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1. 发明授权

US07227009B2 MT-SP1 polynucleotides and polypeptides 有权
标题翻译： MT-SP1多核苷酸和多肽
公开(公告)号：US07227009B2
公开(公告)日：2007-06-05
申请号：US11253869
申请日：2005-10-18
申请人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： C12N15/11
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

2. 发明授权

US07030231B1 Membrane type serine protease 1 (MT-SP1) and uses thereof 失效
标题翻译：膜型丝氨酸蛋白酶1（MT-SP1）及其用途
公开(公告)号：US07030231B1
公开(公告)日：2006-04-18
申请号：US09410362
申请日：1999-09-30
申请人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： C12N15/11
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

3. 发明申请

US20090155248A1 Antibodies to MT-SP1 serine protease 审中-公开
标题翻译： MT-SP1丝氨酸蛋白酶的抗体
公开(公告)号：US20090155248A1
公开(公告)日：2009-06-18
申请号：US12014067
申请日：2008-01-14
申请人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles S. Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： A61K39/395 , C07K16/00 , C12N1/00 , G01N33/573 , A61P35/00
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

4. 发明申请

US20080051559A1 MT-SP1 polypeptides 审中-公开
标题翻译： MT-SP1多肽
公开(公告)号：US20080051559A1
公开(公告)日：2008-02-28
申请号：US11669725
申请日：2007-01-31
申请人： Charles Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： C07K16/00
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

5. 发明申请

US20060104979A1 MT-SP1 POLYNUCLEOTIDES AND POLYPEPTIDES 有权
标题翻译： MT-SP1多核苷酸和多肽
公开(公告)号：US20060104979A1
公开(公告)日：2006-05-18
申请号：US11253869
申请日：2005-10-18
申请人： Charles Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

6. 发明申请

US20060099625A1 MT-SP1 serine protease 审中-公开
标题翻译： MT-SP1丝氨酸蛋白酶
公开(公告)号：US20060099625A1
公开(公告)日：2006-05-11
申请号：US11254185
申请日：2005-10-18
申请人： Charles Craik , Toshihiko Takeuchi , Marc Shuman
发明人： Charles Craik , Toshihiko Takeuchi , Marc Shuman
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N9/64 , C07K16/40 , C40B40/10
CPC分类号： C12N9/6408
摘要： This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译：本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶（称为MT-SP1），其表达升高。在一个实施方案中，本发明提供了获得预后或在生物体中检测或分期癌症的方法。该方法包括从生物体提供生物样品，并检测样品中膜型丝氨酸蛋白酶1（MT-SP1）的水平，其中与蛋白酶水平相比，膜型丝氨酸蛋白酶水平升高来自正常健康生物体的生物样品表明癌症的存在或阶段。

7. 发明授权

US08640568B2 Bicycle shift control device 有权
标题翻译：自行车换档控制装置
公开(公告)号：US08640568B2
公开(公告)日：2014-02-04
申请号：US12554065
申请日：2009-09-04
申请人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
发明人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
IPC分类号： F16C1/10
CPC分类号： B62M25/04 , B62K23/06
摘要： A bicycle shift control device is provided with a shifter housing, a gear shifting mechanism, a shift operating member, and a shift switching arrangement. The gear shifting mechanism is disposed in the shifter housing with the gear shifting mechanism having a plurality of operating positions. The shift operating member is movable with respect to the shifter housing to operate the gear shifting mechanism. The shift switching arrangement includes a restricting member movably mounted with respect to the shifter housing between a non-shift restricting position and a shift restricting position. The gear shifting mechanism moves in a first set of the operating positions when the restricting member is in the non-shift restricting position, and moves in a second set of the operating positions that are different from the first set of the operating positions when the restricting member is in the shift restricting position.
摘要翻译：一种自行车变速控制装置设置有变速器壳体，变速机构，变速操作构件和变速切换装置。变速机构设置在变速器壳体中，变速机构具有多个操作位置。变速操作构件可相对于换档器壳体移动以操作变速机构。变速切换装置包括限制构件，其相对于变速器壳体可移动地安装在非换档限制位置和换档限制位置之间。当限制构件处于非换档限制位置时，变速机构在第一组操作位置中移动，并且当限制构件处于非换挡限制位置时，在与第一组操作位置不同的第二组操作位置中移动会员处于班次限制位置。

8. 发明申请

US20110056319A1 BICYCLE SHIFT CONTROL DEVICE 有权
标题翻译：自行车移动控制装置
公开(公告)号：US20110056319A1
公开(公告)日：2011-03-10
申请号：US12554065
申请日：2009-09-04
申请人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
发明人： Toshihiko Takeuchi , Kazutaka Fukao , Yoshimitsu Miki
IPC分类号： B62M25/04 , B62M25/00
CPC分类号： B62M25/04 , B62K23/06
摘要： A bicycle shift control device is provided with a shifter housing, a gear shifting mechanism, a shift operating member, and a shift switching arrangement. The gear shifting mechanism is disposed in the shifter housing with the gear shifting mechanism having a plurality of operating positions. The shift operating member is movable with respect to the shifter housing to operate the gear shifting mechanism. The shift switching arrangement includes a restricting member movably mounted with respect to the shifter housing between a non-shift restricting position and a shift restricting position. The gear shifting mechanism moves in a first set of the operating positions when the restricting member is in the non-shift restricting position, and moves in a second set of the operating positions that are different from the first set of the operating positions when the restricting member is in the shift restricting position.
摘要翻译：一种自行车变速控制装置设置有变速器壳体，变速机构，变速操作构件和变速切换装置。变速机构设置在变速器壳体中，变速机构具有多个操作位置。变速操作构件可相对于换档器壳体移动以操作变速机构。变速切换装置包括限制构件，其相对于变速器壳体可移动地安装在非换档限制位置和换档限制位置之间。当限制构件处于非换档限制位置时，变速机构在第一组操作位置中移动，并且当限制构件处于非换挡限制位置时，在与第一组操作位置不同的第二组操作位置中移动会员处于班次限制位置。

9. 外观设计

USD609252S1 Power shovel 有权
标题翻译：电铲
公开(公告)号：USD609252S1
公开(公告)日：2010-02-02
申请号：US29304155
申请日：2008-02-26
申请人： Yoshihide Shimada , Toshihiko Takeuchi
设计人： Yoshihide Shimada , Toshihiko Takeuchi

10. 发明授权

US09815691B2 Method for manufacturing graphene-coated object, negative electrode of secondary battery including graphene-coated object, and secondary battery including the negative electrode 有权
公开(公告)号：US09815691B2
公开(公告)日：2017-11-14
申请号：US13586126
申请日：2012-08-15
申请人： Teppei Oguni , Takeshi Osada , Toshihiko Takeuchi
发明人： Teppei Oguni , Takeshi Osada , Toshihiko Takeuchi
IPC分类号： H01M4/64 , B82Y30/00 , C25D13/02 , H01M4/04 , H01M4/13 , H01M4/133 , H01M4/134 , H01M4/139 , H01M4/1393 , H01M4/1395 , H01M4/36 , H01M4/587 , H01M10/0525 , C25D13/22 , H01M4/02
CPC分类号： B82Y30/00 , C25D13/02 , C25D13/22 , H01M4/0416 , H01M4/0452 , H01M4/13 , H01M4/133 , H01M4/134 , H01M4/139 , H01M4/1393 , H01M4/1395 , H01M4/366 , H01M4/587 , H01M10/0525 , H01M2004/027
摘要： To form graphene to a practically even thickness on an object having an uneven surface or a complex surface, in particular, an object having a surface with a three-dimensional structure due to complex unevenness, or an object having a curved surface. The object and an electrode are immersed in a graphene oxide solution, and voltage is applied between the object and the electrode. At this time, the object serves as an anode. Graphene oxide is attracted to the anode because of being negatively charged, and deposited on the surface of the object to have a practically even thickness. A portion where graphene oxide is deposited is unlikely coated with another graphene oxide. Thus, deposited graphene oxide is reduced to graphene, whereby graphene can be formed to have a practically even thickness on an object having surface with complex unevenness.

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