act on the peptide C-terminal .alpha.-hydroxyglycine adduct and enzyme-II does not act on the peptide C-terminal glycine adduct. The enzymes may be purified from a biological material such as horse serum by affinity chromatography using a peptide C-terminal glycine adduct as a ligand. The enzymes may also be obtained from host cells transformed with a plasmid containing a cDNA coding for the enzymes. Assay of activity of the enzymes is carried out by measuring the C-terminal .alpha.-hydroxyglycine adduct or the C-terminal amidated compound that has been isolated such as by high performance liquid chromatography with the use of an acetonitrile-containing buffer.
摘要翻译：获得通过作用于肽C-末端甘氨酸加合物以形成肽C末端α-羟基甘氨酸加合物参与C-末端酰胺化的纯化的酶I. 酶的最佳pH为约5至7，最适温度为25至40℃，分子量为约25kDa或约36kDa，金属离子和抗坏血酸用作辅因子。获得了通过作用于肽C-末端α-羟基甘氨酸加合物参与C-末端酰胺化产生C末端酰胺化合物的纯化的酶-II。酶的最佳pH为约5至6，最适温度为15至35℃，分子量为约40kDa或约43kDa。酶-I不对肽C-端α-羟基甘氨酸加合物起作用，酶-II不对肽C-末端甘氨酸加合物起作用。可以使用肽C-末端甘氨酸加合物作为配体通过亲和层析从生物材料如马血清中纯化酶。酶也可以从用含有编码酶的cDNA的质粒转化的宿主细胞获得。酶的活性测定是通过使用含有乙腈的缓冲液，通过高分辨液相色谱法测定已分离的C末端α-羟基甘氨酸加成物或C末端酰胺化合物进行的。

2. 发明授权

US5871995A Purified enzymes participating in C-terminal amidation 失效
标题翻译：纯化酶参与C-末端酰胺化
公开(公告)号：US5871995A
公开(公告)日：1999-02-16
申请号：US070301
申请日：1991-05-24
申请人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
发明人： Toshii Iida , Toshihiko Kaminuma , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto , Jiro Kishimoto , Ohji Ifuku , Ichiro Kato
IPC分类号： C07K1/107 , C12N9/02 , C12N15/53 , C12N15/60 , C12N9/48 , C12N9/14 , C12N9/78 , C12N9/80
CPC分类号： C12N9/0071 , C07K1/107 , C12Y114/17003 , Y10S435/814 , Y10S435/815
摘要： A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal .alpha.-hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of 25.degree. to 40.degree. C. and a molecular weight of about 25 kDa or about 36 kDa, and metal ions and ascorbic acid act as a cofactor. A purified enzyme-II is obtained that participates in C-terminal amidation by acting on a peptide C-terminal .alpha.-hydroxyglycine adduct to produce a C-terminal amidated compound. The enzyme has an optimum pH of about 5 to 6, an optimum temperature of 15.degree. to 35.degree. C. and a molecular weight of about 40 kDa or about 43 kDa. Enzyme-I does not act on the peptide C-terminal .alpha.-hydroxyglycine adduct and enzyme-II does not act on the peptide C-terminal glycine adduct. The enzymes may be purified from a biological material such as horse serum by affinity chromatography using a peptide C-terminal glycine adduct as a ligand. The enzymes may also be obtained from host cells transformed with a plasmid containing a cDNA coding for the enzymes. Assay of activity of the enzymes is carried out by measuring adduct (II) or the compound (III) that has been isolated such as by high performance liquid chromatography with the use of an acetonitrile-containing buffer.
摘要翻译： PCT No.PCT / JP90 / 01036 Sec。 371日期1991年5月24日 102（e）日期1991年5月24日PCT提交1990年4月12日PCT公布。公开号WO91 / 02790 日期1991年3月7日获得通过作用于肽C-末端甘氨酸加合物以形成肽C-末端α-羟基甘氨酸加合物参与C-末端酰胺化的纯化的酶-I。酶的最佳pH为约5至7，最适温度为25至40℃，分子量为约25kDa或约36kDa，金属离子和抗坏血酸用作辅因子。获得了通过作用于肽C-末端α-羟基甘氨酸加合物以产生C末端酰胺化合物而参与C-末端酰胺化的纯化的酶-II。酶的最佳pH为约5至6，最适温度为15-35℃，分子量为约40kDa或约43kDa。酶-I不对肽C-端α-羟基甘氨酸加合物起作用，酶-II不对肽C-末端甘氨酸加合物起作用。可以使用肽C-末端甘氨酸加合物作为配体通过亲和层析从生物材料如马血清中纯化酶。酶也可以从用含有编码酶的cDNA的质粒转化的宿主细胞获得。酶的活性测定是通过使用含乙腈的缓冲液测定加成物（II）或分离的化合物（III），例如通过高效液相色谱法进行的。

3. 发明授权

US5354675A C-terminal amidating enzyme composition, process for preparing, and use of the same 失效
标题翻译： C-末端酰胺化酶组合物，其制备方法及其用途
公开(公告)号：US5354675A
公开(公告)日：1994-10-11
申请号：US459829
申请日：1990-01-29
申请人： Toshii Iida , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto
发明人： Toshii Iida , Yuka Fuse , Masahiro Tajima , Mitsuo Yanagi , Hiroshi Okamoto
IPC分类号： C07K1/107 , C12N9/02 , C12P21/00 , C12N9/00
CPC分类号： C12N9/0071 , C07K1/107 , C12Y114/17003
摘要： A C-terminal amidating enzyme composition is disclosed having the ability to amidate the C-terminus of peptides with a C-terminal glycine. The C-terminal amidating enzyme is characterized by having a stable pH range of 5 to 9, metal ions and L-ascorbic acid as cofactors, two active fractions at molecular weights of about 50,000 and about 100,000 as determined from gel filtration, isoelectric points of about 4.5 pH for the active fraction having a molecular weight of about 50,000 and about 6.7 pH for the active fraction having a molecular weight of about 100,000 according to isoelectric point chromatography, and is activated by addition of catalase.
摘要翻译： PCT No.PCT / JP89 / 00521 Sec。 371 1990年1月29日第 102（e）日期1990年1月29日PCT提交1989年5月25日PCT公布。出版物WO89 / 12096 公开了C端氨酰化酶组合物，其具有用C-末端甘氨酸酰胺化肽的C末端的能力。 C末端酰胺化酶的特征在于具有5至9的稳定的pH范围，金属离子和L-抗坏血酸作为辅因子，分子量约50,000和约100,000的活性级分由凝胶过滤确定，等电点根据等电点色谱法，对于分子量约为50,000的活性级分，对于分子量为约50,000的活性级分和约6.7pH的活性级分为大约4.5的pH，并且通过加入过氧化氢酶来活化。

4. 外观设计

USD798596S1 Storage case 有权
公开(公告)号：USD798596S1
公开(公告)日：2017-10-03
申请号：US29559489
申请日：2016-03-29
申请人： Fuminori Kataoka , Norihide Umeyama , Toshifumi Nishijima , Hiromi Tonegawa , Shigeyuki Susaki , Hiroshi Okamoto , Nobuaki Kuwata , Keizou Tanaka
设计人： Fuminori Kataoka , Norihide Umeyama , Toshifumi Nishijima , Hiromi Tonegawa , Shigeyuki Susaki , Hiroshi Okamoto , Nobuaki Kuwata , Keizou Tanaka

5. 发明申请

US20140168026A1 ANTENNA 有权
标题翻译：天线
公开(公告)号：US20140168026A1
公开(公告)日：2014-06-19
申请号：US14234224
申请日：2012-07-20
申请人： Masaki Nakamura , Hiroshi Okamoto , Hirohiko Miki
发明人： Masaki Nakamura , Hiroshi Okamoto , Hirohiko Miki
IPC分类号： H01Q7/00
CPC分类号： H01Q7/00 , H01F5/04 , H01Q1/40 , H01Q7/06
摘要： An antenna comprising a coreless coil formed by winding a conductor wire, a relay member connected to the coil, and a magnetic plate member covering the coil and part of the relay member; the relay member comprising a substrate having a notch for lead wires of the coil, and a pair of terminal members formed on the substrate; each terminal member comprising an internal terminal portion connected to an end of each lead wire, an external terminal portion connected to an external circuit, and a line portion connecting the internal terminal portion to the external terminal portion; the coil and part of the relay member disposed on the magnetic member being fixed to a first adhesive layer on the non-transmission side of the coil; and the internal terminal portion being positioned in a region overlapping the magnetic member, or in a region surrounded by the notch of the magnetic member.
摘要翻译：一种天线，包括通过缠绕导线而形成的无芯线圈，连接到所述线圈的中继部件和覆盖所述线圈和所述中继部件的一部分的磁性板部件; 所述继电器构件包括具有用于所述线圈的引线的凹口的基板和形成在所述基板上的一对端子构件; 每个端子构件包括连接到每个引线的端部的内部端子部分，连接到外部电路的外部端子部分和将内部端子部分连接到外部端子部分的线路部分; 所述线圈和设置在所述磁性构件上的所述中继构件的一部分被固定到所述线圈的非透射侧上的第一粘合剂层; 并且内部端子部分位于与磁性构件重叠的区域中，或者位于由磁性构件的凹口包围的区域中。

6. 发明授权

US08501303B2 Aromatic polycarbonate resin composition 有权
标题翻译：芳香族聚碳酸酯树脂组合物
公开(公告)号：US08501303B2
公开(公告)日：2013-08-06
申请号：US13502841
申请日：2010-10-18
申请人： Yoji Ohira , Toshiyuki Miyake , Hiroshi Shuto , Hiroshi Okamoto , Takayuki Ozaki , Maiko Murai
发明人： Yoji Ohira , Toshiyuki Miyake , Hiroshi Shuto , Hiroshi Okamoto , Takayuki Ozaki , Maiko Murai
IPC分类号： A61K9/28 , C08C1/14
CPC分类号： C08L69/00 , C08G77/448 , C08K3/016 , C08K5/0066 , C08K5/42 , C08K5/43 , C08K5/5419 , Y10T428/24479
摘要： A resin composition comprising an aromatic polycarbonate resin having excellent transparency and flame retardancy. The resin composition comprises 100 parts by weight of an aromatic polycarbonate resin having a branched structure with a branching ratio of 0.7 to 1.1 mol % (component A) and 0.005 to 12 parts by weight of at least one flame retardant.
摘要翻译：一种包含透明性和阻燃性优异的芳香族聚碳酸酯树脂的树脂组合物。树脂组合物包含100重量份具有分支比为0.7-1.1摩尔％的支化结构的芳族聚碳酸酯树脂（组分A）和0.005-12重量份的至少一种阻燃剂。

7. 发明申请

US20120107673A1 SECONDARY BATTERY 审中-公开
标题翻译：二次电池
公开(公告)号：US20120107673A1
公开(公告)日：2012-05-03
申请号：US13286368
申请日：2011-11-01
申请人： Kazuya SAKASHITA , Kazuo Yamada , Yoshihiro Tsukuda , Yuki Watanabe , Hiroshi Okamoto , Tadashi Nemoto , Takuya Ootani
发明人： Kazuya SAKASHITA , Kazuo Yamada , Yoshihiro Tsukuda , Yuki Watanabe , Hiroshi Okamoto , Tadashi Nemoto , Takuya Ootani
IPC分类号： H01M2/02
CPC分类号： H01M2/04 , H01M2/0217 , H01M2/0404 , H01M2/043 , H01M2/266 , H01M2/30 , H01M4/5825 , H01M4/587 , H01M10/0436 , H01M10/0468 , H01M10/0525 , H01M2220/20 , H01M2220/30 , Y02T10/7011
摘要： To obtain a secondary battery that surely positions and fixes a laminated type of electrode group by effectively curbing lateral deviation and vertical deviation, in secondary batteries RB1 to RB11 that include a laminated type of electrode group 1 in which a positive-electrode plate 2 and a negative-electrode plate 3 are so laminated via a separator 4 as to form a plurality of laminated layers, a structure is employed, in which vertical deviation in a lamination direction and lateral deviation in a lamination surface direction are curbed via a fix means that fixes the electrode group 1 to a predetermined position in an outer case 11 that houses the electrode group 1.
摘要翻译：为了获得二次电池，通过有效地抑制横向偏离和垂直偏移来确定地定位和固定层叠型电极组，在包括正极板2和第二电极组2的层叠型电极组1的二次电池RB1至RB11中负极板3通过隔膜4层叠以形成多个层叠层，采用结构，其中层压方向的垂直偏移和层叠面方向的横向偏移通过固定装置固定的固定装置电极组1到容纳电极组1的外壳11中的预定位置。

8. 发明授权

US07961769B2 Wavelength tunable semiconductor laser device, controller for the same, and control method for the same 有权
标题翻译：波长可调半导体激光器件，控制器相同，控制方法相同
公开(公告)号：US07961769B2
公开(公告)日：2011-06-14
申请号：US12529337
申请日：2008-03-07
申请人： Naoki Fujiwara , Hiroyuki Ishii , Hiromi Oohashi , Hiroshi Okamoto
发明人： Naoki Fujiwara , Hiroyuki Ishii , Hiromi Oohashi , Hiroshi Okamoto
IPC分类号： H01S5/00
CPC分类号： H01S5/06256 , B82Y20/00 , H01S5/0014 , H01S5/024 , H01S5/02407 , H01S5/02461 , H01S5/0268 , H01S5/0425 , H01S5/0612 , H01S5/0617 , H01S5/06808 , H01S5/22 , H01S5/2214 , H01S5/34306 , H01S5/4087 , H01S2301/173
摘要： An object is to provide a wavelength tunable semiconductor laser device, a controller for the same and a control method for the same, which prevent wavelength drifts. The wavelength tunable semiconductor laser device includes an active region for oscillating a laser beam, and a wavelength tuning region for shifting a wavelength of the laser beam. In this device, a thermal compensation region for converting most of the inputted electric power to heat is provided adjacent to the wavelength tuning region, and the sum of an electric power inputted into the wavelength tuning region and an electric power inputted into the thermal compensation region is always kept constant.
摘要翻译：本发明的目的是提供一种波长可调谐半导体激光器件，用于其的控制器及其控制方法，其防止波长漂移。波长可调谐半导体激光器件包括用于振荡激光束的有源区域和用于移动激光束波长的波长调谐区域。在该装置中，与波长调谐区域相邻地设置用于将大部分输入的电力转换为热量的热补偿区域，输入到波长调谐区域的电力和输入到热补偿区域的电力的和始终保持不变。

9. 发明授权

US07919429B2 Zirconia-ceria-yttria-based mixed oxide and process for producing the same 有权
标题翻译：氧化锆 - 氧化铈 - 氧化钇基混合氧化物及其制造方法
公开(公告)号：US07919429B2
公开(公告)日：2011-04-05
申请号：US11871376
申请日：2007-10-12
申请人： Hiroshi Okamoto , Hiroshi Kodama
发明人： Hiroshi Okamoto , Hiroshi Kodama
IPC分类号： B01J23/00 , B01J23/10
CPC分类号： C01G25/006 , B01D53/945 , B01D2255/407 , B01D2255/908 , B01J21/066 , B01J23/10 , B01J35/002 , B01J35/1014 , C01P2002/50 , C01P2002/72 , C01P2004/61 , C01P2006/12 , C01P2006/13 , Y02T10/22
摘要： The present invention provides a zirconia-ceria-yttria-based mixed oxide having a stable crystal structure after 12 hours of heat treatment at 1100° C. under a reducing atmosphere, and a process for producing the mixed oxide.
摘要翻译：本发明提供一种在还原气氛下在1100℃下热处理12小时后具有稳定晶体结构的氧化锆 - 二氧化铈 - 氧化钇混合氧化物，以及该混合氧化物的制造方法。

10. 发明申请

US20100215063A1 PULSE LASER APPARATUS 审中-公开
标题翻译：脉冲激光装置
公开(公告)号：US20100215063A1
公开(公告)日：2010-08-26
申请号：US12686637
申请日：2010-01-13
申请人： Xin GAO , Hiroyuki Ohashi , Kazunori Shinoda , Hiroshi Okamoto , Masayuki Saitoh
发明人： Xin GAO , Hiroyuki Ohashi , Kazunori Shinoda , Hiroshi Okamoto , Masayuki Saitoh
IPC分类号： H01S3/11
CPC分类号： H01S3/1118 , H01S3/0604 , H01S3/0627 , H01S3/09415 , H01S3/10092 , H01S3/1611 , H01S3/1618 , H01S3/1643 , H01S3/2308
摘要： The pulse laser light source 1 is provided with an excitation light source 10, lenses 11 through 13, a dichroic mirror 14, an amplifier medium 21, a first reflection portion 22, a laser medium 23, a third reflection portion 24, a saturable absorber 25 and a second reflection portion 26. The reflection portion 22 and the reflection portion 26 compose a laser resonator having the laser medium 23, the reflection portion 24 and the saturable absorber 25 on a resonance path. Further, the amplifier medium 21, the reflection portion 22, the laser medium 23, the reflection portion 24, the saturable absorber 25 and the reflection portion 26 are disposed in order and are integrated with each other. Therefore, the pulse laser light source 1 is able to output pulse laser light of high energy with a short pulse width.
摘要翻译：脉冲激光光源1设置有激发光源10，透镜11至13，分色镜14，放大器介质21，第一反射部22，激光介质23，第三反射部24，可饱和吸收体 25和第二反射部分26.反射部分22和反射部分26在谐振路径上组成具有激光介质23，反射部分24和可饱和吸收体25的激光谐振器。此外，放大器介质21，反射部分22，激光介质23，反射部分24，可饱和吸收器25和反射部分26依次布置并且彼此一体化。因此，脉冲激光光源1能够以短脉冲宽度输出高能量的脉冲激光。

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