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1. 发明授权

US07285640B2 Antibody to stem cell factor 失效
标题翻译：干细胞因子的抗体
公开(公告)号：US07285640B2
公开(公告)日：2007-10-23
申请号：US10320231
申请日：2002-12-16
申请人： Toshihiko Takeuchi , Adrian Tomkinson , Steven Neben
发明人： Toshihiko Takeuchi , Adrian Tomkinson , Steven Neben
IPC分类号： C07K16/00
CPC分类号： G01N33/564 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73
摘要： The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.
摘要翻译：本发明提供对含有至少一种衍生自组合抗体文库的CDR的干细胞因子特异性的人抗体。本发明还提供了包含抗体的药物组合物和治疗哮喘的方法。本发明还提供了使用抗体检测干细胞因子的方法。

2. 发明申请

US20050112698A1 Antibody inhibiting stem cell factor activity and use for treatment of asthma 审中-公开
标题翻译：抗体抑制干细胞因子活性和用于治疗哮喘
公开(公告)号：US20050112698A1
公开(公告)日：2005-05-26
申请号：US10867506
申请日：2004-06-14
申请人： Steven Neben , Toshihiko Takeuchi , Adrian Tomkinson , Kathy Delaria , Kelly Yan , Teresa Wong , Malinda Longphre
发明人： Steven Neben , Toshihiko Takeuchi , Adrian Tomkinson , Kathy Delaria , Kelly Yan , Teresa Wong , Malinda Longphre
IPC分类号： C07K16/22 , G01N33/564 , G01N33/53 , C12N5/06 , G01N33/567
CPC分类号： G01N33/564 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73
摘要： The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.
摘要翻译：本发明提供对含有至少一种衍生自组合抗体文库的CDR的干细胞因子特异性的人抗体。本发明还提供了包含抗体的药物组合物和治疗哮喘的方法。本发明还提供了使用抗体检测干细胞因子的方法。

3. 发明授权

US08640568B2 Bicycle shift control device 有权
标题翻译：自行车换档控制装置
公开(公告)号：US08640568B2
公开(公告)日：2014-02-04
申请号：US12554065
申请日：2009-09-04
申请人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
发明人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
IPC分类号： F16C1/10
CPC分类号： B62M25/04 , B62K23/06
摘要： A bicycle shift control device is provided with a shifter housing, a gear shifting mechanism, a shift operating member, and a shift switching arrangement. The gear shifting mechanism is disposed in the shifter housing with the gear shifting mechanism having a plurality of operating positions. The shift operating member is movable with respect to the shifter housing to operate the gear shifting mechanism. The shift switching arrangement includes a restricting member movably mounted with respect to the shifter housing between a non-shift restricting position and a shift restricting position. The gear shifting mechanism moves in a first set of the operating positions when the restricting member is in the non-shift restricting position, and moves in a second set of the operating positions that are different from the first set of the operating positions when the restricting member is in the shift restricting position.
摘要翻译：一种自行车变速控制装置设置有变速器壳体，变速机构，变速操作构件和变速切换装置。变速机构设置在变速器壳体中，变速机构具有多个操作位置。变速操作构件可相对于换档器壳体移动以操作变速机构。变速切换装置包括限制构件，其相对于变速器壳体可移动地安装在非换档限制位置和换档限制位置之间。当限制构件处于非换档限制位置时，变速机构在第一组操作位置中移动，并且当限制构件处于非换挡限制位置时，在与第一组操作位置不同的第二组操作位置中移动会员处于班次限制位置。

4. 发明申请

US20110056319A1 BICYCLE SHIFT CONTROL DEVICE 有权
标题翻译：自行车移动控制装置
公开(公告)号：US20110056319A1
公开(公告)日：2011-03-10
申请号：US12554065
申请日：2009-09-04
申请人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
发明人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
IPC分类号： B62M25/04 , B62M25/00
CPC分类号： B62M25/04 , B62K23/06
摘要： A bicycle shift control device is provided with a shifter housing, a gear shifting mechanism, a shift operating member, and a shift switching arrangement. The gear shifting mechanism is disposed in the shifter housing with the gear shifting mechanism having a plurality of operating positions. The shift operating member is movable with respect to the shifter housing to operate the gear shifting mechanism. The shift switching arrangement includes a restricting member movably mounted with respect to the shifter housing between a non-shift restricting position and a shift restricting position. The gear shifting mechanism moves in a first set of the operating positions when the restricting member is in the non-shift restricting position, and moves in a second set of the operating positions that are different from the first set of the operating positions when the restricting member is in the shift restricting position.
摘要翻译：一种自行车变速控制装置设置有变速器壳体，变速机构，变速操作构件和变速切换装置。变速机构设置在变速器壳体中，变速机构具有多个操作位置。变速操作构件可相对于换档器壳体移动以操作变速机构。变速切换装置包括限制构件，其相对于变速器壳体可移动地安装在非换档限制位置和换档限制位置之间。当限制构件处于非换档限制位置时，变速机构在第一组操作位置中移动，并且当限制构件处于非换挡限制位置时，在与第一组操作位置不同的第二组操作位置中移动会员处于班次限制位置。

5. 外观设计

USD609252S1 Power shovel 有权
标题翻译：电铲
公开(公告)号：USD609252S1
公开(公告)日：2010-02-02
申请号：US29304155
申请日：2008-02-26
申请人： Yoshihide Shimada , Toshihiko Takeuchi
设计人： Yoshihide Shimada , Toshihiko Takeuchi

6. 发明授权

US07227009B2 MT-SP1 polynucleotides and polypeptides 有权
标题翻译： MT-SP1多核苷酸和多肽
公开(公告)号：US07227009B2
公开(公告)日：2007-06-05
申请号：US11253869
申请日：2005-10-18
申请人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： C12N15/11
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

7. 发明授权

US07030231B1 Membrane type serine protease 1 (MT-SP1) and uses thereof 失效
标题翻译：膜型丝氨酸蛋白酶1（MT-SP1）及其用途
公开(公告)号：US07030231B1
公开(公告)日：2006-04-18
申请号：US09410362
申请日：1999-09-30
申请人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： C12N15/11
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

8. 发明授权

US11674240B2 Universal antibody libraries 有权
公开(公告)号：US11674240B2
公开(公告)日：2023-06-13
申请号：US11571710
申请日：2005-07-06
申请人： Roberto Crea , Arvind Rajpal , Guido Cappuccilli , Randy Shen , Toshihiko Takeuchi
发明人： Roberto Crea , Arvind Rajpal , Guido Cappuccilli , Randy Shen , Toshihiko Takeuchi
IPC分类号： C40B40/08 , C07K16/00
CPC分类号： C40B40/08 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622
摘要： Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are derived from naturally-occurring antibodies expressed in response to a certain antigen class (e.g., small molecule, polysaccharide, peptide, or protein) and having CDR regions engineered for optimal diversity. Methods for making and screening such libraries for isolating therapeutics suitable for treating disease are also disclosed.

9. 发明授权

US09732143B2 Methods and materials for enhancing functional protein expression in bacteria 有权
公开(公告)号：US09732143B2
公开(公告)日：2017-08-15
申请号：US13982669
申请日：2012-02-03
申请人： Raphael D. Levy , Chung-Leung Chan , Kiranjit K. Ahluwalia , Toshihiko Takeuchi
发明人： Raphael D. Levy , Chung-Leung Chan , Kiranjit K. Ahluwalia , Toshihiko Takeuchi
IPC分类号： C07K16/00 , C07K14/245 , C12N9/90 , C12N15/67 , C07K14/005
CPC分类号： C07K16/00 , C07K14/005 , C07K14/245 , C07K2319/00 , C07K2319/35 , C12N9/90 , C12N15/67 , C12Y502/01008
摘要： Novel materials and methods useful for expressing heterologous proteins in prokaryotic cells are provided, including prokaryotic cells expressing FkpA and/or Skp.

10. 发明授权

US09550544B2 Bicycle handlebar clamp assembly 有权
标题翻译：自行车把手夹具总成
公开(公告)号：US09550544B2
公开(公告)日：2017-01-24
申请号：US13558862
申请日：2012-07-26
申请人： Toshihiko Takeuchi , Yoshimitsu Miki , Shinya Hirotomi
发明人： Toshihiko Takeuchi , Yoshimitsu Miki , Shinya Hirotomi
IPC分类号： F16B7/04 , B62K23/06 , B62K21/12 , F16B33/00 , F16M13/02
CPC分类号： B62K23/06 , B62K21/12 , F16B7/04 , F16B33/00 , F16M13/02 , Y10T74/20256 , Y10T74/20822
摘要： A bicycle handlebar clamp assembly has a handlebar clamp, a fixing nut, and a fixing bolt. The fixing nut includes a threaded bore having a bolt entrance opening and a bolt exit opening. The fixing nut defines a bolt shaft receiving space disposed adjacent the bolt exit opening. The fixing bolt includes a head and a shaft extending from the head. The shaft has a non-threaded portion disposed between two threaded portions. One of threaded portions is disposed closer to the head of the fixing bolt than the other threaded portion. The threaded portions are dimensioned to threadedly engage the threaded bore of the fixing nut. The non-threaded portion has a axial length that is greater than the axial length of the threaded bore of the fixing nut.
摘要翻译：自行车车把夹具组件具有车把夹，固定螺母和固定螺栓。固定螺母包括具有螺栓入口和螺栓出口的螺纹孔。固定螺母限定了一个邻近螺栓出口开口设置的螺栓轴接纳空间。固定螺栓包括头部和从头部延伸的轴。轴具有设置在两个螺纹部分之间的非螺纹部分。一个螺纹部分设置成比另一个螺纹部分更靠近固定螺栓的头部。螺纹部分的尺寸设计成螺纹接合固定螺母的螺纹孔。非螺纹部分的轴向长度大于固定螺母的螺纹孔的轴向长度。

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