专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4424238A Adhesive for bonding polyester fibrous material to rubber compositions 失效
标题翻译：用于将聚酯纤维材料粘合到橡胶组合物上的粘合剂
公开(公告)号：US4424238A
公开(公告)日：1984-01-03
申请号：US366033
申请日：1982-04-06
申请人： Toshihiro Yotsumoto , Kazuo Koyama
发明人： Toshihiro Yotsumoto , Kazuo Koyama
IPC分类号： C08L61/00 , C08G8/00 , C08G8/08 , C08G8/12 , C08G8/20 , C08G8/24 , C08J5/06 , C08L61/04 , C09J161/00 , C09J161/06 , B05D3/02 , C08L61/14
CPC分类号： C08J5/06 , C08G8/08 , C09J161/06 , C08J2321/00
摘要： An adhesive having a high adhesive strength and capable of bonding firmly polyester fibrous material with rubber is disclosed, which comprises a mixture of components A and B in a mixing ratio of A/B of 100/5-100/30, said component A being formaldehyde condensate obtained by reacting formaldehyde with one member selected from the following members (1)-(4): (1) a mixture of resorcin with one of m-cresol, m-methoxyphenol, 3,5-xylenol and m-xylene, (2) a mixture of 5-methylresorcin with m-cresol or with m-methoxyphenol, (3) a mixture of m-cresol with p-chlorophenol and (4) m-cresol, and having substantially an average molecular weight of 300-600; and said component B being one member selected from the following members (5)-(7); (5) a formaldehyde condensate obtained by reacting formaldehyde with one of 3,5-xylenol, m-t-butylphenol and a mixture of m-cresol with m-t-butylphenol and having substantially an average molecular weight of 200-500, (6) 4,4'-thio-bis(6-t-butyl-3-methylphenol) and (7) 1,1'-bis(2,4-dihydroxyphenyl) disulfide.
摘要翻译：公开了一种具有高粘合强度并且能够将聚酯纤维材料与橡胶牢固结合的粘合剂，其包含A / B比为100 / 5-100 / 30的组分A和B的混合物，所述组分A为（1） - （4）：（1）间苯二酚与间甲酚，间甲氧基苯酚，3,5-二甲苯酚和间二甲苯之一的混合物，（2）5-甲基间苯二酚与间甲酚或间甲氧基苯酚的混合物，（3）间甲酚与对氯苯酚和（4）间甲酚的混合物，其平均分子量基本上为300- 600; 并且所述组分B是选自以下组分（5） - （7）中的一种; （5）通过甲醛与3,5-二甲苯酚，叔丁基苯酚和间甲酚与叔丁基苯酚的混合物反应得到的甲醛缩合物，其平均分子量基本上为200-500，（6）4， 4'-硫代双（6-叔丁基-3-甲基苯酚）和（7）1,1'-双（2,4-二羟基苯基）二硫化物。

2. 发明授权

US4374962A Adhesive for polyester fibrous material 失效
标题翻译：聚酯纤维材料用粘合剂
公开(公告)号：US4374962A
公开(公告)日：1983-02-22
申请号：US366032
申请日：1982-04-06
申请人： Toshihiro Yotsumoto , Kazuo Koyama
发明人： Toshihiro Yotsumoto , Kazuo Koyama
IPC分类号： C08L61/06 , B29D30/40 , C08G8/00 , C08G8/12 , C08G8/20 , C08G8/24 , C08J5/06 , C09J161/06 , D06M15/41 , D06M101/00 , D06M101/16 , D06M101/30 , D06M101/32
CPC分类号： C08J5/06 , C08G8/24 , C08J2321/00 , Y10T428/31786 , Y10T428/31794
摘要： An adhesive comprising a cocondensate of formaldehyde with m-alkylphenol or its derivative and alkylresorcin is excellent in the adhesion, heat resistance and flexibility and can bond firmly polyester fibrous material with rubber.
摘要翻译：包含甲醛与间 - 烷基苯酚或其衍生物和烷基间苯二酚的缩聚物的粘合剂具有优异的粘合性，耐热性和柔软性，并且可以将聚酯纤维材料与橡胶粘结牢固。

3. 发明授权

US4378453A Adhesive for polyester fibrous material 失效
标题翻译：聚酯纤维材料用粘合剂
公开(公告)号：US4378453A
公开(公告)日：1983-03-29
申请号：US366017
申请日：1982-04-06
申请人： Toshihiro Yotsumoto , Kazuo Koyama
发明人： Toshihiro Yotsumoto , Kazuo Koyama
IPC分类号： C08L61/06 , B29D30/40 , C08G8/00 , C08G8/12 , C08G8/20 , C08G8/24 , C09J161/06 , D06M15/41 , D06M101/00 , D06M101/16 , D06M101/30 , D06M101/32 , C08G8/22
CPC分类号： D06M15/41 , Y10T428/31786 , Y10T428/31794
摘要： An adhesive consisting comprising an alkoxyphenol derivative/resorcin derivative/formaldehyde cocondensate has a high adhesive strength and can bond firmly polyester fibrous material with rubber.
摘要翻译：包含烷氧基苯酚衍生物/间苯二酚衍生物/甲醛缩聚物的粘合剂具有高的粘合强度，并且可以用橡胶将牢固的聚酯纤维材料粘合。

4. 发明授权

US08766715B2 Amplifier circuit 有权
标题翻译：放大器电路
公开(公告)号：US08766715B2
公开(公告)日：2014-07-01
申请号：US13511233
申请日：2011-08-29
申请人： Kazuo Koyama
发明人： Kazuo Koyama
IPC分类号： H03F3/45
CPC分类号： H03F3/45475 , H03F3/3022 , H03F3/45183 , H03F3/45928 , H03F2203/45082 , H03F2203/45528
摘要： An amplifier circuit capable of reducing load of a circuit at the previous stage by providing increased input impedance producing less noises. The amplifier circuit includes a fully-differential operational amplifier composed of an inverting input terminal, a non-inverting input terminal receiving a signal different from a signal to be input to the inverting input terminal, an inverting output terminal with the same polarity of the inverting input terminal, and a non-inverting output terminal with reverse polarity; an input impedance element with one end connected to the inverting input terminal; an input impedance element with one end connected to the non-inverting input terminal; and positive feedback impedance elements, with one end of connected to the other end of the input impedance element and the other end connected to the inverting output terminal or to the non-inverting output terminal.
摘要翻译：一种放大器电路，其能够通过提供增加的输入阻抗产生较少的噪声来减小前一电路的负载。放大器电路包括由反相输入端子，非反相输入端子接收与要输入到反相输入端子的信号不同的信号的全差分运算放大器，反相输出端子具有与反相输入端子相同极性的反相输出端子输入端子和反相输出端子; 输入阻抗元件，其一端连接到反相输入端子; 输入阻抗元件，其一端连接到非反相输入端子; 和正反馈阻抗元件，其一端连接到输入阻抗元件的另一端，另一端连接到反相输出端或非反相输出端。

5. 发明申请

US20090286809A1 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 审中-公开
公开(公告)号：US20090286809A1
公开(公告)日：2009-11-19
申请号：US12458891
申请日：2009-07-27
申请人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A61K31/4965 , A61K31/505 , C07D239/02 , C07D237/02 , C07D241/02 , A61K31/50 , A61P25/28
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

6. 发明授权

US07589105B2 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 失效
标题翻译：阿尔茨海默病或淀粉样蛋白原纤维形成抑制剂的预防或补救措施，其包括含氮杂芳基化合物
公开(公告)号：US07589105B2
公开(公告)日：2009-09-15
申请号：US10497183
申请日：2002-11-25
申请人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A01N43/60 , A01N43/42
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by the following general formula or a pharmacologically permitted salt thereof; together with nitrogen-containing heteroaryl derivatives, and pharmacologically permitted salts thereof: where, R1, R2, Z1-Z5, and A are as defined herein.
摘要翻译：提供药物组合物和治疗方法用于治疗淀粉样变性，其含有至少一种由以下通式表示的含氮杂芳基化合物或其药理学允许的盐作为活性成分; 连同含氮杂芳基衍生物及其药理学允许的盐：其中，R1，R2，Z1-Z5和A如本文所定义。

7. 发明授权

US07514475B2 Benzylamine analogues 失效
标题翻译：苄胺类似物
公开(公告)号：US07514475B2
公开(公告)日：2009-04-07
申请号：US11583499
申请日：2006-10-19
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/137 , C07C205/04
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is a C1-C6 alkyl, an amino, a (C1-C6 alkyl)amino, a di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are the same or different and are a hydrogen or a C1-C6 alkyl; Arom is an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl; wherein the substituted aryl is substituted at 1 to 5 positions and the substituted heteroaryl is substituted at 1 to 3 positions; wherein the heteroaryl is furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; and wherein the substituents of the substituted aryl and of the substituted heteroaryl are independently halogen, C1-C6 alkyl, halogeno C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C3 alkylenedioxy, C1-C7 alkanoyl, C2-C7 alkyloxycarbonyl, amino, C1-C7 alkanoylamino, hydroxyl, mercapto, cyano, nitro or carboxyl; A is an ethylene or propylene; Ra is a hydrogen, a C1-C6 alkyl or a C2-C6 alkenyl; E is a single bond, an oxygen, a sulfur or —NR4—, wherein R4 is a hydrogen or a C1-C7 alkanoyl; X1 and X2 are the same or different and are an oxygen or a sulfur, or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R1是C1-C6烷基，氨基，（C1-C6烷基）氨基，二（C1-C6烷基）氨基或含氮饱和杂环; R2和R3相同或不同，为氢或C1-C6烷基; Arom是未取代或取代的芳基或未取代或取代的杂芳基; 其中取代的芳基在1至5个位置被取代，并且取代的杂芳基在1至3个位置被取代; 吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基;其中杂芳基为呋喃基，噻吩基，吡咯基，并且其中取代的芳基和取代的杂芳基的取代基独立地为卤素，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，C 1 -C 3亚烷基二氧基，C 1 -C 7烷酰基， C7烷氧基羰基，氨基，C1-C7烷酰基氨基，羟基，巯基，氰基，硝基或羧基; A是乙烯或丙烯; R a是氢，C 1 -C 6烷基或C 2 -C 6烯基; E是单键，氧，硫或-NR4-，其中R4是氢或C1-C7烷酰基; X1和X2相同或不同，为氧或硫，或其药理学上可接受的盐或酯。

8. 发明申请

US20080255095A1 Benzylamine analogues 审中-公开
标题翻译：苄胺类似物
公开(公告)号：US20080255095A1
公开(公告)日：2008-10-16
申请号：US11820218
申请日：2007-06-18
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/55 , C07D333/22 , C07D215/38 , C07D263/34 , A61K31/50 , A61P25/28 , A61K31/4965 , C07D261/02 , C07D277/00 , C07D275/02
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is C1-C6 alkyl, amino, (C1-C6 alkyl)amino, di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are hydrogen or C1-C6 alkyl; Arom is phenyl, idenyl, napthyl, phenanthrenyl, furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; A is C1-C6 alkylene; Ra is hydrogen, C1-C6 alkyl or C2-C6 alkenyl; E is a single bond, oxygen, sulfur or —NR4—, wherein R4 is hydrogen or C1-C7 alkanoyl; X1 and X2 are oxygen or sulfur; or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R 1是C 1 -C 6烷基，氨基，（C 1）（C 1 -C 6烷基）氨基或含氮饱和杂环基;（C 1 -C 6烷基）氨基， R 2和R 3是氢或C 1 -C 6烷基; 芳基是苯基，烯基，萘基，菲基，呋喃基，噻吩基，吡咯基，氮杂基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基。 A是C 1 -C 6亚烷基; R a是氢，C 1 -C 6烷基或C 2 -C 6烷基或C 2 -C 6 - 链烯基; E是单键，氧，硫或-NR 4 - ，其中R 4是氢或C 1 -C 7 烷酰基; X 1和X 2是氧或硫; 或其药理学上可接受的盐或酯。

9. 发明申请

US20080182846A1 Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 失效
标题翻译：包括含氮杂芳基化合物的阿尔茨海默病或淀粉样蛋白原纤维形成抑制剂的预防或治疗
公开(公告)号：US20080182846A1
公开(公告)日：2008-07-31
申请号：US12068407
申请日：2008-02-06
申请人： Masaki Meguro , Tomichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A61K31/53 , C07D251/18 , A61P25/28
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译：本发明涉及阿尔茨海默病的预防药物或补救剂，或淀粉样蛋白原纤维形成抑制剂，其包括作为活性成分的下列通式（I）的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药理学上允许的盐，其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的，或作为淀粉样蛋白原纤维形成抑制剂：（其中R 1，和R 2是H或烷基; Z 1和Z 2是H，烷基，烷氧基，卤代烷基或卤代; Z 3 烷氧基，SH，烷硫基，NH 2，单或二烷基氨基，OH或卤素; Z 4和Z 5 >为H或卤素; A为4,6-嘧啶-1,3-二基，1,3,5-三嗪-2,6-二基等）。

10. 发明授权

US5965591A Isoxazole derivatives 失效
标题翻译：异恶唑衍生物
公开(公告)号：US5965591A
公开(公告)日：1999-10-12
申请号：US806854
申请日：1997-02-26
申请人： Koichi Kojima , Junichi Sakai , Yuichi Aizawa , Naozumi Samata , Masao Kozuka , Kenji Yoshimi , Isao Kaneko , Kazuo Koyama
发明人： Koichi Kojima , Junichi Sakai , Yuichi Aizawa , Naozumi Samata , Masao Kozuka , Kenji Yoshimi , Isao Kaneko , Kazuo Koyama
IPC分类号： A61K31/42 , A61K31/423 , A61K31/424 , A61K31/44 , A61P25/16 , A61P25/24 , A61P25/28 , C07D261/20 , C07D498/02 , C07D498/04
CPC分类号： C07D261/20
摘要： An isoxazole compound having the following formula: wherein R.sup.1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R.sup.2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.
摘要翻译：具有下式的异恶唑化合物：其中R 1表示氢，卤素，烷基，烷氧基，羟基，烷硫基，氨基，烷酰基，烷酰基氨基，烷酰氧基，烷氧基羰基，羧基，（烷硫基）硫代羰基，氨基甲酰基，硝基或氰基; R2代表氨基; m为1; n为1至6; 环A表示苯环或萘环; X表示氧或硫。异恶唑化合物具有优异的单胺氧化酶抑制活性，可用于治疗帕金森病，抑郁症和阿尔茨海默氏病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式